DmATP7

Summary

Gene Symbol: DmATP7
Description: ATP7
Alias: CG1886, DmATP7, Dmel\CG1886, dmATP7, lincRNA.S9122, ATP7, ATP7-PB, ATP7-PC, CG1886-PB, CG1886-PC
Species: fruit fly

Top Publications

  1. Southon A, Farlow A, Norgate M, Burke R, Camakaris J. Malvolio is a copper transporter in Drosophila melanogaster. J Exp Biol. 2008;211:709-16 pubmed publisher
    ..These results demonstrate Mvl is a functional Cu transporter and that despite partial functional redundancy with the Ctr1 proteins, Cu uptake through this pathway is necessary for optimal viability at the cellular and organismal levels. ..
  2. Norgate M, Southon A, Greenough M, Cater M, Farlow A, Batterham P, et al. Syntaxin 5 is required for copper homeostasis in Drosophila and mammals. PLoS ONE. 2010;5:e14303 pubmed publisher
    ..Thus Syx5 plays an essential role in copper homeostasis and is a candidate gene for copper-related disease in humans. ..
  3. Southon A, Burke R, Norgate M, Batterham P, Camakaris J. Copper homoeostasis in Drosophila melanogaster S2 cells. Biochem J. 2004;383:303-9 pubmed
    ..Suppression of DmATP7, the putative homologue of human Cu transporter genes ATP7A and ATP7B, significantly increased Cu accumulation, ..
  4. Balamurugan K, Egli D, Hua H, Rajaram R, Seisenbacher G, Georgiev O, et al. Copper homeostasis in Drosophila by complex interplay of import, storage and behavioral avoidance. EMBO J. 2007;26:1035-44 pubmed
    ..5 mM) copper levels, as well as the ability of DmATP7, the Drosophila homolog of Wilson/Menkes disease copper exporters, to counteract copper toxicity...
  5. Burke R, Commons E, Camakaris J. Expression and localisation of the essential copper transporter DmATP7 in Drosophila neuronal and intestinal tissues. Int J Biochem Cell Biol. 2008;40:1850-60 pubmed publisher
    ..Here, the transcriptional and post-translational regulation of DmATP7, the sole Drosophila melanogaster ortholog of the human MNK and WND copper transport genes, is examined...
  6. Binks T, Lye J, Camakaris J, Burke R. Tissue-specific interplay between copper uptake and efflux in Drosophila. J Biol Inorg Chem. 2010;15:621-8 pubmed publisher
    ..The Ctr1A/B and DmATP7 copper transport proteins have well-established roles in Drosophila copper uptake and efflux, respectively...
  7. Norgate M, Lee E, Southon A, Farlow A, Batterham P, Camakaris J, et al. Essential roles in development and pigmentation for the Drosophila copper transporter DmATP7. Mol Biol Cell. 2006;17:475-84 pubmed
    ..Here, we find that DmATP7, the sole Drosophila orthologue of the Menkes and Wilson genes, is vital for uptake of copper in vivo...
  8. Chang Y, Hung W, Chang Y, Chang H, Wu C, Chiang A, et al. Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a Drosophila IBMPFD model. PLoS Genet. 2011;7:e1001288 pubmed publisher
    ..Taken together, our analyses have defined the nature of IBMPFD-causing VCP mutations and made an unexpected link between cellular ATP level and IBMPFD pathogenesis...
  9. Mercer S, Burke R. Evidence for a role for the putative Drosophila hGRX1 orthologue in copper homeostasis. Biometals. 2016;29:705-13 pubmed publisher
    ..Therefore we conclude that CG6852 is a putative orthologue of hGRX1 and may play an important role in Drosophila copper homeostasis. ..

More Information

Publications23

  1. Mercer S, La Fontaine S, Warr C, Burke R. Reduced glutathione biosynthesis in Drosophila melanogaster causes neuronal defects linked to copper deficiency. J Neurochem. 2016;137:360-70 pubmed publisher
    ..by additional knockdown of the copper uptake transporter Ctr1A, or over-expression of the copper efflux transporter ATP7. Furthermore, when Gclc was knocked down in a subset of neuropeptide-producing cells, this resulted in adult ..
  2. Hwang J, de Bruyne M, Warr C, Burke R. Copper overload and deficiency both adversely affect the central nervous system of Drosophila. Metallomics. 2014;6:2223-9 pubmed publisher
    ..melanogaster nervous system, using targeted manipulation of the copper uptake genes Ctr1A and Ctr1B and efflux gene ATP7 in combination with altered dietary copper levels...
  3. Lang M, Fan Q, Wang L, Zheng Y, Xiao G, Wang X, et al. Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates A?42-induced Alzheimer's disease-like symptoms. Neurobiol Aging. 2013;34:2604-12 pubmed publisher
    ..Similar results were obtained from inhibiting another copper importer Ctr1B and overexpressing a copper exporter DmATP7 in the nervous system of AD flies...
  4. Southon A, Greenough M, Ganio G, Bush A, Burke R, Camakaris J. Presenilin promotes dietary copper uptake. PLoS ONE. 2013;8:e62811 pubmed publisher
    ..These results are consistent with previous studies of mammalian presenilins, supporting a conserved role for these proteins in mediating copper uptake. ..
  5. Lye J, Hwang J, Paterson D, de Jonge M, Howard D, Burke R. Detection of genetically altered copper levels in Drosophila tissues by synchrotron x-ray fluorescence microscopy. PLoS ONE. 2011;6:e26867 pubmed publisher
  6. Southon A, Palstra N, Veldhuis N, Gaeth A, Robin C, Burke R, et al. Conservation of copper-transporting P(IB)-type ATPase function. Biometals. 2010;23:681-94 pubmed publisher
    ..We examined the localization and function of DmATP7, the single Drosophila melanogaster orthologue, in cultured D...
  7. Bahadorani S, Bahadorani P, Marcon E, Walker D, Hilliker A. A Drosophila model of Menkes disease reveals a role for DmATP7 in copper absorption and neurodevelopment. Dis Model Mech. 2010;3:84-91 pubmed publisher
    ..we attempted to construct a Drosophila model of Menkes disease by RNA interference (RNAi)-induced silencing of DmATP7, the Drosophila orthologue of mammalian ATP7A, in the digestive tract...
  8. Doumanis J, Wada K, Kino Y, Moore A, Nukina N. RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation. PLoS ONE. 2009;4:e7275 pubmed publisher
    ..Newly identified modifiers including genes related to nuclear transport, nucleotide processes, and signaling, may be involved in polyglutamine aggregate formation and Huntington disease cascades. ..
  9. Cui J, Sackton K, Horner V, Kumar K, Wolfner M. Wispy, the Drosophila homolog of GLD-2, is required during oogenesis and egg activation. Genetics. 2008;178:2017-29 pubmed publisher
    ..Finally, we find that WISP function is also needed during oogenesis to regulate the poly(A) tail length of dmos during oocyte maturation and to maintain a high level of active (phospho-) mitogen-activated protein kinases (MAPKs). ..
  10. Sellami A, Wegener C, Veenstra J. Functional significance of the copper transporter ATP7 in peptidergic neurons and endocrine cells in Drosophila melanogaster. FEBS Lett. 2012;586:3633-8 pubmed publisher
    The Drosophila ATP7 copper transporter has sequence homology to the human copper transporters ATP7A and ATP7B, which are defective in Menkes and Wilson disease, respectively...
  11. Xiao G, Fan Q, Wang X, Zhou B. Huntington disease arises from a combinatory toxicity of polyglutamine and copper binding. Proc Natl Acad Sci U S A. 2013;110:14995-5000 pubmed publisher
    ..The existence of these two parallel pathways converging into Htt toxicity also suggests that an ideal HD therapy would be a multipronged approach that takes both these actions into consideration. ..
  12. Wang J, Binks T, Warr C, Burke R. Vacuolar-type H(+)-ATPase subunits and the neurogenic protein big brain are required for optimal copper and zinc uptake. Metallomics. 2014;6:2100-8 pubmed publisher
    ..These results suggest that metal ion transport is particularly sensitive to disturbances in cellular protein localization processes. ..
  13. Zlatic S, Comstra H, Gokhale A, Petris M, Faundez V. Molecular basis of neurodegeneration and neurodevelopmental defects in Menkes disease. Neurobiol Dis. 2015;81:154-61 pubmed publisher
  14. Mercer S, Wang J, Burke R. In Vivo Modeling of the Pathogenic Effect of Copper Transporter Mutations That Cause Menkes and Wilson Diseases, Motor Neuropathy, and Susceptibility to Alzheimer's Disease. J Biol Chem. 2017;292:4113-4122 pubmed publisher
    ..We have generated a single, in vivo model for studying multiple pathogenic mutations in ATP7 proteins using Drosophila melanogaster, which has a single orthologue of ATP7A and ATP7B...