Desat1

Summary

Gene Symbol: Desat1
Description: Desaturase 1
Alias: BEST:SD05462, CG5887, Dmel\CG5887, Fad, anon-WO0118547.726, anon-WO0118547.730, desat, desat1, ds1, fad, l(3)S028813, desaturase 1, CG5887-PA, CG5887-PB, CG5887-PC, CG5887-PD, CG5887-PE, Desat1-PA, Desat1-PB, Desat1-PC, Desat1-PD, Desat1-PE, desat1, desaturase, desaturase1, fatty acid desaturase, lethal (3) S028813, stearoyl CoA desaturase, stearoyl-CoA 9-desaturase
Species: fruit fly

Top Publications

  1. Lacaille F, Hiroi M, Twele R, Inoshita T, Umemoto D, Manière G, et al. An inhibitory sex pheromone tastes bitter for Drosophila males. PLoS ONE. 2007;2:e661 pubmed
    ..Furthermore, the two substances induced similar behavioral responses both in courtship and feeding tests. We conclude that the inhibitory pheromone tastes bitter to the fly. ..
  2. Dallerac R, Labeur C, Jallon J, Knipple D, Roelofs W, Wicker Thomas C. A delta 9 desaturase gene with a different substrate specificity is responsible for the cuticular diene hydrocarbon polymorphism in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2000;97:9449-54 pubmed
    ..We have previously isolated a desaturase gene, desat1, from the Canton-S strain (CS), a 7,11 HD-2-rich morph of D. melanogaster...
  3. Lacaille F, Everaerts C, Ferveur J. Feminization and alteration of Drosophila taste neurons induce reciprocal effects on male avoidance behavior. Behav Genet. 2009;39:554-63 pubmed publisher
  4. Marcillac F, Grosjean Y, Ferveur J. A single mutation alters production and discrimination of Drosophila sex pheromones. Proc Biol Sci. 2005;272:303-9 pubmed
    ..This indicates that the emission and perception of pheromones are coded by differ-ent products of the same gene, reflecting the pleiotropic activity of desatl . ..
  5. Coyne J, Wicker Thomas C, Jallon J. A gene responsible for a cuticular hydrocarbon polymorphism in Drosophila melanogaster. Genet Res. 1999;73:189-203 pubmed
    ..5 and cytological position 87C-D. This is precisely the position of a desaturase gene previously sequenced using primers derived from yeast and mouse, and localized by in situ hybridization to ..
  6. Wicker Thomas C, Henriet C, Dallerac R. Partial characterization of a fatty acid desaturase gene in Drosophila melanogaster. Insect Biochem Mol Biol. 1997;27:963-72 pubmed
    ..This is the first description of a desaturase sequence in insects. Two cDNAs were cloned: the combined 1...
  7. Labeur C, Dallerac R, Wicker Thomas C. Involvement of desat1 gene in the control of Drosophila melanogaster pheromone biosynthesis. Genetica. 2002;114:269-74 pubmed
    ..We have previously shown that a desaturase gene, desat1, located in chromosome region 87 C could be involved in this process: the Desat1 enzyme ..
  8. Marcillac F, Bousquet F, Alabouvette J, Savarit F, Ferveur J. A mutation with major effects on Drosophila melanogaster sex pheromones. Genetics. 2005;171:1617-28 pubmed publisher
    ..sexual difference depends largely upon the number of double bonds (one in males and two in females) added by desaturase enzymes...
  9. Chertemps T, Duportets L, Labeur C, Ueyama M, Wicker Thomas C. A female-specific desaturase gene responsible for diene hydrocarbon biosynthesis and courtship behaviour in Drosophila melanogaster. Insect Mol Biol. 2006;15:465-73 pubmed
    ..Here we describe a female-specific desaturase gene, desatF...

More Information

Publications48

  1. Greenberg A, Moran J, Fang S, Wu C. Adaptive loss of an old duplicated gene during incipient speciation. Mol Biol Evol. 2006;23:401-10 pubmed publisher
    ..We also find that ds2, as well as its duplicate pair ds1, has been maintained in the Drosophila genus for at least 40 Myr without any sign of adaptive change...
  2. Roelofs W, Rooney A. Molecular genetics and evolution of pheromone biosynthesis in Lepidoptera. Proc Natl Acad Sci U S A. 2003;100:9179-84 pubmed
    ..species has revealed that one way to make a major shift in the pheromone blend is by activation of a different desaturase from mRNA that already exists in the pheromone gland...
  3. Grillet M, Dartevelle L, Ferveur J. A Drosophila male pheromone affects female sexual receptivity. Proc Biol Sci. 2006;273:315-23 pubmed
    ..Control females-but not antenna-less females-could detect small variation of 7-T. Finally, our finding that desat1 mutant female showed altered response towards 7-T provides an additional role for this gene which affects the ..
  4. Marcillac F, Ferveur J. A set of female pheromones affects reproduction before, during and after mating in Drosophila. J Exp Biol. 2004;207:3927-33 pubmed
    ..The fact that female pheromones induced reciprocal effects on the frequency of the genes contributed by females and males suggests that these substances regulate coevolutionary processes between the sexes. ..
  5. Houot B, Bousquet F, Ferveur J. The consequences of regulation of desat1 expression for pheromone emission and detection in Drosophila melanogaster. Genetics. 2010;185:1297-309 pubmed publisher
    ..b>desat1 determines both aspects of communication-a mutation in desat1 simultaneously alters both sex pheromone emission ..
  6. Chertemps T, Duportets L, Labeur C, Ueda R, Takahashi K, Saigo K, et al. A female-biased expressed elongase involved in long-chain hydrocarbon biosynthesis and courtship behavior in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2007;104:4273-8 pubmed
    ..These results strongly support the hypothesis that eloF is a crucial enzyme for female pheromone biosynthesis and courtship behavior in D. melanogaster. ..
  7. Takahashi A, Tsaur S, Coyne J, Wu C. The nucleotide changes governing cuticular hydrocarbon variation and their evolution in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2001;98:3920-5 pubmed
    ..This is a 16-bp deletion in the 5' region of a desaturase gene (desat2) that was recently suggested to be responsible for the CH polymorphism on the basis of its ..
  8. Wicker Thomas C, Guenachi I, Keita Y. Contribution of oenocytes and pheromones to courtship behaviour in Drosophila. BMC Biochem. 2009;10:21 pubmed publisher
    ..To address this question, we RNAi silenced two main genes of the biosynthesis pathway, desat1 and desatF, in the oenocytes of D. melanogaster, without modifying their fat body expression...
  9. Ueyama M, Chertemps T, Labeur C, Wicker Thomas C. Mutations in the desat1 gene reduces the production of courtship stimulatory pheromones through a marked effect on fatty acids in Drosophila melanogaster. Insect Biochem Mol Biol. 2005;35:911-20 pubmed
    In Drosophila melanogaster, desat1 is involved in the synthesis of fatty acids (FAs), some of which are precursors in the production of unsaturated hydrocarbons (HCs) in position 7 (7-HC) that play an important role in mating behaviour...
  10. Siwicki K, Riccio P, Ladewski L, Marcillac F, Dartevelle L, Cross S, et al. The role of cuticular pheromones in courtship conditioning of Drosophila males. Learn Mem. 2005;12:636-45 pubmed
    ..Thus, 9-P can contribute significantly to the conditioned suppression of male courtship toward targets that express this pheromone. ..
  11. Billeter J, Atallah J, Krupp J, Millar J, Levine J. Specialized cells tag sexual and species identity in Drosophila melanogaster. Nature. 2009;461:987-91 pubmed publisher
    ..These results identify a common mechanism for sexual and species recognition regulated by cuticular hydrocarbons. ..
  12. Kuo T, Fedina T, Hansen I, Dreisewerd K, Dierick H, Yew J, et al. Insulin signaling mediates sexual attractiveness in Drosophila. PLoS Genet. 2012;8:e1002684 pubmed publisher
    ..These results suggest that the activity of conserved molecular regulators of longevity and reproductive output may manifest in different species as external characteristics that are perceived as honest indicators of fitness potential. ..
  13. Krupp J, Kent C, Billeter J, Azanchi R, So A, Schonfeld J, et al. Social experience modifies pheromone expression and mating behavior in male Drosophila melanogaster. Curr Biol. 2008;18:1373-83 pubmed publisher
    ..circadian clocks that appear to regulate the synthesis of pheromones by controlling the transcription of desaturase1 (desat1), a gene required for production of male cuticular sex pheromones...
  14. Tillman J, Seybold S, Jurenka R, Blomquist G. Insect pheromones--an overview of biosynthesis and endocrine regulation. Insect Biochem Mol Biol. 1999;29:481-514 pubmed
  15. Fang S, Ting C, Lee C, Chu K, Wang C, Tsaur S. Molecular evolution and functional diversification of fatty acid desaturases after recurrent gene duplication in Drosophila. Mol Biol Evol. 2009;26:1447-56 pubmed publisher
    ..This mechanism in the desaturase gene family has been proposed to be important in triggering the pheromonal diversification in insects...
  16. Li Y, Hoxha V, Lama C, Dinh B, Vo C, Dauwalder B. The hector G-protein coupled receptor is required in a subset of fruitless neurons for male courtship behavior. PLoS ONE. 2011;6:e28269 pubmed publisher
    ..Expression of 4395-RNAi in GH146 projection neurons lowers courtship. This suggests that signaling through the CG4395 GPCR in this subset of fru neurons is critical for male courtship behavior. ..
  17. Inoshita T, Martin J, Marion Poll F, Ferveur J. Peripheral, central and behavioral responses to the cuticular pheromone bouquet in Drosophila melanogaster males. PLoS ONE. 2011;6:e19770 pubmed publisher
    ..centers receiving these gustatory inputs and (iii) the behavioral reaction induced in control males and in mutant desat1 males, which show abnormal pheromone production and perception...
  18. Shen L, Lai C, Feng X, Parnell L, Wan J, Wang J, et al. Drosophila lacks C20 and C22 PUFAs. J Lipid Res. 2010;51:2985-92 pubmed publisher
    ..These findings demonstrate that Drosophila lacks the capability to synthesize the biologically important C20 and C22 PUFAs, and thereby argue that Drosophila is not a valid model for the study of lipid metabolism and related diseases. ..
  19. Grosjean Y, Grillet M, Augustin H, Ferveur J, Featherstone D. A glial amino-acid transporter controls synapse strength and courtship in Drosophila. Nat Neurosci. 2008;11:54-61 pubmed
  20. Montooth K, Siebenthall K, Clark A. Membrane lipid physiology and toxin catabolism underlie ethanol and acetic acid tolerance in Drosophila melanogaster. J Exp Biol. 2006;209:3837-50 pubmed
  21. Laayouni H, García Franco F, Chávez Sandoval B, Trotta V, Beltran S, Corominas M, et al. Thermal evolution of gene expression profiles in Drosophila subobscura. BMC Evol Biol. 2007;7:42 pubmed
    ..Furthermore, some clustering of genes within inverted chromosomal sections was detected. Disentangling the effects of inversions will be obviously required in any future approach if we want to identify the relevant candidate genes. ..
  22. Musselman L, Fink J, Ramachandran P, Patterson B, Okunade A, Maier E, et al. Role of fat body lipogenesis in protection against the effects of caloric overload in Drosophila. J Biol Chem. 2013;288:8028-42 pubmed publisher
    ..feeding as tissue-specific loss of orthologs of carbohydrate response element-binding protein or stearoyl-CoA desaturase 1 resulted in lethality on high sugar diets...
  23. Flaven Pouchon J, Farine J, Ewer J, Ferveur J. Regulation of cuticular hydrocarbon profile maturation by Drosophila tanning hormone, bursicon, and its interaction with desaturase activity. Insect Biochem Mol Biol. 2016;79:87-96 pubmed publisher
    ..Interestingly, this effect is mostly abrogated by mutations in the ?9 desaturase encoded by the desaturase1 gene, which introduces a first double bond into elongated fatty-acid chains, suggesting that desaturase1 acts ..
  24. Bousquet F, Nojima T, Houot B, Chauvel I, Chaudy S, Dupas S, et al. Expression of a desaturase gene, desat1, in neural and nonneural tissues separately affects perception and emission of sex pheromones in Drosophila. Proc Natl Acad Sci U S A. 2012;109:249-54 pubmed publisher
    ..We characterized the five desat1 transcripts-all of which yielded the same desaturase protein-and constructed transgenes with the different desat1 putative regulatory regions...
  25. Houot B, Fraichard S, Greenspan R, Ferveur J. Genes involved in sex pheromone discrimination in Drosophila melanogaster and their background-dependent effect. PLoS ONE. 2012;7:e30799 pubmed publisher
    ..This experimental selection was carried out in parallel on two different genetic backgrounds: wild-type and desat1 mutant, in which parental males showed high and low sex pheromone discrimination ability respectively...
  26. Gutierrez E, Wiggins D, Fielding B, Gould A. Specialized hepatocyte-like cells regulate Drosophila lipid metabolism. Nature. 2007;445:275-80 pubmed
    ..These findings provide evidence that some lipid-processing functions of the mammalian liver are performed in insects by oenocytes...
  27. Gleason J, James R, Wicker Thomas C, Ritchie M. Identification of quantitative trait loci function through analysis of multiple cuticular hydrocarbons differing between Drosophila simulans and Drosophila sechellia females. Heredity (Edinb). 2009;103:416-24 pubmed publisher
    ..simulans is not. Epistatic interactions, only detected for CHCs limited to D. sechellia, imply that complex interactions among loci may also be having a role in these compounds that affect mating isolation. ..
  28. Seegmiller A, Dobrosotskaya I, Goldstein J, Ho Y, Brown M, Rawson R. The SREBP pathway in Drosophila: regulation by palmitate, not sterols. Dev Cell. 2002;2:229-38 pubmed
    ..Instead, dSREBP processing is blocked by palmitic acid. These findings suggest that the ancestral SREBP pathway functions to maintain membrane integrity rather than to control cholesterol homeostasis. ..
  29. Kohler K, Brunner E, Guan X, Boucke K, Greber U, Mohanty S, et al. A combined proteomic and genetic analysis identifies a role for the lipid desaturase Desat1 in starvation-induced autophagy in Drosophila. Autophagy. 2009;5:980-90 pubmed
    ..One of these genes, Desat1, encodes a lipid desaturase. Desat1 mutant cells fail to induce autophagy upon starvation...
  30. Grifoni D, Bellosta P. Drosophila Myc: A master regulator of cellular performance. Biochim Biophys Acta. 2015;1849:570-81 pubmed publisher
    ..This article is part of a Special Issue entitled: Myc proteins in cell biology and pathology. ..
  31. Grillet M, Everaerts C, Houot B, Ritchie M, Cobb M, Ferveur J. Incipient speciation in Drosophila melanogaster involves chemical signals. Sci Rep. 2012;2:224 pubmed publisher
    ..Variation in transcription levels of two hydrocarbon-determining genes, desat1 and desat2, did not correlate with the observed mating patterns...
  32. Murakami A, Nagao K, Juni N, Hara Y, Umeda M. An N-terminal di-proline motif is essential for fatty acid-dependent degradation of ?9-desaturase in Drosophila. J Biol Chem. 2017;292:19976-19986 pubmed publisher
    The ?9-fatty acid desaturase introduces a double bond at the ?9 position of the acyl moiety of acyl-CoA and regulates the cellular levels of unsaturated fatty acids...
  33. Krupp J, Billeter J, Wong A, Choi C, Nitabach M, Levine J. Pigment-dispersing factor modulates pheromone production in clock cells that influence mating in drosophila. Neuron. 2013;79:54-68 pubmed publisher
    ..Our findings highlight the role of neuropeptide signaling and the circadian system in synchronizing the physiological and behavioral processes that govern social interactions. ..
  34. Kent C, Azanchi R, Smith B, Chu A, Levine J. A model-based analysis of chemical and temporal patterns of cuticular hydrocarbons in male Drosophila melanogaster. PLoS ONE. 2007;2:e962 pubmed
  35. Laturney M, Billeter J. Drosophila melanogaster females restore their attractiveness after mating by removing male anti-aphrodisiac pheromones. Nat Commun. 2016;7:12322 pubmed publisher
    ..To our knowledge, female AAP ejection provides the first example of a female mechanism that counter-acts chemical mate-guarding. ..
  36. Parisi F, Riccardo S, Zola S, Lora C, Grifoni D, Brown L, et al. dMyc expression in the fat body affects DILP2 release and increases the expression of the fat desaturase Desat1 resulting in organismal growth. Dev Biol. 2013;379:64-75 pubmed publisher
    ..We also found the expression of Stearoyl-CoA desaturase, Desat1 mRNA significantly higher in FB overexpressing dMyc...
  37. Havula E, Teesalu M, Hyötyläinen T, Seppälä H, Hasygar K, Auvinen P, et al. Mondo/ChREBP-Mlx-regulated transcriptional network is essential for dietary sugar tolerance in Drosophila. PLoS Genet. 2013;9:e1003438 pubmed publisher
    ..Our data demonstrate that the transcriptional network regulated by Mondo-Mlx is a critical determinant of the healthful dietary spectrum allowing Drosophila to exploit sugar-rich nutrient sources. ..
  38. Thibert J, Farine J, Cortot J, Ferveur J. Drosophila Food-Associated Pheromones: Effect of Experience, Genotype and Antibiotics on Larval Behavior. PLoS ONE. 2016;11:e0151451 pubmed publisher
    ..The antagonistic effect of attractive vs. aversive compounds could modulate larval choice of a pupariation site and impact the dispersion of individuals in nature. ..
  39. Marcillac F, Houot B, Ferveur J. Revisited roles of Drosophila female pheromones. Chem Senses. 2005;30 Suppl 1:i273-4 pubmed