Diap1

Summary

Gene Symbol: Diap1
Description: Death-associated inhibitor of apoptosis 1
Alias: 0736/01, 1065/03, CG12284, D-IAP1, D-iap1, DIAP, DIAP I, DIAP-1, DIAP1, DIAPI, Diap, Diap-1, Diap-1/Th, Dmel\CG12284, E(rpr)3-1, IAP, IAP1, Iap1, S048915, Thread, dIAP, dIAP-1, dIAP1, dIap1, diap, diap 1, diap-1, diap1, diap1/thread, l(3)72CDe, l(3)72Dc, l(3)S030605, l(3)S030605b, l(3)S106503, l(3)j5C8, thread, Death-associated inhibitor of apoptosis 1, CG12284-PA, CG12284-PB, CG12284-PC, CG12284-PD, CG12284-PE, CG12284-PF, DIAP1, Diap1-PA, Diap1-PB, Diap1-PC, Diap1-PD, Diap1-PE, Diap1-PF, degradation of inhibitors of apoptosis, drosophila IAP1, drosophila inhibitor of apoptosis, drosophila inhibitor of apoptosis 1, drosophila inhibitor of apoptosis Protein-1, drosophila inhibitor of apoptosis protein, drosophila inhibitor of apoptosis protein 1, drosophila inhibitor-of-apoptosis protein 1, drosophila thread/inhibitor of apoptosis protein-1, inhibitor of apoptosis, inhibitor of apoptosis 1, inhibitor of apoptosis protein 1, inhibitor of apoptosis-1, inhibitor of apoptotic protein 1, inhibitors of apoptosis protein, lethal (3) 72CDe, thread
Species: fruit fly

Top Publications

  1. Udan R, Kango Singh M, Nolo R, Tao C, Halder G. Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nat Cell Biol. 2003;5:914-20 pubmed
    ..negatively regulates expression of Cyclin E to restrict cell proliferation, downregulates the Drosophila inhibitor of apoptosis protein DIAP1, and induces the proapoptotic gene head involution defective (hid) to promote apoptosis...
  2. Silva E, Tsatskis Y, Gardano L, Tapon N, McNeill H. The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway. Curr Biol. 2006;16:2081-9 pubmed
    ..apoptosis, resulting in massive tissue overgrowth through increased expression of targets such as Cyclin E and Diap1. The cytoskeletal proteins Merlin and Expanded colocalize at apical junctions and function redundantly upstream of ..
  3. Lee N, Hong Y, Yu S, Han S, Geum D, Cho K. dXNP, a Drosophila homolog of XNP/ATRX, induces apoptosis via Jun-N-terminal kinase activation. FEBS Lett. 2007;581:2625-32 pubmed
    ..The dXNP-induced apoptosis was strongly suppressed by DJNKK/hemipterous mutation, and dXNP increased JNK activity. Taken together, these results suggest that dXNP regulates apoptosis via JNK activation. ..
  4. Grzeschik N, Parsons L, Allott M, Harvey K, Richardson H. Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms. Curr Biol. 2010;20:573-81 pubmed publisher
    ..Thus, our study implicates Lgl, aPKC, and Crumbs as regulators of tissue growth via the SWH pathway. ..
  5. White K. Cell death: drosophila Apaf-1 - no longer in the (d)Ark. Curr Biol. 2000;10:R167-9 pubmed
    ..The new findings also suggest that cell death in flies is very similar to that in mammals after all. ..
  6. Kuranaga E, Kanuka H, Igaki T, Sawamoto K, Ichijo H, Okano H, et al. Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila. Nat Cell Biol. 2002;4:705-10 pubmed
    ..We show that Reaper modulates the JNK pathway through Drosophila inhibitor-of-apoptosis protein 1 (DIAP1), which negatively regulates DTRAF1 by proteasome-mediated degradation...
  7. Freel C, Richardson D, Thomenius M, Gan E, Horn S, Olson M, et al. Mitochondrial localization of Reaper to promote inhibitors of apoptosis protein degradation conferred by GH3 domain-lipid interactions. J Biol Chem. 2008;283:367-79 pubmed
    ..Through direct binding, Reaper can bring the Drosophila IAP (DIAP1) to mitochondria, concomitantly promoting IAP auto-ubiquitination and destruction...
  8. Cordero J, Cagan R. Canonical wingless signaling regulates cone cell specification in the Drosophila retina. Dev Dyn. 2010;239:875-84 pubmed publisher
    ..the more widely studied mid-pupal cell death ("late death") in a process that involves regulation of DIAP1. Furthermore, our data suggest that wg has a previously unreported role in specifying the glial-like cone cells...
  9. Marinari E, Mehonic A, Curran S, Gale J, Duke T, Baum B. Live-cell delamination counterbalances epithelial growth to limit tissue overcrowding. Nature. 2012;484:542-5 pubmed publisher
    ..Because live-cell delamination constitutes a mechanistic link between epithelial hyperplasia and cell invasion, this is likely to have important implications for our understanding of the early stages of cancer development. ..

More Information

Publications110 found, 100 shown here

  1. Ditzel M, Wilson R, Tenev T, Zachariou A, Paul A, Deas E, et al. Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis. Nat Cell Biol. 2003;5:467-73 pubmed
    Some members of the inhibitor of apoptosis (IAP) protein family block apoptosis by binding to and neutralizing active caspases...
  2. Ryoo H, Gorenc T, Steller H. Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways. Dev Cell. 2004;7:491-501 pubmed
    ..Finally, we provide evidence that the DIAP1 antagonists reaper and hid can activate the JNK pathway and that this pathway is required for inducing wg and cell ..
  3. Kanuka H, Kuranaga E, Takemoto K, Hiratou T, Okano H, Miura M. Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development. EMBO J. 2005;24:3793-806 pubmed
    ..These results imply a novel role for caspases in modulating cell signaling pathways through substrate cleavage in neural precursor development...
  4. Edgar B. From cell structure to transcription: Hippo forges a new path. Cell. 2006;124:267-73 pubmed
    ..This conserved signaling pathway contains several tumor-suppressor genes and regulates the contact inhibition of proliferation in cultured cells. ..
  5. Oshima K, Takeda M, Kuranaga E, Ueda R, Aigaki T, Miura M, et al. IKK epsilon regulates F actin assembly and interacts with Drosophila IAP1 in cellular morphogenesis. Curr Biol. 2006;16:1531-7 pubmed
    ..These phenotypes were sensitive to a change in the dosage of Drosophila inhibitor of apoptosis protein 1 (DIAP1) and the caspase DRONC without apparent change in cell viability...
  6. Colussi P, Quinn L, Huang D, Coombe M, Read S, Richardson H, et al. Debcl, a proapoptotic Bcl-2 homologue, is a component of the Drosophila melanogaster cell death machinery. J Cell Biol. 2000;148:703-14 pubmed
    ..We also show that debcl genetically interacts with diap1 and dark, and that debcl-mediated apoptosis is not affected by gene dosage of rpr, hid, and grim...
  7. Yoo S, Huh J, Muro I, Yu H, Wang L, Wang S, et al. Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms. Nat Cell Biol. 2002;4:416-24 pubmed
    b>Inhibitor of apoptosis (IAP) proteins suppress apoptosis and inhibit caspases. Several IAPs also function as ubiquitin-protein ligases. Regulators of IAP auto-ubiquitination, and thus IAP levels, have yet to be identified...
  8. Means J, Muro I, Clem R. Lack of involvement of mitochondrial factors in caspase activation in a Drosophila cell-free system. Cell Death Differ. 2006;13:1222-34 pubmed
    ..The Hid peptide also induced apoptosis when introduced into S2 cells. These results suggest that caspase activation in Drosophila is regulated solely by cytoplasmic factors and does not involve any mitochondrial factors. ..
  9. Ling C, Zheng Y, Yin F, Yu J, Huang J, Hong Y, et al. The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded. Proc Natl Acad Sci U S A. 2010;107:10532-7 pubmed publisher
    ..Furthermore, our studies implicate Crb as a putative cell surface receptor for Hippo signaling by uncovering a transmembrane protein that directly binds to an apical component of the Hippo pathway. ..
  10. Lisi S, Mazzon I, White K. Diverse domains of THREAD/DIAP1 are required to inhibit apoptosis induced by REAPER and HID in Drosophila. Genetics. 2000;154:669-78 pubmed
    ..The Drosophila IAP homolog THREAD/DIAP1 (TH/DIAP1), encoded by the thread (th) gene, negatively regulates apoptosis during development...
  11. Danial N, Korsmeyer S. Cell death: critical control points. Cell. 2004;116:205-19 pubmed
    ..The identification of critical control points in the cell death pathway has yielded fundamental insights for basic biology, as well as provided rational targets for new therapeutics. ..
  12. Ghosh S, Feany M. Comparison of pathways controlling toxicity in the eye and brain in Drosophila models of human neurodegenerative diseases. Hum Mol Genet. 2004;13:2011-8 pubmed
    ..These findings outline common pathways of neurotoxicity, demonstrate disease- and cell-type specific pathways and identify a common vitamin as a potential therapy in polyglutamine disorders. ..
  13. Koto A, Kuranaga E, Miura M. Temporal regulation of Drosophila IAP1 determines caspase functions in sensory organ development. J Cell Biol. 2009;187:219-31 pubmed publisher
    ..To address this issue, we monitored the protein turnover of an endogenous caspase inhibitor, Drosophila IAP1 (DIAP1)...
  14. Neisch A, Speck O, Stronach B, Fehon R. Rho1 regulates apoptosis via activation of the JNK signaling pathway at the plasma membrane. J Cell Biol. 2010;189:311-23 pubmed publisher
    ..Together, these results suggest that Rho1 functions at the cell cortex to regulate JNK activity and implicate Rho1 and Moe in epithelial cell survival. ..
  15. Peterson J, Barkett M, McCall K. Stage-specific regulation of caspase activity in drosophila oogenesis. Dev Biol. 2003;260:113-23 pubmed
    ..Overexpression of the caspase inhibitor DIAP1 suppressed cell death induced by Dcp-1 but had no effect on cell death during late oogenesis...
  16. Scott R, Juhasz G, Neufeld T. Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death. Curr Biol. 2007;17:1-11 pubmed
    ..Furthermore, this work identifies autophagy as a critical mechanism by which inhibition of TOR signaling leads to reduced cell growth. ..
  17. Oh H, Irvine K. In vivo regulation of Yorkie phosphorylation and localization. Development. 2008;135:1081-8 pubmed publisher
    ..These results identify modulation of subcellular localization as a mechanism of Yki regulation, and establish that this regulation occurs in vivo through multiple sites of Warts-dependent phosphorylation on Yki. ..
  18. Vandergaast R, Schultz K, Cerio R, Friesen P. Active depletion of host cell inhibitor-of-apoptosis proteins triggers apoptosis upon baculovirus DNA replication. J Virol. 2011;85:8348-58 pubmed publisher
    ..We report here that the principal IAPs, DIAP1 and SfIAP, of the model insects Drosophila melanogaster and Spodoptera frugiperda, respectively, are rapidly ..
  19. Cho E, Feng Y, Rauskolb C, Maitra S, Fehon R, Irvine K. Delineation of a Fat tumor suppressor pathway. Nat Genet. 2006;38:1142-50 pubmed
    ..melanogaster tumor suppressors, establish a basic framework for Fat signaling from receptor to transcription factor and implicate Warts as an integrator of multiple growth control signals. ..
  20. Florentin A, Arama E. Caspase levels and execution efficiencies determine the apoptotic potential of the cell. J Cell Biol. 2012;196:513-27 pubmed publisher
    ..Finally, we provide evidence for the existence of a cellular execution threshold of caspase activity, which must be reached to induce apoptosis. ..
  21. Yeh T, Bratton S. Caspase-dependent regulation of the ubiquitin-proteasome system through direct substrate targeting. Proc Natl Acad Sci U S A. 2013;110:14284-9 pubmed publisher
    b>Drosophila inhibitor of apoptosis (IAP) 1 (DIAP1) is an E3 ubiquitin ligase that regulates apoptosis in flies, in large part through direct inhibition and/or ubiquitinylation of caspases...
  22. Lee H, Jan L, Jan Y. Drosophila IKK-related kinase Ik2 and Katanin p60-like 1 regulate dendrite pruning of sensory neuron during metamorphosis. Proc Natl Acad Sci U S A. 2009;106:6363-8 pubmed publisher
    ..Our study thus implicates Ik2 and Kat-60L1 in dendrite severing that involves local microtubule disassembly. ..
  23. Yu J, Zheng Y, Dong J, Klusza S, Deng W, Pan D. Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded. Dev Cell. 2010;18:288-99 pubmed publisher
    ..These results shed light on the mechanism of Ex and Mer function and implicate Kibra as a potential tumor suppressor with relevance to neurofibromatosis. ..
  24. Das Thakur M, Feng Y, Jagannathan R, Seppa M, Skeath J, Longmore G. Ajuba LIM proteins are negative regulators of the Hippo signaling pathway. Curr Biol. 2010;20:657-62 pubmed publisher
    ..decreased cell numbers as a result of increased apoptosis and decreased proliferation, due to downregulation of DIAP1 and cyclin E. This phenocopies tissues deficient for Yorkie (Yki), the downstream target of the Hippo pathway...
  25. Hays R, Wickline L, Cagan R. Morgue mediates apoptosis in the Drosophila melanogaster retina by promoting degradation of DIAP1. Nat Cell Biol. 2002;4:425-31 pubmed
    b>Inhibitor of apoptosis proteins (IAPs) provide a critical barrier to inappropriate apoptotic cell death through direct binding and inhibition of caspases...
  26. Bergmann A, Yang A, Srivastava M. Regulators of IAP function: coming to grips with the grim reaper. Curr Opin Cell Biol. 2003;15:717-24 pubmed
    b>Inhibitor of apoptosis proteins (IAPs) are a conserved class of proteins that control apoptosis in both vertebrates and invertebrates...
  27. Lai Z, Wei X, Shimizu T, Ramos E, Rohrbaugh M, Nikolaidis N, et al. Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Cell. 2005;120:675-85 pubmed
    ..A human Mats ortholog (Mats1) can rescue the lethality associated with loss of Mats function in Drosophila. As Mats1 is mutated in human tumors, Mats-mediated growth inhibition and tumor suppression is likely conserved in humans. ..
  28. Tyler D, Baker N. Expanded and fat regulate growth and differentiation in the Drosophila eye through multiple signaling pathways. Dev Biol. 2007;305:187-201 pubmed
    ..During disc growth, ex was largely epistatic to ft, and the Warts pathway mutation hippo largely epistatic to ex. Our data suggest that ft and ex act partially through the Warts pathway. ..
  29. Rhiner C, Diaz B, Portela M, Poyatos J, Fernández Ruíz I, López Gay J, et al. Persistent competition among stem cells and their daughters in the Drosophila ovary germline niche. Development. 2009;136:995-1006 pubmed publisher
    ..Moreover, competitive interactions among stem cells may be relevant for the successful application of stem cell therapies in humans. ..
  30. Yan Y, Denef N, Tang C, Schupbach T. Drosophila PI4KIIIalpha is required in follicle cells for oocyte polarization and Hippo signaling. Development. 2011;138:1697-703 pubmed publisher
    ..In PI4KIIIalpha mutant follicle cells, Merlin fails to localize to the apical domain. Our analysis of PI4KIIIalpha mutants provides a new link in Hippo signal transduction from the cell membrane to its core kinase cascade. ..
  31. Yin V, Thummel C, Bashirullah A. Down-regulation of inhibitor of apoptosis levels provides competence for steroid-triggered cell death. J Cell Biol. 2007;178:85-92 pubmed
    ..a mid-third instar ecdysone pulse, when CBP is necessary and sufficient for down-regulation of the Drosophila inhibitor of apoptosis 1 (DIAP1)...
  32. Zhao M, Szafranski P, Hall C, Goode S. Basolateral junctions utilize warts signaling to control epithelial-mesenchymal transition and proliferation crucial for migration and invasion of Drosophila ovarian epithelial cells. Genetics. 2008;178:1947-71 pubmed publisher
    ..This is further indicated in that Wts targets, CyclinE and DIAP1, are elevated in Fas2, dlg, lgl, wts, and roe cells, but not Fat, ex, or mer cells...
  33. Shapiro P, Hsu H, Jung H, Robbins E, Ryoo H. Regulation of the Drosophila apoptosome through feedback inhibition. Nat Cell Biol. 2008;10:1440-6 pubmed publisher
    ..Moreover, the Drosophila inhibitor of apoptosis protein 1 (Diap1) is required for this process...
  34. Song Z, Steller H. Death by design: mechanism and control of apoptosis. Trends Cell Biol. 1999;9:M49-52 pubmed
    ..However, recent results suggest that these apparent differences in the control of cell death reflect our incomplete knowledge, rather than genuine mechanistic differences between different organisms. ..
  35. Shaw R, Kohlmaier A, Polesello C, Veelken C, Edgar B, Tapon N. The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration. Development. 2010;137:4147-58 pubmed publisher
    ..Our results suggest that the Hpo pathway is a mediator of the regenerative response in the Drosophila midgut. ..
  36. Huh J, Vernooy S, Yu H, Yan N, Shi Y, Guo M, et al. Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization. PLoS Biol. 2004;2:E15 pubmed
    ..These proteins promote cell death, at least in part, by disrupting interactions between the caspase inhibitor DIAP1 and the apical caspase DRONC, which is continually activated in many viable cells through interactions with ARK, ..
  37. Thompson B, Cohen S. The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila. Cell. 2006;126:767-74 pubmed
    ..Yorkie is known to activate Cyclin E (CycE) and the apoptosis inhibitor DIAP1. However, overexpression of these targets is not sufficient to cause tissue overgrowth...
  38. Ryoo H, Bergmann A, Gonen H, Ciechanover A, Steller H. Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1. Nat Cell Biol. 2002;4:432-8 pubmed
    Cell death in higher organisms is negatively regulated by Inhibitor of Apoptosis Proteins (IAPs), which contain a ubiquitin ligase motif, but how ubiquitin-mediated protein degradation is regulated during apoptosis is poorly understood...
  39. Menendez J, Pérez Garijo A, Calleja M, Morata G. A tumor-suppressing mechanism in Drosophila involving cell competition and the Hippo pathway. Proc Natl Acad Sci U S A. 2010;107:14651-6 pubmed publisher
    ..The formation of a tumor requires in addition the formation of a microenvironment that allows mutant cells to evade cell competition. ..
  40. Harvey N, Daish T, Mills K, Dorstyn L, Quinn L, Read S, et al. Characterization of the Drosophila caspase, DAMM. J Biol Chem. 2001;276:25342-50 pubmed
  41. Hawkins C, Ekert P, Uren A, Holmgreen S, Vaux D. Anti-apoptotic potential of insect cellular and viral IAPs in mammalian cells. Cell Death Differ. 1998;5:569-76 pubmed
    ..apoptotic mechanism, but as none of these IAPs could bind TRAF proteins, TRAFs are not likely to be important for IAP mediated apoptosis inhibition...
  42. Cullen K, McCall K. Role of programmed cell death in patterning the Drosophila antennal arista. Dev Biol. 2004;275:82-92 pubmed
    ..A homozygous viable mutation in the thread gene, which encodes an inhibitor of apoptosis protein, produces a branchless arista...
  43. Hamaratoglu F, Willecke M, Kango Singh M, Nolo R, Hyun E, Tao C, et al. The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol. 2006;8:27-36 pubmed
    ..Our genetic and biochemical data place Merlin and Expanded upstream of Hippo and identify a pathway through which they act as tumour-suppressor genes. ..
  44. Nolo R, Morrison C, Tao C, Zhang X, Halder G. The bantam microRNA is a target of the hippo tumor-suppressor pathway. Curr Biol. 2006;16:1895-904 pubmed
    ..Hippo regulates bantam independently of cyclin E and diap1, two other Hippo targets, and overexpression of bantam mimics overgrowth phenotypes of hippo mutant cells...
  45. Bardet P, Kolahgar G, Mynett A, Miguel Aliaga I, Briscoe J, Meier P, et al. A fluorescent reporter of caspase activity for live imaging. Proc Natl Acad Sci U S A. 2008;105:13901-5 pubmed publisher
    ..As expected from the high conservation of caspases, it is also cleaved in dying cells of chick embryos. It is therefore likely to be generally useful to track the spatiotemporal pattern of caspase activity in a variety of species. ..
  46. Doumanis J, Wada K, Kino Y, Moore A, Nukina N. RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation. PLoS ONE. 2009;4:e7275 pubmed publisher
    ..Newly identified modifiers including genes related to nuclear transport, nucleotide processes, and signaling, may be involved in polyglutamine aggregate formation and Huntington disease cascades. ..
  47. Abrams J. An emerging blueprint for apoptosis in Drosophila. Trends Cell Biol. 1999;9:435-40 pubmed
    ..The death inducers Reaper, Grim and Hid relay signals, possibly through IAPs (inhibitor of apoptosis proteins) and Dark (an Apaf-1/Ced-4 homologue), to trigger caspase function...
  48. Muro I, Means J, Clem R. Cleavage of the apoptosis inhibitor DIAP1 by the apical caspase DRONC in both normal and apoptotic Drosophila cells. J Biol Chem. 2005;280:18683-8 pubmed
    ..Unintended apoptosis is prevented by the inhibitor of apoptosis DIAP1, which targets the processed form of DRONC for degradation through its E3 ubiquitin protein ligase ..
  49. Leulier F, Ribeiro P, Palmer E, Tenev T, Takahashi K, Robertson D, et al. Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery. Cell Death Differ. 2006;13:1663-74 pubmed
    ..apoptosis requires a broader range of caspases than apoptosis initiated by loss of the caspase inhibitor DIAP1, suggesting that Hid causes apoptosis not only by antagonizing DIAP1 but also by activating DIAP1-independent ..
  50. Choi Y, Lee G, Park J. Programmed cell death mechanisms of identifiable peptidergic neurons in Drosophila melanogaster. Development. 2006;133:2223-32 pubmed
    ..Our data further suggest that diap1 does not play a role as a central regulator of the PCD of vCrz neurons...
  51. Yu J, Poulton J, Huang Y, Deng W. The hippo pathway promotes Notch signaling in regulation of cell differentiation, proliferation, and oocyte polarity. PLoS ONE. 2008;3:e1761 pubmed publisher
  52. Kanao T, Venderova K, Park D, Unterman T, Lu B, Imai Y. Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila. Hum Mol Genet. 2010;19:3747-58 pubmed publisher
    ..These data suggest that the cell death molecules regulated by FoxO are key factors during the neurodegeneration in LRRK2-linked PD. ..
  53. Lee T, Fan Y, Wang S, Srivastava M, Broemer M, Meier P, et al. Drosophila IAP1-mediated ubiquitylation controls activation of the initiator caspase DRONC independent of protein degradation. PLoS Genet. 2011;7:e1002261 pubmed publisher
    ..However, non-proteolytic functions of ubiquitylation are also known. In Drosophila, the inhibitor of apoptosis protein 1 (DIAP1) is known to ubiquitylate the initiator caspase DRONC in vitro...
  54. Oh H, Slattery M, Ma L, Crofts A, White K, Mann R, et al. Genome-wide association of Yorkie with chromatin and chromatin-remodeling complexes. Cell Rep. 2013;3:309-18 pubmed publisher
    ..Our studies suggest a widespread role for Yorkie as a regulator of transcription and identify recruitment of the chromatin-modifying GAF protein and BRM complex as a molecular mechanism for transcriptional activation by Yorkie. ..
  55. Holley C, Olson M, COLON RAMOS D, Kornbluth S. Reaper eliminates IAP proteins through stimulated IAP degradation and generalized translational inhibition. Nat Cell Biol. 2002;4:439-44 pubmed
    ..Grim, and HID, and the mammalian proteins Smac/Diablo and Omi/HtrA2, all of which share a conserved amino-terminal IAP-binding motif. We report here that Rpr not only inhibits IAP function, but also greatly decreases IAP abundance...
  56. Muro I, Hay B, Clem R. The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated, processed form of the apical caspase DRONC. J Biol Chem. 2002;277:49644-50 pubmed
    Although loss of the inhibitor of apoptosis (IAP) protein DIAP1 has been shown to result in caspase activation and spontaneous cell death in Drosophila cells and embryos, the point at which DIAP1 normally functions to inhibit caspase ..
  57. Vidal M, Larson D, Cagan R. Csk-deficient boundary cells are eliminated from normal Drosophila epithelia by exclusion, migration, and apoptosis. Dev Cell. 2006;10:33-44 pubmed
  58. Kuo C, Zhu S, Younger S, Jan L, Jan Y. Identification of E2/E3 ubiquitinating enzymes and caspase activity regulating Drosophila sensory neuron dendrite pruning. Neuron. 2006;51:283-90 pubmed
    ..Further, we found that UPS activation likely leads to UbcD1-mediated degradation of DIAP1, a caspase-antagonizing E3 ligase...
  59. Willecke M, Hamaratoglu F, Sansores Garcia L, Tao C, Halder G. Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation. Proc Natl Acad Sci U S A. 2008;105:14897-902 pubmed publisher
    ..The Ds/Fj signaling system thus defines a cell-to-cell signaling mechanism that regulates the Hippo pathway, thereby contributing to the control of organ size. ..
  60. Doumanis J, Quinn L, Richardson H, Kumar S. STRICA, a novel Drosophila melanogaster caspase with an unusual serine/threonine-rich prodomain, interacts with DIAP1 and DIAP2. Cell Death Differ. 2001;8:387-94 pubmed
    ..that, upon overexpression, caused apoptosis in cultured Drosophila SL2 cells that was partially suppressed by DIAP1. Interestingly, unlike other fly caspases, STRICA showed physical association with DIAP2, in cotransfection ..
  61. Kornbluth S, White K. Apoptosis in Drosophila: neither fish nor fowl (nor man, nor worm). J Cell Sci. 2005;118:1779-87 pubmed
    ..there is a clear evolutionary conservation of apoptotic regulators such as caspases, Bcl-2 family members, inhibitor of apoptosis (IAP) proteins, IAP antagonists and caspase activators...
  62. Colombani J, Polesello C, Josué F, Tapon N. Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage. Curr Biol. 2006;16:1453-8 pubmed
    ..This pathway has been shown to restrict cell division and promote apoptosis. The caspase repressor DIAP1 appears to be a primary target of the Hpo pathway in cell-death control...
  63. Pellock B, Buff E, White K, Hariharan I. The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling. Dev Biol. 2007;304:102-15 pubmed
    ..Finally, ex has a role in regulating Wingless protein levels in the eye that is not obviously shared by either mer or hpo. Taken together, our data suggest that Mer and Ex differentially regulate multiple downstream pathways. ..
  64. Bergmann A, Agapite J, Steller H. Mechanisms and control of programmed cell death in invertebrates. Oncogene. 1998;17:3215-23 pubmed
    ..This review summarizes some of the key findings in this area, but also touches on some of the many unresolved questions and challenges that remain. ..
  65. Zimmermann K, Ricci J, Droin N, Green D. The role of ARK in stress-induced apoptosis in Drosophila cells. J Cell Biol. 2002;156:1077-87 pubmed
    ..Reduction of DIAP1 induced rapid apoptosis in these cells, whereas the inhibition of DIAP2 expression did not but resulted in ..
  66. Wells B, Yoshida E, Johnston L. Compensatory proliferation in Drosophila imaginal discs requires Dronc-dependent p53 activity. Curr Biol. 2006;16:1606-15 pubmed
    ..Our data suggest that dp53 may carry out an ancestral function that promotes animal survival through the coordination of responses leading to compensatory growth after tissue damage. ..
  67. Lee T, Ding T, Chen Z, Rajendran V, Scherr H, Lackey M, et al. The E1 ubiquitin-activating enzyme Uba1 in Drosophila controls apoptosis autonomously and tissue growth non-autonomously. Development. 2008;135:43-52 pubmed
    ..In summary, the phenotypic analysis of Uba1 demonstrates that impaired ubiquitin conjugation has significant consequences for the organism, and may implicate Uba1 as a tumor suppressor gene. ..
  68. Robinson B, Huang J, Hong Y, Moberg K. Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded. Curr Biol. 2010;20:582-90 pubmed publisher
  69. Igaki T, Kanda H, Yamamoto Goto Y, Kanuka H, Kuranaga E, Aigaki T, et al. Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway. EMBO J. 2002;21:3009-18 pubmed
    ..Although this cell death process is blocked by Drosophila inhibitor-of-apoptosis protein 1 (DIAP1), it does not require caspase activity...
  70. Pantalacci S, Tapon N, Leopold P. The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila. Nat Cell Biol. 2003;5:921-7 pubmed
    ..Whereas Sav and Hpo normally restrict cellular quantities of the Drosophila inhibitor of apoptosis protein DIAP1, overexpression of Hpo destabilizes DIAP1 in cell culture...
  71. Jassim O, Fink J, Cagan R. Dmp53 protects the Drosophila retina during a developmentally regulated DNA damage response. EMBO J. 2003;22:5622-32 pubmed
    ..Utilizing genetic and microarray data, we provide evidence for the central role of Hid expression and for Diap1 protein stability in controlling the UV response...
  72. Huang J, Wu S, Barrera J, Matthews K, Pan D. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell. 2005;122:421-34 pubmed
    ..mechanisms, negatively regulates the transcription of cell-cycle and cell-death regulators such as cycE and diap1. Here we identify Yorkie (Yki), the Drosophila ortholog of the mammalian transcriptional coactivator yes-..
  73. Xu D, Woodfield S, Lee T, Fan Y, Antonio C, Bergmann A. Genetic control of programmed cell death (apoptosis) in Drosophila. Fly (Austin). 2009;3:78-90 pubmed
    ..Here, we review the key players of the cell death pathway in Drosophila and discuss their roles in apoptotic and non-apoptotic processes. ..
  74. Wang S, Hawkins C, Yoo S, Muller H, Hay B. The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID. Cell. 1999;98:453-63 pubmed
    ..HID), and GRIM induce caspase-dependent cell death and physically interact with the cell death inhibitor DIAP1. Here we show that HID blocks DIAP1's ability to inhibit caspase activity and provide evidence suggesting that RPR ..
  75. Christich A, Kauppila S, Chen P, Sogame N, Ho S, Abrams J. The damage-responsive Drosophila gene sickle encodes a novel IAP binding protein similar to but distinct from reaper, grim, and hid. Curr Biol. 2002;12:137-40 pubmed
    In flies and mammals, critical regulators of cell death function by antagonizing Inhibitor of Apoptosis Proteins (IAPs), which themselves directly block caspase action...
  76. Moreno E, Yan M, Basler K. Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily. Curr Biol. 2002;12:1263-8 pubmed
    ..A direct mode of action via the apical FADD/caspase-8 pathway may have been coopted by some TNF signaling systems only at subsequent stages of evolution. ..
  77. Perea D, Molohon K, Edwards K, Diaz Benjumea F. Multiple roles of the gene zinc finger homeodomain-2 in the development of the Drosophila wing. Mech Dev. 2013;130:467-81 pubmed publisher
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    ..caspases are under positive control via the CED-4/Apaf-1/Dark adaptors and negative control via IAPs (inhibitor of apoptosis proteins). However, the in vivo genetic relationship between these opposing regulators is not known...
  79. Janody F, Treisman J. Actin capping protein alpha maintains vestigial-expressing cells within the Drosophila wing disc epithelium. Development. 2006;133:3349-57 pubmed
    ..Our results suggest that Vestigial specifies the cytoskeletal changes that lead to morphogenesis of the adult wing. ..
  80. Latouche M, Lasbleiz C, Martin E, Monnier V, Debeir T, Mouatt Prigent A, et al. A conditional pan-neuronal Drosophila model of spinocerebellar ataxia 7 with a reversible adult phenotype suitable for identifying modifier genes. J Neurosci. 2007;27:2483-92 pubmed
    ..Sodium butyrate, a histone deacetylase inhibitor, improved the survival time of the neurons. This model is therefore a powerful tool for studying SCA7 and for the development of potential therapies for polyQ diseases. ..
  81. Pfleger C, Harvey K, Yan H, Hariharan I. Mutation of the gene encoding the ubiquitin activating enzyme ubal causes tissue overgrowth in Drosophila. Fly (Austin). 2007;1:95-105 pubmed
    ..Our studies show that a reduction in E1 activity can promote tissue growth in a multicellular organism and raise the possibility that changes in E1 activity may occur during normal development or in cancer. ..
  82. Wang Z, Kalderon D. Cyclin E-dependent protein kinase activity regulates niche retention of Drosophila ovarian follicle stem cells. Proc Natl Acad Sci U S A. 2009;106:21701-6 pubmed publisher
    ..We speculate that a positive connection between central regulators of the cell cycle and niche retention may be a common feature of highly proliferative stem cells. ..
  83. Koontz L, Liu Chittenden Y, Yin F, Zheng Y, Yu J, Huang B, et al. The Hippo effector Yorkie controls normal tissue growth by antagonizing scalloped-mediated default repression. Dev Cell. 2013;25:388-401 pubmed publisher
    ..These findings fill a major gap in Hippo-mediated transcriptional regulation and open up possibilities for modulating the YAP oncoprotein in cancer and regenerative medicine. ..
  84. Olson M, Holley C, Gan E, COLON RAMOS D, Kaplan B, Kornbluth S. A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation. J Biol Chem. 2003;278:44758-68 pubmed
    ..functions have been ascribed to this protein, including inhibition of IAPs (inhibitors of apoptosis); induction of IAP degradation; inhibition of protein translation; and when expressed in vertebrate cells, induction of mitochondrial ..
  85. Yin V, Thummel C. A balance between the diap1 death inhibitor and reaper and hid death inducers controls steroid-triggered cell death in Drosophila. Proc Natl Acad Sci U S A. 2004;101:8022-7 pubmed
    ..We also identify the Drosophila inhibitor of apoptosis 1 as a survival factor in the larval cell death pathway, delaying death until its inhibitory effect ..
  86. Huh J, Guo M, Hay B. Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase Dronc in a nonapoptotic role. Curr Biol. 2004;14:1262-6 pubmed
    ..We speculate that dying cells may communicate cell fate or behavior instructions to their neighbors in other contexts as well. ..
  87. Yokokura T, Dresnek D, Huseinovic N, Lisi S, Abdelwahid E, Bangs P, et al. Dissection of DIAP1 functional domains via a mutant replacement strategy. J Biol Chem. 2004;279:52603-12 pubmed
    b>Inhibitor of apoptosis proteins (IAPs) act as endogenous inhibitors of active caspases. Drosophila IAP1 (DIAP1) activity is required to keep cells from undergoing apoptosis...
  88. Arama E, Bader M, Rieckhof G, Steller H. A ubiquitin ligase complex regulates caspase activation during sperm differentiation in Drosophila. PLoS Biol. 2007;5:e251 pubmed
    ..Finally, the BIR domain region of the giant inhibitor of apoptosis-like protein dBruce is sufficient to bind to Klhl10, which is consistent with the idea that dBruce is a ..
  89. Olson M, Holley C, Yoo S, Huh J, Hay B, Kornbluth S. Reaper is regulated by IAP-mediated ubiquitination. J Biol Chem. 2003;278:4028-34 pubmed
    ..Disruption of IAP-mediated caspase inhibition has been shown to be an important activity for pro-apoptotic proteins in Drosophila (..
  90. Yoo S. Grim stimulates Diap1 poly-ubiquitination by binding to UbcD1. Mol Cells. 2005;20:446-51 pubmed
    b>Diap1 is an essential Drosophila cell death regulator that binds to caspases and inhibits their activity. Reaper, Grim and Hid each antagonize Diap1 by binding to its BIR domain, activating the caspases and eventually causing cell death...
  91. Lannan E, Vandergaast R, Friesen P. Baculovirus caspase inhibitors P49 and P35 block virus-induced apoptosis downstream of effector caspase DrICE activation in Drosophila melanogaster cells. J Virol. 2007;81:9319-30 pubmed
    ..Activation was blocked by overexpression of the cellular inhibitor-of-apoptosis proteins DIAP1 and SfIAP but not by the baculovirus caspase inhibitor P49 or P35...
  92. Li X, Wang J, Shi Y. Structural mechanisms of DIAP1 auto-inhibition and DIAP1-mediated inhibition of drICE. Nat Commun. 2011;2:408 pubmed publisher
    The Drosophila inhibitor of apoptosis protein DIAP1 exists in an auto-inhibited conformation, unable to suppress the effector caspase drICE. Auto-inhibition is disabled by caspase-mediated cleavage of DIAP1 after Asp20...