Dcp-1

Summary

Gene Symbol: Dcp-1
Description: Death caspase-1
Alias: CG5370, DCP-1, DCP1, Dcp1, Dmel\CG5370, ccp1, dcp-1, dcp1, l(2)01862, l(2)02132, death caspase-1, CG5370-PA, Dcp-1-PA, caspase, caspase 1, caspase-1
Species: fruit fly
Products:     Dcp-1

Top Publications

  1. Hawkins C, Yoo S, Peterson E, Wang S, Vernooy S, Hay B. The Drosophila caspase DRONC cleaves following glutamate or aspartate and is regulated by DIAP1, HID, and GRIM. J Biol Chem. 2000;275:27084-93 pubmed
    The caspase family of cysteine proteases plays important roles in bringing about apoptotic cell death. All caspases studied to date cleave substrates COOH-terminal to an aspartate...
  2. Lee G, Wang Z, Sehgal R, Chen C, Kikuno K, Hay B, et al. Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis. J Comp Neurol. 2011;519:34-48 pubmed publisher
    ..neurons initiates within 1 hour after pupariation, as demonstrated by the cytological signs of cell death and caspase activation...
  3. Denton D, Shravage B, Simin R, Mills K, Berry D, Baehrecke E, et al. Autophagy, not apoptosis, is essential for midgut cell death in Drosophila. Curr Biol. 2009;19:1741-6 pubmed publisher
    ..The initiator caspase Dronc and its activator Ark are required for the death of salivary glands, but not for midgut removal [2, 3]...
  4. Wang S, Hawkins C, Yoo S, Muller H, Hay B. The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID. Cell. 1999;98:453-63 pubmed
    Drosophila Reaper (RPR), Head Involution Defective (HID), and GRIM induce caspase-dependent cell death and physically interact with the cell death inhibitor DIAP1...
  5. Dorstyn L, Read S, Quinn L, Richardson H, Kumar S. DECAY, a novel Drosophila caspase related to mammalian caspase-3 and caspase-7. J Biol Chem. 1999;274:30778-83 pubmed
    ..Here we describe the identification and characterization of the fifth Drosophila caspase, DECAY...
  6. Danial N, Korsmeyer S. Cell death: critical control points. Cell. 2004;116:205-19 pubmed
    ..The identification of critical control points in the cell death pathway has yielded fundamental insights for basic biology, as well as provided rational targets for new therapeutics. ..
  7. Laundrie B, Peterson J, Baum J, Chang J, Fileppo D, Thompson S, et al. Germline cell death is inhibited by P-element insertions disrupting the dcp-1/pita nested gene pair in Drosophila. Genetics. 2003;165:1881-8 pubmed
    ..P-element insertions in the caspase gene dcp-1 disrupt both dcp-1 and the outlying gene, pita, leading to lethality and defective nurse cell death in ..
  8. Kondo S, Senoo Matsuda N, Hiromi Y, Miura M. DRONC coordinates cell death and compensatory proliferation. Mol Cell Biol. 2006;26:7258-68 pubmed
    ..Here, we provide genetic evidence that the Drosophila initiator caspase DRONC governs both apoptosis execution and subsequent compensatory proliferation...
  9. Fan Y, Bergmann A. The cleaved-Caspase-3 antibody is a marker of Caspase-9-like DRONC activity in Drosophila. Cell Death Differ. 2010;17:534-9 pubmed publisher
    The cleaved-Caspase-3 antibody is a popular tool in apoptosis research in Drosophila...

More Information

Publications78

  1. Zachariou A, Tenev T, Goyal L, Agapite J, Steller H, Meier P. IAP-antagonists exhibit non-redundant modes of action through differential DIAP1 binding. EMBO J. 2003;22:6642-52 pubmed
    ..Surprisingly, we also find that the caspase-binding residues of XIAP predicted to be strictly conserved in caspase-binding IAPs, are absent in DIAP1...
  2. Kornbluth S, White K. Apoptosis in Drosophila: neither fish nor fowl (nor man, nor worm). J Cell Sci. 2005;118:1779-87 pubmed
    ..model for the induction of apoptosis in which multiple signaling pathways lead ultimately to activation of the caspase family of proteases...
  3. Kondo T, Yokokura T, Nagata S. Activation of distinct caspase-like proteases by Fas and reaper in Drosophila cells. Proc Natl Acad Sci U S A. 1997;94:11951-6 pubmed
    ..Both Ac-YVAD aldehyde and Ac-DEVD aldehyde, specific inhibitors of caspase 1- and caspase 3-like proteases, respectively, inhibited the FasC-induced death of Drosophila cells...
  4. Yu S, Yoo S, Yang L, Zapata C, Srinivasan A, Hay B, et al. A pathway of signals regulating effector and initiator caspases in the developing Drosophila eye. Development. 2002;129:3269-78 pubmed
    ..An antibody raised against a peptide from human caspase 3 was used to investigate how extracellular signals controlled spatial patterning of cell death...
  5. Fraser A, McCarthy N, Evan G. drICE is an essential caspase required for apoptotic activity in Drosophila cells. EMBO J. 1997;16:6192-9 pubmed
    ..While Caenorhabditis elegans has only a single identified caspase, CED-3, whose activity is absolutely required for all developmental programmed cell deaths, most mammalian cell ..
  6. Leulier F, Ribeiro P, Palmer E, Tenev T, Takahashi K, Robertson D, et al. Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery. Cell Death Differ. 2006;13:1663-74 pubmed
    ..Using RNA interference (RNAi) in vivo, we have studied the requirement of all Drosophila caspases and caspase-adaptors in different paradigms of apoptosis...
  7. Baum J, Arama E, Steller H, McCall K. The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis. Cell Death Differ. 2007;14:1508-17 pubmed
    ..We have analyzed the role of caspases in PCD of the female germline by examining caspase mutants and overexpressing caspase inhibitors...
  8. Fan Y, Bergmann A. Distinct mechanisms of apoptosis-induced compensatory proliferation in proliferating and differentiating tissues in the Drosophila eye. Dev Cell. 2008;14:399-410 pubmed publisher
    ..This process is under control of the initiator caspase Dronc, but not effector caspases...
  9. Kanuka H, Kuranaga E, Takemoto K, Hiratou T, Okano H, Miura M. Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development. EMBO J. 2005;24:3793-806 pubmed
    ..by the sgg gene and essential for the negative regulation of Wingless signaling, is cleaved by the Dark-dependent caspase. This cleavage converts it to an active kinase, which contributes to the formation of neural precursor (sensory ..
  10. Etchegaray J, Timmons A, Klein A, Pritchett T, Welch E, Meehan T, et al. Draper acts through the JNK pathway to control synchronous engulfment of dying germline cells by follicular epithelial cells. Development. 2012;139:4029-39 pubmed publisher
    ..The induction of JNK and Draper in follicle cells occurs independently of caspase activity in the germline, indicating that at least two pathways are necessary to coordinate germline cell death ..
  11. Song Z, Guan B, Bergman A, Nicholson D, Thornberry N, Peterson E, et al. Biochemical and genetic interactions between Drosophila caspases and the proapoptotic genes rpr, hid, and grim. Mol Cell Biol. 2000;20:2907-14 pubmed
    ..The products of these genes induce apoptosis by activating a caspase pathway. Two very similar Drosophila caspases, DCP-1 and drICE, have been previously identified...
  12. Zhou L, Song Z, Tittel J, Steller H. HAC-1, a Drosophila homolog of APAF-1 and CED-4 functions in developmental and radiation-induced apoptosis. Mol Cell. 1999;4:745-55 pubmed
    ..Our data indicate that caspase activation and apoptosis in Drosophila are independently controlled by at least two distinct regulatory pathways ..
  13. Florentin A, Arama E. Caspase levels and execution efficiencies determine the apoptotic potential of the cell. J Cell Biol. 2012;196:513-27 pubmed publisher
    ..Both caspases were activated by the apoptosome after irradiation. However, whereas each caspase alone could induce apoptosis, Drice was a more effective inducer of apoptosis than Dcp-1, which instead had a ..
  14. Hawkins C, Wang S, Hay B. A cloning method to identify caspases and their regulators in yeast: identification of Drosophila IAP1 as an inhibitor of the Drosophila caspase DCP-1. Proc Natl Acad Sci U S A. 1999;96:2885-90 pubmed
    ..Introduction of an active caspase into cells that express a caspase-cleavable reporter results in the release of the transcription factor from the ..
  15. Jones G, Jones D, Zhou L, Steller H, Chu Y. Deterin, a new inhibitor of apoptosis from Drosophila melanogaster. J Biol Chem. 2000;275:22157-65 pubmed
    ..the expressed protein acts in the cytoplasm to inhibit or deter cells from apoptosis otherwise induced by the caspase-dependent apoptosis activator reaper or by cytotoxicants...
  16. Song Z, McCall K, Steller H. DCP-1, a Drosophila cell death protease essential for development. Science. 1997;275:536-40 pubmed
    ..Cell killing by reaper and two genetically linked apoptotic activators, hid and grim, requires caspase activity...
  17. Tenev T, Zachariou A, Wilson R, Ditzel M, Meier P. IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms. Nat Cell Biol. 2005;7:70-7 pubmed
    ..The current model suggests that all caspase-regulatory IAPs function as direct enzyme inhibitors, blocking effector caspases by binding to their ..
  18. Peterson J, Barkett M, McCall K. Stage-specific regulation of caspase activity in drosophila oogenesis. Dev Biol. 2003;260:113-23 pubmed
    ..In this report, we show that the effector caspase Drice is activated during cell death in both mid- and late oogenesis, but that the level and localization of ..
  19. Keller L, Cheng L, Locke C, Muller M, Fetter R, Davis G. Glial-derived prodegenerative signaling in the Drosophila neuromuscular system. Neuron. 2011;72:760-75 pubmed publisher
    ..for a prodegenerative, glial-derived signaling framework in the Drosophila neuromuscular system that includes caspase and mitochondria-dependent signaling...
  20. Xu D, Woodfield S, Lee T, Fan Y, Antonio C, Bergmann A. Genetic control of programmed cell death (apoptosis) in Drosophila. Fly (Austin). 2009;3:78-90 pubmed
    ..Here, we review the key players of the cell death pathway in Drosophila and discuss their roles in apoptotic and non-apoptotic processes. ..
  21. Tanner E, Blute T, Brachmann C, McCall K. Bcl-2 proteins and autophagy regulate mitochondrial dynamics during programmed cell death in the Drosophila ovary. Development. 2011;138:327-38 pubmed publisher
    ..Furthermore, Bcl-2 family mutants show a striking defect in cell death in the ovary. These data indicate that a mitochondrial pathway is a major mechanism for activation of cell death in Drosophila oogenesis. ..
  22. Schoenmann Z, Assa Kunik E, Tiomny S, Minis A, Haklai Topper L, Arama E, et al. Axonal degeneration is regulated by the apoptotic machinery or a NAD+-sensitive pathway in insects and mammals. J Neurosci. 2010;30:6375-86 pubmed publisher
    ..These findings indicate that two distinct autodestruction pathways act separately or in concert to regulate developmental neurite pruning. ..
  23. Varkey J, Chen P, Jemmerson R, Abrams J. Altered cytochrome c display precedes apoptotic cell death in Drosophila. J Cell Biol. 1999;144:701-10 pubmed
    ..It offers a powerful extension to in vitro models that have implicated a requirement for cytochrome c in caspase activation and apoptosis...
  24. Bergmann A, Agapite J, Steller H. Mechanisms and control of programmed cell death in invertebrates. Oncogene. 1998;17:3215-23 pubmed
    ..This review summarizes some of the key findings in this area, but also touches on some of the many unresolved questions and challenges that remain. ..
  25. Bose R, Chen P, Loconti A, Grullich C, Abrams J, Kolesnick R. Ceramide generation by the Reaper protein is not blocked by the caspase inhibitor, p35. J Biol Chem. 1998;273:28852-9 pubmed
    ..that Rpr expression induced generation of the lipid second messenger ceramide and through use of the peptide caspase inhibitor N-benzyloxycarbonyl-VAD-fluoromethylketone(zVAD...
  26. Harvey N, Daish T, Mills K, Dorstyn L, Quinn L, Read S, et al. Characterization of the Drosophila caspase, DAMM. J Biol Chem. 2001;276:25342-50 pubmed
    ..Here we describe the cloning and characterization of the last Drosophila caspase, DAMM. Similar to mammalian effector caspases, DAMM lacks a long prodomain...
  27. McCall K, Steller H. Requirement for DCP-1 caspase during Drosophila oogenesis. Science. 1998;279:230-4 pubmed
    ..Loss of function for the dcp-1 gene, which encodes a caspase, caused female sterility by inhibiting this transfer...
  28. Muro I, Berry D, Huh J, Chen C, Huang H, Yoo S, et al. The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process. Development. 2006;133:3305-15 pubmed
    b>Caspase family proteases play important roles in the regulation of apoptotic cell death...
  29. Igaki T, Yamamoto Goto Y, Tokushige N, Kanda H, Miura M. Down-regulation of DIAP1 triggers a novel Drosophila cell death pathway mediated by Dark and DRONC. J Biol Chem. 2002;277:23103-6 pubmed
    ..Although this cell death process was accompanied by elevated caspase activity, this activation was not essential for cell death...
  30. Xu D, Wang Y, Willecke R, Chen Z, Ding T, Bergmann A. The effector caspases drICE and dcp-1 have partially overlapping functions in the apoptotic pathway in Drosophila. Cell Death Differ. 2006;13:1697-706 pubmed
    ..Here, we report the isolation of a mutant allele of the Drosophila effector caspase drICE as a strong suppressor of hid- (head involution defective-) induced apoptosis...
  31. Lee G, Kikuno K, Nair S, Park J. Mechanisms of postecdysis-associated programmed cell death of peptidergic neurons in Drosophila melanogaster. J Comp Neurol. 2013;521:3972-91 pubmed publisher
    ..Expression of a versatile caspase inhibitor, p35, blocked PCD of bursCCAP neurons, suggesting caspase-dependent apoptosis...
  32. Kumar S, Doumanis J. The fly caspases. Cell Death Differ. 2000;7:1039-44 pubmed
    ..For example, the transcript for the fly caspase DRONC is regulated by the hormone ecdysone during programmed cell death in specific tissues...
  33. Zheng J, Edelman S, Tharmarajah G, Walker D, Pletcher S, Seroude L. Differential patterns of apoptosis in response to aging in Drosophila. Proc Natl Acad Sci U S A. 2005;102:12083-8 pubmed
    ..The analysis across the lifespan of caspase activity and DNA fragmentation shows that apoptosis occurs in adult flies at all ages and that it is linked to ..
  34. White K. The third horseman takes wing. Nat Cell Biol. 1999;1:E123-4 pubmed
  35. Kessler T, Müller H. Cleavage of Armadillo/beta-catenin by the caspase DrICE in Drosophila apoptotic epithelial cells. BMC Dev Biol. 2009;9:15 pubmed publisher
    ..Arm is cleaved by caspases in embryo extracts and we provide evidence that the caspase-3 homolog drICE cleaves Arm in vitro and in vivo...
  36. Buszczak M, Cooley L. Eggs to die for: cell death during Drosophila oogenesis. Cell Death Differ. 2000;7:1071-4 pubmed
    ..These studies suggest that the morphological changes that occur during the late stages of Drosophila oogenesis may be initiated and driven by a modified form of programmed cell death. ..
  37. Devorkin L, Go N, Hou Y, Moradian A, Morin G, Gorski S. The Drosophila effector caspase Dcp-1 regulates mitochondrial dynamics and autophagic flux via SesB. J Cell Biol. 2014;205:477-92 pubmed publisher
    ..In this paper, we show that the Drosophila effector caspase, Drosophila caspase 1 (Dcp-1), localizes within mitochondria and regulates mitochondrial morphology and autophagic flux...
  38. Pritchett T, McCall K. Role of the insulin/Tor signaling network in starvation-induced programmed cell death in Drosophila oogenesis. Cell Death Differ. 2012;19:1069-79 pubmed publisher
    ..Furthermore, starvation-induced PCD is regulated by Tor signaling converging with the canonical insulin signaling pathway. ..
  39. Su T. Non-autonomous consequences of cell death and other perks of being metazoan. AIMS Genet. 2015;2:54-69 pubmed
    ..Key insights from Drosophila will be discussed in the context of analogous processes in mammalian development and cancer biology. ..
  40. Adams J, Cory S. Apoptosomes: engines for caspase activation. Curr Opin Cell Biol. 2002;14:715-20 pubmed
    ..CED-4 is essential for apoptosis in the worm and Dark for many apoptotic responses in the fly, but the Apaf-1/caspase-9 system probably amplifies rather than initiates the mammalian caspase cascade.
  41. Chihara T, Kitabayashi A, Morimoto M, Takeuchi K, Masuyama K, Tonoki A, et al. Caspase inhibition in select olfactory neurons restores innate attraction behavior in aged Drosophila. PLoS Genet. 2014;10:e1004437 pubmed publisher
    ..Using a genetic probe for caspase-3-like activity (DEVDase activity), we have mapped age-dependent neuronal changes in the adult brain throughout ..
  42. Lee G, Sehgal R, Wang Z, Nair S, Kikuno K, Chen C, et al. Essential role of grim-led programmed cell death for the establishment of corazonin-producing peptidergic nervous system during embryogenesis and metamorphosis in Drosophila melanogaster. Biol Open. 2013;2:283-94 pubmed publisher
    ..The death of vCrz neurons and EW3-sib is triggered by ecdysone and the Notch signaling pathway, respectively, suggesting distinct regulatory mechanisms of grim expression in a cell- and developmental stage-specific manner. ..
  43. Mendes C, Levet C, Chatelain G, Dourlen P, Fouillet A, Dichtel Danjoy M, et al. ER stress protects from retinal degeneration. EMBO J. 2009;28:1296-307 pubmed publisher
    ..We show that a specific ER-mediated signal promotes antioxidant defences and inhibits caspase-dependent cell death...
  44. Bhogal B, Plaza Jennings A, Gavis E. Nanos-mediated repression of hid protects larval sensory neurons after a global switch in sensitivity to apoptotic signals. Development. 2016;143:2147-59 pubmed publisher
    ..in class IV da neurons and that upregulation of hid results in decreased branching because of an increase in caspase activity...
  45. Bergmann A, Yang A, Srivastava M. Regulators of IAP function: coming to grips with the grim reaper. Curr Opin Cell Biol. 2003;15:717-24 pubmed
    ..The apoptosis-inducing genes grim, reaper and hid modulate these mechanisms, and determine the outcome. ..
  46. Creagh E, Brumatti G, Sheridan C, Duriez P, Taylor R, Cullen S, et al. Bicaudal is a conserved substrate for Drosophila and mammalian caspases and is essential for cell survival. PLoS ONE. 2009;4:e5055 pubmed publisher
    Members of the caspase family of cysteine proteases coordinate cell death through restricted proteolysis of diverse protein substrates and play a conserved role in apoptosis from nematodes to man...
  47. Jabbour A, Ekert P, Coulson E, Knight M, Ashley D, Hawkins C. The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis. Cell Death Differ. 2002;9:1311-20 pubmed
    ..The caspase cleavage site in p49 was determined, and mutation of the P1 residue of this site abolished the ability of p49 to ..
  48. Shin J, Min S, Kim S, Kim Y, Park J, Lee H, et al. TAK1 regulates autophagic cell death by suppressing the phosphorylation of p70 S6 kinase 1. Sci Rep. 2013;3:1561 pubmed publisher
    ..This study provides the first in vitro and in vivo evidence of TAK1-induced autophagy and we believe that our findings significantly contribute to the understanding of the mechanisms underlying the induction of autophagy. ..
  49. Khammari A, Agnes F, Gandille P, Pret A. Physiological apoptosis of polar cells during Drosophila oogenesis is mediated by Hid-dependent regulation of Diap1. Cell Death Differ. 2011;18:793-805 pubmed publisher
    ..the RHG family of pro-apoptotic factors, Hid is specifically necessary for PC apoptosis, as well as the initiator caspase Dronc and its adaptor Dark/Apaf-1, and likely several effector caspases, in particular Drice...
  50. Lim A, Tao L, Kai T. piRNAs mediate posttranscriptional retroelement silencing and localization to pi-bodies in the Drosophila germline. J Cell Biol. 2009;186:333-42 pubmed publisher
    ..These mRNA degradation proteins, decapping protein 1/2 (DCP1/2), Me31B (maternal expression at 31B), and pacman (PCM), are normally thought of as components of processing ..
  51. Fan Y, Gittis A, Juge F, Qiu C, Xu Y, Rabinow L. Multifunctional RNA processing protein SRm160 induces apoptosis and regulates eye and genital development in Drosophila. Genetics. 2014;197:1251-65 pubmed publisher
    ..Also of interest, transcripts are restricted almost exclusively to the developing nervous system in mature embryos. ..
  52. Babcock D, Ganetzky B. Non-cell autonomous cell death caused by transmission of Huntingtin aggregates in Drosophila. Fly (Austin). 2015;9:107-9 pubmed publisher
    ..of driving expression of mutant Huntingtin in Olfactory Receptor Neurons (ORNs) by using a marker for cleaved caspase activity to monitor neuronal apoptosis as a function of age...
  53. Peterson J, McCall K. Combined inhibition of autophagy and caspases fails to prevent developmental nurse cell death in the Drosophila melanogaster ovary. PLoS ONE. 2013;8:e76046 pubmed publisher
    ..This process involves at least two cell death mechanisms, caspase-dependent cell death and autophagy, as indicated by apoptosis and autophagy markers...
  54. Kumar S. Cell death in the fly comes of age. Cell Death Differ. 2000;7:1021-4 pubmed
  55. Khan F, Fujioka M, Datta P, Fernandes Alnemri T, Jaynes J, Alnemri E. The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila. Cell Death Differ. 2008;15:1073-83 pubmed publisher
    ..The ability of IAPs to bind to and ubiquitinate mitochondrial proteins such as dOmi may be a key conserved function to counterbalance the lethal effects of these proteins if accidentally released into the cytosol. ..
  56. Primrose D, Chaudhry S, Johnson A, Hrdlicka A, Schindler A, Tran D, et al. Interactions of DNR1 with the apoptotic machinery of Drosophila melanogaster. J Cell Sci. 2007;120:1189-99 pubmed
    ..In Drosophila, the caspase-9 counterpart Dronc is essential for most apoptotic death, whereas the caspase-8 homolog Dredd activates NF-..
  57. Arya R, White K. Cell death in development: Signaling pathways and core mechanisms. Semin Cell Dev Biol. 2015;39:12-9 pubmed publisher
    ..Understanding how the cell death is regulated during development may provide insight into how this process can be manipulated in the treatment of disease. ..
  58. Hasan S, Hétié P, MATUNIS E. Niche signaling promotes stem cell survival in the Drosophila testis via the JAK-STAT target DIAP1. Dev Biol. 2015;404:27-39 pubmed publisher
  59. McNeill H, Downward J. Apoptosis: Ras to the rescue in the fly eye. Curr Biol. 1999;9:R176-9 pubmed
    ..Recent results on the way Ras and downstream pathways can influence cell-death induction suggest the regulatory pathways in these distinct organisms might be more similar than was at first sight apparent. ..
  60. Nandi N, Tyra L, Stenesen D, Krämer H. Acinus integrates AKT1 and subapoptotic caspase activities to regulate basal autophagy. J Cell Biol. 2014;207:253-68 pubmed publisher
    ..We show that cell type-specific regulation of Acn depends on proteolysis by the caspase Dcp-1...
  61. Zhang B, Rotelli M, Dixon M, Calvi B. The function of Drosophila p53 isoforms in apoptosis. Cell Death Differ. 2015;22:2058-67 pubmed publisher
    ..Together, our data show that it is the shorter p53A isoform that mediates the apoptotic response to DNA damage, and further suggest that p53B and shorter isoforms have specialized functions. ..
  62. Baehrecke E. Steroid regulation of programmed cell death during Drosophila development. Cell Death Differ. 2000;7:1057-62 pubmed
    ..This article reviews the current knowledge of steroid signaling and the regulation of programmed cell death during development of Drosophila. ..
  63. Ditzel M, Wilson R, Tenev T, Zachariou A, Paul A, Deas E, et al. Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis. Nat Cell Biol. 2003;5:467-73 pubmed
    ..b>Caspase-mediated cleavage of DIAP1 at position 20 converts the more stable pro-N-degron of DIAP1 into the highly unstable,..
  64. Minakhina S, Steward R. Melanotic mutants in Drosophila: pathways and phenotypes. Genetics. 2006;174:253-63 pubmed
    ..Our results show that the phenotype of each mutant not only reflects its connection to a particular genetic pathway but also points to the tissue-specific role of the individual gene. ..
  65. Cory S, Adams J. Matters of life and death: programmed cell death at Cold Spring Harbor. Biochim Biophys Acta. 1998;1377:R25-44 pubmed
  66. Pushpavalli S, Ramaiah M, Lavanya A, Ganesh A, Kumbhare R, Bhadra K, et al. Imidazo-benzothiazoles a potent microRNA modulator involved in cell proliferation. Bioorg Med Chem Lett. 2012;22:6418-24 pubmed publisher
    ..Interestingly, these conjugates downregulate the genes involved in microRNA biogenesis such as Drosha, Pasha and Dicer-1. Our findings have elucidated the microRNA inhibitory role of imidazo-benzothiazole conjugates. ..
  67. Meier P, Evan G. Dying like flies. Cell. 1998;95:295-8 pubmed
  68. Sudmeier L, Howard S, Ganetzky B. A Drosophila model to investigate the neurotoxic side effects of radiation exposure. Dis Model Mech. 2015;8:669-77 pubmed publisher
    ..A dose-dependent decrease in adult longevity was paralleled by a dose-dependent increase in activated Death caspase-1 (Dcp1) in adult brains...
  69. Sage B, Jones J, Holmes A, Wu M, Csink A. Sequence elements in cis influence heterochromatic silencing in trans. Mol Cell Biol. 2005;25:377-88 pubmed
    ..Intriguingly, this region encompasses the upstream regions of two divergently transcribed genes and contains a sequence motif that may bind BEAF, a protein involved in delimiting chromatin boundaries. ..