Gene Symbol: defl
Alias: CG18176, Dmel\CG18176, Int7, IntS7, deflated, CG18176-PA, defl-PA, integrator 7
Species: fruit fly
Chen J, Waltenspiel B, Warren W, Wagner E. Functional analysis of the integrator subunit 12 identifies a microdomain that mediates activation of the Drosophila integrator complex. J Biol Chem. 2013;288:4867-77 pubmed publisher
..Collectively, these results identify an unexpected interaction between the largest and smallest integrator subunits that is essential for the 3' end formation of Drosophila snRNA. ..
Oikemus S, Queiroz Machado J, Lai K, McGinnis N, Sunkel C, Brodsky M. Epigenetic telomere protection by Drosophila DNA damage response pathways. PLoS Genet. 2006;2:e71 pubmed
..Given the conserved roles of DNA damage response proteins in telomere function, related mechanisms may act at the telomeres of other organisms. ..
Mavrich T, Jiang C, Ioshikhes I, Li X, Venters B, Zanton S, et al
. Nucleosome organization in the Drosophila genome. Nature. 2008;453:358-62 pubmed publisher
..At thousands of genes, RNA polymerase II engages the +1 nucleosome and pauses. How the transcription initiation machinery contends with the +1 nucleosome seems to be fundamentally different across major eukaryotic lines. ..
Rutkowski R, Warren W. Phenotypic analysis of deflated/Ints7 function in Drosophila development. Dev Dyn. 2009;238:1131-9 pubmed publisher
The Drosophila gene deflated (CG18176; renamed after the pupal lethal abdominal phenotype of mutant individuals) is a member of a conserved gene family found in all multicellular organisms...
Doumanis J, Wada K, Kino Y, Moore A, Nukina N. RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation. PLoS ONE. 2009;4:e7275 pubmed publisher
..Newly identified modifiers including genes related to nuclear transport, nucleotide processes, and signaling, may be involved in polyglutamine aggregate formation and Huntington disease cascades. ..