Gene Symbol: Dlc90F
Description: Dynein light chain 90F
Alias: CG12363, Dmel\CG12363, TcTex-1, Tctex, Tctex-1, Tctex1, bs35g12.y1, dlc90F, dtctex-1, l(3)04091, tctex, tctex-1, dynein light chain 90F, CG12363-PA, Dlc90F-PA, dynein light chain; tctex-1
Species: fruit fly

Top Publications

  1. Caggese C, Moschetti R, Ragone G, Barsanti P, Caizzi R. dtctex-1, the Drosophila melanogaster homolog of a putative murine t-complex distorter encoding a dynein light chain, is required for production of functional sperm. Mol Genet Genomics. 2001;265:436-44 pubmed
    b>Tctex-1 is a light chain of the cytoplasmic and flagellar dyneins and a candidate for one of the distorter products that cause transmission ratio distortion in mice...
  2. Makokha M, Hare M, Li M, Hays T, Barbar E. Interactions of cytoplasmic dynein light chains Tctex-1 and LC8 with the intermediate chain IC74. Biochemistry. 2002;41:4302-11 pubmed
    The interactions of three subunits of cytoplasmic dynein from Drosophila melanogaster, LC8, Tctex-1, and the N-terminal domain of IC74 (N-IC74, residues 1-289), were characterized in vitro by affinity methods, limited proteolysis, and ..
  3. Li M, Serr M, Newman E, Hays T. The Drosophila tctex-1 light chain is dispensable for essential cytoplasmic dynein functions but is required during spermatid differentiation. Mol Biol Cell. 2004;15:3005-14 pubmed
    ..Here, we examine the role of the Drosophila ortholog of tctex-1, the 14-kDa dynein light chain...
  4. Williams J, Xie H, Hendrickson W. Crystal structure of dynein light chain TcTex-1. J Biol Chem. 2005;280:21981-6 pubmed
    b>TcTex-1, one of three dynein light chains of the dynein motor complex, has been implicated in targeting and binding cargoes to cytoplasmic dynein for retrograde or apical transport...
  5. Folker E, Schulman V, Baylies M. Muscle length and myonuclear position are independently regulated by distinct Dynein pathways. Development. 2012;139:3827-37 pubmed
    ..Finally, defects in muscle length or myonuclear positioning correlate with impaired muscle function in vivo, suggesting that both processes are essential for muscle function. ..
  6. Caggese C, Ragone G, Perrini B, Moschetti R, De Pinto V, Caizzi R, et al. Identification of nuclear genes encoding mitochondrial proteins: isolation of a collection of D. melanogaster cDNAs homologous to sequences in the Human Gene Index database. Mol Gen Genet. 1999;261:64-70 pubmed
    ..Our experimental strategy represents an efficient approach to the identification and interspecies comparison of genes encoding products targeted to the mitochondrion. ..
  7. Paik D, Jang Y, Lee Y, Lee Y, Yamamoto R, Gee H, et al. Misexpression screen delineates novel genes controlling Drosophila lifespan. Mech Ageing Dev. 2012;133:234-45 pubmed publisher
  8. Williams J, Roulhac P, Roy A, Vallee R, Fitzgerald M, Hendrickson W. Structural and thermodynamic characterization of a cytoplasmic dynein light chain-intermediate chain complex. Proc Natl Acad Sci U S A. 2007;104:10028-33 pubmed
    ..The dynein light chains (LCs) LC8 and TcTex1 form a subcomplex with dynein intermediate chains, and they also interact with numerous protein and ..
  9. Texada M, Simonette R, Johnson C, Deery W, Beckingham K. Yuri gagarin is required for actin, tubulin and basal body functions in Drosophila spermatogenesis. J Cell Sci. 2008;121:1926-36 pubmed publisher
    ..The structure of the axonemes that grow out from the basal bodies is affected in the yuri mutant, suggesting a possible role for the CA in axoneme formation. ..

More Information


  1. Mische S, He Y, Ma L, Li M, Serr M, Hays T. Dynein light intermediate chain: an essential subunit that contributes to spindle checkpoint inactivation. Mol Biol Cell. 2008;19:4918-29 pubmed publisher
    ..Our observations suggest the LIC contributes to a broad range of dynein functions. ..
  2. Benison G, Nyarko A, Barbar E. Heteronuclear NMR identifies a nascent helix in intrinsically disordered dynein intermediate chain: implications for folding and dimerization. J Mol Biol. 2006;362:1082-93 pubmed
    The intermediate chain of dynein forms a tight subcomplex with dimeric light chains LC8 and Tctex-1, and together they constitute the cargo attachment complex...
  3. Sitaram P, Anderson M, Jodoin J, Lee E, Lee L. Regulation of dynein localization and centrosome positioning by Lis-1 and asunder during Drosophila spermatogenesis. Development. 2012;139:2945-54 pubmed publisher
    ..phenotypes are due to loss of dynein regulation, as we observed similar phenotypes in flies null for Tctex-1, a dynein light chain...
  4. Batlevi Y, Martin D, Pandey U, Simon C, Powers C, Taylor J, et al. Dynein light chain 1 is required for autophagy, protein clearance, and cell death in Drosophila. Proc Natl Acad Sci U S A. 2010;107:742-7 pubmed publisher
    ..These results indicate that DDLC1 is required for protein clearance by autophagy that is associated with autophagic cell death and neurodegeneration. ..
  5. Nyarko A, Barbar E. Light chain-dependent self-association of dynein intermediate chain. J Biol Chem. 2011;286:1556-66 pubmed publisher
    ..Such flexibility in association modes may function in maintaining a stable and versatile light chain-intermediate chain assembly under changing cellular conditions. ..
  6. Pfister K, Shah P, Hummerich H, Russ A, Cotton J, Annuar A, et al. Genetic analysis of the cytoplasmic dynein subunit families. PLoS Genet. 2006;2:e1 pubmed
  7. Song Y, Benison G, Nyarko A, Hays T, Barbar E. Potential role for phosphorylation in differential regulation of the assembly of dynein light chains. J Biol Chem. 2007;282:17272-9 pubmed
    The homodimeric light chains LC8 and Tctex-1 are integral parts of the microtubule motor cytoplasmic dynein, as they directly associate with dynein intermediate chain IC and various cellular cargoes...
  8. Yang J, Bai J, Lee T. Dynein-dynactin complex is essential for dendritic restriction of TM1-containing Drosophila Dscam. PLoS ONE. 2008;3:e3504 pubmed publisher
    ..The results of this study suggest multiple mechanisms of dendritic protein targeting. Notably, dynein-dynactin plays a role in excluding dendritic Dscam, but not Rdl, from axons by retrograde transport. ..
  9. Hall J, Karplus P, Barbar E. Multivalency in the assembly of intrinsically disordered Dynein intermediate chain. J Biol Chem. 2009;284:33115-21 pubmed publisher
    ..complex of a 60-amino acid segment of dynein intermediate chain (IC) bound to two homodimeric dynein light chains Tctex1 and LC8, there is a 50-fold affinity enhancement for the second light chain binding...
  10. Hall J, Song Y, Karplus P, Barbar E. The crystal structure of dynein intermediate chain-light chain roadblock complex gives new insights into dynein assembly. J Biol Chem. 2010;285:22566-75 pubmed publisher
    ..The IC x LC7 structure further shows that the naturally occurring robl(Z) deletion mutation contains the majority of the IC binding site and suggests that promotion of IC binding by phosphorylation of LC7 is an indirect effect. ..
  11. Kracklauer M, Wiora H, Deery W, Chen X, Bolival B, Romanowicz D, et al. The Drosophila SUN protein Spag4 cooperates with the coiled-coil protein Yuri Gagarin to maintain association of the basal body and spermatid nucleus. J Cell Sci. 2010;123:2763-72 pubmed publisher
    ..The later defects in spermatogenesis seen for yuri and spag4 mutants are similar, suggesting they could be secondary to initial disruption of events at the nuclear surface. ..