Gene Symbol: Dg
Description: Dystroglycan
Alias: CG18250, CT41273, DmDG, Dmel\CG18250, atu, dgn, dys, dystroglycan, CG18250-PA, CG18250-PB, CG18250-PC, CG18250-PD, Dg-PA, Dg-PB, Dg-PC, Dg-PD, alphaDystroglycan, atsugari, dystroglican, dystroglycan-like
Species: fruit fly

Top Publications

  1. Christoforou C, Greer C, Challoner B, Charizanos D, Ray R. The detached locus encodes Drosophila Dystrophin, which acts with other components of the Dystrophin Associated Protein Complex to influence intercellular signalling in developing wing veins. Dev Biol. 2008;313:519-32 pubmed
    Dystrophin and Dystroglycan are the two central components of the multimeric Dystrophin Associated Protein Complex, or DAPC, that is thought to provide a mechanical link between the extracellular matrix and the actin cytoskeleton, ..
  2. Marrone A, Edeleva E, Kucherenko M, Hsiao N, Shcherbata H. Dg-Dys-Syn1 signaling in Drosophila regulates the microRNA profile. BMC Cell Biol. 2012;13:26 pubmed publisher
    ..Our results support the hypothesis that there is a Dystrophin and Dystroglycan dependent circuitry of processes linking stress response, dystrophic conditions and cellular signaling and that ..
  3. Pilgram G, Potikanond S, Baines R, Fradkin L, Noordermeer J. The roles of the dystrophin-associated glycoprotein complex at the synapse. Mol Neurobiol. 2010;41:1-21 pubmed publisher
    ..The challenges ahead include the integration of the behavioral and mechanistic studies and the use of this information to identify therapeutic targets...
  4. Qian L, Liu J, Bodmer R. Slit and Robo control cardiac cell polarity and morphogenesis. Curr Biol. 2005;15:2271-8 pubmed
  5. Marrone A, Kucherenko M, Rishko V, Shcherbata H. New dystrophin/dystroglycan interactors control neuron behavior in Drosophila eye. BMC Neurosci. 2011;12:93 pubmed publisher
    ..When the main components of the DGC, Dystrophin (Dys) and Dystroglycan (Dg) are affected cognitive impairment and mental retardation in addition to muscle degeneration can occur...
  6. Wolfstetter G, Holz A. The role of LamininB2 (LanB2) during mesoderm differentiation in Drosophila. Cell Mol Life Sci. 2012;69:267-82 pubmed publisher
    ..We also observed genetic interactions with kon-tiki and thrombospondin, indicating a role for laminin during muscle attachment. ..
  7. Kucherenko M, Marrone A, Rishko V, Magliarelli H, Shcherbata H. Stress and muscular dystrophy: a genetic screen for dystroglycan and dystrophin interactors in Drosophila identifies cellular stress response components. Dev Biol. 2011;352:228-42 pubmed publisher
    ..been shown before to have a role in the development of muscular dystrophy and interact with dystrophin and/or dystroglycan. Mutations in many of the found interacting genes cause age-dependent morphological and heat-induced ..
  8. Yatsenko A, Gray E, Shcherbata H, Patterson L, Sood V, Kucherenko M, et al. A putative Src homology 3 domain binding motif but not the C-terminal dystrophin WW domain binding motif is required for dystroglycan function in cellular polarity in Drosophila. J Biol Chem. 2007;282:15159-69 pubmed
    The conserved dystroglycan-dystrophin (Dg.Dys) complex connects the extracellular matrix to the cytoskeleton...
  9. Deng W, Schneider M, Frock R, Castillejo Lopez C, Gaman E, Baumgartner S, et al. Dystroglycan is required for polarizing the epithelial cells and the oocyte in Drosophila. Development. 2003;130:173-84 pubmed
    The transmembrane protein Dystroglycan is a central element of the dystrophin-associated glycoprotein complex, which is involved in the pathogenesis of many forms of muscular dystrophy...

More Information


  1. Poulton J, Deng W. Dystroglycan down-regulation links EGF receptor signaling and anterior-posterior polarity formation in the Drosophila oocyte. Proc Natl Acad Sci U S A. 2006;103:12775-80 pubmed
    ..Here, we show that an extracellular matrix receptor, Dystroglycan, is down-regulated in the PFC by EGFR signaling, and this down-regulation is necessary for proper localization ..
  2. Haines N, Seabrooke S, Stewart B. Dystroglycan and protein O-mannosyltransferases 1 and 2 are required to maintain integrity of Drosophila larval muscles. Mol Biol Cell. 2007;18:4721-30 pubmed
    ..or POMT2 are associated with muscular dystrophy due to a requirement for O-linked mannose glycans on the Dystroglycan (Dg) protein...
  3. Zhan Y, Melian N, Pantoja M, Haines N, Ruohola Baker H, Bourque C, et al. Dystroglycan and mitochondrial ribosomal protein L34 regulate differentiation in the Drosophila eye. PLoS ONE. 2010;5:e10488 pubmed publisher
    Mutations that diminish the function of the extracellular matrix receptor Dystroglycan (DG) result in muscular dystrophies, with associated neuronal migration defects in the brain and mental retardation e.g. Muscle Eye Brain Disease...
  4. Nakamura N, Stalnaker S, Lyalin D, Lavrova O, Wells L, Panin V. Drosophila Dystroglycan is a target of O-mannosyltransferase activity of two protein O-mannosyltransferases, Rotated Abdomen and Twisted. Glycobiology. 2010;20:381-94 pubmed publisher
    ..muscular dystrophies, called dystroglycanopathies, resulting from the abnormal glycosylation of alpha-dystroglycan. Several of these diseases are associated with defects in O-mannosylation, one of the most prominent types of ..
  5. Marrone A, Kucherenko M, Wiek R, Gopfert M, Shcherbata H. Hyperthermic seizures and aberrant cellular homeostasis in Drosophila dystrophic muscles. Sci Rep. 2011;1:47 pubmed publisher
    ..leads to heat-sensitive abnormal muscle contractions that are repressed by mutations in Dys's binding partner, Dystroglycan (Dg)...
  6. Medioni C, Astier M, Zmojdzian M, Jagla K, Semeriva M. Genetic control of cell morphogenesis during Drosophila melanogaster cardiac tube formation. J Cell Biol. 2008;182:249-61 pubmed publisher
    ..Furthermore, we identify a genetic pathway in which roundabout, slit, held out wings, and dystroglycan control cardiac lumen formation by establishing nonadherent luminal membranes and regulating cell shape changes...
  7. Greener M, Roberts R. Conservation of components of the dystrophin complex in Drosophila. FEBS Lett. 2000;482:13-8 pubmed
    ..components (three dystrophin-related proteins, two dystrobrevins, five sarcoglycans, five syntrophins, one dystroglycan and one sarcospan) appear to be reduced to eight in Drosophila (one, one, three, two, one and none, ..
  8. Vanderploeg J, Vazquez Paz L, MacMullin A, Jacobs J. Integrins are required for cardioblast polarisation in Drosophila. BMC Dev Biol. 2012;12:8 pubmed publisher
    ..Our findings reveal an instructive role for Integrins in communicating polarising information to cells during migration, and during transition to an epithelial tube structure. ..
  9. Dekkers L, van der Plas M, van Loenen P, den Dunnen J, van Ommen G, Fradkin L, et al. Embryonic expression patterns of the Drosophila dystrophin-associated glycoprotein complex orthologs. Gene Expr Patterns. 2004;4:153-9 pubmed
    ..Dystrophin, dystrobrevin-like, dystroglycan-like, syntrophin-like 1, and all three sarcoglycan orthologs are found in the brain and the ventral nerve cord, ..
  10. Schneider M, Khalil A, Poulton J, Castillejo Lopez C, Egger Adam D, Wodarz A, et al. Perlecan and Dystroglycan act at the basal side of the Drosophila follicular epithelium to maintain epithelial organization. Development. 2006;133:3805-15 pubmed
    b>Dystroglycan (Dg) is a widely expressed extracellular matrix (ECM) receptor required for muscle viability, synaptogenesis, basementmembrane formation and epithelial development...
  11. Bogdanik L, Framery B, Frölich A, Franco B, Mornet D, Bockaert J, et al. Muscle dystroglycan organizes the postsynapse and regulates presynaptic neurotransmitter release at the Drosophila neuromuscular junction. PLoS ONE. 2008;3:e2084 pubmed publisher
    The Dystrophin-glycoprotein complex (DGC) comprises dystrophin, dystroglycan, sarcoglycan, dystrobrevin and syntrophin subunits...
  12. Takeuchi K, Nakano Y, Kato U, Kaneda M, Aizu M, Awano W, et al. Changes in temperature preferences and energy homeostasis in dystroglycan mutants. Science. 2009;323:1740-3 pubmed publisher
    ..Reduced expression of the Drosophila ortholog of dystroglycan (DmDG) induced tolerance to cold as well as preference for the low temperature...
  13. Shcherbata H, Yatsenko A, Patterson L, Sood V, Nudel U, Yaffe D, et al. Dissecting muscle and neuronal disorders in a Drosophila model of muscular dystrophy. EMBO J. 2007;26:481-93 pubmed
    Perturbation in the Dystroglycan (Dg)-Dystrophin (Dys) complex results in muscular dystrophies and brain abnormalities in human...
  14. Wairkar Y, Fradkin L, Noordermeer J, DiAntonio A. Synaptic defects in a Drosophila model of congenital muscular dystrophy. J Neurosci. 2008;28:3781-9 pubmed publisher
    ..Many of these inherited disorders share a common etiology: defective O-glycosylation of alpha-dystroglycan, a component of the dystrophin complex...
  15. Yatsenko A, Shcherbata H. Drosophila miR-9a targets the ECM receptor Dystroglycan to canalize myotendinous junction formation. Dev Cell. 2014;28:335-48 pubmed publisher
    ..We find that precise levels of the ECM receptor Dystroglycan (Dg) are required for MTJ formation in Drosophila and that Dg levels in this process are controlled by miR-9a...
  16. Tanentzapf G, Devenport D, Godt D, Brown N. Integrin-dependent anchoring of a stem-cell niche. Nat Cell Biol. 2007;9:1413-8 pubmed
    ..On the basis of our data, we propose that integrins are required for the attachment of the hub cells to the ECM, which is essential for maintaining the stem-cell niche. ..
  17. Yatsenko A, Marrone A, Shcherbata H. miRNA-based buffering of the cobblestone-lissencephaly-associated extracellular matrix receptor dystroglycan via its alternative 3'-UTR. Nat Commun. 2014;5:4906 pubmed publisher
    ..as an executive mechanism to buffer levels of the muscular dystrophy-associated extracellular matrix receptor dystroglycan via its alternative 3'-UTR...
  18. Conder R, Yu H, Zahedi B, Harden N. The serine/threonine kinase dPak is required for polarized assembly of F-actin bundles and apical-basal polarity in the Drosophila follicular epithelium. Dev Biol. 2007;305:470-82 pubmed
    ..We propose that dPak mediates communication between the basement membrane and intracellular proteins required for polarization of the basal F-actin and for apical-basal polarity. ..
  19. Taghli Lamallem O, Jagla K, Chamberlain J, Bodmer R. Mechanical and non-mechanical functions of Dystrophin can prevent cardiac abnormalities in Drosophila. Exp Gerontol. 2014;49:26-34 pubmed publisher
    ..These findings suggest that the signaling functions of Dystrophin protein are able to ameliorate the dilated cardiomyopathy, and thus might help to improve heart muscle function in micro-Dystrophin-based gene therapy approaches. ..
  20. Meignin C, Alvarez Garcia I, Davis I, Palacios I. The salvador-warts-hippo pathway is required for epithelial proliferation and axis specification in Drosophila. Curr Biol. 2007;17:1871-8 pubmed
    ..This work highlights a novel connection between cell proliferation, cell growth, and axis specification in egg chambers. ..
  21. Yatsenko A, Marrone A, Kucherenko M, Shcherbata H. Measurement of metabolic rate in Drosophila using respirometry. J Vis Exp. 2014;:e51681 pubmed publisher
    ..In this protocol we introduce a simple method to measure CO2 output from flies. This technique can potentially aid in the identification of genetic perturbations affecting metabolic rate. ..
  22. Panin V, Wells L. Protein O-mannosylation in metazoan organisms. Curr Protoc Protein Sci. 2014;75:Unit 12.12. pubmed publisher
    ..A major biological effect of O-mannosylation involves the regulation of ?-dystroglycan, a membrane glycoprotein mediating cell-extracellular matrix interactions...
  23. Genevet A, Polesello C, Blight K, Robertson F, Collinson L, Pichaud F, et al. The Hippo pathway regulates apical-domain size independently of its growth-control function. J Cell Sci. 2009;122:2360-70 pubmed publisher
    ..Therefore, Hippo signalling controls growth and apical domain size by distinct mechanisms. ..
  24. Yatsenko A, Kucherenko M, Pantoja M, Fischer K, Madeoy J, Deng W, et al. The conserved WW-domain binding sites in Dystroglycan C-terminus are essential but partially redundant for Dystroglycan function. BMC Dev Biol. 2009;9:18 pubmed publisher
    b>Dystroglycan (Dg) is a transmembrane protein that is a part of the Dystrophin Glycoprotein Complex (DGC) which connects the extracellular matrix to the actin cytoskeleton...
  25. Harpaz N, Ordan E, Ocorr K, Bodmer R, Volk T. Multiplexin promotes heart but not aorta morphogenesis by polarized enhancement of slit/robo activity at the heart lumen. PLoS Genet. 2013;9:e1003597 pubmed publisher
    ..This regulation is essential for the morphogenetic changes that sculpt the heart tube in Drosophila, and possibly in forming the vertebrates primary heart tube. ..
  26. Peterson S, Krasnow M. Subcellular trafficking of FGF controls tracheal invasion of Drosophila flight muscle. Cell. 2015;160:313-23 pubmed publisher
    ..We propose that tracheal invasion is controlled by an AP-1-dependent switch in FGF trafficking. Thus, subcellular targeting of a chemoattractant can direct outgrowth to specific domains, including inside the cell. ..
  27. Sciandra F, Schneider M, Giardina B, Baumgartner S, Petrucci T, Brancaccio A. Identification of the beta-dystroglycan binding epitope within the C-terminal region of alpha-dystroglycan. Eur J Biochem. 2001;268:4590-7 pubmed
    b>Dystroglycan is a receptor for extracellular matrix proteins that plays a crucial role during embryogenesis in addition to adult tissue stabilization...
  28. Schneider M, Baumgartner S. Differential expression of Dystroglycan-spliceforms with and without the mucin-like domain during Drosophila embryogenesis. Fly (Austin). 2008;2:29-35 pubmed
    b>Dystroglycan (DG) is a widely expressed extracellular matrix (ECM) receptor required for muscle viability, synaptogenesis, basement-membrane formation and epithelial development...
  29. Syed Z, Bouge A, Byri S, Chavoshi T, Tång E, Bouhin H, et al. A luminal glycoprotein drives dose-dependent diameter expansion of the Drosophila melanogaster hindgut tube. PLoS Genet. 2012;8:e1002850 pubmed publisher
    ..Together, the results show that epithelial tube diameter can be modelled by regulating the levels and pattern of expression of a single luminal glycoprotein. ..
  30. Koper A, Schenck A, Prokop A. Analysis of adhesion molecules and basement membrane contributions to synaptic adhesion at the Drosophila embryonic NMJ. PLoS ONE. 2012;7:e36339 pubmed publisher
    ..Therefore, future developmental studies of these synaptic junctions in Drosophila need to consider the important contribution made by BM-dependent mechanisms, in addition to CAM-dependent adhesion. ..
  31. Stone B, Evans L, Coleman J, Kuebler D. Genetic and pharmacological manipulations that alter metabolism suppress seizure-like activity in Drosophila. Brain Res. 2013;1496:94-103 pubmed publisher
    ..The atu mutants, which exhibit reduced expression of the Drosophila ortholog of dystroglycan gene, have previously been shown to have a higher metabolic rate than wild type flies...
  32. Morais de Sá E, Sunkel C. Adherens junctions determine the apical position of the midbody during follicular epithelial cell division. EMBO Rep. 2013;14:696-703 pubmed publisher
    ..Thus, apical midbody localization is essential to maintain epithelial tissue architecture during proliferation. ..
  33. Urbano J, Domínguez Giménez P, Estrada B, Martin Bermudo M. PS integrins and laminins: key regulators of cell migration during Drosophila embryogenesis. PLoS ONE. 2011;6:e23893 pubmed publisher
    ..Furthermore, we show that, as it is the case in vertebrates, integrins, and specifically PS2, contributes to CVM movement by participating in the correct assembly of the ECM that serves as tracks for migration. ..
  34. Ueyama M, Akimoto Y, Ichimiya T, Ueda R, Kawakami H, Aigaki T, et al. Increased apoptosis of myoblasts in Drosophila model for the Walker-Warburg syndrome. PLoS ONE. 2010;5:e11557 pubmed publisher
    ..In this paper, we propose a novel mechanism for the development of muscular dystrophy: POMT mutation causes high myoblast density and position derangement, which result in apoptosis, muscle disorganization, and muscle cell defects. ..
  35. Haack T, Bergstralh D, St Johnston D. Damage to the Drosophila follicle cell epithelium produces "false clones" with apparent polarity phenotypes. Biol Open. 2013;2:1313-20 pubmed publisher
    ..This phenotype is identical to that reported for several mutants, including ampk and Dystroglycan mutant clones under conditions of energetic stress...
  36. Polesello C, Tapon N. Salvador-warts-hippo signaling promotes Drosophila posterior follicle cell maturation downstream of notch. Curr Biol. 2007;17:1864-70 pubmed
    ..The PCP members of the SWH network are not involved in this process, indicating that signaling upstream of Hpo varies according to developmental context. ..
  37. Vanderploeg J, Jacobs J. Talin is required to position and expand the luminal domain of the Drosophila heart tube. Dev Biol. 2015;405:189-201 pubmed publisher
    ..Talin is essential for subsequent polarization of luminal determinants Slit, Robo, and Dystroglycan as well as stabilization of extracellular and intracellular integrin adhesion factors...
  38. Tögel M, Meyer H, Lehmacher C, Heinisch J, Pass G, Paululat A. The bHLH transcription factor hand is required for proper wing heart formation in Drosophila. Dev Biol. 2013;381:446-59 pubmed publisher
    ..At the protein level, ?-Spectrin and Dystroglycan are misdistributed suggesting a defect in the costameric network...
  39. Woolworth J, Nallamothu G, Hsu T. The Drosophila metastasis suppressor gene Nm23 homolog, awd, regulates epithelial integrity during oogenesis. Mol Cell Biol. 2009;29:4679-90 pubmed publisher
    ..Therefore, awd modulates the level and localization of adherens junction components via endocytosis. This is the first demonstration of an in vivo function of Nm23 family genes in regulating epithelial morphogenesis. ..
  40. Breloy I, Schwientek T, Lehr S, Hanisch F. Glucuronic acid can extend O-linked core 1 glycans, but it contributes only weakly to the negative surface charge of Drosophila melanogaster Schneider-2 cells. FEBS Lett. 2008;582:1593-8 pubmed publisher
  41. Plantie E, Migocka Patrzałek M, Daczewska M, Jagla K. Model organisms in the fight against muscular dystrophy: lessons from drosophila and Zebrafish. Molecules. 2015;20:6237-53 pubmed publisher
    ..This review discusses how zebrafish and Drosophila MD have helped to identify genetic determinants of MDs and design innovative therapeutic strategies with a special focus on DMD, DM1 and congenital MDs. ..
  42. Qian L, Liu J, Bodmer R. Neuromancer Tbx20-related genes (H15/midline) promote cell fate specification and morphogenesis of the Drosophila heart. Dev Biol. 2005;279:509-24 pubmed
    ..We propose that nmr is another determinant of cardiogenesis, along with tinman and pannier. ..