Gene Symbol: Drl-2
Description: Derailed 2
Alias: CG12463, CG3915, DNT-like, DRL-2, Dmel\CG3915, dnl, drl-2, derailed 2, CG3915-PB, CG3915-PC, Drl-2-PB, Drl-2-PC, derailed-2, doughnut-like
Species: fruit fly

Top Publications

  1. Harris K, Beckendorf S. Different Wnt signals act through the Frizzled and RYK receptors during Drosophila salivary gland migration. Development. 2007;134:2017-25 pubmed
    ..Our results suggest that both the Wnt4-frizzled pathway and a separate Wnt5-derailed pathway are needed for proper salivary gland migration. ..
  2. Inaki M, Yoshikawa S, Thomas J, Aburatani H, Nose A. Wnt4 is a local repulsive cue that determines synaptic target specificity. Curr Biol. 2007;17:1574-9 pubmed
    ..These results demonstrate an important role for local repulsion in regulating cell-to-cell target specificity. ..
  3. Sakurai M, Aoki T, Yoshikawa S, Santschi L, Saito H, Endo K, et al. Differentially expressed Drl and Drl-2 play opposing roles in Wnt5 signaling during Drosophila olfactory system development. J Neurosci. 2009;29:4972-80 pubmed publisher
    ..These molecules work cooperatively to establish the olfactory circuitry in Drosophila. ..
  4. Fradkin L, Dura J, Noordermeer J. Ryks: new partners for Wnts in the developing and regenerating nervous system. Trends Neurosci. 2010;33:84-92 pubmed publisher
    ..Recent findings that injury-induced Wnt/Ryk pathway activation inhibits axon regeneration underscore the importance of further understanding this novel pathway. ..
  5. Park S, Schwartz Y, Kahn T, Asker D, Pirrotta V. Regulation of Polycomb group genes Psc and Su(z)2 in Drosophila melanogaster. Mech Dev. 2012;128:536-47 pubmed publisher
    ..Deletion of one of these regions results in extension of the domain of H3K27me3 into a region containing other genes, whose expression becomes silenced in the early embryo. ..
  6. Morillo Prado J, Chen X, Fuller M. Polycomb group genes Psc and Su(z)2 maintain somatic stem cell identity and activity in Drosophila. PLoS ONE. 2012;7:e52892 pubmed publisher
    ..Furthermore, we show that tumorigenesis in the CySC lineage interferes non-cell autonomously with maintenance of GSCs most likely by displacing them from their niche. ..
  7. Cridland J, Macdonald S, Long A, Thornton K. Abundance and distribution of transposable elements in two Drosophila QTL mapping resources. Mol Biol Evol. 2013;30:2311-27 pubmed publisher
    ..Our data suggest that "burden tests" that test for the effect of TEs as a class may be more fruitful. ..
  8. Lahaye L, Wouda R, de Jong A, Fradkin L, Noordermeer J. WNT5 interacts with the Ryk receptors doughnut and derailed to mediate muscle attachment site selection in Drosophila melanogaster. PLoS ONE. 2012;7:e32297 pubmed publisher
    ..These results extend previous findings that at least some of the molecular pathways that guide axons towards their targets are also employed for guidance of muscle fibers to their appropriate attachment sites. ..
  9. Sopko R, Perrimon N. Receptor tyrosine kinases in Drosophila development. Cold Spring Harb Perspect Biol. 2013;5: pubmed publisher
    ..In this comprehensive review, we summarize what is known regarding each receptor tyrosine kinase during Drosophila development. Astonishingly, very little is known for approximately half of all Drosophila receptor tyrosine kinases. ..

More Information


  1. Petrova I, Lahaye L, Martiáñez T, de Jong A, Malessy M, Verhaagen J, et al. Homodimerization of the Wnt receptor DERAILED recruits the Src family kinase SRC64B. Mol Cell Biol. 2013;33:4116-27 pubmed publisher
  2. Reynaud E, Lahaye L, Boulanger A, Petrova I, Marquilly C, Flandre A, et al. Guidance of Drosophila Mushroom Body Axons Depends upon DRL-Wnt Receptor Cleavage in the Brain Dorsomedial Lineage Precursors. Cell Rep. 2015;11:1293-304 pubmed publisher
    ..Thus, the interaction of MB-extrinsic and -intrinsic Ryks via their common ligand acts to guide MB α axons. ..
  3. Yasunaga K, Tezuka A, Ishikawa N, Dairyo Y, Togashi K, Koizumi H, et al. Adult Drosophila sensory neurons specify dendritic territories independently of dendritic contacts through the Wnt5-Drl signaling pathway. Genes Dev. 2015;29:1763-75 pubmed publisher
  4. Li X, Wang Y, Wang H, Liu T, Guo J, Yi W, et al. Epithelia-derived wingless regulates dendrite directional growth of drosophila ddaE neuron through the Fz-Fmi-Dsh-Rac1 pathway. Mol Brain. 2016;9:46 pubmed publisher
    ..Thus, our findings provide strong in vivo evidence on how environmental signals serve as spatial cues for dendrite patterning. ..