Gene Symbol: Dl
Description: Delta
Alias: 0495/20, 0926/11, 1053/14, 1119/09, 1304/03, 1423/11, 1440/11, 1485/04, CG3619, CT12133, Dmel\CG3619, E(ls)2, EC3-5, anon-WO0118547.269, delta, delta D1, dmDelta, l(3)05151, l(3)92Ab, l(3)j8C3, delta, CG3619-PA, CG3619-PB, CG3619-PC, Dl-PA, Dl-PB, Dl-PC, complementation group 1, overflow
Species: fruit fly
Products:     Dl

Top Publications

  1. Urban S, Freeman M. Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain. Mol Cell. 2003;11:1425-34 pubmed
    ..These results provide an explanation of how rhomboid proteases achieve specificity, and allow some rhomboid substrates to be predicted from sequence information. ..
  2. Troost T, Klein T. Sequential Notch signalling at the boundary of fringe expressing and non-expressing cells. PLoS ONE. 2012;7:e49007 pubmed publisher
    ..that mutual signalling from dorsal to ventral and ventral to dorsal cells by the Notch ligands Serrate (Ser) and Delta (Dl) respectively establishes a symmetric domain of Wg that straddles the D/V boundary...
  3. Hutterer A, Knoblich J. Numb and alpha-Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs. EMBO Rep. 2005;6:836-42 pubmed
    ..We show that Sanpodo is cortical in pIIa, but colocalizes with Notch and Delta in Rab5- and Rab7-positive endocytic vesicles in pIIb...
  4. Bernard F, Dutriaux A, Silber J, Lalouette A. Notch pathway repression by vestigial is required to promote indirect flight muscle differentiation in Drosophila melanogaster. Dev Biol. 2006;295:164-77 pubmed
    ..Moreover, close examination of the cellular location of several of the main actors of the N pathway (Notch, Delta, neuralized, Serrate, Mind bomb1 and fringe) during dorsal longitudinal muscle development enabled us to find that ..
  5. Hochmuth C, Biteau B, Bohmann D, Jasper H. Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila. Cell Stem Cell. 2011;8:188-99 pubmed publisher
    ..Our findings establish Keap1 and Nrf2 as a critical redox management system that regulates stem cell function in high-turnover tissues. ..
  6. Overstreet E, Chen X, Wendland B, Fischer J. Either part of a Drosophila epsin protein, divided after the ENTH domain, functions in endocytosis of delta in the developing eye. Curr Biol. 2003;13:854-60 pubmed
    ..Specifically, we find that Lqf is essential for internalization of the Delta (Dl) transmembrane ligand in the developing eye...
  7. Shepherd A, Wesley U, Wesley C. Notch and delta mRNAs in early-stage and mid-stage drosophila embryos exhibit complementary patterns of protein-producing potentials. Dev Dyn. 2010;239:1220-33 pubmed publisher
    Notch and Delta proteins generate Notch signaling that specifies cell fates during animal development...
  8. Strand M, Micchelli C. Quiescent gastric stem cells maintain the adult Drosophila stomach. Proc Natl Acad Sci U S A. 2011;108:17696-701 pubmed publisher
    ..Characterization of the GSSC lineage in Drosophila, with striking similarities to mammals, will advance the study of both homeostatic and pathogenic processes in the stomach. ..
  9. Campuzano S. Emc, a negative HLH regulator with multiple functions in Drosophila development. Oncogene. 2001;20:8299-307 pubmed
    ..However, while maintaining this repressive molecular mechanism, emc also appears to act as a positive regulator of differentiation...

More Information

Publications107 found, 100 shown here

  1. Dobens L, Jaeger A, Peterson J, Raftery L. Bunched sets a boundary for Notch signaling to pattern anterior eggshell structures during Drosophila oogenesis. Dev Biol. 2005;287:425-37 pubmed
  2. Herz H, Madden L, Chen Z, Bolduc C, Buff E, Gupta R, et al. The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila. Mol Cell Biol. 2010;30:2485-97 pubmed publisher
    ..In summary, these data suggest that dUTX is a suppressor of Notch- and Rbf-dependent tumors in Drosophila melanogaster and may provide a model for UTX-dependent tumorigenesis in humans. ..
  3. Singh A, Kango Singh M, Choi K, Sun Y. Dorso-ventral asymmetric functions of teashirt in Drosophila eye development depend on spatial cues provided by early DV patterning genes. Mech Dev. 2004;121:365-70 pubmed
    ..The dorsal Iroquois-Complex (Iro-C) genes and Delta (Dl) are required and sufficient for the tsh dorsal functions...
  4. Ahimou F, Mok L, Bardot B, Wesley C. The adhesion force of Notch with Delta and the rate of Notch signaling. J Cell Biol. 2004;167:1217-29 pubmed
    ..show that the rate of Notch signaling is linked to the adhesion force between cells expressing Notch receptors and Delta ligand. Both the Notch extracellular and intracellular domains are required for the high adhesion force with Delta...
  5. Yasugi T, Sugie A, Umetsu D, Tabata T. Coordinated sequential action of EGFR and Notch signaling pathways regulates proneural wave progression in the Drosophila optic lobe. Development. 2010;137:3193-203 pubmed publisher
    ..This study also provides new insights into the role of Notch signaling. Expression of the Notch ligand Delta is induced by EGFR, and Notch signaling prolongs the proneural state...
  6. Ahmed A, Chandra S, Magarinos M, Vaessin H. Echinoid mutants exhibit neurogenic phenotypes and show synergistic interactions with the Notch signaling pathway. Development. 2003;130:6295-304 pubmed
    ..Thus the extra wing vein phenotype of ed is enhanced upon reduction of Delta (Dl) or Enhancer of split [E(spl)] proteins...
  7. de Renzis S, Yu J, Zinzen R, Wieschaus E. Dorsal-ventral pattern of Delta trafficking is established by a Snail-Tom-Neuralized pathway. Dev Cell. 2006;10:257-64 pubmed
    The intracellular trafficking of the Notch ligand Delta plays an important role in the activation of the Notch pathway...
  8. Eun S, Banks S, Fischer J. Auxilin is essential for Delta signaling. Development. 2008;135:1089-95 pubmed publisher
    ..We discuss these observations in the light of current models for the role of Epsin in ligand endocytosis and the role of ligand endocytosis in Notch signaling. ..
  9. De Joussineau C, Soule J, Martin M, Anguille C, Montcourrier P, Alexandre D. Delta-promoted filopodia mediate long-range lateral inhibition in Drosophila. Nature. 2003;426:555-9 pubmed
    ..Neural competence is restricted to individual sensory organ precursors (SOPs) by Delta/Notch-mediated 'lateral inhibition', whereas other cells in the proneural field adopt an epidermal fate...
  10. Wang X, Adam J, Montell D. Spatially localized Kuzbanian required for specific activation of Notch during border cell migration. Dev Biol. 2007;301:532-40 pubmed
    ..cells at stage 6 but then at stage 9 was restricted to migrating border cells, despite uniform expression of Delta. Expression of Kuzbanian (KUZ), a metalloproteinase that can activate Notch as well as cleave other substrates, is ..
  11. Chatterjee M, Ip Y. Pathogenic stimulation of intestinal stem cell response in Drosophila. J Cell Physiol. 2009;220:664-71 pubmed publisher
    ..This system should allow molecular and genetic analyses of stem cell-mediated tissue repair. ..
  12. Bossuyt W, De Geest N, Aerts S, Leenaerts I, Marynen P, Hassan B. The atonal proneural transcription factor links differentiation and tumor formation in Drosophila. PLoS Biol. 2009;7:e40 pubmed publisher
    ..Combined with evidence that atonal's mammalian homolog, ATOH1, is a tumor suppressor gene, our data support a critical, evolutionarily conserved, function for ato in oncogenesis. ..
  13. Wang W, Struhl G. Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling in Drosophila. Development. 2005;132:2883-94 pubmed
    Ligands of the Delta/Serrate/Lag2 (DSL) family must normally be endocytosed in signal-sending cells to activate Notch in signal-receiving cells...
  14. Skwarek L, Garroni M, Commisso C, Boulianne G. Neuralized contains a phosphoinositide-binding motif required downstream of ubiquitination for delta endocytosis and notch signaling. Dev Cell. 2007;13:783-95 pubmed
    ..Endocytosis of the Drosophila ligands, Delta and Serrate, is required in the signaling cell for signal initiation and requires one of two ubiquitin ligases, ..
  15. Lieber T, Kidd S, Struhl G. DSL-Notch signaling in the Drosophila brain in response to olfactory stimulation. Neuron. 2011;69:468-81 pubmed publisher
    b>Delta/Serrate/Lag2 (DSL) ligands and their Notch family receptors have profound and pervasive roles in development. They are also expressed in adult tissues, notably in mature neurons and glia in the brain, where their roles are unknown...
  16. Schweisguth F. Regulation of notch signaling activity. Curr Biol. 2004;14:R129-38 pubmed
    ..Recent analyses of the cell biology of the Notch receptor have identified several fundamental mechanisms that contribute to regulate Notch signaling activity in space and time. ..
  17. Acar M, Jafar Nejad H, Takeuchi H, Rajan A, Ibrani D, Rana N, et al. Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling. Cell. 2008;132:247-58 pubmed publisher
    ..intracellularly and at the cell membrane of rumi cells but fails to be properly cleaved, despite normal binding to Delta. Rumi is an endoplasmic reticulum-retained protein with a highly conserved CAP10 domain...
  18. Perdigoto C, Schweisguth F, Bardin A. Distinct levels of Notch activity for commitment and terminal differentiation of stem cells in the adult fly intestine. Development. 2011;138:4585-95 pubmed publisher
    ..Our work suggests that a commitment requirement for high-level Notch activity safeguards the stem cells from loss through differentiation, revealing a novel role for the importance of Notch signaling levels in this system. ..
  19. Bardot B, Mok L, Thayer T, Ahimou F, Wesley C. The Notch amino terminus regulates protein levels and Delta-induced clustering of Drosophila Notch receptors. Exp Cell Res. 2005;304:202-23 pubmed
    ..It is a cell surface receptor that generates intracellular signals in response to Delta binding its extracellular domain...
  20. Firth L, Baker N. Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev Cell. 2005;8:541-51 pubmed
    ..These studies identify the specific extracellular signals that pattern the retinal cell cycles and show how differentiation can be uncoupled from cell cycle exit. ..
  21. Lu H, Bilder D. Endocytic control of epithelial polarity and proliferation in Drosophila. Nat Cell Biol. 2005;7:1232-9 pubmed
    ..Our findings reveal a critical and specific role for endocytic traffic in the control of both apico-basal polarity and cell proliferation. ..
  22. Herranz H, Milan M. Notch and affinity boundaries in Drosophila. Bioessays. 2006;28:113-6 pubmed
    ..The second report analyzes the differential requirements of Notch and the transcription factor Suppressor of Hairless in generating the affinity boundary. ..
  23. Rusten T, Rodahl L, Pattni K, Englund C, Samakovlis C, Dove S, et al. Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors. Mol Biol Cell. 2006;17:3989-4001 pubmed
    ..This is consistent with the possibility that Fab1 functions at a late stage in endocytic receptor trafficking, at a point when signal termination has occurred. ..
  24. Guichard A, McGillivray S, Cruz Moreno B, van Sorge N, Nizet V, Bier E. Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst. Nature. 2010;467:854-8 pubmed publisher
    ..Convergent effects of EF and LF on Rab11/Sec15 inhibit expression of and signalling by the Notch ligand Delta and reduce DE-cadherin levels at adherens junctions...
  25. Overstreet E, Fitch E, Fischer J. Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells. Development. 2004;131:5355-66 pubmed
    ..One recent hypothesis is that endocytosis of the ligand Delta by the signaling cells is essential for Notch activation in the receiving cells...
  26. Kandachar V, Bai T, Chang H. The clathrin-binding motif and the J-domain of Drosophila Auxilin are essential for facilitating Notch ligand endocytosis. BMC Dev Biol. 2008;8:50 pubmed publisher
    ..In support of the genetic evidences, the level of Delta appears elevated in dAux deficient cells, suggesting that the endocytosis of Notch ligand is disrupted...
  27. Sun J, Smith L, Armento A, Deng W. Regulation of the endocycle/gene amplification switch by Notch and ecdysone signaling. J Cell Biol. 2008;182:885-96 pubmed publisher
  28. Coumailleau F, Fürthauer M, Knoblich J, Gonzalez Gaitan M. Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division. Nature. 2009;458:1051-5 pubmed publisher
    ..fly sensory organ precursors (SOPs): directional signalling is mediated by differential endocytosis of the ligand Delta and the Notch effector Sanpodo in one of the SOP daughters, pIIb...
  29. Martinez A, Schuettengruber B, Sakr S, Janic A, Gonzalez C, Cavalli G. Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling. Nat Genet. 2009;41:1076-82 pubmed publisher
    ..These data show that ph is a tumor suppressor locus that controls cellular proliferation by silencing multiple Notch signaling components. ..
  30. Vallejo D, Caparros E, Dominguez M. Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells. EMBO J. 2011;30:756-69 pubmed publisher
    ..Together, these data define a new way to attenuate or boost Notch signalling that may have clinical interest. ..
  31. Escudero L, Wei S, Chiu W, Modolell J, Hsu J. Echinoid synergizes with the Notch signaling pathway in Drosophila mesothorax bristle patterning. Development. 2003;130:6305-16 pubmed
    ..Consistently, we find that Ed also antagonizes the bristle-promoting activity of the Egfr pathway, either by the enhancement of N signalling or, similar to the eye, by a more direct action on the Egfr pathway. ..
  32. Fuwa T, Hori K, Sasamura T, Higgs J, Baron M, Matsuno K. The first deltex null mutant indicates tissue-specific deltex-dependent Notch signaling in Drosophila. Mol Genet Genomics. 2006;275:251-63 pubmed
    ..Our epistatic analyses suggested that dx functions downstream of the ligands and upstream of activated Su(H). We also uncovered a novel dx activity that suppressed N signaling downstream of N. ..
  33. Lin G, Xu N, Xi R. Paracrine unpaired signaling through the JAK/STAT pathway controls self-renewal and lineage differentiation of drosophila intestinal stem cells. J Mol Cell Biol. 2010;2:37-49 pubmed publisher
  34. Wang W, Liu W, Wang Y, Zhou L, Tang X, Luo H. Notch signaling regulates neuroepithelial stem cell maintenance and neuroblast formation in Drosophila optic lobe development. Dev Biol. 2011;350:414-28 pubmed publisher
    ..Loss of function in Notch or its ligand Delta leads to loss of the lamina and a smaller medulla...
  35. Klein T. kuzbanian is required cell autonomously during Notch signalling in the Drosophila wing. Dev Genes Evol. 2002;212:251-5 pubmed
    ..that Kuz is required on the signal-emitting side for the generation of an active secreted form of the ligand Delta. In this scenario, kuz should act cell non-autonomously...
  36. Hori K, Fostier M, Ito M, Fuwa T, Go M, Okano H, et al. Drosophila deltex mediates suppressor of Hairless-independent and late-endosomal activation of Notch signaling. Development. 2004;131:5527-37 pubmed
    ..the dorsoventral compartment boundary enhancer of vestigial (vgBE), in a manner that was independent of the Delta (Dl)/Serrate (Ser) ligands- or Su(H)...
  37. Li Y, Baker N. The roles of cis-inactivation by Notch ligands and of neuralized during eye and bristle patterning in Drosophila. BMC Dev Biol. 2004;4:5 pubmed
    The receptor protein Notch and its ligand Delta are expressed throughout proneural regions yet non-neural precursor cells are defined by Notch activity and neural precursor cells by Notch inactivity...
  38. Miller A, Lyons E, Herman T. cis-Inhibition of Notch by endogenous Delta biases the outcome of lateral inhibition. Curr Biol. 2009;19:1378-83 pubmed publisher
    Lateral inhibition mediated by Delta/Notch (Dl/N) signaling is used throughout development to limit the number of initially equivalent cells that adopt a particular fate...
  39. Carmena A, Buff E, Halfon M, Gisselbrecht S, Jimenez F, Baylies M, et al. Reciprocal regulatory interactions between the Notch and Ras signaling pathways in the Drosophila embryonic mesoderm. Dev Biol. 2002;244:226-42 pubmed
    ..Ras induces Notch, its ligand Delta, and the epidermal growth factor receptor antagonist, Argos...
  40. Kondylis V, Rabouille C. A novel role for dp115 in the organization of tER sites in Drosophila. J Cell Biol. 2003;162:185-98 pubmed
    ..Taken together, these studies suggest that dp115 could be implicated in the architecture of both the Golgi stacks and the tER sites. ..
  41. Kamimura K, Rhodes J, Ueda R, McNeely M, Shukla D, Kimata K, et al. Regulation of Notch signaling by Drosophila heparan sulfate 3-O sulfotransferase. J Cell Biol. 2004;166:1069-79 pubmed
    ..These findings suggest that Hs3st-B is involved in Notch signaling by affecting stability or intracellular trafficking of Notch protein. ..
  42. Gallagher C, Knoblich J. The conserved c2 domain protein lethal (2) giant discs regulates protein trafficking in Drosophila. Dev Cell. 2006;11:641-53 pubmed
    ..Our experiments suggest that Lgd is a critical regulator of endocytosis that is not present in yeast and acts in the degradative pathway after Hrs. ..
  43. Okajima T, Xu A, Lei L, Irvine K. Chaperone activity of protein O-fucosyltransferase 1 promotes notch receptor folding. Science. 2005;307:1599-603 pubmed
    ..This ability of OFUT1 to facilitate folding of Notch did not require its fucosyltransferase activity. Thus, a glycosyltransferase can bind its substrate in the endoplasmic reticulum to facilitate normal folding. ..
  44. Ward E, Zhou X, Riddiford L, Berg C, Ruohola Baker H. Border of Notch activity establishes a boundary between the two dorsal appendage tube cell types. Dev Biol. 2006;297:461-70 pubmed
    ..Generating a boundary by the Notch pathway might constitute an evolutionarily conserved first step during organ formation in many tissues. ..
  45. Becam I, Fiuza U, Arias A, Milan M. A role of receptor Notch in ligand cis-inhibition in Drosophila. Curr Biol. 2010;20:554-60 pubmed publisher
  46. Sprinzak D, Lakhanpal A, Lebon L, Garcia Ojalvo J, Elowitz M. Mutual inactivation of Notch receptors and ligands facilitates developmental patterning. PLoS Comput Biol. 2011;7:e1002069 pubmed publisher
    ..Recent work has shown that Notch and Delta, the canonical metazoan juxtacrine signaling receptor and ligand, mutually inactivate each other in the same cell...
  47. de Navascués J, Perdigoto C, Bian Y, Schneider M, Bardin A, Martínez Arias A, et al. Drosophila midgut homeostasis involves neutral competition between symmetrically dividing intestinal stem cells. EMBO J. 2012;31:2473-85 pubmed publisher
  48. Giebel B, Wodarz A. Tumor suppressors: control of signaling by endocytosis. Curr Biol. 2006;16:R91-2 pubmed
    ..These results can be attributed to defective endocytosis of transmembrane proteins that control cell polarity and proliferation, including Crumbs and Notch. ..
  49. Ohlstein B, Spradling A. Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential notch signaling. Science. 2007;315:988-92 pubmed
    ..ISCs containing high levels of cytoplasmic Delta-rich vesicles activate the canonical Notch pathway and down-regulate Delta within their daughters, a process that ..
  50. Nystul T, Spradling A. Regulation of epithelial stem cell replacement and follicle formation in the Drosophila ovary. Genetics. 2010;184:503-15 pubmed publisher
    ..These studies provide new insight into the mechanisms that underlie stem cell replacement and follicle formation during Drosophila oogenesis. ..
  51. Takashima S, Adams K, Ortiz P, Ying C, Moridzadeh R, Younossi Hartenstein A, et al. Development of the Drosophila entero-endocrine lineage and its specification by the Notch signaling pathway. Dev Biol. 2011;353:161-72 pubmed publisher
    ..Activation of Notch in pISCs forces these cells into an enterocyte fate. Loss of Notch function causes an increase in the proliferatory activity of pISCs, as well as a higher ratio of Prospero-positive cells. ..
  52. Renaud O, Simpson P. scabrous modifies epithelial cell adhesion and extends the range of lateral signalling during development of the spaced bristle pattern in Drosophila. Dev Biol. 2001;240:361-76 pubmed
    ..and epidermal cells from a group of equipotential cells relies on lateral inhibition mediated by Notch and Delta (Dl)...
  53. Cowden J, Levine M. The Snail repressor positions Notch signaling in the Drosophila embryo. Development. 2002;129:1785-93 pubmed
    ..We suggest that these dual activities of Snail, repression of Notch target genes and stimulation of Notch signaling, help define precise lines of sim expression within the neurogenic ectoderm. ..
  54. Panin V, Shao L, Lei L, Moloney D, Irvine K, Haltiwanger R. Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe. J Biol Chem. 2002;277:29945-52 pubmed
    ..Indeed, O-fucose on mammalian Delta 1 and Jagged1 can be elongated with Manic Fringe in vivo, and Drosophila Delta and Serrate are substrates for ..
  55. Baonza A, Freeman M. Control of cell proliferation in the Drosophila eye by Notch signaling. Dev Cell. 2005;8:529-39 pubmed
    ..b>Delta to Notch signaling derepresses the inhibition of dE2F1 by RBF, and Delta expression depends on the secreted ..
  56. Langdon T, Hayward P, Brennan K, Wirtz Peitz F, Sanders P, Zecchini V, et al. Notch receptor encodes two structurally separable functions in Drosophila: a genetic analysis. Dev Dyn. 2006;235:998-1013 pubmed
    ..The activation of Notch during lateral inhibition is mediated by the transmembrane ligand Delta (Dl) and effected by the transcription factor Suppressor of Hairless (Su(H))...
  57. Benhra N, Vignaux F, Dussert A, Schweisguth F, Le Borgne R. Neuralized promotes basal to apical transcytosis of delta in epithelial cells. Mol Biol Cell. 2010;21:2078-86 pubmed publisher
    ..Activation of Notch requires the ubiquitin-dependent endocytosis of its ligand Delta. How ligand endocytosis in signal-sending cells regulates receptor activation in juxtaposed signal-receiving cells ..
  58. Domanitskaya E, Schupbach T. CoREST acts as a positive regulator of Notch signaling in the follicle cells of Drosophila melanogaster. J Cell Sci. 2012;125:399-410 pubmed publisher
    ..Given its high degree of conservation among species, CoREST probably also functions as a regulator of Notch-dependent cellular events in other organisms. ..
  59. Althauser C, Jordan K, Deng W, Ruohola Baker H. Fringe-dependent notch activation and tramtrack function are required for specification of the polar cells in Drosophila oogenesis. Dev Dyn. 2005;232:1013-20 pubmed
    ..We now demonstrate that Notch signaling, activated by Delta and transduced by the transcription factor Tramtrack, is involved in the process of refining the prepolar cell ..
  60. Liefke R, Oswald F, Alvarado C, Ferres Marco D, Mittler G, Rodriguez P, et al. Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex. Genes Dev. 2010;24:590-601 pubmed publisher
    ..KDM5A interacts physically with RBP-J; this interaction is conserved in Drosophila and is crucial for Notch-induced growth and tumorigenesis responses. ..
  61. Okajima T, Irvine K. Regulation of notch signaling by o-linked fucose. Cell. 2002;111:893-904 pubmed
  62. Sun J, Deng W. Notch-dependent downregulation of the homeodomain gene cut is required for the mitotic cycle/endocycle switch and cell differentiation in Drosophila follicle cells. Development. 2005;132:4299-308 pubmed
    ..Our data suggest that Cut functions in regulating both cell differentiation and the cell cycle, and that downregulation of Cut by Notch contributes to the mitotic cycle/endocycle switch and cell differentiation in follicle cells. ..
  63. Le Borgne R, Schweisguth F. Unequal segregation of Neuralized biases Notch activation during asymmetric cell division. Dev Cell. 2003;5:139-48 pubmed
    ..Furthermore, Neuralized upregulates endocytosis of the Notch ligand Delta in the pIIb cell and acts in the pIIb cell to promote activation of Notch in the pIIa cell...
  64. Torres I, Lopez Schier H, St Johnston D. A Notch/Delta-dependent relay mechanism establishes anterior-posterior polarity in Drosophila. Dev Cell. 2003;5:547-58 pubmed
    ..b>Delta signaling from the older cyst induces the anterior polar follicle cells, the anterior polar cells signal through ..
  65. Yan S, Gu Y, Li W, Fleming R. Multiple signaling pathways and a selector protein sequentially regulate Drosophila wing development. Development. 2004;131:285-98 pubmed
    ..Such a mechanism is possibly conserved in the appendage outgrowth of other arthropods and vertebrates. ..
  66. Childress J, Acar M, Tao C, Halder G. Lethal giant discs, a novel C2-domain protein, restricts notch activation during endocytosis. Curr Biol. 2006;16:2228-33 pubmed
    ..Taken together, our data identify Lgd as a novel tumor-suppressor protein that regulates Notch signaling by targeting Notch for degradation or recycling. ..
  67. Biteau B, Hochmuth C, Jasper H. JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut. Cell Stem Cell. 2008;3:442-55 pubmed publisher
    ..Ectopic Delta/Notch signaling in these cells causes their abnormal differentiation but also limits JNK-induced proliferation...
  68. Matsuno K, Ito M, Hori K, Miyashita F, Suzuki S, Kishi N, et al. Involvement of a proline-rich motif and RING-H2 finger of Deltex in the regulation of Notch signaling. Development. 2002;129:1049-59 pubmed
    ..Therefore, oligomerization mediated by the RING-H2 finger motif is an integral step in the signaling function of Deltex. ..
  69. Okajima T, Xu A, Irvine K. Modulation of notch-ligand binding by protein O-fucosyltransferase 1 and fringe. J Biol Chem. 2003;278:42340-5 pubmed
    ..Notch, we assayed the ability of tagged, soluble forms of the Notch extracellular domain to bind to its ligands, Delta and Serrate...
  70. Herranz H, Stamataki E, Feiguin F, Milan M. Self-refinement of Notch activity through the transmembrane protein Crumbs: modulation of gamma-secretase activity. EMBO Rep. 2006;7:297-302 pubmed
    ..These results indicate a novel molecular mechanism of the regulation of Notch signal, and also that defects in Crumbs might be involved in similar abnormal gamma-Secretase complex activity observed in Alzheimer's disease. ..
  71. Glittenberg M, Pitsouli C, Garvey C, Delidakis C, Bray S. Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis. EMBO J. 2006;25:4697-706 pubmed
    ..The balance of ubiquitinated/unubiquitinated ligand will thus affect the signalling capacity of the cell at several levels. ..
  72. Grammont M. Adherens junction remodeling by the Notch pathway in Drosophila melanogaster oogenesis. J Cell Biol. 2007;177:139-50 pubmed
    ..that the rate of AJ disassembly between the StCs is affected in follicles with somatic clones mutant for fringe or Delta and Serrate. This results in abnormal StC flattening and delayed MBFC displacement...
  73. Rajan A, Tien A, Haueter C, Schulze K, Bellen H. The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursors. Nat Cell Biol. 2009;11:815-24 pubmed publisher
    ..Our data reveal that during ESO fate specification, most endocytosed vesicles containing the ligand Delta traffic to a prominent apical actin-rich structure (ARS) formed in the SOP daughter cells...
  74. Fiuza U, Klein T, Martinez Arias A, Hayward P. Mechanisms of ligand-mediated inhibition in Notch signaling activity in Drosophila. Dev Dyn. 2010;239:798-805 pubmed publisher
    The transmembrane proteins Delta and Serrate act as ligands for the signaling receptor Notch. In addition to this activating role, Delta and Serrate can also inhibit Notch signaling activity...
  75. Biteau B, Karpac J, Supoyo S, Degennaro M, Lehmann R, Jasper H. Lifespan extension by preserving proliferative homeostasis in Drosophila. PLoS Genet. 2010;6:e1001159 pubmed publisher
  76. Sasamura T, Sasaki N, Miyashita F, Nakao S, Ishikawa H, Ito M, et al. neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions. Development. 2003;130:4785-95 pubmed
    ..Finally, Neurotic is essential for the physical interaction of Notch with its ligand Delta, and for the ability of Fringe to modulate this interaction in Drosophila cultured cells...
  77. Lai E. Notch signaling: control of cell communication and cell fate. Development. 2004;131:965-73 pubmed
    ..This primer describes the mechanism of Notch signal transduction and how it is used to control the formation of biological patterns. ..
  78. Bardin A, Schweisguth F. Bearded family members inhibit Neuralized-mediated endocytosis and signaling activity of Delta in Drosophila. Dev Cell. 2006;10:245-55 pubmed
    ..the E3 ubiquitin ligase Neuralized (Neur) promotes the endocytosis and signaling activity of the ligand Delta (Dl). In this study, we identify proteins of the Bearded (Brd) family as interactors of Neur...
  79. Lopez Schier H, St Johnston D. Drosophila nicastrin is essential for the intramembranous cleavage of notch. Dev Cell. 2002;2:79-89 pubmed
    ..nicastrin and presenilin mutations also disrupt the spectrin cytoskeleton, suggesting that the gamma-secretase complex has another function in Drosophila in addition to its role in processing Notch and APP. ..
  80. Brachmann C, Cagan R. Patterning the fly eye: the role of apoptosis. Trends Genet. 2003;19:91-6 pubmed
    ..But, we have yet to understand how this signaling is regulated spatially to result in such precision. In this article, we describe and speculate on the role of selective cell death during maturation of the fly eye. ..
  81. Kondylis V, Spoorendonk K, Rabouille C. dGRASP localization and function in the early exocytic pathway in Drosophila S2 cells. Mol Biol Cell. 2005;16:4061-72 pubmed
    ..Overall, dGRASP exhibits a dynamic association to the membrane of the early exocytic pathway and is involved in Golgi stack architecture. ..
  82. Zeng X, Chauhan C, Hou S. Characterization of midgut stem cell- and enteroblast-specific Gal4 lines in drosophila. Genesis. 2010;48:607-11 pubmed publisher
    ..Here we report the generation and characterization of Dl-Gal4 and Su(H)GBE-Gal4 lines, which are expressed specifically in the ISCs and EBs separately...
  83. Couturier L, Vodovar N, Schweisguth F. Endocytosis by Numb breaks Notch symmetry at cytokinesis. Nat Cell Biol. 2012;14:131-9 pubmed publisher
    ..We propose that unequal segregation of Numb results in increased endocytosis in one daughter cell, hence asymmetry of Notch at the cytokinetic furrow, directional signalling and binary fate choice. ..
  84. Commisso C, Boulianne G. The NHR1 domain of Neuralized binds Delta and mediates Delta trafficking and Notch signaling. Mol Biol Cell. 2007;18:1-13 pubmed
    Notch signaling, which is crucial to metazoan development, requires endocytosis of Notch ligands, such as Delta and Serrate...
  85. Herz H, Woodfield S, Chen Z, Bolduc C, Bergmann A. Common and distinct genetic properties of ESCRT-II components in Drosophila. PLoS ONE. 2009;4:e4165 pubmed publisher
    ..Our data redefine the role of Notch for hyperplastic and neoplastic overgrowth in these mutants. While Notch is required for hyperplastic growth, it appears to be dispensable for neoplastic transformation. ..
  86. Jiang H, Edgar B. EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors. Development. 2009;136:483-93 pubmed publisher
    ..Two stronger EGFR ligands, Spitz and Keren, are expressed by the AMPs themselves and provide an additional, autocrine mitogenic stimulus to the AMPs during late larval stages. ..
  87. Biteau B, Jasper H. EGF signaling regulates the proliferation of intestinal stem cells in Drosophila. Development. 2011;138:1045-55 pubmed publisher
  88. Delwig A, Bland C, Beem Miller M, Kimberly P, Rand M. Endocytosis-independent mechanisms of Delta ligand proteolysis. Exp Cell Res. 2006;312:1345-60 pubmed
    b>Delta proteins function as cell surface ligands for Notch receptors in a highly conserved signal transduction mechanism...
  89. Hagedorn E, Bayraktar J, Kandachar V, Bai T, Englert D, Chang H. Drosophila melanogaster auxilin regulates the internalization of Delta to control activity of the Notch signaling pathway. J Cell Biol. 2006;173:443-52 pubmed
    ..receptor activation, suggesting that the relevant cargo for this auxilin-mediated endocytosis is the Notch ligand Delta. Indeed, the localization of Delta protein is disrupted in auxilin mutant tissues...
  90. Nagaraj R, Banerjee U. Regulation of Notch and Wingless signalling by phyllopod, a transcriptional target of the EGFR pathway. EMBO J. 2009;28:337-46 pubmed publisher
    ..Furthermore, this study identifies a Phyl-regulated class of endosomal vesicles that specifically include components of Notch and Wg signalling. ..
  91. Lieber T, Kidd S, Young M. kuzbanian-mediated cleavage of Drosophila Notch. Genes Dev. 2002;16:209-21 pubmed
    ..It has been suggested that this results from a requirement for kuzbanian-mediated cleavage of the Notch ligand Delta. Using transgenic Drosophila expressing transmembrane Notch proteins, we show that kuzbanian, independent of any ..
  92. Schaeffer V, Althauser C, Shcherbata H, Deng W, Ruohola Baker H. Notch-dependent Fizzy-related/Hec1/Cdh1 expression is required for the mitotic-to-endocycle transition in Drosophila follicle cells. Curr Biol. 2004;14:630-6 pubmed
    ..Loss of either Notch function or its ligand Delta (Dl) disrupts the normal transition; this disruption causes mitotic cycling to continue and leads to an ..