dco

Summary

Gene Symbol: dco
Description: discs overgrown
Alias: 0538/13, 0915/10, 1396/02, 1447/01, 1460/09, CG2048, CK1delta/epsilon, CK1epsilon, CKIepsilon, DBT, DBT/CK1epsilon, DCO, DCO/CKIe, Dbt, Dco, Dco/CK1, Dmel\CG2048, ck1epsilon, dCKIepsilon, dbt, dco-1, ddbt, l(3)S053813, l(3)S144701, l(3)dco, l(3)dco-1, l(3)discs overgrown, l(3)discs overgrown-1, l(3)j3B9, l(3)rK215, CG2048 gene product from transcript CG2048-RD, CG2048-PA, CG2048-PB, CG2048-PC, CG2048-PD, casein kinase 1, casein kinase I epsilon, casein kinase iepsilon, dco-PA, dco-PB, dco-PC, dco-PD, disc overgrown, double time, double-time, doubletime
Species: fruit fly

Top Publications

  1. pmc Identification of domains responsible for ubiquitin-dependent degradation of dMyc by glycogen synthase kinase 3beta and casein kinase 1 kinases
    Margherita Galletti
    Department of Biology, City College of the City University of New York, 138th at Convent Ave, New York, NY 10031, USA
    Mol Cell Biol 29:3424-34. 2009
  2. ncbi DCP-1, a Drosophila cell death protease essential for development
    Z Song
    Howard Hughes Medical Institute, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 275:536-40. 1997
  3. pmc The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock
    Joanna C Chiu
    Rutgers University, Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey 08854, USA
    Genes Dev 22:1758-72. 2008
  4. pmc A small conserved domain of Drosophila PERIOD is important for circadian phosphorylation, nuclear localization, and transcriptional repressor activity
    Pipat Nawathean
    Howard Hughes Medical Institute and Department of Biology, Brandeis University, Waltham, MA 02454, USA
    Mol Cell Biol 27:5002-13. 2007
  5. ncbi Genetic analysis of the circadian system in Drosophila melanogaster and mammals
    Ralf Stanewsky
    Universitat Regensburg, Institut fur Zoologie, Lehrstuhl für Entwicklungsbiologie, Universitatsstrasse 31, 93040 Regensburg, Germany
    J Neurobiol 54:111-47. 2003
  6. ncbi The F-box protein slimb controls the levels of clock proteins period and timeless
    Brigitte Grima
    Institut de Neurobiologie Alfred Fessard NGI, CNRS UPR 2216, Centre National de la Recherche Scientifique, av de la Terrasse, 91198 Gif sur Yvette, France
    Nature 420:178-82. 2002
  7. pmc Drosophila DBT lacking protein kinase activity produces long-period and arrhythmic circadian behavioral and molecular rhythms
    Michael J Muskus
    School of Biological Sciences, University of Missouri Kansas City, 5100 Rockhill Rd, Kansas City, MO 64110, USA
    Mol Cell Biol 27:8049-64. 2007
  8. pmc The LARK RNA-binding protein selectively regulates the circadian eclosion rhythm by controlling E74 protein expression
    Yanmei Huang
    Department of Neuroscience, Center for Neuroscience Research, Tufts University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 2:e1107. 2007
  9. pmc Fat and expanded act in parallel to regulate growth through warts
    Yongqiang Feng
    Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 104:20362-7. 2007
  10. doi Casein kinase I epsilon does not rescue double-time function in Drosophila despite evolutionarily conserved roles in the circadian clock
    Tatsumori Sekine
    Division of Insect Sciences, National Institute of Agrobiological Sciences, Ohwashi 1 2, Tsukuba, Ibaraki 305 8634, Japan
    J Biol Rhythms 23:3-15. 2008

Research Grants

  1. Problem Solving Environment for Modeling the Cell Cycle
    John Tyson; Fiscal Year: 2002
  2. Analysis of fringe-dependent cell-signaling
    Kenneth Irvine; Fiscal Year: 2004
  3. NOVEL CIRCADIAN MUTANT OF DROSOPHILA
    Jeffrey Price; Fiscal Year: 2007
  4. Genetic Analysis of Olfactory Coding in Drosophilia
    LESLIE VOSSHALL; Fiscal Year: 2009
  5. Experimental and Computational Studies of Exit from Mitosis in Budding Yeast
    John J Tyson; Fiscal Year: 2010
  6. Formation of an Olfactory Sensory Map
    LESLIE VOSSHALL; Fiscal Year: 2006
  7. IDENTIFICATION AND ANALYSIS OF CLOCK CONTROLLED GENES
    Jennifer Loros; Fiscal Year: 2007
  8. A transgenic model of ocular inflammation
    Russell Van Gelder; Fiscal Year: 2007
  9. GENETIC AND MOLECULAR DISSECTION OF THE NEUROSPORA CLOCK
    Jay Dunlap; Fiscal Year: 2007
  10. Molecular Biology of the Odorant Receptors
    Leslie B Vosshall; Fiscal Year: 2011

Scientific Experts

Detail Information

Publications98

  1. pmc Identification of domains responsible for ubiquitin-dependent degradation of dMyc by glycogen synthase kinase 3beta and casein kinase 1 kinases
    Margherita Galletti
    Department of Biology, City College of the City University of New York, 138th at Convent Ave, New York, NY 10031, USA
    Mol Cell Biol 29:3424-34. 2009
    ..Drosophila homologue of the human c-myc proto-oncogene, is regulated in vitro and in vivo by members of the casein kinase 1 (CK1) family and by glycogen synthase kinase 3beta (GSK3beta)...
  2. ncbi DCP-1, a Drosophila cell death protease essential for development
    Z Song
    Howard Hughes Medical Institute, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 275:536-40. 1997
    ..Loss of zygotic DCP-1 function in Drosophila caused larval lethality and melanotic tumors, showing that this gene is essential for normal development...
  3. pmc The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock
    Joanna C Chiu
    Rutgers University, Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey 08854, USA
    Genes Dev 22:1758-72. 2008
    ..of PERIOD (PER) proteins, which is highly dependent on casein kinase Idelta/epsilon (CKIdelta/epsilon; termed DOUBLETIME [DBT] in Drosophila) and ultimately leads to the rapid degradation of hyperphosphorylated isoforms via a ..
  4. pmc A small conserved domain of Drosophila PERIOD is important for circadian phosphorylation, nuclear localization, and transcriptional repressor activity
    Pipat Nawathean
    Howard Hughes Medical Institute and Department of Biology, Brandeis University, Waltham, MA 02454, USA
    Mol Cell Biol 27:5002-13. 2007
    ..of PER lacking this motif (PER Delta) shows that it is important for phosphorylation of Drosophila PER by casein kinase I epsilon (CKI epsilon; doubletime protein or DBT) and CKII...
  5. ncbi Genetic analysis of the circadian system in Drosophila melanogaster and mammals
    Ralf Stanewsky
    Universitat Regensburg, Institut fur Zoologie, Lehrstuhl für Entwicklungsbiologie, Universitatsstrasse 31, 93040 Regensburg, Germany
    J Neurobiol 54:111-47. 2003
    ..This review will try to give a comparative overview about the two systems, highlighting similarities as well as specifics of both insect and murine clocks...
  6. ncbi The F-box protein slimb controls the levels of clock proteins period and timeless
    Brigitte Grima
    Institut de Neurobiologie Alfred Fessard NGI, CNRS UPR 2216, Centre National de la Recherche Scientifique, av de la Terrasse, 91198 Gif sur Yvette, France
    Nature 420:178-82. 2002
    ..Because levels of Per and Tim oscillate in slmb mutants maintained in light:dark conditions, light- and clock-controlled degradation of Per and Tim do not rely on the same mechanisms...
  7. pmc Drosophila DBT lacking protein kinase activity produces long-period and arrhythmic circadian behavioral and molecular rhythms
    Michael J Muskus
    School of Biological Sciences, University of Missouri Kansas City, 5100 Rockhill Rd, Kansas City, MO 64110, USA
    Mol Cell Biol 27:8049-64. 2007
    ..K38R) which specifically eliminates kinase activity was created in the Drosophila melanogaster ckI gene (doubletime [dbt])...
  8. pmc The LARK RNA-binding protein selectively regulates the circadian eclosion rhythm by controlling E74 protein expression
    Yanmei Huang
    Department of Neuroscience, Center for Neuroscience Research, Tufts University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 2:e1107. 2007
    ..Our results suggest a model wherein LARK mediates the transfer of temporal information from the molecular oscillator to different output pathways by interacting with distinct RNA targets...
  9. pmc Fat and expanded act in parallel to regulate growth through warts
    Yongqiang Feng
    Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 104:20362-7. 2007
    ....
  10. doi Casein kinase I epsilon does not rescue double-time function in Drosophila despite evolutionarily conserved roles in the circadian clock
    Tatsumori Sekine
    Division of Insect Sciences, National Institute of Agrobiological Sciences, Ohwashi 1 2, Tsukuba, Ibaraki 305 8634, Japan
    J Biol Rhythms 23:3-15. 2008
    ..Genetic and biochemical studies have shown that dbt and its mammalian ortholog casein kinase I epsilon (hckI epsilon) regulate the circadian phosphorylation of period (per), thus controlling per subcellular ..
  11. ncbi Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1
    Mary Ann Price
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Cell 108:823-35. 2002
    ..Conversely, Ci-155 levels are reduced in Hedgehog-responding cells by overexpression of PKA and the Drosophila CK1, Double-time, a regulator of circadian rhythms...
  12. pmc A DOUBLETIME kinase binding domain on the Drosophila PERIOD protein is essential for its hyperphosphorylation, transcriptional repression, and circadian clock function
    Eun Young Kim
    Rutgers University, Center for Advanced Biotechnology and Medicine, Piscataway, NJ 08854, USA
    Mol Cell Biol 27:5014-28. 2007
    ..of PERIOD (PER) proteins from hypo- to hyperphosphorylated species, events that are highly dependent on casein kinase 1 epsilon (termed DOUBLETIME [DBT] in Drosophila melanogaster) and necessary for normal clock progression...
  13. ncbi The Drosophila double-timeS mutation delays the nuclear accumulation of period protein and affects the feedback regulation of period mRNA
    S Bao
    Department of Biology, West Virginia University, Morgantown, West Virginia 26506, USA
    J Neurosci 21:7117-26. 2001
    The Drosophila double-time (dbt) gene, which encodes a protein similar to vertebrate epsilon and delta isoforms of casein kinase I, is essential for circadian rhythmicity because it regulates the phosphorylation and stability of period (..
  14. ncbi Modeling circadian oscillations with interlocking positive and negative feedback loops
    P Smolen
    Department of Neurobiology and Anatomy, W M Keck Center for the Neurobiology of Learning and Memory, The University of Texas Houston Medical School, Houston, Texas 77225, USA
    J Neurosci 21:6644-56. 2001
    ..Circadian oscillations were only obtained if time delays were included to represent processes not modeled in detail (e.g., transcription and translation). In both models, oscillations were preserved when positive feedback was removed...
  15. pmc Activating PER repressor through a DBT-directed phosphorylation switch
    Saul Kivimäe
    Laboratory of Genetics, The Rockefeller University, New York, New York, USA
    PLoS Biol 6:e183. 2008
    ..This study examines the role of the protein kinase Doubletime (DBT), a Drosophila ortholog of human casein kinase I (CKI)epsilon/delta...
  16. ncbi Phosphorylation of period is influenced by cycling physical associations of double-time, period, and timeless in the Drosophila clock
    B Kloss
    Laboratory of Genetics and, National Science Foundation Science and Technology Center for Biological Timing, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 30:699-706. 2001
    The clock gene double-time (dbt) encodes an ortholog of casein kinase Iepsilon that promotes phosphorylation and turnover of the PERIOD protein...
  17. pmc DOUBLETIME plays a noncatalytic role to mediate CLOCK phosphorylation and repress CLOCK-dependent transcription within the Drosophila circadian clock
    Wangjie Yu
    Department of Biology, Texas A and M University, College Station, TX 77843, USA
    Mol Cell Biol 29:1452-8. 2009
    ..Within the Drosophila melanogaster circadian clock, DOUBLETIME (DBT) kinase is necessary for the phosphorylation of PERIOD (PER), a transcriptional repressor, and CLOCK (CLK), ..
  18. ncbi Robust oscillations within the interlocked feedback model of Drosophila circadian rhythm
    H R Ueda
    ERATO Kitano Symbiotic Systems Group, Suite 6A, M31, 6 31 15 Jinguumae, Shibuya, Tokyo, 150 0001, Japan
    J Theor Biol 210:401-6. 2001
    ..Moreover, the interlocked feedback model has robust properties in oscillations...
  19. pmc Drosophila doubletime mutations which either shorten or lengthen the period of circadian rhythms decrease the protein kinase activity of casein kinase I
    Fabian Preuss
    School of Biological Sciences, University of Missouri Kansas City, 5100 Rockhill Road, Kansas City, MO 64110, USA
    Mol Cell Biol 24:886-98. 2004
    ..In Drosophila melanogaster, mutations affecting a casein kinase I (CKI) ortholog called doubletime (dbt) can produce short or long periods...
  20. ncbi The doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity
    Pipat Nawathean
    Howard Hughes Medical Institute, Biology Department MS 008, Brandeis University, 415 South Street, Waltham, MA 02454, USA
    Mol Cell 13:213-23. 2004
    ..The results indicate that the two putative PER kinases DBT and CKII work together to phosphorylate PER and increase repression activity...
  21. pmc Regulation of wingless signaling by the CKI family in Drosophila limb development
    Lei Zhang
    Center for Developmental Biology, Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Dev Biol 299:221-37. 2006
    ..We find that increased CKIepsilon stimulates whereas dominant-negative or a null CKIepsilon mutation inhibits Wg signaling...
  22. ncbi Delineation of a Fat tumor suppressor pathway
    Eunjoo Cho
    Howard Hughes Medical Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Nat Genet 38:1142-50. 2006
    ..melanogaster tumor suppressors, establish a basic framework for Fat signaling from receptor to transcription factor and implicate Warts as an integrator of multiple growth control signals...
  23. ncbi Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A
    Sriram Sathyanarayanan
    Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell 116:603-15. 2004
    ..PP2A also affects PER phosphorylation in vitro and in vivo. We propose that the posttranslational mechanisms that drive cycling of PER require the rhythmic expression of PP2A...
  24. pmc Simulation of Drosophila circadian oscillations, mutations, and light responses by a model with VRI, PDP-1, and CLK
    Paul Smolen
    Department of Neurobiology and Anatomy, W M Keck Center for the Neurobiology of Learning and Memory, The University of Texas Houston Medical School, Houston, Texas 77225, USA
    Biophys J 86:2786-802. 2004
    ..Temperature compensation of oscillation period could be simulated if temperature elevation slowed PER nuclear entry or PER phosphorylation. The model makes experimental predictions, some of which could be tested in transgenic Drosophila...
  25. ncbi CKIepsilon/discs overgrown promotes both Wnt-Fz/beta-catenin and Fz/PCP signaling in Drosophila
    Thomas J Klein
    Department of Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, New York 10029, USA
    Curr Biol 16:1337-43. 2006
    ..Recent work in cell culture has suggested that phosphorylation of Dsh by Casein Kinase I epsilon (CKIepsilon) may act as a molecular "switch," promoting Wnt/beta-catenin while inhibiting Fz/PCP ..
  26. ncbi Crystal structure and interactions of the PAS repeat region of the Drosophila clock protein PERIOD
    Ozkan Yildiz
    Department of Structural Biology, Max Planck Institute for Molecular Physiology, Otto Hahn Strasse 11, 44227 Dortmund, Germany
    Mol Cell 17:69-82. 2005
    ..We show that alphaF is essential for dPER homodimerization and that the PAS-A-alphaF interaction plays a crucial role in dPER clock function, as it is affected by the 29 hr long-period perL mutation...
  27. ncbi Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome
    Ying Xu
    Department of Neurology, University of California, San Francisco, San Francisco, California 94143 2922, USA
    Nature 434:640-4. 2005
    ..These results show that CKIdelta is a central component in the mammalian clock, and suggest that mammalian and fly clocks might have different regulatory mechanisms despite the highly conserved nature of their individual components...
  28. pmc The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period
    Shawn A Cyran
    Department of Biology, New York University, New York, New York 10003, USA
    J Neurosci 25:5430-7. 2005
    The Period (PER), Timeless (TIM), and Double-Time (DBT) proteins are essential components of one feedback loop in the Drosophila circadian molecular clock. PER and TIM physically interact...
  29. ncbi The circadian timekeeping system of Drosophila
    Paul E Hardin
    Department of Biology and Biochemistry, University of Houston, 4800 Calhoun Road, Houston, Texas 77204 5001, USA
    Curr Biol 15:R714-22. 2005
    ..I will also discuss where work remains to be done to give a comprehensive picture of the circadian clock in Drosophila and likely many other organisms...
  30. ncbi Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing
    Jianhang Jia
    Center for Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Dev Cell 9:819-30. 2005
    ..Here we show that Double-time (DBT)/CKIepsilon and CKIalpha act in conjunction to promote Ci processing...
  31. pmc PER-dependent rhythms in CLK phosphorylation and E-box binding regulate circadian transcription
    Wangjie Yu
    Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204 5001, USA
    Genes Dev 20:723-33. 2006
    ..This hyperphosphorylation occurs in parallel with the PER-dependent entry of DOUBLE-TIME (DBT) kinase into a complex with CLK-CYC, where DBT destabilizes both CLK and PER...
  32. pmc Balance between DBT/CKIepsilon kinase and protein phosphatase activities regulate phosphorylation and stability of Drosophila CLOCK protein
    Eun Young Kim
    Department of Molecular Biology and Biochemistry, Rutgers University, Center for Advanced Biotechnology and Medicine, 679 Hoes Lane, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 103:6178-83. 2006
    The first circadian-relevant kinase to be identified was DOUBLE-TIME (DBT) in Drosophila, a homolog of vertebrate CKIepsilon, which regulates the progressive phosphorylation and stability of PERIOD (PER) proteins in animals...
  33. ncbi The ins and outs of circadian timekeeping
    S A Brown
    Départment de Biologie Moleculaire Université de Genéve Sciences II 30 quai Ernest Ansermet, 1211, Geneve 4, Switzerland steven
    Curr Opin Genet Dev 9:588-94. 1999
    ..Taken together, these observations are reshaping thinking about inputs and outputs of metazoan circadian clocks...
  34. pmc Signal transduction by the Fat cytoplasmic domain
    Guohui Pan
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 140:831-42. 2013
    ..Fat-Hippo signaling requires the Drosophila Casein kinase 1ε encoded by discs overgrown (Dco), and we characterize candidate Dco phosphorylation sites in the Fat ..
  35. ncbi Defective gap-junctional communication associated with imaginal disc overgrowth and degeneration caused by mutations of the dco gene in Drosophila
    V A Jursnich
    Developmental Biology Center, University of California, Irvine 92717
    Dev Biol 140:413-29. 1990
    The lethal(3)discs overgrown (dco) locus of Drosophila melanogaster, located on the third chromosome at cytogenetic position 100A5,6-100B1,2, is necessary for normal development and growth control in the imaginal discs of the larva...
  36. pmc Drosophila CLOCK target gene characterization: implications for circadian tissue-specific gene expression
    Katharine Compton Abruzzi
    Howard Hughes Medical Institute, National Center for Behavioral Genomics, Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    Genes Dev 25:2374-86. 2011
    ..CLK has specific targets in different tissues, implying that important CLK partner proteins and/or mechanisms contribute to gene-specific and tissue-specific regulation...
  37. ncbi The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation
    R W Justice
    Developmental Biology Center, University of California, Irvine 92717
    Genes Dev 9:534-46. 1995
    ..Our results raise the possibility that homozygous loss of the myotonic dystrophy kinase may contribute to the development of these tumors...
  38. ncbi double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation
    J L Price
    Laboratory of Genetics and National Science Foundation Science and Technology Center for Biological Timing, The Rockefeller University, New York, New York 10021, USA
    Cell 94:83-95. 1998
    ..We propose that the normal function of DOUBLETIME protein is to reduce the stability and thus the level of accumulation of monomeric PER proteins...
  39. ncbi The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon
    B Kloss
    Laboratory of Genetics and National Science Foundation Science and Technology Center for Biological Timing, The Rockefeller University, New York, New York 10021, USA
    Cell 94:97-107. 1998
    The cloning of double-time (dbt) is reported. DOUBLETIME protein (DBT) is most closely related to human casein kinase Iepsilon. dbtS and dbtL mutations, which alter period length of Drosophila circadian rhythms, produce single amino acid ..
  40. pmc Zyxin links fat signaling to the hippo pathway
    Cordelia Rauskolb
    Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey, United States of America
    PLoS Biol 9:e1000624. 2011
    ..tests, we position the requirement for Zyx within the Fat branch of Hippo signaling, downstream of Fat and Dco, and upstream of the Yorkie kinase Warts, and we find that Zyx is required for the influence of Fat on Warts ..
  41. ncbi The molecular control of circadian behavioral rhythms and their entrainment in Drosophila
    M W Young
    National Science Foundation Science and Technology Center for Biological Timing, Rockefeller University, New York, New York 10021, USA
    Annu Rev Biochem 67:135-52. 1998
    ..pacemaker requires the activities of proteins encoded by three genes: period (per), timeless (tim), and doubletime (dbt). RNA from two of these genes, per and tim, is expressed with a circadian rhythm...
  42. pmc NEMO/NLK phosphorylates PERIOD to initiate a time-delay phosphorylation circuit that sets circadian clock speed
    Joanna C Chiu
    Department of Molecular Biology and Biochemistry, Rutgers University, Center for Advanced Biotechnology and Medicine, Piscataway, NJ 08854, USA
    Cell 145:357-70. 2011
    ..Phosphorylation by the NEMO/NLK kinase at the "per-short" domain on PER stimulates phosphorylation by DOUBLETIME (DBT/CK1δ/ɛ) at several nearby sites...
  43. pmc A hierarchical phosphorylation cascade that regulates the timing of PERIOD nuclear entry reveals novel roles for proline-directed kinases and GSK-3beta/SGG in circadian clocks
    Hyuk Wan Ko
    Neurodegeneration Control Research Center, School of Medicine, Kyung Hee University, Seoul, 130 701, South Korea
    J Neurosci 30:12664-75. 2010
    ....
  44. ncbi Molecular bases for circadian clocks
    J C Dunlap
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Cell 96:271-90. 1999
  45. doi Differential requirement of Salvador-Warts-Hippo pathway members for organ size control in Drosophila melanogaster
    Claire C Milton
    Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    Development 137:735-43. 2010
    ..This study highlights the complexity employed by different SWH pathway proteins to control organ size at different stages of development...
  46. ncbi double-time is identical to discs overgrown, which is required for cell survival, proliferation and growth arrest in Drosophila imaginal discs
    O Zilian
    Institute for Molecular Biology and Zoological Institute, University of Zurich, CH 8057 Zurich, Switzerland
    Development 126:5409-20. 1999
    ....
  47. ncbi Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock
    A Rothenfluh
    Laboratory of Genetics, and National Science Foundation Science and Technology Center for Biological Timing, The Rockefeller University, New York, New York 10021, USA
    Curr Biol 10:1399-402. 2000
    Circadian (24 hour) PERIOD (PER) protein oscillation is dependent on the double-time (dbt) gene, a casein kinase Ivarepsilon homolog [1-3]...
  48. ncbi Two novel doubletime mutants alter circadian properties and eliminate the delay between RNA and protein in Drosophila
    V Suri
    Graduate Departments of Biochemistry and Biology, Howard Hughes Medical Institute, and National Science Foundation Center for Biological Timing, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 20:7547-55. 2000
    ..Genetic and biochemical evidence suggests involvement of the casein kinase I homolog doubletime (dbt) in the Drosophila circadian pacemaker. We have characterized two novel dbt mutants...
  49. pmc Isolation and analysis of six timeless alleles that cause short- or long-period circadian rhythms in Drosophila
    A Rothenfluh
    Laboratory of Genetics, and National Science Foundation Science and Technology Center for Biological Timing, The Rockefeller University, New York, New York 10021, USA
    Genetics 156:665-75. 2000
    ..The lengthened period is partly caused by delayed nuclear translocation of TIM(L1) protein, shown directly by immunocytochemistry and indirectly by an analysis of the phase response curve of tim(L1) flies...
  50. pmc Phosphorylation of the tumor suppressor fat is regulated by its ligand Dachsous and the kinase discs overgrown
    Richelle Sopko
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Curr Biol 19:1112-7. 2009
    ..The tumor suppressor discs overgrown (dco)/Casein Kinase I delta/epsilon also regulates Hippo activity and PCP...
  51. pmc Processing and phosphorylation of the Fat receptor
    Yongqiang Feng
    Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway NJ 08854, USA
    Proc Natl Acad Sci U S A 106:11989-94. 2009
    The Drosophila tumor suppressors fat and discs overgrown (dco) function within an intercellular signaling pathway that controls growth and polarity...
  52. ncbi dCLOCK is present in limiting amounts and likely mediates daily interactions between the dCLOCK-CYC transcription factor and the PER-TIM complex
    K Bae
    Graduate Program in Microbiology, Rutgers University, Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey 08854, USA
    J Neurosci 20:1746-53. 2000
    ..Our results suggest that dCLK is the main component regulating the daily abundance of transcriptionally active dCLK-CYC complexes...
  53. ncbi Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime
    Hyuk Wan Ko
    Graduate Program in Physiology and Neurobiology, Rutgers University, Center for Advanced Biotechnology and Medicine, 679 Hoes Lane, Piscataway, New Jersey 08854, USA
    Nature 420:673-8. 2002
    ..b>Casein kinase Iepsilon (CKIepsilon) has a prominent role in regulating the phosphorylation and abundance of Per proteins in ..
  54. ncbi Time flies for Drosophila
    A L Scully
    Department of Cell Biology and NSF Center for Biological Timing, The Scripps Research Institute, La Jolla, California 92037, USA
    Cell 100:297-300. 2000
  55. ncbi Circadian clocks in the mammalian brain
    M Hastings
    Department of Anatomy, University of Cambridge, Cambridge, UK
    Bioessays 22:23-31. 2000
    ..BioEssays 22:23-31, 2000...
  56. doi Ac-ing the clock
    Amita Sehgal
    Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuron 57:8-10. 2008
    ..Degradation of these proteins usually involves ubiquitylation or sumoylation, and some of the relevant E3 ligases are known. In addition, Hirayama et al. recently identified acetylation as a clock regulatory mechanism...
  57. pmc Fluorescence/Luminescence circadian imaging of complex tissues at single-cell resolution
    Michael T Sellix
    Department of Biology, University of Virginia, Charlottesville, Virginia
    J Biol Rhythms 25:228-32. 2010
    ....
  58. doi Casein kinase I epsilon somatic mutations found in breast cancer cause overgrowth in Drosophila
    Tomas Dolezal
    Department of Molecular Biology, Faculty of Science, University of South Bohemia in Ceske Budejovice, Czech Republic
    Int J Dev Biol 54:1419-24. 2010
    ..Somatic mutations were found in breast cancer samples in the human casein kinase I epsilon (CKIepsilon) gene, a homolog of the Drosophila gene dco in which certain point mutations lead to imaginal ..
  59. pmc Kinetics of doubletime kinase-dependent degradation of the Drosophila period protein
    Sheyum Syed
    Laboratory of Genetics, The Rockefeller University, New York, New York 10065, USA
    J Biol Chem 286:27654-62. 2011
    ..Early morning phosphorylation of PER by the kinase Doubletime (DBT) and subsequent PER turnover is an essential step in the functioning of the Drosophila circadian clock...
  60. ncbi The fruit fly Drosophila and the fish Xiphophorus as model systems for cancer studies
    B Mechler
    Department of Development Genetics, Deutsches Krebsforschungszentrum, German Cancer Research Center, Heidelberg
    Cancer Surv 9:505-27. 1990
    ..This gene encodes a receptor tyrosine kinase related to the EGF-receptor, and its activation and overexpression are thought to play a critical part in melanoma formation...
  61. ncbi Planar polarity is positively regulated by casein kinase Iepsilon in Drosophila
    Helen Strutt
    Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
    Curr Biol 16:1329-36. 2006
    ..By examining hypomorphic mutations of the Drosophila CKIepsilon homolog discs overgrown (dco)/double-time, we now show that it is an essential component of the noncanonical/..
  62. pmc Genetic modifiers of dFMR1 encode RNA granule components in Drosophila
    Anne Marie J Cziko
    Smurfit Institute of Genetics and Trinity College Institute for Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    Genetics 182:1051-60. 2009
    ..Several mutations in dco, orb2, pAbp, rm62, and smD3 genes dominantly suppress the sev-dfmr1 rough-eye phenotype, suggesting that they are ..
  63. pmc Rap1 maintains adhesion between cells to affect Egfr signaling and planar cell polarity in Drosophila
    David D O'Keefe
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Dev Biol 333:143-60. 2009
    ..Finally, we show that Rap1 acts through the effector Canoe to regulate these developmental processes...
  64. doi Developmental profiles of PERIOD and DOUBLETIME in Drosophila melanogaster ovary
    Joanna Kotwica
    Department of Zoology, Oregon State University, 3029 Cordley Hall, Corvallis, OR 97331, USA
    J Insect Physiol 55:419-25. 2009
    ..circadian cycle, we investigated the status of PER phosphorylation in the ovary and the expression patterns of DOUBLETIME (DBT), a kinase known to affect PER in the clock cells...
  65. ncbi Egg-laying rhythm in Drosophila melanogaster
    Manjunatha T
    Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560 064, India
    J Genet 87:495-504. 2008
    ..In this review, we discuss our current understanding of the circadian egg-laying rhythm in D. melanogaster, and the possible molecular and physiological mechanisms that control the rhythmic output of the egg-laying process...
  66. pmc Requirement for cell-proliferation control genes in Drosophila oogenesis
    J Szabad
    Howard Hughes Medical Institute, Department of Biology, University of Utah, Salt Lake City 84112
    Genetics 127:525-33. 1991
    ..developing oocytes and nurse cells were mutant at one of five imaginal disc overgrowth loci (fat, lgd, lgl, c43 and dco) while the enveloping follicle cells were normal...
  67. ncbi Genome-wide analysis of Polycomb targets in Drosophila melanogaster
    Yuri B Schwartz
    Rutgers University, Department of Molecular Biology and Biochemistry, 604 Allison Road, Piscataway, New Jersey 08854, USA
    Nat Genet 38:700-5. 2006
    ..PcG targets are highly enriched in genes encoding transcription factors, but they also include genes coding for receptors, signaling proteins, morphogens and regulators representing all major developmental pathways...
  68. ncbi Circadian rhythm biochemistry: from protein degradation to sleep and mating
    N Ishida
    Clock Cell Biology, National Institute of Advanced Industrial Science and Technology AIST, IMCB 6 5, 1 1 1 Higashi, Tsukuba 305 8566, Japan
    Biochem Biophys Res Commun 286:1-5. 2001
  69. pmc Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila
    Shin ichi Yanagawa
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    EMBO J 21:1733-42. 2002
    ..Surprisingly, CKIalpha- or CKIepsilon-RNAi markedly elevated the Armadillo (Arm) protein levels in Drosophila Schneider S2R+ cells, without affecting ..
  70. ncbi Cocaine addiction: clues from Drosophila on drugs
    M E Wolf
    Department of Neuroscience, The Chicago Medical School, 3333 Green Bay Road, North Chicago, Illinois, 60064 3095, USA
    Curr Biol 9:R770-2. 1999
    ....
  71. ncbi Requirement of circadian genes for cocaine sensitization in Drosophila
    R Andretic
    Department of Biology, Gilmer Hall, University of Virginia, Charlottesville, VA 22903, USA
    Science 285:1066-8. 1999
    ..models and associated with enhanced drug craving, is eliminated in flies mutant for period, clock, cycle, and doubletime, but not in flies lacking the gene timeless...
  72. ncbi Eukaryotic circadian systems: cycles in common
    J C Dunlap
    Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA
    Genes Cells 4:1-10. 1999
    ..Post-transcriptional control governs the amount and type of FRQ and makes the clock responsive to temperature...
  73. ncbi The Drosophila clock protein Timeless is a member of the Arm/HEAT family
    Nicolas Vodovar
    Curr Biol 12:R610-1. 2002
  74. ncbi Neural substrates of Drosophila rhythms revealed by mutants and molecular manipulations
    M Kaneko
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    Curr Opin Neurobiol 8:652-8. 1998
    ..Similar studies in other insect species have suggested considerable diversity in the anatomical and neurochemical properties of pacemaker cells, as well as in the mechanisms of clock-gene regulation...
  75. ncbi Functional and evolutionary implications of natural variation in clock genes
    R Costa
    Dipartimento di Biologia, Universita di Padova, Italy
    Curr Opin Neurobiol 8:659-64. 1998
    ..Interspecific analysis of per expression patterns reveals evolutionary alterations in this clock gene's regulation...
  76. ncbi Activating inhibitors and inhibiting activators: a day in the life of a fly
    P E Hardin
    Department of Biology and Biochemistry, University of Houston, Texas 77204 5513, USA
    Curr Opin Neurobiol 8:642-7. 1998
    ..These studies, along with those in other organisms, suggest that circadian feedback loops are widespread and that genes within these feedback loops are conserved between Drosophila and mammals...
  77. ncbi Time marches on
    C B Green
    Dept of Biology, NSF Center for Biological Timing, University of Virginia, Charlottesville 22903, USA
    Trends Cell Biol 8:342-3. 1998
  78. pmc Casein kinase Iepsilon modulates the signaling specificities of dishevelled
    Feng Cong
    Program in Cell Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Cell Biol 24:2000-11. 2004
    ..We also found that casein kinase Iepsilon (CKIepsilon), a previously identified positive regulator of Wnt signaling, stimulated Dvl activity in the ..
  79. ncbi A clockwork explosion!
    S M Reppert
    Pediatric Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Neuron 21:1-4. 1998
  80. ncbi Drosophila central brain formation requires Robo proteins
    Emmanuelle Nicolas
    Institut Jacques Monod, Tour 42 43, 5éme étage 2 place jussieu, 75005 Paris, France
    Dev Genes Evol 215:530-6. 2005
    ..We conclude that the Robo2 and Robo3 receptors play postembryonic roles during central brain formation...
  81. ncbi Circadian rhythms: new functions for old clock genes
    P L Lakin-Thomas
    Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge UK
    Trends Genet 16:135-42. 2000
    ..Our a priori assumptions about the nature of circadian clocks might have restricted our search for new mutants in ways that prevent us from finding important clock genes...
  82. ncbi Circadian rhythms: mop up the clock!
    S A Brown
    Departement de Biologie Moleculaire, Sciences II, Université de Genève 30, Quai Ernest Ansermet, CH 1211 Geneve 4, Switzerland
    Curr Biol 11:R268-70. 2001
    ..Similarities and differences have been identified between insect and mammalian oscillators. Recent studies have shed new light on two mammalian clock components: Mop3 and Per2...
  83. ncbi Circadian rhythms. Marking time for a kingdom
    M W Young
    Laboratory of Genetics and National Science Foundation Center for Biological Timing, The Rockefeller University, New York, NY 10021
    Science 288:451-3. 2000
  84. pmc The self-same beat of time's wide wings
    V M Cassone
    Department of Biology, Texas A and M University, College Station, TX 77843 3258, USA
    Proc Natl Acad Sci U S A 97:11677-9. 2000
  85. ncbi A brief history of circadian time
    A S Loudon
    School of Biological Sciences, University of Manchester, Oxford Road, M13 9PT, Manchester, UK
    Trends Genet 16:477-81. 2000
    ..We now know that tau is the mammalian homologue of a Drosophila circadian clock component (double-time) that plays an important role in regulating clock protein turnover...
  86. pmc From biological clock to biological rhythms
    P E Hardin
    Department of Biology and Biochemistry, University of Houston, Houston, TX 77204 5513, USA
    Genome Biol 1:REVIEWS1023. 2000
    ..Completion of whole genome sequences and the use of differential gene expression technology will hasten the discovery of the clock output pathways that control diverse rhythmic phenomena...
  87. ncbi Circadian regulation of gene expression in animals
    J A Ripperger
    Departement de Biologie Moleculaire, Science II, Universite de Geneve, 30 Quai Ernest Ansermet, CH 1211 Geneva 4, Switzerland
    Curr Opin Cell Biol 13:357-62. 2001
    ..In mammals, a master pacemaker localized in the suprachiasmatic nucleus synchronizes peripheral clocks via humoral cues. However, restricted feeding can uncouple peripheral oscillators from the suprachiasmatic pacemaker...
  88. pmc B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster
    Xinghai Li
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112 5550, USA
    Mol Cell Biol 22:3674-84. 2002
    ....
  89. ncbi Circadian rhythms from flies to human
    Satchidananda Panda
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 417:329-35. 2002
    ..To gain the initial insights into circadian mechanisms, researchers turned to genetically tractable model organisms such as Drosophila...
  90. ncbi Clock mechanisms in Drosophila
    Ralf Stanewsky
    Universitat Regensburg, Institut fur Zoologie, Lehrstuhl für Entwicklungsbiologie, Universitatsstrasse 31, 93040 Regensburg, Germany
    Cell Tissue Res 309:11-26. 2002
    ..Although their regulation depends on the major clock genes, the majority of the clock-controlled genes are not direct targets of clock factors...
  91. ncbi Ci proteolysis: regulation by a constellation of phosphorylation sites
    Mark A Lefers
    Department of Biochemistry, Molecular Biology and Cell Biology, Robert H Lurie Comprehensive Cancer Center, Northwestern University, 2153 Sheridan Road, Evanston, Illinois 60208, USA
    Curr Biol 12:R422-3. 2002
    ..The newly identified phosphorylation sites form clusters with previously described PKA sites in which phosphorylation by PKA acts to prime subsequent phosphorylation by Sgg/GSK3 and CK1...
  92. ncbi Invited review: Sleeping flies don't lie: the use of Drosophila melanogaster to study sleep and circadian rhythms
    Joan C Hendricks
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Appl Physiol (1985) 94:1660-72; discussion 1673. 2003
    ..Nonetheless, studies have already established that two transcription factors alter rest and rest homeostasis. The implications of these advances for the future of sleep research are summarized...
  93. pmc The Drosophila casein kinase Iepsilon/delta Discs overgrown promotes cell survival via activation of DIAP1 expression
    Ju Guan
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Building, Ann Arbor, MI 48109 1048, USA
    Dev Biol 303:16-28. 2007
    ..In this report, we demonstrate that the Drosophila casein kinase Iepsilon/delta, known as Discs overgrown (Dco), is required for maintaining this low level of apoptosis...
  94. ncbi Kinases and circadian clocks: per goes it alone
    Jay C Dunlap
    Department of Genetics, Dartmouth Medical School, 7400 Remsen, Hanover, NH 03755, USA
    Dev Cell 6:160-1. 2004
    ....
  95. ncbi Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction
    Sergey Apionishev
    Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York, NY 10027, USA
    Nat Cell Biol 7:86-92. 2005
    ..Together, Protein Kinase A, Casein Kinase 1 and Glycogen Synthase Kinase 3 silence the pathway in the absence of ligand by phosphorylating Ci at a ..
  96. pmc The contributions of protein kinase A and smoothened phosphorylation to hedgehog signal transduction in Drosophila melanogaster
    Qianhe Zhou
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Genetics 173:2049-62. 2006
    ..is essential for Hh signal transduction but loses activity if three specific PKA sites or adjacent PKA-primed casein kinase 1 (CK1) sites are replaced by alanine residues...
  97. ncbi Insect circadian clocks: is it all in their heads?
    J M Giebultowicz
    Department of Entomology, Oregon State University, Corvallis, USA
    J Insect Physiol 45:791-800. 1999
    ..This approach may increase our understanding of how circadian clocks are organized into the circadian system that orchestrates temporal integration of life processess in insects...
  98. ncbi Tumor-suppressor genes of Drosophila melanogaster
    E Gateff
    Institute of Genetics, Johannes Gutenberg University, Mainz, West Germany
    Crit Rev Oncog 1:221-45. 1989

Research Grants10

  1. Problem Solving Environment for Modeling the Cell Cycle
    John Tyson; Fiscal Year: 2002
    ..and some outstanding collaborators (Sible and Cross, experimental cell cycle research; Kitano and Bolouri, software development for molecular cell biology; and Kohn, bioinformatics of mammalian cell cycle controls). ..
  2. Analysis of fringe-dependent cell-signaling
    Kenneth Irvine; Fiscal Year: 2004
    ....
  3. NOVEL CIRCADIAN MUTANT OF DROSOPHILA
    Jeffrey Price; Fiscal Year: 2007
    ..For instance, the doubletime casein kinase (DBT) is thought to regulate the cytoplasmic and nuclear accumulation of another clock protein (..
  4. Genetic Analysis of Olfactory Coding in Drosophilia
    LESLIE VOSSHALL; Fiscal Year: 2009
    ..The health relatedness of these studies is that an understanding of circuits underlying sensory perception is relevant for brain disorders with a neurological or psychiatric basis. ..
  5. Experimental and Computational Studies of Exit from Mitosis in Budding Yeast
    John J Tyson; Fiscal Year: 2010
    ..g., embryonic development, tissue regeneration, wound healing, and carcinogenesis. ..
  6. Formation of an Olfactory Sensory Map
    LESLIE VOSSHALL; Fiscal Year: 2006
    ..The health relatedness of these studies is that cellular and molecular factors that regulate axonal pathfinding may have direct application to neurological and psychiatric disorders with a developmental basis. ..
  7. IDENTIFICATION AND ANALYSIS OF CLOCK CONTROLLED GENES
    Jennifer Loros; Fiscal Year: 2007
    ..These approaches will be illuminated by the insights afforded through our work with both a simple eukaryotic model system and a mammalian cell culture model of the clock. ..
  8. A transgenic model of ocular inflammation
    Russell Van Gelder; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  9. GENETIC AND MOLECULAR DISSECTION OF THE NEUROSPORA CLOCK
    Jay Dunlap; Fiscal Year: 2007
    ..the organization of the cells as a function of time.[unreadable]..
  10. Molecular Biology of the Odorant Receptors
    Leslie B Vosshall; Fiscal Year: 2011
    ..The Health-Relatedness of this proposal is that such chemical agents may act to reduce infectious disease transmission by vector insects in the future. ..