Det

Summary

Gene Symbol: Det
Description: Deterin
Alias: CG12265, Dmel\CG12265, det, scpo, svn, deterin, CG12265-PA, Det-PA, dSurvivin, scapolo, survivin
Species: fruit fly

Top Publications

  1. Jones G, Jones D, Zhou L, Steller H, Chu Y. Deterin, a new inhibitor of apoptosis from Drosophila melanogaster. J Biol Chem. 2000;275:22157-65 pubmed
    ..Whereas the nematode survivin-type IAP has thus far been implicated only as a mitotic regulator, Drosophila deterin constitutes the first ..
  2. Giansanti M, Farkas R, Bonaccorsi S, Lindsley D, Wakimoto B, Fuller M, et al. Genetic dissection of meiotic cytokinesis in Drosophila males. Mol Biol Cell. 2004;15:2509-22 pubmed
  3. Reed J, Bischoff J. BIRinging chromosomes through cell division--and survivin' the experience. Cell. 2000;102:545-8 pubmed
  4. Tittel J, Steller H. A comparison of programmed cell death between species. Genome Biol. 2000;1:REVIEWS0003 pubmed
    ..The search for additional homologs has been facilitated by the availability of the entire genomic sequence for each of these organisms. ..
  5. Szafer Glusman E, Fuller M, Giansanti M. Role of Survivin in cytokinesis revealed by a separation-of-function allele. Mol Biol Cell. 2011;22:3779-90 pubmed publisher
    The chromosomal passenger complex (CPC), containing Aurora B kinase, Inner Centromere Protein, Survivin, and Borealin, regulates chromosome condensation and interaction between kinetochores and microtubules at metaphase, then relocalizes ..
  6. Capalbo L, Montembault E, Takeda T, Bassi Z, Glover D, D Avino P. The chromosomal passenger complex controls the function of endosomal sorting complex required for transport-III Snf7 proteins during cytokinesis. Open Biol. 2012;2:120070 pubmed publisher
  7. Arya R, White K. Cell death in development: Signaling pathways and core mechanisms. Semin Cell Dev Biol. 2015;39:12-9 pubmed publisher
    ..Understanding how the cell death is regulated during development may provide insight into how this process can be manipulated in the treatment of disease. ..
  8. Roth M, Roubinet C, Iffländer N, Ferrand A, Cabernard C. Asymmetrically dividing Drosophila neuroblasts utilize two spatially and temporally independent cytokinesis pathways. Nat Commun. 2015;6:6551 pubmed publisher
    ..neuroblasts, the mitotic spindle, but not polarity cues, controls the localization of the CPC component Survivin. We also show that Survivin and the mitotic spindle are required to stabilize the position of the cleavage furrow ..
  9. Lenhart K, Dinardo S. Somatic cell encystment promotes abscission in germline stem cells following a regulated block in cytokinesis. Dev Cell. 2015;34:192-205 pubmed publisher
    ..These findings reveal the mechanisms by which cytokinesis is inhibited and reinitiated in GSCs and why such complex regulation exists within the stem cell niche. ..

More Information

Publications15

  1. Das A, Shah S, Fan B, Paik D, DiSanto D, Hinman A, et al. Spindle Assembly and Chromosome Segregation Requires Central Spindle Proteins in Drosophila Oocytes. Genetics. 2016;202:61-75 pubmed publisher
    ..In combination our results support a model where the meiotic central spindle and associated proteins are essential for acentrosomal chromosome segregation. ..
  2. Meier P, Finch A, Evan G. Apoptosis in development. Nature. 2000;407:796-801 pubmed
    ..Dysfunctions in the regulation or execution of cell suicide are implicated in a wide range of developmental abnormalities and diseases. ..
  3. Xu D, Woodfield S, Lee T, Fan Y, Antonio C, Bergmann A. Genetic control of programmed cell death (apoptosis) in Drosophila. Fly (Austin). 2009;3:78-90 pubmed
    ..Here, we review the key players of the cell death pathway in Drosophila and discuss their roles in apoptotic and non-apoptotic processes. ..
  4. Mathieu J, Cauvin C, Moch C, Radford S, Sampaio P, Perdigoto C, et al. Aurora B and cyclin B have opposite effects on the timing of cytokinesis abscission in Drosophila germ cells and in vertebrate somatic cells. Dev Cell. 2013;26:250-65 pubmed publisher
    ..Here, we show that Aurora B and Survivin regulate the number of germ cells in each Drosophila egg chamber by inhibiting abscission during differentiation...
  5. Carmena M, Pinson X, Platani M, Salloum Z, Xu Z, Clark A, et al. The chromosomal passenger complex activates Polo kinase at centromeres. PLoS Biol. 2012;10:e1001250 pubmed publisher
    ..a key scaffolding subunit of the chromosomal passenger complex (CPC), which consists of Aurora B kinase, INCENP, Survivin, and Borealin/Dasra B, also interacts with Polo kinase in Drosophila cells...
  6. Muñoz Soriano V, Nieto Arellano R, Paricio N. Septin 4, the drosophila ortholog of human CDCrel-1, accumulates in parkin mutant brains and is functionally related to the Nedd4 E3 ubiquitin ligase. J Mol Neurosci. 2012;48:136-43 pubmed publisher
    ..Furthermore, we demonstrate that Nedd4, another E3 ubiquitin ligase that may have a role in PD, is functionally related to Sep4 and could be involved in regulating Sep4 subcellular localization/trafficking. ..