Gene Symbol: dpp
Description: decapentaplegic
Alias: BMP, CG9885, DPP, DPP-C, Dm-DPP, Dmel\CG9885, Dpp, Hin-d, M(2)23AB, M(2)LS1, TGF-b, TGF-beta, TGF-betagr;/SMAD, TGFbeta, blk, l(2)10638, l(2)22Fa, l(2)k17036, shv, decapentaplegic, CG9885-PA, CG9885-PB, CG9885-PC, CG9885-PE, Decapentaplegic/Bone morphogenetic protein, Haplo-insufficient, blink, bone morphogenetic protein, bone morphogenic protein, dpp-PA, dpp-PB, dpp-PC, dpp-PE, heldout, shortvein, tegula
Species: fruit fly

Top Publications

  1. Yavari A, Nagaraj R, Owusu Ansah E, Folick A, Ngo K, Hillman T, et al. Role of lipid metabolism in smoothened derepression in hedgehog signaling. Dev Cell. 2010;19:54-65 pubmed publisher
    ..Taken together, our results suggest a model in which Ptc directly or indirectly functions to suppress the accumulation of PI4P. Binding of Hh to Ptc derepresses the levels of PI4P, which, in turn, promotes Smo activation. ..
  2. Kolahi K, White P, Shreter D, Classen A, Bilder D, Mofrad M. Quantitative analysis of epithelial morphogenesis in Drosophila oogenesis: New insights based on morphometric analysis and mechanical modeling. Dev Biol. 2009;331:129-39 pubmed publisher
    ..We utilize mechanical modeling involving finite element computational technologies to demonstrate that time-varying viscoelastic properties and growth are sufficient to account for the bulk of the FC morphogenetic changes. ..
  3. Martín F, Pérez Garijo A, Morata G. Apoptosis in Drosophila: compensatory proliferation and undead cells. Int J Dev Biol. 2009;53:1341-7 pubmed publisher
    ..These "undead" cells acquire special features, such as the emission of the growth signals Dpp and Wg, changes in cellular morphology and induction of proliferation in neighbouring cells...
  4. Rogulja D, Rauskolb C, Irvine K. Morphogen control of wing growth through the Fat signaling pathway. Dev Cell. 2008;15:309-21 pubmed publisher
    ..We show that the Dpp morphogen gradient in the Drosophila wing influences growth by modulating the activity of the Fat signaling pathway...
  5. Gavin Smyth J, Wang Y, Butler I, Ferguson E. A genetic network conferring canalization to a bistable patterning system in Drosophila. Curr Biol. 2013;23:2296-2302 pubmed publisher
    ..Drosophila blastoderm embryo, staining with antibodies against the active, phosphorylated form of the bone morphogenetic protein (BMP) signal transducer Mad, pMad, or visualization of the spatial pattern of BMP-receptor interactions ..
  6. Roy S, Hsiung F, Kornberg T. Specificity of Drosophila cytonemes for distinct signaling pathways. Science. 2011;332:354-8 pubmed publisher
    ..Cells in wing discs made cytonemes that responded specifically to Decapentaplegic (Dpp) and cells in eye discs made cytonemes that responded specifically to Spitz (the Drosophila epidermal ..
  7. Callejo A, Bilioni A, Mollica E, Gorfinkiel N, Andres G, Ibañez C, et al. Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium. Proc Natl Acad Sci U S A. 2011;108:12591-8 pubmed publisher
    ..We also show that Dlp is needed in Hh-producing cells to allow for Hh release and that Ihog, which has been previously described as an Hh coreceptor, anchors Hh to the basolateral part of the disk epithelium. ..
  8. Mathur D, Bost A, Driver I, Ohlstein B. A transient niche regulates the specification of Drosophila intestinal stem cells. Science. 2010;327:210-3 pubmed publisher
    ..Here, we show that an ISC progenitor generates a niche cell via Notch signaling. This niche uses the bone morphogenetic protein 2/4 homolog, decapentaplegic, to allow progenitors to divide in an undifferentiated state and ..
  9. Schwank G, Restrepo S, Basler K. Growth regulation by Dpp: an essential role for Brinker and a non-essential role for graded signaling levels. Development. 2008;135:4003-13 pubmed publisher
    ..Here we use the model system of the Drosophila wing imaginal disc to address how the patterning signal Decapentaplegic (Dpp) regulates cell proliferation...

More Information


  1. Lawrence P, Struhl G, Casal J. Planar cell polarity: one or two pathways?. Nat Rev Genet. 2007;8:555-63 pubmed
    ..We argue that the prevailing opinion that planar polarity depends on a single genetic pathway is wrong and conclude that there are (at least) two independently acting processes. This conclusion has major consequences for the PCP field. ..
  2. Hufnagel L, Teleman A, Rouault H, Cohen S, Shraiman B. On the mechanism of wing size determination in fly development. Proc Natl Acad Sci U S A. 2007;104:3835-40 pubmed
    ..Here, we present evidence that the decapentaplegic (Dpp) morphogen distribution in the developing Drosophila wing imaginal disk does not adapt to disk size...
  3. Escudero L, Freeman M. Mechanism of G1 arrest in the Drosophila eye imaginal disc. BMC Dev Biol. 2007;7:13 pubmed
    ..This barrier depends on both the primary secreted signals that drive retinal development, Dpp and Hh...
  4. Zahedi B, Shen W, Xu X, Chen X, Mahey M, Harden N. Leading edge-secreted Dpp cooperates with ACK-dependent signaling from the amnioserosa to regulate myosin levels during dorsal closure. Dev Dyn. 2008;237:2936-46 pubmed publisher
    ..b>Dpp signaling is required for the morphogenesis of both tissues, where it promotes transcription of myosin from the ..
  5. Ratnaparkhi G, Jia S, Courey A. Uncoupling dorsal-mediated activation from dorsal-mediated repression in the Drosophila embryo. Development. 2006;133:4409-14 pubmed
    ..axis of the Drosophila embryo by activating genes such as twist and snail and repressing genes such as decapentaplegic and zerknüllt. Dorsal represses transcription by recruiting the co-repressor Groucho...
  6. Bates K, Higley M, Letsou A. Raw mediates antagonism of AP-1 activity in Drosophila. Genetics. 2008;178:1989-2002 pubmed publisher
  7. Martinez A, Schuettengruber B, Sakr S, Janic A, Gonzalez C, Cavalli G. Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling. Nat Genet. 2009;41:1076-82 pubmed publisher
    ..These data show that ph is a tumor suppressor locus that controls cellular proliferation by silencing multiple Notch signaling components. ..
  8. Chen S, Kaneko S, Ma X, Chen X, Ip Y, Xu L, et al. Lissencephaly-1 controls germline stem cell self-renewal through modulating bone morphogenetic protein signaling and niche adhesion. Proc Natl Acad Sci U S A. 2010;107:19939-44 pubmed publisher
    In the Drosophila ovary, bone morphogenetic protein (BMP) signaling activated by the niche promotes germline stem cell (GSC) self-renewal and proliferation, whereas E-cadherin-mediated cell adhesion anchors GSCs in the niche for their ..
  9. Quijano J, Stinchfield M, Newfeld S. Wg signaling via Zw3 and mad restricts self-renewal of sensory organ precursor cells in Drosophila. Genetics. 2011;189:809-24 pubmed publisher
    It is well known that the Dpp signal transducer Mad is activated by phosphorylation at its carboxy-terminus. The role of phosphorylation on other regions of Mad is not as well understood...
  10. Molnar C, Holguin H, Mayor F, Ruiz Gomez A, de Celis J. The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila. Proc Natl Acad Sci U S A. 2007;104:7963-8 pubmed
    ..Interestingly, the expression of Gprk2 in the wing disc is regulated in part by Smo, generating a positive feedback loop that maintains high Smo activity close to the anterior-posterior compartment boundary. ..
  11. Zhang X, Luo D, Pflugfelder G, Shen J. Dpp signaling inhibits proliferation in the Drosophila wing by Omb-dependent regional control of bantam. Development. 2013;140:2917-22 pubmed publisher
    ..The morphogen Dpp has long been considered as a general promoter of cell proliferation during Drosophila wing development...
  12. Bickel D, Shah R, Gesualdi S, Haerry T. Drosophila Follistatin exhibits unique structural modifications and interacts with several TGF-beta family members. Mech Dev. 2008;125:117-29 pubmed
    ..dFS primarily inhibits signaling of Drosophila Activin (dACT) but can also inhibit other ligands like Decapentaplegic (DPP)...
  13. Eivers E, Fuentealba L, Sander V, Clemens J, Hartnett L, De Robertis E. Mad is required for wingless signaling in wing development and segment patterning in Drosophila. PLoS ONE. 2009;4:e6543 pubmed publisher
    ..In this study we investigated the integration of the Drosophila BMP and Wingless/GSK3 signaling pathways via phosphorylations of the transcription factor Mad...
  14. Brooks A, Dou W, Yang X, Brosnan T, Pargett M, Raftery L, et al. BMP signaling in wing development: A critical perspective on quantitative image analysis. FEBS Lett. 2012;586:1942-52 pubmed publisher
    ..Quantitative analyses of BMP gradients are powerful tools to investigate the regulation of BMP signaling pathways during development...
  15. Miles W, Jaffray E, Campbell S, Takeda S, Bayston L, Basu S, et al. Medea SUMOylation restricts the signaling range of the Dpp morphogen in the Drosophila embryo. Genes Dev. 2008;22:2578-90 pubmed publisher
    ..One of the best characterized morphogens is Drosophila Decapentaplegic (Dpp), a BMP signaling molecule that patterns the dorsal ectoderm of the embryo by activating the Mad and ..
  16. Vuilleumier R, Springhorn A, Patterson L, Koidl S, Hammerschmidt M, Affolter M, et al. Control of Dpp morphogen signalling by a secreted feedback regulator. Nat Cell Biol. 2010;12:611-7 pubmed publisher
    ..In the Drosophila melanogaster wing imaginal disc, Decapentaplegic (Dpp), a bone morphogenetic protein (BMP), functions as a long-range morphogen to control patterning and growth...
  17. Kirilly D, Wang S, Xie T. Self-maintained escort cells form a germline stem cell differentiation niche. Development. 2011;138:5087-97 pubmed publisher
    ..disruption of long EC cellular processes and the accumulation of ill-differentiated single germ cells by increasing BMP signaling activity outside the GSC niche, and also causes gradual EC loss...
  18. Wahlström G, Norokorpi H, Heino T. Drosophila alpha-actinin in ovarian follicle cells is regulated by EGFR and Dpp signalling and required for cytoskeletal remodelling. Mech Dev. 2006;123:801-18 pubmed
    ..that this is the result of a negative regulation by combined Epidermal growth factor receptor (EGFR) and Decapentaplegic signalling...
  19. Estella C, Mckay D, Mann R. Molecular integration of wingless, decapentaplegic, and autoregulatory inputs into Distalless during Drosophila leg development. Dev Cell. 2008;14:86-96 pubmed publisher
    The development of the Drosophila leg requires both Decapentaplegic (Dpp) and Wingless (Wg), two signals that establish the proximo-distal (PD) axis by activating target genes such as Distalless (Dll)...
  20. Jia H, Liu Y, Yan W, Jia J. PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation. Development. 2009;136:307-16 pubmed publisher
    ..Taken together, our results suggest that PP4 and PP2A are two phosphatases that act at different positions of the Hh signaling cascade. ..
  21. Guo Z, Driver I, Ohlstein B. Injury-induced BMP signaling negatively regulates Drosophila midgut homeostasis. J Cell Biol. 2013;201:945-61 pubmed publisher
    ..In this paper, we show that the bone morphogenetic protein (BMP) signaling pathway has dual functions during midgut homeostasis...
  22. Aegerter Wilmsen T, Aegerter C, Hafen E, Basler K. Model for the regulation of size in the wing imaginal disc of Drosophila. Mech Dev. 2007;124:318-26 pubmed
    ..Paradoxically, it has been observed that growth occurs uniformly throughout the disc, even though Decapentaplegic (Dpp), a key inducer of growth, forms a gradient...
  23. Akiyama T, Kamimura K, Firkus C, Takeo S, Shimmi O, Nakato H. Dally regulates Dpp morphogen gradient formation by stabilizing Dpp on the cell surface. Dev Biol. 2008;313:408-19 pubmed
    b>Decapentaplegic (Dpp), a Drosophila homologue of bone morphogenetic proteins, acts as a morphogen to regulate patterning along the anterior-posterior axis of the developing wing...
  24. Lindner J, Hillman P, Barrett A, Jackson M, Perry T, Park Y, et al. The Drosophila Perlecan gene trol regulates multiple signaling pathways in different developmental contexts. BMC Dev Biol. 2007;7:121 pubmed
    ..in second instar brains but not third instar brain lobes and eye discs, mutations in trol affect signaling by Decapentaplegic (a Transforming Growth Factor family member), Wingless (a Wnt growth factor) and Hedgehog...
  25. Ramel M, Emery C, Emery C, Foulger R, Goberdhan D, van den Heuvel M, et al. Drosophila SnoN modulates growth and patterning by antagonizing TGF-beta signalling. Mech Dev. 2007;124:304-17 pubmed
    ..in multiple tissues to selectively and cell autonomously antagonise signalling by TGF-beta ligands from both the BMP and Activin sub-families...
  26. Li Z, Zhang Y, Han L, Shi L, Lin X. Trachea-derived dpp controls adult midgut homeostasis in Drosophila. Dev Cell. 2013;24:133-43 pubmed publisher
    ..Here we demonstrate that trachea-derived Decapentaplegic (Dpp), the main bone morphogenetic protein ligand in Drosophila, is essential for adult midgut homeostasis...
  27. De Velasco B, Erclik T, Shy D, Sclafani J, Lipshitz H, McInnes R, et al. Specification and development of the pars intercerebralis and pars lateralis, neuroendocrine command centers in the Drosophila brain. Dev Biol. 2007;302:309-23 pubmed
    ..NSCs of the PL can be followed throughout development by their expression of the adhesion molecule FasII. Decapentaplegic (Dpp), secreted along the dorsal midline of the early embryo, inhibits the formation of the PI and PL ..
  28. Pérez Garijo A, Shlevkov E, Morata G. The role of Dpp and Wg in compensatory proliferation and in the formation of hyperplastic overgrowths caused by apoptotic cells in the Drosophila wing disc. Development. 2009;136:1169-77 pubmed publisher
    ..The finding that apoptotic cells ectopically express dpp and wg suggested that ectopic Dpp/Wg signalling might be responsible for compensatory proliferation...
  29. Suzanne M, Steller H. Shaping organisms with apoptosis. Cell Death Differ. 2013;20:669-75 pubmed publisher
    ..In this review, we will focus exclusively on developmental cell death by apoptosis and its role in tissue remodeling. ..
  30. Wada A, Kato K, Uwo M, Yonemura S, Hayashi S. Specialized extraembryonic cells connect embryonic and extraembryonic epidermis in response to Dpp during dorsal closure in Drosophila. Dev Biol. 2007;301:340-9 pubmed
    ..The secreted signaling molecule Dpp is expressed in the leading edge of the dorsal epidermis and is essential for dorsal closure...
  31. Holmqvist P, Boija A, Philip P, Crona F, Stenberg P, Mannervik M. Preferential genome targeting of the CBP co-activator by Rel and Smad proteins in early Drosophila melanogaster embryos. PLoS Genet. 2012;8:e1002769 pubmed publisher
    ..CBP peaks in mutant embryos lacking nuclear Dorsal are best correlated with TGF-ß/Dpp-signaling and Smad-protein binding...
  32. Chen J, Honeyager S, Schleede J, Avanesov A, Laughon A, Blair S. Crossveinless d is a vitellogenin-like lipoprotein that binds BMPs and HSPGs, and is required for normal BMP signaling in the Drosophila wing. Development. 2012;139:2170-6 pubmed publisher
    The sensitivity of the posterior crossvein in the pupal wing of Drosophila to reductions in the levels and range of BMP signaling has been used to isolate and characterize novel regulators of this pathway...
  33. Smith Bolton R, Worley M, Kanda H, Hariharan I. Regenerative growth in Drosophila imaginal discs is regulated by Wingless and Myc. Dev Cell. 2009;16:797-809 pubmed publisher
    ..This system is conducive to forward genetic screens, enabling an unbiased search for genes that regulate both the extent of and the capacity for regeneration. ..
  34. Zhou Q, Kalderon D. Hedgehog activates fused through phosphorylation to elicit a full spectrum of pathway responses. Dev Cell. 2011;20:802-14 pubmed publisher
    ..In this model, Smo acts like many transmembrane receptors associated with cytoplasmic kinases, such that pathway activation is mediated by kinase oligomerization and trans-phosphorylation. ..
  35. Manjón C, Sánchez Herrero E, Suzanne M. Sharp boundaries of Dpp signalling trigger local cell death required for Drosophila leg morphogenesis. Nat Cell Biol. 2007;9:57-63 pubmed
    ..In the Drosophila wing disc, the transforming growth factor beta (TGFbeta) homologue Decapentaplegic (Dpp) forms a smooth gradient and specifies cell fate by conferring a defined value of morphogen activity...
  36. Umulis D, Shimmi O, O Connor M, Othmer H. Organism-scale modeling of early Drosophila patterning via bone morphogenetic proteins. Dev Cell. 2010;18:260-74 pubmed publisher
    ..Here, we develop a data-driven, geometrically accurate model of early Drosophila embryonic bone morphogenetic protein (BMP)-mediated patterning...
  37. Raisin S, Ruel L, Ranieri N, Staccini Lavenant L, Thérond P. Dynamic phosphorylation of the kinesin Costal-2 in vivo reveals requirement of fused kinase activity for all levels of hedgehog signalling. Dev Biol. 2010;344:119-28 pubmed publisher
    ..Therefore, we propose that the extracellular Hh information is conveyed to an intracellular signal through graded Fu kinase activity. ..
  38. Szuperák M, Salah S, Meyer E, Nagarajan U, Ikmi A, Gibson M. Feedback regulation of Drosophila BMP signaling by the novel extracellular protein larval translucida. Development. 2011;138:715-24 pubmed publisher
    The cellular response to the Drosophila BMP 2/4-like ligand Decapentaplegic (DPP) serves as one of the best-studied models for understanding the long-range control of tissue growth and pattern formation during animal development...
  39. Eugster C, Panàkovà D, Mahmoud A, Eaton S. Lipoprotein-heparan sulfate interactions in the Hh pathway. Dev Cell. 2007;13:57-71 pubmed
    ..They further suggest that the complement of proteins present on lipoprotein particles can regulate the activity of morphogens. ..
  40. Li H, Qi Y, Jasper H. Dpp signaling determines regional stem cell identity in the regenerating adult Drosophila gastrointestinal tract. Cell Rep. 2013;4:10-8 pubmed publisher
    ..Here, we identify a role for the BMP-like Dpp signaling pathway in diversifying regenerative processes in the adult gastrointestinal tract of Drosophila...
  41. Cruz C, Glavic A, Casado M, de Celis J. A gain-of-function screen identifying genes required for growth and pattern formation of the Drosophila melanogaster wing. Genetics. 2009;183:1005-26 pubmed publisher
    ..Finally, we present a preliminary characterization of a gene identified in the screen, the function of which is required for the development of the L5 longitudinal vein. ..
  42. Crickmore M, Mann R. Hox control of morphogen mobility and organ development through regulation of glypican expression. Development. 2007;134:327-34 pubmed
    ..We also show that one molecular consequence of dally repression in the posterior haltere is to reduce Dpp diffusion into and through the P compartment...
  43. Shravage B, Altmann G, Technau M, Roth S. The role of Dpp and its inhibitors during eggshell patterning in Drosophila. Development. 2007;134:2261-71 pubmed
    ..action of the epidermal growth factor [EGF; Gurken (Grk)] and transforming growth factor beta [TGF-beta; Decapentaplegic (Dpp)] signaling cascades...
  44. Widmann T, Dahmann C. Dpp signaling promotes the cuboidal-to-columnar shape transition of Drosophila wing disc epithelia by regulating Rho1. J Cell Sci. 2009;122:1362-73 pubmed publisher
    ..Here, we show that the onset of TGFbeta/Dpp signaling activity correlates with the transition from cuboidal to columnar cell shape in developing ..
  45. Braid L, Verheyen E. Drosophila nemo promotes eye specification directed by the retinal determination gene network. Genetics. 2008;180:283-99 pubmed publisher
    ..Together, our genetic analyses reveal that nmo promotes normal and ectopic eye development directed by the RDGN. ..
  46. Haley B, Hendrix D, Trang V, Levine M. A simplified miRNA-based gene silencing method for Drosophila melanogaster. Dev Biol. 2008;321:482-90 pubmed publisher
    ..As proof of concept, this method was used for the efficient silencing of dpp gene activity in the adult wing, and the analysis of the general RNA Polymerase II (Pol II) elongation factor, Nelf-..
  47. Malpel S, Claret S, Sanial M, Brigui A, Piolot T, Daviet L, et al. The last 59 amino acids of Smoothened cytoplasmic tail directly bind the protein kinase Fused and negatively regulate the Hedgehog pathway. Dev Biol. 2007;303:121-33 pubmed
    ..We propose that FU could act as a switch, activator in presence of HH signal or inhibitor in absence of HH. ..
  48. Kicheva A, Pantazis P, Bollenbach T, Kalaidzidis Y, Bittig T, Jülicher F, et al. Kinetics of morphogen gradient formation. Science. 2007;315:521-5 pubmed
    In the developing fly wing, secreted morphogens such as Decapentaplegic (Dpp) and Wingless (Wg) form gradients of concentration providing positional information. Dpp forms a longer-range gradient than Wg...
  49. Ogiso Y, Tsuneizumi K, Masuda N, Sato M, Tabata T. Robustness of the Dpp morphogen activity gradient depends on negative feedback regulation by the inhibitory Smad, Dad. Dev Growth Differ. 2011;53:668-78 pubmed publisher
    ..In this report, we examine the robustness of the Decapentaplegic (Dpp) (a Drosophila homologue of bone morphogenetic protein [BMP]) activity gradient in the presence of fluctuations in Dpp receptor levels...
  50. Eade K, Allan D. Neuronal phenotype in the mature nervous system is maintained by persistent retrograde bone morphogenetic protein signaling. J Neurosci. 2009;29:3852-64 pubmed publisher
    ..Previously, we demonstrated that retrograde bone morphogenetic protein (BMP) signaling induces expression of a phenotypic marker of Drosophila Tv neurons, the neuropeptide ..
  51. Fuller M, Spradling A. Male and female Drosophila germline stem cells: two versions of immortality. Science. 2007;316:402-4 pubmed
    ..Comparing these two stem cells and their niches in detail is likely to reveal how a common heritage has been adapted to the differing requirements of male and female gamete production. ..
  52. Wang L, Li Z, Cai Y. The JAK/STAT pathway positively regulates DPP signaling in the Drosophila germline stem cell niche. J Cell Biol. 2008;180:721-8 pubmed publisher
    ..In the Drosophila female germline stem cell (GSC) niche, Decapentaplegic (DPP) is an important niche factor for GSC self-renewal...
  53. Ni J, Liu L, Binari R, Hardy R, Shim H, Cavallaro A, et al. A Drosophila resource of transgenic RNAi lines for neurogenetics. Genetics. 2009;182:1089-100 pubmed publisher
  54. Umemori M, Takemura M, Maeda K, Ohba K, Adachi Yamada T. Drosophila T-box transcription factor Optomotor-blind prevents pathological folding and local overgrowth in wing epithelium through confining Hh signal. Dev Biol. 2007;308:68-81 pubmed
    ..focus on the Drosophila T-box gene optomotor-blind (omb), a transcriptional target of a long-range morphogen Decapentaplegic (Dpp)...
  55. Serpe M, Umulis D, Ralston A, Chen J, Olson D, Avanesov A, et al. The BMP-binding protein Crossveinless 2 is a short-range, concentration-dependent, biphasic modulator of BMP signaling in Drosophila. Dev Cell. 2008;14:940-53 pubmed publisher
    In Drosophila, the secreted BMP-binding protein Short gastrulation (Sog) inhibits signaling by sequestering BMPs from receptors, but enhances signaling by transporting BMPs through tissues...
  56. Yao L, Phin S, Cho J, Rushlow C, Arora K, Warrior R. Multiple modular promoter elements drive graded brinker expression in response to the Dpp morphogen gradient. Development. 2008;135:2183-92 pubmed publisher
    ..In Drosophila, Decapentaplegic (Dpp), the BMP2/4 homolog, downregulates transcription of the nuclear repressor brinker (brk) in a ..
  57. Gallet A, Staccini Lavenant L, Therond P. Cellular trafficking of the glypican Dally-like is required for full-strength Hedgehog signaling and wingless transcytosis. Dev Cell. 2008;14:712-25 pubmed publisher
    ..Thus, Dlp endocytosis is a common regulatory mechanism of both Hh and Wg morphogen action. ..
  58. Pfleger C, Harvey K, Yan H, Hariharan I. Mutation of the gene encoding the ubiquitin activating enzyme ubal causes tissue overgrowth in Drosophila. Fly (Austin). 2007;1:95-105 pubmed
    ..Our studies show that a reduction in E1 activity can promote tissue growth in a multicellular organism and raise the possibility that changes in E1 activity may occur during normal development or in cancer. ..
  59. Parker D, White M, Ramos A, Cohen B, Barolo S. The cis-regulatory logic of Hedgehog gradient responses: key roles for gli binding affinity, competition, and cooperativity. Sci Signal. 2011;4:ra38 pubmed publisher
    ..that low-affinity binding sites for Ci were required for proper spatial expression of the Hh target gene decapentaplegic (dpp) in regions of low Hh signal...
  60. Zhao R, Xuan Y, Li X, Xi R. Age-related changes of germline stem cell activity, niche signaling activity and egg production in Drosophila. Aging Cell. 2008;7:344-54 pubmed publisher
    ..that germline stem cell (GSC) division rate progressively declines with age, which is accompanied by reduced decapentaplegic (dpp) niche signaling pathway activation within GSCs...
  61. Foronda D, Pérez Garijo A, Martín F. Dpp of posterior origin patterns the proximal region of the wing. Mech Dev. 2009;126:99-106 pubmed publisher
    The decapentaplegic (dpp) gene encodes a long-range morphogen that plays a key role in the patterning of the wing imaginal disc of Drosophila (Nellen, D., Burke, R., Struhl, G. and Basler, K. 1996...
  62. Ogden S, Fei D, Schilling N, Ahmed Y, Hwa J, Robbins D. G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling. Nature. 2008;456:967-70 pubmed publisher
    ..Our results demonstrate that Smo functions as a canonical GPCR, which signals through Galphai to regulate Hh pathway activation. ..
  63. Wang Z, Flax L, Kemp M, Linhardt R, Baron M. Host and pathogen glycosaminoglycan-binding proteins modulate antimicrobial peptide responses in Drosophila melanogaster. Infect Immun. 2011;79:606-16 pubmed publisher
    ..streptococci was enhanced among flies overexpressing the endogenous glycosaminoglycan/HSPG-binding morphogen Decapentaplegic-a transforming growth factor ?-like Drosophila homolog of mammalian bone morphogenetic proteins-but not by ..
  64. Zhang Y, Mao F, Lu Y, Wu W, Zhang L, Zhao Y. Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus. Cell Res. 2011;21:1436-51 pubmed publisher
    ..We further show that this process promotes the dissociation of the full-length Ci (Ci155) and Cos2 or Su(fu), and results in the translocation of Ci155 into the nucleus, activating the expression of target genes. ..
  65. Seong K, Akimaru H, Dai P, Nomura T, Okada M, Ishii S. Inhibition of the nuclear import of cubitus interruptus by roadkill in the presence of strong hedgehog signal. PLoS ONE. 2010;5:e15365 pubmed publisher
    ..Thus, two different mechanisms by which Rdx negatively regulates Ci may play an important role in the fine-tuning of Hh responses. ..
  66. Bollenbach T, Pantazis P, Kicheva A, Bökel C, Gonzalez Gaitan M, Jülicher F. Precision of the Dpp gradient. Development. 2008;135:1137-46 pubmed publisher
    ..Here we investigate these issues for the TGF-beta-type morphogen Dpp. We first studied theoretically how cell-to-cell variability in the source, the target tissue, or both, contribute ..
  67. Ling J, Dubruille R, Emery P. KAYAK-? modulates circadian transcriptional feedback loops in Drosophila pacemaker neurons. J Neurosci. 2012;32:16959-70 pubmed publisher
    ..We propose that the double role of KAY-? in the two transcriptional loops controlling Drosophila circadian behavior brings precision and stability to their oscillations...
  68. Ekas L, Baeg G, Flaherty M, Ayala Camargo A, Bach E. JAK/STAT signaling promotes regional specification by negatively regulating wingless expression in Drosophila. Development. 2006;133:4721-9 pubmed
    ..Taken together, our study is the first to demonstrate a role for the JAK/STAT pathway in regional specification by acting antagonistically to wg. ..
  69. Wylie A, Lu W, D Brot A, Buszczak M, Abrams J. p53 activity is selectively licensed in the Drosophila stem cell compartment. elife. 2014;3:e01530 pubmed publisher
    ..Furthermore, the findings uncover ancestral links between p53 and aberrant proliferation that are independent of DNA breaks and predate evolution of the ARF/Mdm2 axis. DOI: http://dx.doi.org/10.7554/eLife.01530.001. ..
  70. Hatton Ellis E, Ainsworth C, Sushama Y, Wan S, Vijayraghavan K, Skaer H. Genetic regulation of patterned tubular branching in Drosophila. Proc Natl Acad Sci U S A. 2007;104:169-74 pubmed
    ..We show that patterning of the tubule primordium into two distinct pairs is critical for the eversion of tubule branches, as well as for their asymmetric morphogenesis. ..
  71. Haerry T. The interaction between two TGF-beta type I receptors plays important roles in ligand binding, SMAD activation, and gradient formation. Mech Dev. 2010;127:358-70 pubmed publisher
    ..contributions of the Drosophila TGF-beta type I receptors TKV and SAX to the activity gradient formed by the two BMP family members DPP and GBB that play important roles in growth and patterning of imaginal discs...
  72. Wang X, Harris R, Bayston L, Ashe H. Type IV collagens regulate BMP signalling in Drosophila. Nature. 2008;455:72-7 pubmed publisher
    ..and invertebrate embryos is mediated by a conserved system of secreted proteins that establishes a bone morphogenetic protein (BMP) gradient...
  73. Harterink M, Port F, Lorenowicz M, McGough I, Silhankova M, Betist M, et al. A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion. Nat Cell Biol. 2011;13:914-923 pubmed publisher
    ..These results demonstrate that SNX3 is part of an alternative retromer pathway that functionally separates the retrograde transport of Wls from other retromer cargo. ..
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    ..In Drosophila, the zinc finger protein Schnurri (Shn) plays a key role in signaling by the Bmp2/Bmp4 homolog Decapentaplegic (Dpp), by forming a Shn/Smad repression complex on defined promoter elements in the brinker (brk) gene...
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    ..The optimized LexA system facilitates precise analyses of complex biological phenomena and signaling pathways in Drosophila. ..
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    Morphogens, such as Decapentaplegic (Dpp) in the fly imaginal discs, form graded concentration profiles that control patterning and growth of developing organs...
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    ..Our studies identify USP8 as a positive regulator in Hh signaling by down-regulating Smo ubiquitination and thereby mediating Smo intracellular trafficking. ..
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    ..requires eiger (egr), a tumor necrosis factor ligand (TNF) homologue, which is induced in pole cells by decapentaplegic (dpp)...
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    ..The role of Decapentaplegic/Bone morphogenetic protein (Dpp/BMP) signaling in cellular morphogenesis during epithelial development is poorly understood...
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    ..In decapentaplegic (dpp) loss-of-function mutant embryos, eg was ectopically expressed in the dorsal region, while in dpp gain-..
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    ..We propose that Ptc normally regulates Smo degradation by changing the lipid composition of endosomes through which Smo passes, and that the presence of Hh on lipoproteins inhibits utilization of their lipids by Ptc. ..
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    ..BIP2 is a TATA-binding protein associated factor (also known as dTAFII3) that links ANTP to the basal transcriptional machinery. ..
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    ..We show here that Ubx regulates the activity of the Decapentaplegic (Dpp) signaling pathway at different levels, and that this regulation is instrumental in establishing the ..