Gene Symbol: Dh44-R1
Description: Diuretic hormone 44 receptor 1
Alias: CG8422, DH-R, DH44-R1, DH[[44]]-R1, Dh44R1, DmeCG8422, Dmel\CG8422, anon-WO0170980.100, anon-WO0170980.101, diuretic hormone 44 receptor 1, CG8422-PA, CRF-like diuretic hormone receptor 1, DH44 receptor, DH44-receptor, DH[[44]] receptor, Dh44-R1-PA
Species: fruit fly

Top Publications

  1. Johnson E, Bohn L, Taghert P. Drosophila CG8422 encodes a functional diuretic hormone receptor. J Exp Biol. 2004;207:743-8 pubmed
    ..The Drosophila genome contains two genes (CG8422 and CG12370) orthologous to Manduca and Acheta DH-Rs...
  2. Johnson E, Shafer O, Trigg J, Park J, Schooley D, Dow J, et al. A novel diuretic hormone receptor in Drosophila: evidence for conservation of CGRP signaling. J Exp Biol. 2005;208:1239-46 pubmed
    ..DH31 receptor-expressing neurons produce the neuropeptide corazonin, and also express the CRFR-related receptor CG8422, which is a receptor for the neuropeptide diuretic hormone 44 (DH44)...
  3. Hector C, Bretz C, Zhao Y, Johnson E. Functional differences between two CRF-related diuretic hormone receptors in Drosophila. J Exp Biol. 2009;212:3142-7 pubmed publisher
    ..We have previously reported that one of these receptors, encoded by CG8422 is a functional receptor for a diuretic hormone, DH(44)...
  4. Harmar A. Family-B G-protein-coupled receptors. Genome Biol. 2001;2:REVIEWS3013 pubmed
    ..In this article, I describe the structures and functions of family-B GPCRs and propose a simplified nomenclature for these proteins. ..
  5. Li C, Chen M, Sang M, Liu X, Wu W, Li B. Comparative genomic analysis and evolution of family-B G protein-coupled receptors from six model insect species. Gene. 2013;519:1-12 pubmed publisher
    ..On the other hand, this study provides us with multiple function of GPCR-Bs in differential organisms, which will be also the potential attacking targets for new pesticides and drugs. ..
  6. Cardoso J, Pinto V, Vieira F, Clark M, Power D. Evolution of secretin family GPCR members in the metazoa. BMC Evol Biol. 2006;6:108 pubmed
    ..In this study a comprehensive description of family 2 GPCR evolution is given based on in silico and expression analyses of the invertebrate receptor genes...
  7. Hyun S, Lee Y, Hong S, Bang S, Paik D, Kang J, et al. Drosophila GPCR Han is a receptor for the circadian clock neuropeptide PDF. Neuron. 2005;48:267-78 pubmed
    ..Therefore, we herein propose that Han is a PDF receptor regulating circadian behavioral rhythm through coordination of activities of clock neurons. ..
  8. Cardoso J, Félix R, Power D. Nematode and arthropod genomes provide new insights into the evolution of class 2 B1 GPCRs. PLoS ONE. 2014;9:e92220 pubmed publisher
  9. Dus M, Lai J, Gunapala K, Min S, Tayler T, Hergarden A, et al. Nutrient Sensor in the Brain Directs the Action of the Brain-Gut Axis in Drosophila. Neuron. 2015;87:139-51 pubmed publisher
    ..Manipulation of the function of Dh44 receptors had a similar effect. Notably, artificial activation of Dh44 receptor-1 neurons resulted in proboscis extensions and frequent episodes of excretion...

More Information


  1. Mohammad F, Aryal S, Ho J, Stewart J, Norman N, Tan T, et al. Ancient Anxiety Pathways Influence Drosophila Defense Behaviors. Curr Biol. 2016;26:981-6 pubmed publisher
    ..The presence of conserved neurogenetic pathways in the insect brain identifies Drosophila as an attractive genetic model for the study of anxiety and anxiety-related disorders, complementing existing rodent systems. ..
  2. Bowser P, Tobe S. Bioinformatic analysis of neuropeptide and receptor expression profiles during midgut metamorphosis in Drosophila melanogaster. Peptides. 2006;27:583-9 pubmed
  3. Johnson E, Tift F, McCauley A, Liu L, Roman G. Functional characterization of kurtz, a Drosophila non-visual arrestin, reveals conservation of GPCR desensitization mechanisms. Insect Biochem Mol Biol. 2008;38:1016-22 pubmed publisher
    ..Furthermore, we report that kurtz mutants exhibit hypersensitivity to osmotic stress, implicating GPCR desensitization as an important feature of the endocrine events that shape this stress response. ..
  4. Choi C, Fortin J, McCarthy E, Oksman L, Kopin A, Nitabach M. Cellular dissection of circadian peptide signals with genetically encoded membrane-tethered ligands. Curr Biol. 2009;19:1167-75 pubmed publisher
    ..The t-peptide technology should provide a useful tool for cellular dissection of bioactive peptide signaling in a variety of organisms and physiological contexts. ..
  5. Lee K, Daubnerová I, Isaac R, Zhang C, Choi S, Chung J, et al. A neuronal pathway that controls sperm ejection and storage in female Drosophila. Curr Biol. 2015;25:790-7 pubmed publisher
    ..hormone 44 (Dh44), a neuropeptide related to vertebrate corticotropin-releasing factor (CRF), and its receptor, Dh44R1. Suppression of Dh44 signals in the brain expedites sperm ejection from the uterus, resulting in marked reduction ..