Dhc64C

Summary

Gene Symbol: Dhc64C
Description: Dynein heavy chain 64C
Alias: CG7507, Cdhc, DHC, DHC1, DHC64C, DYHC, Dhc, Dhc46C, Dhc64, Dhc64c, Dmel\CG7507, Dynein, FCP-A, Fs(3)Lab, Fs(3)Laborc, Fs(3)Sz18, HMW MAP, Lab, Su(Gl)77, cDhc, cDhc64C, dhc, dhc64C, dhc64c, l(3)64Ca, dynein heavy chain 64C, CG7507-PA, CG7507-PC, CG7507-PD, CG7507-PE, CG7507-PF, CG7507-PG, CG7507-PH, CG7507-PI, Dhc64C-PA, Dhc64C-PC, Dhc64C-PD, Dhc64C-PE, Dhc64C-PF, Dhc64C-PG, Dhc64C-PH, Dhc64C-PI, cytoplasmic dynein, cytoplasmic dynein heavy chain, cytoplasmic dynenin, dynein, dynein HC, dynein heavy chain, dynein heavy chain 64c, dynein heavy chain at 64C, dynein heavy-chain, female sterile(3)Laborc, laborc, suppressor of glued 77
Species: fruit fly
Products:     Dhc64C

Top Publications

  1. Gindhart J, Desai C, Beushausen S, Zinn K, Goldstein L. Kinesin light chains are essential for axonal transport in Drosophila. J Cell Biol. 1998;141:443-54 pubmed
    ..vesicle precursors as well as organelles that may be transported by kinesin, kinesin-like protein 68D, and cytoplasmic dynein, thus providing evidence that the loss of Klc function blocks multiple pathways of axonal transport...
  2. Harte P, Kankel D. Genetic analysis of mutations at the Glued locus and interacting loci in Drosophila melanogaster. Genetics. 1982;101:477-501 pubmed
    ..All "revertants" that alter the abnormal eye phenotype towards the wild type have similar impact on the organization of the optic lobe. ..
  3. Boylan K, Hays T. The gene for the intermediate chain subunit of cytoplasmic dynein is essential in Drosophila. Genetics. 2002;162:1211-20 pubmed
    The microtubule motor cytoplasmic dynein powers a variety of intracellular transport events that are essential for cellular and developmental processes...
  4. Boylan K, Serr M, Hays T. A molecular genetic analysis of the interaction between the cytoplasmic dynein intermediate chain and the glued (dynactin) complex. Mol Biol Cell. 2000;11:3791-803 pubmed
    The microtubule motor cytoplasmic dynein performs multiple cellular functions; however, the regulation and targeting of the motor to different cargoes is not well understood...
  5. Otani T, Oshima K, Onishi S, Takeda M, Shinmyozu K, Yonemura S, et al. IKK? regulates cell elongation through recycling endosome shuttling. Dev Cell. 2011;20:219-32 pubmed publisher
    ..IKK? regulates the localization of recycling endosome regulators Rab11 and Dynein and phosphorylates their adaptor molecule, Nuclear fallout (Nuf)...
  6. Mische S, He Y, Ma L, Li M, Serr M, Hays T. Dynein light intermediate chain: an essential subunit that contributes to spindle checkpoint inactivation. Mol Biol Cell. 2008;19:4918-29 pubmed publisher
    ..Previous work has established that the LIC homodimer binds directly to the dynein heavy chain and may mediate the attachment of dynein to centrosomes and other cargoes...
  7. Folker E, Schulman V, Baylies M. Translocating myonuclei have distinct leading and lagging edges that require kinesin and dynein. Development. 2014;141:355-66 pubmed publisher
    ..Myonuclear positioning is dependent on Kinesin and Dynein, but interactions between these motor proteins and their mechanisms of action are unclear...
  8. Griffis E, Stuurman N, Vale R. Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore. J Cell Biol. 2007;177:1005-15 pubmed
    ..In higher eukaryotes, cytoplasmic dynein is involved in silencing the SAC by removing the checkpoint proteins Mad2 and the Rod-Zw10-Zwilch complex (..
  9. Mische S, Li M, Serr M, Hays T. Direct observation of regulated ribonucleoprotein transport across the nurse cell/oocyte boundary. Mol Biol Cell. 2007;18:2254-63 pubmed
    ..The microtubule motors dynein and kinesin are required for the proper localization of the determinant ribonucleoprotein (RNP) complexes, but the ..
  10. Gepner J, Li M, Ludmann S, Kortas C, Boylan K, Iyadurai S, et al. Cytoplasmic dynein function is essential in Drosophila melanogaster. Genetics. 1996;142:865-78 pubmed
    ..We previously identified and characterized the Drosophila gene Dhc64C, which encodes a cytoplasmic dynein heavy chain. To investigate the function of the cytoplasmic dynein motor, we initiated a mutational analysis of ..

Detail Information

Publications67

  1. Gindhart J, Desai C, Beushausen S, Zinn K, Goldstein L. Kinesin light chains are essential for axonal transport in Drosophila. J Cell Biol. 1998;141:443-54 pubmed
    ..vesicle precursors as well as organelles that may be transported by kinesin, kinesin-like protein 68D, and cytoplasmic dynein, thus providing evidence that the loss of Klc function blocks multiple pathways of axonal transport...
  2. Harte P, Kankel D. Genetic analysis of mutations at the Glued locus and interacting loci in Drosophila melanogaster. Genetics. 1982;101:477-501 pubmed
    ..All "revertants" that alter the abnormal eye phenotype towards the wild type have similar impact on the organization of the optic lobe. ..
  3. Boylan K, Hays T. The gene for the intermediate chain subunit of cytoplasmic dynein is essential in Drosophila. Genetics. 2002;162:1211-20 pubmed
    The microtubule motor cytoplasmic dynein powers a variety of intracellular transport events that are essential for cellular and developmental processes...
  4. Boylan K, Serr M, Hays T. A molecular genetic analysis of the interaction between the cytoplasmic dynein intermediate chain and the glued (dynactin) complex. Mol Biol Cell. 2000;11:3791-803 pubmed
    The microtubule motor cytoplasmic dynein performs multiple cellular functions; however, the regulation and targeting of the motor to different cargoes is not well understood...
  5. Otani T, Oshima K, Onishi S, Takeda M, Shinmyozu K, Yonemura S, et al. IKK? regulates cell elongation through recycling endosome shuttling. Dev Cell. 2011;20:219-32 pubmed publisher
    ..IKK? regulates the localization of recycling endosome regulators Rab11 and Dynein and phosphorylates their adaptor molecule, Nuclear fallout (Nuf)...
  6. Mische S, He Y, Ma L, Li M, Serr M, Hays T. Dynein light intermediate chain: an essential subunit that contributes to spindle checkpoint inactivation. Mol Biol Cell. 2008;19:4918-29 pubmed publisher
    ..Previous work has established that the LIC homodimer binds directly to the dynein heavy chain and may mediate the attachment of dynein to centrosomes and other cargoes...
  7. Folker E, Schulman V, Baylies M. Translocating myonuclei have distinct leading and lagging edges that require kinesin and dynein. Development. 2014;141:355-66 pubmed publisher
    ..Myonuclear positioning is dependent on Kinesin and Dynein, but interactions between these motor proteins and their mechanisms of action are unclear...
  8. Griffis E, Stuurman N, Vale R. Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore. J Cell Biol. 2007;177:1005-15 pubmed
    ..In higher eukaryotes, cytoplasmic dynein is involved in silencing the SAC by removing the checkpoint proteins Mad2 and the Rod-Zw10-Zwilch complex (..
  9. Mische S, Li M, Serr M, Hays T. Direct observation of regulated ribonucleoprotein transport across the nurse cell/oocyte boundary. Mol Biol Cell. 2007;18:2254-63 pubmed
    ..The microtubule motors dynein and kinesin are required for the proper localization of the determinant ribonucleoprotein (RNP) complexes, but the ..
  10. Gepner J, Li M, Ludmann S, Kortas C, Boylan K, Iyadurai S, et al. Cytoplasmic dynein function is essential in Drosophila melanogaster. Genetics. 1996;142:865-78 pubmed
    ..We previously identified and characterized the Drosophila gene Dhc64C, which encodes a cytoplasmic dynein heavy chain. To investigate the function of the cytoplasmic dynein motor, we initiated a mutational analysis of ..
  11. Ally S, Larson A, Barlan K, Rice S, Gelfand V. Opposite-polarity motors activate one another to trigger cargo transport in live cells. J Cell Biol. 2009;187:1071-82 pubmed publisher
    ..Kinesin-1 and cytoplasmic dynein require each other for bidirectional transport of intracellular cargo along microtubules; i.e...
  12. Saxton W. Microtubules, motors, and mRNA localization mechanisms: watching fluorescent messages move. Cell. 2001;107:707-10 pubmed
    ..To dissect the mechanisms of localization, several groups are employing advanced fluorescence microscopy to track RNA movements in live oocytes and embryos. ..
  13. Brendza R, Serbus L, Saxton W, Duffy J. Posterior localization of dynein and dorsal-ventral axis formation depend on kinesin in Drosophila oocytes. Curr Biol. 2002;12:1541-5 pubmed
    ..Likewise, minus end-directed motors may move cargoes toward anterior destinations. Contradicting this, cytoplasmic dynein, a minus-end motor, accumulates at the posterior...
  14. Lei Y, Warrior R. The Drosophila Lissencephaly1 (DLis1) gene is required for nuclear migration. Dev Biol. 2000;226:57-72 pubmed
    ..DLis1 shows genetic interactions with the Glued and Dynein heavy chain subunits of the dynein/dynactin complex, supporting the idea that the Lis1 family of proteins plays a role ..
  15. Kim H, Ling S, Rogers G, Kural C, Selvin P, Rogers S, et al. Microtubule binding by dynactin is required for microtubule organization but not cargo transport. J Cell Biol. 2007;176:641-51 pubmed
    Dynactin links cytoplasmic dynein and other motors to cargo and is involved in organizing radial microtubule arrays...
  16. Siller K, Serr M, Steward R, Hays T, Doe C. Live imaging of Drosophila brain neuroblasts reveals a role for Lis1/dynactin in spindle assembly and mitotic checkpoint control. Mol Biol Cell. 2005;16:5127-40 pubmed
    ..Lis1 binds dynactin and the dynein motor complex, but the role of Lis1 in many dynein/dynactin-dependent processes is not clearly understood...
  17. Lloyd T, Machamer J, O Hara K, Kim J, Collins S, Wong M, et al. The p150(Glued) CAP-Gly domain regulates initiation of retrograde transport at synaptic termini. Neuron. 2012;74:344-60 pubmed publisher
    p150(Glued) is the major subunit of dynactin, a complex that functions with dynein in minus-end-directed microtubule transport...
  18. Swan A, Nguyen T, Suter B. Drosophila Lissencephaly-1 functions with Bic-D and dynein in oocyte determination and nuclear positioning. Nat Cell Biol. 1999;1:444-9 pubmed
    ..the Drosophila homologue of Lissencephaly-1, DLis-1, acts together with Bicaudal-D (Bic-D), Egalitarian (Egl), dynein and microtubules to determine oocyte identity...
  19. Hays T, Porter M, McGrail M, Grissom P, Gosch P, Fuller M, et al. A cytoplasmic dynein motor in Drosophila: identification and localization during embryogenesis. J Cell Sci. 1994;107 ( Pt 6):1557-69 pubmed
    ..A polyclonal antibody raised against the dynein heavy chain polypeptide was used to localize the dynein antigen in whole-mount preparations of embryos by ..
  20. Bullock S, Nicol A, Gross S, Zicha D. Guidance of bidirectional motor complexes by mRNA cargoes through control of dynein number and activity. Curr Biol. 2006;16:1447-52 pubmed
    ..We show that these proteins, together with the dynein motor, are recruited differentially to different RNA signals...
  21. Basto R, Scaƫrou F, Mische S, Wojcik E, Lefebvre C, Gomes R, et al. In vivo dynamics of the rough deal checkpoint protein during Drosophila mitosis. Curr Biol. 2004;14:56-61 pubmed
    ..Rod) and Zw10 are components of a complex required for the metazoan metaphase checkpoint and for recruitment of dynein/dynactin to the kinetochore...
  22. Pilling A, Horiuchi D, Lively C, Saxton W. Kinesin-1 and Dynein are the primary motors for fast transport of mitochondria in Drosophila motor axons. Mol Biol Cell. 2006;17:2057-68 pubmed
    ..that the primary motors for mitochondrial movement in larval motor axons are kinesin-1 (anterograde) and cytoplasmic dynein (retrograde), and interestingly that kinesin-1 is critical for retrograde transport by dynein...
  23. Satoh D, Sato D, Tsuyama T, Saito M, Ohkura H, Rolls M, et al. Spatial control of branching within dendritic arbors by dynein-dependent transport of Rab5-endosomes. Nat Cell Biol. 2008;10:1164-71 pubmed publisher
    ..Here we report that mutations of motor-protein genes, including a dynein subunit gene (dlic) and kinesin heavy chain (khc), caused not only downsizing of the overall arbor, but also a ..
  24. Swaroop A, Sun J, Paco Larson M, Garen A. Molecular organization and expression of the genetic locus glued in Drosophila melanogaster. Mol Cell Biol. 1986;6:833-41 pubmed
    ..It remains to be determined whether this gene is also involved with the Glued function. ..
  25. Steinhauer J, Kalderon D. The RNA-binding protein Squid is required for the establishment of anteroposterior polarity in the Drosophila oocyte. Development. 2005;132:5515-25 pubmed
    ..Loss of Sqd does not affect polarity in follicle cells, wings or eyes, indicating a specific role in the determination of MT polarity within the germline. ..
  26. Dzhindzhev N, Rogers S, Vale R, Ohkura H. Distinct mechanisms govern the localisation of Drosophila CLIP-190 to unattached kinetochores and microtubule plus-ends. J Cell Sci. 2005;118:3781-90 pubmed
    ..This localisation depends on the dynein-dynactin complex and Lis1 which also localise to unattached kinetochores...
  27. Maiato H, Rieder C, Khodjakov A. Kinetochore-driven formation of kinetochore fibers contributes to spindle assembly during animal mitosis. J Cell Biol. 2004;167:831-40 pubmed
    ..but, as they grow, their minus ends are captured by astral microtubules (MTs) and transported poleward through a dynein-dependent mechanism. This poleward transport results in chromosome bi-orientation and congression...
  28. Navarro C, Puthalakath H, Adams J, Strasser A, Lehmann R. Egalitarian binds dynein light chain to establish oocyte polarity and maintain oocyte fate. Nat Cell Biol. 2004;6:427-35 pubmed
    ..The cytoplasmic dynein microtubule motor complex is involved in this process...
  29. Van de Bor V, Zimniak G, Cerezo D, Schaub S, Noselli S. Asymmetric localisation of cytokine mRNA is essential for JAK/STAT activation during cell invasiveness. Development. 2011;138:1383-93 pubmed publisher
    ..stable and polarised network of microtubules along which upd transcripts are asymmetrically transported in a Dynein-dependent manner...
  30. Sharp D, Brown H, Kwon M, Rogers G, Holland G, Scholey J. Functional coordination of three mitotic motors in Drosophila embryos. Mol Biol Cell. 2000;11:241-53 pubmed
    ..pole movements are directed by a temporally coordinated balance of forces generated by three mitotic motors, cytoplasmic dynein, KLP61F, and Ncd...
  31. Delanoue R, Davis I. Dynein anchors its mRNA cargo after apical transport in the Drosophila blastoderm embryo. Cell. 2005;122:97-106 pubmed
    ..One class of cargo is localized mRNAs, which are transported by myosin on actin filaments or by kinesin and dynein on microtubules...
  32. Martin M, Iyadurai S, Gassman A, Gindhart J, Hays T, Saxton W. Cytoplasmic dynein, the dynactin complex, and kinesin are interdependent and essential for fast axonal transport. Mol Biol Cell. 1999;10:3717-28 pubmed
    ..We have tested the functions of the cytoplasmic dynein heavy chain (cDhc64C) and the p150(Glued) (Glued) component of the dynactin complex with the use of genetic ..
  33. Loiseau P, Davies T, Williams L, Mishima M, Palacios I. Drosophila PAT1 is required for Kinesin-1 to transport cargo and to maximize its motility. Development. 2010;137:2763-72 pubmed publisher
    ..KHC is also essential for the localization of Dynein and for all ooplasmic flows...
  34. McGrail M, Gepner J, Silvanovich A, Ludmann S, Serr M, Hays T. Regulation of cytoplasmic dynein function in vivo by the Drosophila Glued complex. J Cell Biol. 1995;131:411-25 pubmed
    ..In genetic complementation studies, we find that certain mutations in the cytoplasmic dynein heavy chain gene Dhc64C act as dominant suppressors or enhancers of the rough eye phenotype of the dominant Glued ..
  35. Li X, Kuromi H, Briggs L, Green D, Rocha J, Sweeney S, et al. Bicaudal-D binds clathrin heavy chain to promote its transport and augments synaptic vesicle recycling. EMBO J. 2010;29:992-1006 pubmed publisher
    ..The Bicaudal-D (BicD) protein participates in the transport of a subset of cargoes by the minus-end-directed motor dynein, although the full extent of its functions is unclear...
  36. McGrail M, Hays T. The microtubule motor cytoplasmic dynein is required for spindle orientation during germline cell divisions and oocyte differentiation in Drosophila. Development. 1997;124:2409-19 pubmed
    ..Using mutations in the Drosophila cytoplasmic dynein heavy chain gene, Dhc64C, we show that cytoplasmic dynein is required at two stages of oogenesis...
  37. Cox R, Spradling A. Milton controls the early acquisition of mitochondria by Drosophila oocytes. Development. 2006;133:3371-7 pubmed
  38. King J, Hays T, Nicklas R. Dynein is a transient kinetochore component whose binding is regulated by microtubule attachment, not tension. J Cell Biol. 2000;151:739-48 pubmed
    b>Cytoplasmic dynein is the only known kinetochore protein capable of driving chromosome movement toward spindle poles...
  39. Sharp D, Rogers G, Scholey J. Cytoplasmic dynein is required for poleward chromosome movement during mitosis in Drosophila embryos. Nat Cell Biol. 2000;2:922-30 pubmed
    ..chromosome movements that occur during prometaphase and anaphase A are driven by the microtubule motor cytoplasmic dynein, which binds to kinetochores and transports them toward the minus ends of spindle microtubules...
  40. Wilkie G, Davis I. Drosophila wingless and pair-rule transcripts localize apically by dynein-mediated transport of RNA particles. Cell. 2001;105:209-19 pubmed
    ..b>Cytoplasmic dynein is required for correct localization of endogenous transcripts and apical movement of injected RNA particles...
  41. Morales Mulia S, Scholey J. Spindle pole organization in Drosophila S2 cells by dynein, abnormal spindle protein (Asp), and KLP10A. Mol Biol Cell. 2005;16:3176-86 pubmed
    b>Dynein is a critical mitotic motor whose inhibition causes defects in spindle pole organization and separation, chromosome congression or segregation, and anaphase spindle elongation, but results differ in different systems...
  42. Li M, Serr M, Newman E, Hays T. The Drosophila tctex-1 light chain is dispensable for essential cytoplasmic dynein functions but is required during spermatid differentiation. Mol Biol Cell. 2004;15:3005-14 pubmed
    Variations in subunit composition and modification have been proposed to regulate the multiple functions of cytoplasmic dynein. Here, we examine the role of the Drosophila ortholog of tctex-1, the 14-kDa dynein light chain...
  43. Delanoue R, Herpers B, Soetaert J, Davis I, Rabouille C. Drosophila Squid/hnRNP helps Dynein switch from a gurken mRNA transport motor to an ultrastructural static anchor in sponge bodies. Dev Cell. 2007;13:523-38 pubmed
    In Drosophila oocytes, dorso-anterior transport of gurken mRNA requires both the Dynein motor and the heterogeneous nuclear ribonucleoprotein (hnRNP) Squid...
  44. Iyadurai S, Li M, Gilbert S, Hays T. Evidence for cooperative interactions between the two motor domains of cytoplasmic dynein. Curr Biol. 1999;9:771-4 pubmed
    b>Cytoplasmic dynein is a force-transducing ATPase that powers the movement of cellular cargoes along microtubules...
  45. Li M, McGrail M, Serr M, Hays T. Drosophila cytoplasmic dynein, a microtubule motor that is asymmetrically localized in the oocyte. J Cell Biol. 1994;126:1475-94 pubmed
    ..In this report, we characterize the Drosophila gene, Dhc64C, that encodes a cytoplasmic dynein heavy chain polypeptide...
  46. Folker E, Schulman V, Baylies M. Muscle length and myonuclear position are independently regulated by distinct Dynein pathways. Development. 2012;139:3827-37 pubmed
    ..Dynein-interacting proteins during Drosophila muscle development and found that several factors, including Dynein heavy chain, Dynein light chain and Partner of inscuteable, contribute to the regulation of both muscle length and ..
  47. LORENZO D, Li M, Mische S, Armbrust K, Ranum L, Hays T. Spectrin mutations that cause spinocerebellar ataxia type 5 impair axonal transport and induce neurodegeneration in Drosophila. J Cell Biol. 2010;189:143-58 pubmed publisher
    ..These phenotypes are genetically enhanced by both dynein and dynactin loss-of-function mutations...
  48. Wojcik E, Basto R, Serr M, Scaerou F, Karess R, Hays T. Kinetochore dynein: its dynamics and role in the transport of the Rough deal checkpoint protein. Nat Cell Biol. 2001;3:1001-7 pubmed
    We describe the dynamics of kinetochore dynein-dynactin in living Drosophila embryos and examine the effect of mutant dynein on the metaphase checkpoint...
  49. Haghnia M, Cavalli V, Shah S, Schimmelpfeng K, Brusch R, Yang G, et al. Dynactin is required for coordinated bidirectional motility, but not for dynein membrane attachment. Mol Biol Cell. 2007;18:2081-9 pubmed
    ..and neuronal vesicles, organelles, and other particles along microtubules requires the molecular motor protein dynein (Mallik and Gross, 2004)...
  50. Wainman A, Creque J, Williams B, Williams E, Bonaccorsi S, Gatti M, et al. Roles of the Drosophila NudE protein in kinetochore function and centrosome migration. J Cell Sci. 2009;122:1747-58 pubmed publisher
    We examined the distribution of the dynein-associated protein NudE in Drosophila larval brain neuroblasts and spermatocytes, and analyzed the phenotypic consequences of a nudE null mutation...
  51. Horne Badovinac S, Bilder D. Dynein regulates epithelial polarity and the apical localization of stardust A mRNA. PLoS Genet. 2008;4:e8 pubmed publisher
    ..Through a genetic screen for epithelial defects in the Drosophila follicle cells, we have found that the cytoplasmic Dynein motor is an essential regulator of apico-basal polarity...
  52. Starr D, Williams B, Hays T, Goldberg M. ZW10 helps recruit dynactin and dynein to the kinetochore. J Cell Biol. 1998;142:763-74 pubmed
    ..melanogaster zw10 gene, which encodes a conserved, essential kinetochore component, abolish the ability of dynein to localize to kinetochores...
  53. Robinson J, Wojcik E, Sanders M, McGrail M, Hays T. Cytoplasmic dynein is required for the nuclear attachment and migration of centrosomes during mitosis in Drosophila. J Cell Biol. 1999;146:597-608 pubmed
    ..Embryos lacking wild-type cytoplasmic dynein heavy chain were analyzed by in vivo analysis of rhodamine-labeled microtubules, as well as by immunofluorescence ..
  54. Anderson M, Jodoin J, Lee E, Hales K, Hays T, Lee L. Asunder is a critical regulator of dynein-dynactin localization during Drosophila spermatogenesis. Mol Biol Cell. 2009;20:2709-21 pubmed publisher
    ..We find that asun spermatocytes and spermatids exhibit drastic reduction of perinuclear dynein-dynactin, a microtubule motor complex...
  55. Gross S, Welte M, Block S, Wieschaus E. Dynein-mediated cargo transport in vivo. A switch controls travel distance. J Cell Biol. 2000;148:945-56 pubmed
    b>Cytoplasmic dynein is a microtubule-based motor with diverse cellular roles...
  56. Clark A, Meignin C, Davis I. A Dynein-dependent shortcut rapidly delivers axis determination transcripts into the Drosophila oocyte. Development. 2007;134:1955-65 pubmed
    ..gurken transcripts, but not control transcripts, recruit the cytoplasmic Dynein-associated co-factors Bicaudal D (BicD) and Egalitarian in the nurse cells...
  57. Weil T, Forrest K, Gavis E. Localization of bicoid mRNA in late oocytes is maintained by continual active transport. Dev Cell. 2006;11:251-62 pubmed
    ..for bicoid localization in late oocytes that utilizes a specialized subpopulation of anterior microtubules and dynein. The directional movement of bicoid RNA particles within the oocyte observed here is consistent with dynein-..
  58. Gross S, Welte M, Block S, Wieschaus E. Coordination of opposite-polarity microtubule motors. J Cell Biol. 2002;156:715-24 pubmed
    ..To this end we impaired the minus-end transport machinery using dynein and dynactin mutations, and then investigated whether plus-end motion was improved or disrupted...
  59. MacDougall N, Clark A, MacDougall E, Davis I. Drosophila gurken (TGFalpha) mRNA localizes as particles that move within the oocyte in two dynein-dependent steps. Dev Cell. 2003;4:307-19 pubmed
    ..gurken RNA assembles into particles that move in two distinct steps, both requiring microtubules and cytoplasmic Dynein. gurken particles first move toward the anterior and then turn and move dorsally toward the oocyte nucleus...
  60. Zimyanin V, Belaya K, Pecreaux J, Gilchrist M, Clark A, Davis I, et al. In vivo imaging of oskar mRNA transport reveals the mechanism of posterior localization. Cell. 2008;134:843-53 pubmed publisher
    ..We also show that each component of the oskar mRNA complex plays a distinct role in particle formation and transport. ..
  61. Pfister K, Shah P, Hummerich H, Russ A, Cotton J, Annuar A, et al. Genetic analysis of the cytoplasmic dynein subunit families. PLoS Genet. 2006;2:e1 pubmed
    ..relationships among the dynein subunits of mammals and other model organisms, and sheds new light on the role of this diverse group of proteins, highlighting the existence of two cytoplasmic dynein complexes with distinct cellular roles.
  62. Palacios I, St Johnston D. Kinesin light chain-independent function of the Kinesin heavy chain in cytoplasmic streaming and posterior localisation in the Drosophila oocyte. Development. 2002;129:5473-85 pubmed
    ..We show that the Kinesin heavy chain is also required for the posterior localisation of Dynein, and for all cytoplasmic movements within the oocyte...
  63. Harris T, Peifer M. The positioning and segregation of apical cues during epithelial polarity establishment in Drosophila. J Cell Biol. 2005;170:813-23 pubmed
    ..is independent of aPKC and PAR-6 relying instead on cytoskeletal cues, including an apical scaffold and dynein-mediated basal-to-apical transport...
  64. Papoulas O, Hays T, Sisson J. The golgin Lava lamp mediates dynein-based Golgi movements during Drosophila cellularization. Nat Cell Biol. 2005;7:612-8 pubmed
    ..Here we show that Golgi movements and furrow formation depend on cytoplasmic dynein. Furthermore, we demonstrate that Lava lamp (Lva), a golgin protein that is required for cellularization, ..
  65. Miller K, DeProto J, Kaufmann N, Patel B, Duckworth A, Van Vactor D. Direct observation demonstrates that Liprin-alpha is required for trafficking of synaptic vesicles. Curr Biol. 2005;15:684-9 pubmed
    ..Pull-down assays reveal that Liprin-alpha interacts with Drosophila Kinesin-1 (Khc) but not dynein. Together, these findings suggest that Liprin-alpha promotes the delivery of synaptic material by a direct ..
  66. Waterman Storer C, Holzbaur E. The product of the Drosophila gene, Glued, is the functional homologue of the p150Glued component of the vertebrate dynactin complex. J Biol Chem. 1996;271:1153-9 pubmed
    ..in the dynactin complex, a protein heteromultimer that binds to and may mediate the microtubule-based motor cytoplasmic dynein. Cloning of a cDNA encoding p150Glued from rat revealed 31% amino acid sequence identity with the product of ..
  67. Silvanovich A, Li M, Serr M, Mische S, Hays T. The third P-loop domain in cytoplasmic dynein heavy chain is essential for dynein motor function and ATP-sensitive microtubule binding. Mol Biol Cell. 2003;14:1355-65 pubmed
    ..a mutational analysis of P-loop function within the first and third AAA domains of the Drosophila cytoplasmic dynein heavy chain. Here we report the first evidence that P-loop-3 function is essential for dynein function...