DptB

Summary

Gene Symbol: DptB
Description: Diptericin B
Alias: 147473_at, BcDNA:RH29451, CG10794, DiptB, Diptericin, Dmel\CG10794, dpt B, dptlp, CG10794-PA, Diptericin-B, DiptericinB, DptB-PA, diptercin B, diptericin, diptericin B, diptericin-like protein
Species: fruit fly

Top Publications

  1. ncbi Diptericin-like protein: an immune response gene regulated by the anti-bacterial gene induction pathway in Drosophila
    J H Lee
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Kusong Dong, Yusong, Taejon 305 701, South Korea
    Gene 271:233-8. 2001
  2. pmc Pathogenesis of listeria-infected Drosophila wntD mutants is associated with elevated levels of the novel immunity gene edin
    Michael D Gordon
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Pathog 4:e1000111. 2008
  3. pmc Effective but costly, evolved mechanisms of defense against a virulent opportunistic pathogen in Drosophila melanogaster
    Yixin H Ye
    School of Biological Sciences, The University of Queensland, St Lucia, Queensland, Australia
    PLoS Pathog 5:e1000385. 2009
  4. ncbi Pirk is a negative regulator of the Drosophila Imd pathway
    Anni Kleino
    Institute of Medical Technology, University of Tampere, Finland
    J Immunol 180:5413-22. 2008
  5. pmc Comparative profiling of the transcriptional response to infection in two species of Drosophila by short-read cDNA sequencing
    Timothy B Sackton
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    BMC Genomics 10:259. 2009
  6. pmc Genetic variation in Drosophila melanogaster resistance to infection: a comparison across bacteria
    Brian P Lazzaro
    Department of Entomology, Field of Ecology and Evolutionary Biology, Cornell University, Ithaca, New York 14853, USA
    Genetics 174:1539-54. 2006
  7. ncbi Genetic basis of natural variation in D. melanogaster antibacterial immunity
    Brian P Lazzaro
    Department of Entomology, 4138 Comstock Hall, Cornell University, Ithaca, NY 14853, USA
    Science 303:1873-6. 2004
  8. ncbi Identification of new immune induced molecules in the haemolymph of Drosophila melanogaster by 2D-nanoLC MS/MS
    Peter Verleyen
    Laboratory of Developmental Physiology, Genomics and Proteomics, K U Leuven, Naamsestraat 59, B 3000 Leuven, Belgium
    J Insect Physiol 52:379-88. 2006
  9. pmc The relative importance of innate immune priming in Wolbachia-mediated dengue interference
    Edwige Rancès
    School of Biological Sciences, Monash University, Clayton, Australia
    PLoS Pathog 8:e1002548. 2012
  10. pmc Epigenetic effects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual conflict
    Bernardo Lemos
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 107:15826-31. 2010

Scientific Experts

  • BRIAN LAZZARO
  • Bernardo Lemos
  • Elizabeth A McGraw
  • Peter Verleyen
  • Timothy B Sackton
  • Yixin H Ye
  • Leena Maija Vanha-Aho
  • Mika Ramet
  • Susanna Valanne
  • Dan Hultmark
  • Anni Kleino
  • Zhijing Huang
  • Christopher J Sampson
  • Edwige Rancès
  • W Cheng
  • Zhee Sheen Wong
  • Huiwen W Zhao
  • Johanna Ulvila
  • Madeleine G Moule
  • Keetae Kim
  • Deniz Erturk-Hasdemir
  • David S Schneider
  • Zhiguo Feng
  • Michael D Gordon
  • Theodore Tsichritzis
  • Elena V Domanitskaya
  • Feng Liu
  • Caroline R Craig
  • Guang Ho Cha
  • Richard W Hardy
  • Vasanthi Avadhanula
  • Megan B Kingsolver
  • Bettina Wilke
  • Michael J Williams
  • Marie Odile Fauvarque
  • Meri Kaustio
  • J H Lee
  • SCOTT L O'NEILL
  • Megan Woolfit
  • Lauren M Hedges
  • Karyn N Johnson
  • J Chen
  • D Li
  • H Zhou
  • Jeremy C Brownlie
  • C Song
  • K M Anjum
  • W Wang
  • M Chen
  • Gabriel G Haddad
  • Yongkyu Park
  • Dan Zhou
  • Denise M Monack
  • Victor Nizet
  • M Hedengren
  • Yuh Ru Lin
  • Meike Broemer
  • François Leulier
  • Yanjiao Li
  • ZhengWang Chen
  • Svenja Stoven
  • Chan Hee Kim
  • Pascal Meier
  • Daye Hwang
  • Muya Shu
  • Huijuan Liu
  • Stephen F Chenoweth
  • William S Lane
  • Neal Silverman
  • Nicholas Paquette
  • Jun Lang
  • Jenni Kallio
  • Roel Nusse
  • Kaisa Oksanen
  • Henna Myllymäki
  • Janelle S Ayres
  • Eric Kubli
  • Petros Ligoxygakis
  • Anthony E Brown
  • Huanfa Liu
  • Shanjun Chen
  • George Mosialos
  • Stylianos Kosmidis
  • Peer C Gaentzsch
  • EFTHIMIOS M SKOULAKIS
  • Geert Wets
  • Geert Baggerman
  • Liliane Schoofs
  • Wannes D'Hertog
  • Y Tony Ip

Detail Information

Publications27

  1. ncbi Diptericin-like protein: an immune response gene regulated by the anti-bacterial gene induction pathway in Drosophila
    J H Lee
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Kusong Dong, Yusong, Taejon 305 701, South Korea
    Gene 271:233-8. 2001
    Insects produce various anti-microbial peptides in response to injury and infection. In Drosophila, diptericin has previously been studied as an anti-bacterial immune response gene...
  2. pmc Pathogenesis of listeria-infected Drosophila wntD mutants is associated with elevated levels of the novel immunity gene edin
    Michael D Gordon
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Pathog 4:e1000111. 2008
    ..These results are consistent with a model in which the regulation of host factors, including edin, must be tightly controlled to avoid the detrimental consequences of having too much or too little activity...
  3. pmc Effective but costly, evolved mechanisms of defense against a virulent opportunistic pathogen in Drosophila melanogaster
    Yixin H Ye
    School of Biological Sciences, The University of Queensland, St Lucia, Queensland, Australia
    PLoS Pathog 5:e1000385. 2009
    ..aeruginosa infection than previously reported. This work reveals novel pathways by which Drosophila can survive infection with a virulent pathogen that may be rare in wild populations, however, due to their cost...
  4. ncbi Pirk is a negative regulator of the Drosophila Imd pathway
    Anni Kleino
    Institute of Medical Technology, University of Tampere, Finland
    J Immunol 180:5413-22. 2008
    ..Furthermore, pirk-overexpressing flies were more susceptible to Gram-negative bacterial infection than wild-type flies. We conclude that Pirk is a negative regulator of the Imd pathway...
  5. pmc Comparative profiling of the transcriptional response to infection in two species of Drosophila by short-read cDNA sequencing
    Timothy B Sackton
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    BMC Genomics 10:259. 2009
    ..However, limited functional annotation in non-model systems has hindered understanding of evolutionary novelties in the insect innate immune system...
  6. pmc Genetic variation in Drosophila melanogaster resistance to infection: a comparison across bacteria
    Brian P Lazzaro
    Department of Entomology, Field of Ecology and Evolutionary Biology, Cornell University, Ithaca, New York 14853, USA
    Genetics 174:1539-54. 2006
    ..lactis and E. faecalis, respectively, most of the molecular polymorphisms tested explain <10% of the total variance in bacterial load sustained after infection...
  7. ncbi Genetic basis of natural variation in D. melanogaster antibacterial immunity
    Brian P Lazzaro
    Department of Entomology, 4138 Comstock Hall, Cornell University, Ithaca, NY 14853, USA
    Science 303:1873-6. 2004
    ..Variation in these genes, therefore, seems to drive variability in immunocompetence among wild Drosophila...
  8. ncbi Identification of new immune induced molecules in the haemolymph of Drosophila melanogaster by 2D-nanoLC MS/MS
    Peter Verleyen
    Laboratory of Developmental Physiology, Genomics and Proteomics, K U Leuven, Naamsestraat 59, B 3000 Leuven, Belgium
    J Insect Physiol 52:379-88. 2006
    ..Many of the identified peptides are post-translationally modified by an N-terminal pyroglutamic acid and/or a C-terminal amide. Haemolymph of control larvae was treated in the same way and revealed only one peptide...
  9. pmc The relative importance of innate immune priming in Wolbachia-mediated dengue interference
    Edwige Rancès
    School of Biological Sciences, Monash University, Clayton, Australia
    PLoS Pathog 8:e1002548. 2012
    ....
  10. pmc Epigenetic effects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual conflict
    Bernardo Lemos
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 107:15826-31. 2010
    ....
  11. doi Enhancement of stress resistances and downregulation of Imd pathway by lower developmental temperature in Drosophila melanogaster
    Keetae Kim
    Department of Cell Biology and Molecular Medicine, UMDNJ New Jersey Medical School, Newark, NJ 07103, United States
    Exp Gerontol 45:984-7. 2010
    ..We also showed that development at a lower temperature represented by 18°C significantly downregulates anti-microbial peptide genes, AttA and DptB, of Imd pathway.
  12. pmc Reciprocal analysis of Francisella novicida infections of a Drosophila melanogaster model reveal host-pathogen conflicts mediated by reactive oxygen and imd-regulated innate immune response
    Madeleine G Moule
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Pathog 6:e1001065. 2010
    ..Our work suggests that there may be more to learn about the fly immune system, as not all of the phenotypes we observe can be readily explained by its interactions with known immune responses...
  13. doi The RhoGEF Zizimin-related acts in the Drosophila cellular immune response via the Rho GTPases Rac2 and Cdc42
    Christopher J Sampson
    Institute of Biological and Environmental Sciences, University of Aberdeen, Tillydrone Avenue, Aberdeen, UK
    Dev Comp Immunol 38:160-8. 2012
    ..Finally, Zir is dispensable for the humoral immune response against bacteria. We propose that Zir is necessary to activate the Rho-family GTPases Rac2 and Cdc42 during the Drosophila cellular immune response...
  14. pmc Functional characterization of the infection-inducible peptide Edin in Drosophila melanogaster
    Leena Maija Vanha-Aho
    BioMediTech and Institute of Biomedical Technology, University of Tampere, Tampere, Finland
    PLoS ONE 7:e37153. 2012
    ..faecalis infection via an uncharacterized mechanism. Further studies are still required to elucidate the exact role of Edin in the Drosophila immune response...
  15. doi Coenzyme Q plays opposing roles on bacteria/fungi and viruses in Drosophila innate immunity
    W Cheng
    The Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, Fujian, China
    Int J Immunogenet 38:331-7. 2011
    ..We further showed that CoQ was essential for normal induction of anti-microbial peptides and amplification of viruses. Our work determined CoQ content in Drosophila and described its function in immunity for the first time...
  16. pmc Wolbachia-mediated antibacterial protection and immune gene regulation in Drosophila
    Zhee Sheen Wong
    School of Biological Sciences, The University of Queensland, Brisbane, Queensland, Australia
    PLoS ONE 6:e25430. 2011
    ..are naturally infected with Wolbachia showed no upregulation of the antibacterial immune genes TepIV, Defensin, Diptericin B, PGRP-SD, Cecropin A1 and Attacin D compared to paired flies without Wolbachia...
  17. pmc Adult Drosophila melanogaster evolved for antibacterial defense invest in infection-induced expression of both humoral and cellular immunity genes
    Yixin H Ye
    School of Biological Sciences, Monash University, Melbourne, VIC 3800, Australia
    BMC Res Notes 4:305. 2011
    ..abstract:..
  18. pmc Experimental selection for Drosophila survival in extremely high O2 environments
    Huiwen W Zhao
    Division of Respiratory Medicine, Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 5:e11701. 2010
    ..genes including Tropomyosin 1, Glycerol 3 phosphate dehydrogenase, CG33129, and UGP as well as up-regulation of Diptericin and Attacin conferred tolerance to severe hyperoxia...
  19. pmc An antiviral role for antimicrobial peptides during the arthropod response to alphavirus replication
    Zhijing Huang
    Department of Biology, Indiana University, Bloomington, Indiana, USA
    J Virol 87:4272-80. 2013
    ..We identified two antimicrobial peptide genes, attC and dptB, which are SINrep sensitive and regulated by STAT and Rel, respectively...
  20. ncbi The hydroxyproline motif of male sex peptide elicits the innate immune response in Drosophila females
    Elena V Domanitskaya
    Zoologisches Institut Universität Zürich Irchel, Zurich, Switzerland
    FEBS J 274:5659-68. 2007
    ..We suggest that SP acts by chemical mimicry of sugar components of the bacterial cell wall. Thus, SP may induce the immune system via pattern recognition receptors...
  21. pmc Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes
    Deniz Erturk-Hasdemir
    Division of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 106:9779-84. 2009
    ..Instead they are critical for recruitment of RNA polymerase II and antimicrobial peptide gene induction, whereas IKK functions noncatalytically to support Dredd-mediated cleavage of Relish...
  22. pmc Discrete functions of TRAF1 and TRAF2 in Drosophila melanogaster mediated by c-Jun N-terminal kinase and NF-kappaB-dependent signaling pathways
    Guang Ho Cha
    National Creative Research Initiatives Center for Cell Growth Regulation, and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Kusong Dong, Yusong, Taejon 305 701, Republic of Korea
    Mol Cell Biol 23:7982-91. 2003
    ..NF-kappaBs, DIF and Relish, consequently activating the transcription of the antimicrobial peptide genes diptericin, diptericin-like protein, and drosomycin...
  23. pmc A Drosophila p38 orthologue is required for environmental stress responses
    Caroline R Craig
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8103, Saint Louis, Missouri 63110, USA
    EMBO Rep 5:1058-63. 2004
    ..These phenotypes only partially overlap those caused by mutations in D-MEKK1 and dTAK1, suggesting that the D-p38a gene is required to mediate some, but not all, of the functions ascribed to p38 signalling...
  24. ncbi In silico identification of new secretory peptide genes in Drosophila melanogaster
    Feng Liu
    Laboratory for Developmental Physiology, Genomics, and Proteomics, Katholieke Universiteit Leuven, Naamsestraat 59, B 3000 Leuven, Belgium
    Mol Cell Proteomics 5:510-22. 2006
    ..This bioinformatic study opens perspectives for the genome-wide analysis of peptide genes in other eukaryotic model organisms...
  25. ncbi A Drosophila ortholog of the human cylindromatosis tumor suppressor gene regulates triglyceride content and antibacterial defense
    Theodore Tsichritzis
    Institute of Immunology, Biomedical Sciences Research Center Al Fleming, 34 Al Fleming Street, 16672 Vari, Greece
    Development 134:2605-14. 2007
    ..All mutant phenotypes described were reversible upon conditional expression of CYLD transgenes. Our results implicate CYLD in a broad range of functions associated with fat homeostasis and host defence in Drosophila...
  26. ncbi SK66-his, a novel glycine-rich peptide derived from Drosophila with antibacterial activity
    Zhiguo Feng
    Key Laboratory of Molecular Biophysics, Ministry of Education, Huazhong University of Science and Technology, Wuhan, Hubei, China
    Biosci Biotechnol Biochem 73:769-71. 2009
    ..063 mg/l). It showed significant activity against Gram-positive bacteria. We determined a MIC value of 9 microg ml(-1) with Bacillus thuringiensis...
  27. ncbi Expression and evolution of the Drosophila attacin/diptericin gene family
    M Hedengren
    Umea Centre for Molecular Pathogenesis, Umea University, Umea, S 901 87, Sweden
    Biochem Biophys Res Commun 279:574-81. 2000
    ..the genes for three new glycine-rich antimicrobial peptides in Drosophila, two attacins (AttC and AttD) and one diptericin (DptB)...

Research Grants7

  1. Evolutionary Genomics of Anti-Malaria Genes in Mosquito
    BRIAN LAZZARO; Fiscal Year: 2007
    ..Evolutionary patterns in mosquito defense genes will be used to identify proteins that coevolve with malaria parasites. This work may suggest genetic targets that could be manipulated to limit malaria transmission. ..
  2. Genetic Network Linking Immunity to Energetic Stress, Metabolism and Reproduction
    Brian P Lazzaro; Fiscal Year: 2010
    ..REVISED PUBLIC HEALTH RELEVANCE STATEMENT SECTION Program Director/Principal Investigator (Last, First, Middle): Swain, Susan L. 1R01 AI076534-01A1 NO text ..
  3. Evolutionary Genomics of Anti-Malaria Genes in Mosquito
    Brian P Lazzaro; Fiscal Year: 2010
    ..Evolutionary patterns in mosquito defense genes will be used to identify proteins that coevolve with malaria parasites. This work may suggest genetic targets that could be manipulated to limit malaria transmission. ..