Gene Symbol: Dh31
Description: Diuretic hormone 31
Alias: CG13094, DH 31, DH-II, DH31, DH[[31], DH[[31]], Dh[[31]], Dmel\CG13094, Drm-DH[[31]], Drome-DH[[31]], anon-EST:Posey114, anon-WO02059370.45, dh31, drome-DH31, diuretic hormone 31, CG13094-PA, CG13094-PC, Calcitonin-like diuretic hormone (31 residues), Dh31-PA, Dh31-PC, calcitonin, diuretic hormone
Species: fruit fly

Top Publications

  1. Johnson E, Shafer O, Trigg J, Park J, Schooley D, Dow J, et al. A novel diuretic hormone receptor in Drosophila: evidence for conservation of CGRP signaling. J Exp Biol. 2005;208:1239-46 pubmed
    ..we report that co-expression of the mammalian or Drosophila RCP or mammalian RAMPs permitted neuropeptide diuretic hormone 31 (DH31) signaling from the CG17415 receptor...
  2. Coast G, Webster S, Schegg K, Tobe S, Schooley D. The Drosophila melanogaster homologue of an insect calcitonin-like diuretic peptide stimulates V-ATPase activity in fruit fly Malpighian tubules. J Exp Biol. 2001;204:1795-804 pubmed
    The Drosophila melanogaster homologue of an insect calcitonin-like diuretic hormone was identified in a BLAST search of the Drosophila genome database. The predicted 31-residue amidated peptide (D...
  3. Birse R, Johnson E, Taghert P, Nassel D. Widely distributed Drosophila G-protein-coupled receptor (CG7887) is activated by endogenous tachykinin-related peptides. J Neurobiol. 2006;66:33-46 pubmed
    ..Our findings suggest that DTKR is a DTK receptor in Drosophila and that this ligand-receptor system plays multiple functional roles. ..
  4. Mertens I, Vandingenen A, Johnson E, Shafer O, Li W, Trigg J, et al. PDF receptor signaling in Drosophila contributes to both circadian and geotactic behaviors. Neuron. 2005;48:213-9 pubmed
    ..Class II (secretin-related) G protein-coupled receptor (GPCR) that is specifically responsive to PDF and also to calcitonin-like peptides and to PACAP...
  5. Shafer O, Kim D, Dunbar Yaffe R, Nikolaev V, Lohse M, Taghert P. Widespread receptivity to neuropeptide PDF throughout the neuronal circadian clock network of Drosophila revealed by real-time cyclic AMP imaging. Neuron. 2008;58:223-37 pubmed publisher
    ..In contrast, an unrelated Drosophila neuropeptide, DH31, stimulates large cAMP increases in all PDF-expressing clock neurons...
  6. Kunst M, Tso M, Ghosh D, Herzog E, Nitabach M. Rhythmic control of activity and sleep by class B1 GPCRs. Crit Rev Biochem Mol Biol. 2015;50:18-30 pubmed publisher
  7. Vanderveken M, O Donnell M. Effects of diuretic hormone 31, drosokinin, and allatostatin A on transepithelial K? transport and contraction frequency in the midgut and hindgut of larval Drosophila melanogaster. Arch Insect Biochem Physiol. 2014;85:76-93 pubmed publisher
    ..We have measured the effects of diuretic hormone 31 (DH31), drosokinin and allatostatin A (AST-A) on both K(+) transport and muscle contraction frequency in ..
  8. Hector C, Bretz C, Zhao Y, Johnson E. Functional differences between two CRF-related diuretic hormone receptors in Drosophila. J Exp Biol. 2009;212:3142-7 pubmed publisher
    ..We have previously reported that one of these receptors, encoded by CG8422 is a functional receptor for a diuretic hormone, DH(44)...
  9. Song W, Veenstra J, Perrimon N. Control of lipid metabolism by tachykinin in Drosophila. Cell Rep. 2014;9:40-7 pubmed publisher

More Information


  1. Amcheslavsky A, Song W, Li Q, Nie Y, Bragatto I, Ferrandon D, et al. Enteroendocrine cells support intestinal stem-cell-mediated homeostasis in Drosophila. Cell Rep. 2014;9:32-9 pubmed publisher
    ..These results establish that enteroendocrine cells serve as an important link between diet and visceral muscle expression of an insulin-like growth factor to stimulate intestinal stem cell proliferation and tissue growth. ..
  2. Duvall L, Taghert P. The circadian neuropeptide PDF signals preferentially through a specific adenylate cyclase isoform AC3 in M pacemakers of Drosophila. PLoS Biol. 2012;10:e1001337 pubmed publisher
    ..These findings support a hypothesis that PDF signaling components within target cells are sequestered into "circadian signalosomes," whose compositions differ between E and M pacemaker cell types. ..
  3. LaJeunesse D, Johnson B, Presnell J, Catignas K, Zapotoczny G. Peristalsis in the junction region of the Drosophila larval midgut is modulated by DH31 expressing enteroendocrine cells. BMC Physiol. 2010;10:14 pubmed publisher
    ..the acidic portions of the midgut and are a group of enteroendocrine cells that express the peptide hormone Diuretic Hormone 31 in this region of the gut...
  4. Choi C, Fortin J, McCarthy E, Oksman L, Kopin A, Nitabach M. Cellular dissection of circadian peptide signals with genetically encoded membrane-tethered ligands. Curr Biol. 2009;19:1167-75 pubmed publisher
    ..The t-peptide technology should provide a useful tool for cellular dissection of bioactive peptide signaling in a variety of organisms and physiological contexts. ..
  5. Wegener C, Gorbashov A. Molecular evolution of neuropeptides in the genus Drosophila. Genome Biol. 2008;9:R131 pubmed publisher
    ..The last common ancestor of Drosophila obviously had a set of neuropeptides and peptide hormones identical to that of modern fruit flies. This is remarkable, since drosophilid flies have adapted to very different environments. ..
  6. Kunst M, Hughes M, Raccuglia D, Felix M, Li M, Barnett G, et al. Calcitonin gene-related peptide neurons mediate sleep-specific circadian output in Drosophila. Curr Biol. 2014;24:2652-64 pubmed publisher
    ..In this study, we describe a novel role for diuretic hormone 31 (DH31), the fly homolog of the vertebrate neuropeptide calcitonin gene-related peptide, as a circadian wake-..
  7. Head L, Tang X, Hayley S, Goda T, Umezaki Y, Chang E, et al. The influence of light on temperature preference in Drosophila. Curr Biol. 2015;25:1063-8 pubmed publisher
    ..Given that both Drosophila and mammals respond to acute light by increasing their body temperature, the effect of acute light on temperature regulation may be conserved evolutionarily between flies and humans. ..
  8. Goda T, Tang X, Umezaki Y, Chu M, Kunst M, Nitabach M, et al. Drosophila DH31 Neuropeptide and PDF Receptor Regulate Night-Onset Temperature Preference. J Neurosci. 2016;36:11739-11754 pubmed
    ..Here, we demonstrate that the neuropeptide diuretic hormone 31 (DH31) and pigment-dispersing factor receptor (PDFR) contribute to regulate the preferred temperature ..
  9. Choi C, Cao G, Tanenhaus A, McCarthy E, Jung M, Schleyer W, et al. Autoreceptor control of peptide/neurotransmitter corelease from PDF neurons determines allocation of circadian activity in drosophila. Cell Rep. 2012;2:332-44 pubmed publisher
    ..These results suggest another mechanism for environmental control of the allocation of circadian activity and provide new general insight into the role of neuropeptide autoreceptors in behavioral control circuits. ..
  10. Reiher W, Shirras C, Kahnt J, Baumeister S, Isaac R, Wegener C. Peptidomics and peptide hormone processing in the Drosophila midgut. J Proteome Res. 2011;10:1881-92 pubmed publisher
    ..The identification of enteroendocrine peptides in the fruit fly provides a platform to address functions of gut peptide hormones in the regulation of feeding and metabolism. ..
  11. Johnson E, Bohn L, Taghert P. Drosophila CG8422 encodes a functional diuretic hormone receptor. J Exp Biol. 2004;207:743-8 pubmed
    b>Diuretic hormone 44 (DH) is a bioactive neuropeptide that mediates osmotic balance in a wide variety of insects through increases in cAMP. It is structurally similar to mammalian corticotrophin releasing factor (CRF) peptides...
  12. O Donnell M, Ianowski J, Linton S, Rheault M. Inorganic and organic anion transport by insect renal epithelia. Biochim Biophys Acta. 2003;1618:194-206 pubmed
    ..Insect renal epithelia are also important in excretion of potentially toxic organic anions, and the transporters involved may play a role in resistance to insecticides of natural or anthropogenic origin. ..