DNApol-epsilon58

Summary

Gene Symbol: DNApol-epsilon58
Description: DNA polymerase epsilon 58kD subunit
Alias: 10489, CG10489, DNApol-epsilon, Dmel\CG10489, POLE2, Pole2, dpolepsilonp58, DNA polymerase epsilon 58kD subunit, CG10489-PA, DNA polymerase epsilon B subunit, DNApol-epsilon58-PA, Pole2
Species: fruit fly

Top Publications

  1. Oshige M, Takeuchi R, Ruike T, Ruike R, Kuroda K, Sakaguchi K. Subunit protein-affinity isolation of Drosophila DNA polymerase catalytic subunit. Protein Expr Purif. 2004;35:248-56 pubmed
    ..catalytic subunit synthesized DNA processively in the presence of both Mn(2+) and Mg(2+) ions, but Mn(2+) inhibited the 3'-5' proofreading activity, thereby decreasing the fidelity of DNA replication by 50%. ..
  2. Sun D, Lee G, Lee J, Kim H, Rhee H, Park S, et al. A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses. Nat Struct Mol Biol. 2010;17:1188-94 pubmed publisher
    ..These data suggest that metazoan SpoT orthologs have an evolutionarily conserved function in starvation responses. ..
  3. Sahashi R, Matsuda R, Suyari O, Kawai M, Yoshida H, Cotterill S, et al. Functional analysis of Drosophila DNA polymerase ? p58 subunit. Am J Cancer Res. 2013;3:478-89 pubmed
    ..Furthermore we detect a putative functional interaction between dpol? and ORC2 in discs suggesting that pol? plays a role in the initiation of DNA replication in Drosophila. ..