Gene Symbol: Damm
Description: Death associated molecule related to Mch2 caspase
Alias: CG18188, DAMM, Damm/Daydream, Daydream, Dmel\CG18188, damm, death associated molecule related to Mch2 caspase, CG18188-PA, CG18188-PB, Damm-PA, Damm-PB, daydream, death associated molecule related to Mch2
Species: fruit fly

Top Publications

  1. Lee G, Wang Z, Sehgal R, Chen C, Kikuno K, Hay B, et al. Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis. J Comp Neurol. 2011;519:34-48 pubmed publisher
    ..Two remaining effector caspase genes, decay and damm, found no apparent functions in the neuronal PCD, at least during early metamorphosis...
  2. Yu S, Yoo S, Yang L, Zapata C, Srinivasan A, Hay B, et al. A pathway of signals regulating effector and initiator caspases in the developing Drosophila eye. Development. 2002;129:3269-78 pubmed
    ..Taken together, these findings indicate that in eye development spatial regulation of cell death and survival is integrated through a single intracellular pathway. ..
  3. Denton D, Kumar S. Studying Apoptosis in Drosophila. Cold Spring Harb Protoc. 2015;2015:609-13 pubmed publisher
    ..The focus of this discussion is to introduce methodologies for monitoring apoptosis during Drosophila development and also in Drosophila cell lines. ..
  4. Lee G, Kikuno K, Nair S, Park J. Mechanisms of postecdysis-associated programmed cell death of peptidergic neurons in Drosophila melanogaster. J Comp Neurol. 2013;521:3972-91 pubmed publisher
    ..We did not find a role for other known caspases, Strica, Dredd, Damm, or Decay...
  5. Xu D, Woodfield S, Lee T, Fan Y, Antonio C, Bergmann A. Genetic control of programmed cell death (apoptosis) in Drosophila. Fly (Austin). 2009;3:78-90 pubmed
    ..Here, we review the key players of the cell death pathway in Drosophila and discuss their roles in apoptotic and non-apoptotic processes. ..
  6. Harvey N, Daish T, Mills K, Dorstyn L, Quinn L, Read S, et al. Characterization of the Drosophila caspase, DAMM. J Biol Chem. 2001;276:25342-50 pubmed
    ..Here we describe the cloning and characterization of the last Drosophila caspase, DAMM. Similar to mammalian effector caspases, DAMM lacks a long prodomain...
  7. Arya R, White K. Cell death in development: Signaling pathways and core mechanisms. Semin Cell Dev Biol. 2015;39:12-9 pubmed publisher
    ..Understanding how the cell death is regulated during development may provide insight into how this process can be manipulated in the treatment of disease. ..
  8. Khammari A, Agnes F, Gandille P, Pret A. Physiological apoptosis of polar cells during Drosophila oogenesis is mediated by Hid-dependent regulation of Diap1. Cell Death Differ. 2011;18:793-805 pubmed publisher
    ..Therefore, our results implicate the Hid-Diap1 module as an important regulatory point in a developmental case of apoptosis. ..
  9. Fan Y, Bergmann A. The cleaved-Caspase-3 antibody is a marker of Caspase-9-like DRONC activity in Drosophila. Cell Death Differ. 2010;17:534-9 pubmed publisher

More Information


  1. Denton D, Shravage B, Simin R, Mills K, Berry D, Baehrecke E, et al. Autophagy, not apoptosis, is essential for midgut cell death in Drosophila. Curr Biol. 2009;19:1741-6 pubmed publisher
  2. Leulier F, Ribeiro P, Palmer E, Tenev T, Takahashi K, Robertson D, et al. Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery. Cell Death Differ. 2006;13:1663-74 pubmed
    ..Consistently, we show that DIAP2 binds active drICE. Since DIAP2 associates with Hid, we propose a model whereby Hid co-ordinately targets both DIAP1 and DIAP2 to unleash drICE. ..
  3. Wildonger J, Sosinsky A, Honig B, Mann R. Lozenge directly activates argos and klumpfuss to regulate programmed cell death. Genes Dev. 2005;19:1034-9 pubmed
    ..These results provide novel insights into the control of programmed cell death (PCD) by Lz during Drosophila eye development. ..
  4. Kornbluth S, White K. Apoptosis in Drosophila: neither fish nor fowl (nor man, nor worm). J Cell Sci. 2005;118:1779-87 pubmed
    ..Thus, although Drosophila, worms and humans share a host of apoptotic regulators, the way in which they function may not be identical. ..
  5. Doumanis J, Quinn L, Richardson H, Kumar S. STRICA, a novel Drosophila melanogaster caspase with an unusual serine/threonine-rich prodomain, interacts with DIAP1 and DIAP2. Cell Death Differ. 2001;8:387-94 pubmed
    ..Interestingly, unlike other fly caspases, STRICA showed physical association with DIAP2, in cotransfection experiments. These results suggest that STRICA may have a unique cellular function. ..
  6. Kumar S, Doumanis J. The fly caspases. Cell Death Differ. 2000;7:1039-44 pubmed
    ..The presence of multiple caspases in Drosophila indicates that apoptotic pathways in insects are likely to be as complex as in vertebrates. ..
  7. Amarneh B, Matthews K, Rawson R. Activation of sterol regulatory element-binding protein by the caspase Drice in Drosophila larvae. J Biol Chem. 2009;284:9674-82 pubmed publisher
    ..Drice-dependent activation of dSREBP explains why flies lacking dS2P are viable, and flies lacking dSREBP itself are not...
  8. Primrose D, Chaudhry S, Johnson A, Hrdlicka A, Schindler A, Tran D, et al. Interactions of DNR1 with the apoptotic machinery of Drosophila melanogaster. J Cell Sci. 2007;120:1189-99 pubmed
    ..Furthermore, we show that Dnr1 overexpression significantly reduces Dronc protein levels and identify the domains of Dnr1 necessary for these effects. From these data, we propose that Dnr1 inhibits initiator caspases in S2 cells. ..
  9. Liang C, Chang Y, Chang H, Wang C, Hung Y, Lin Y, et al. Derlin-1 regulates mutant VCP-linked pathogenesis and endoplasmic reticulum stress-induced apoptosis. PLoS Genet. 2014;10:e1004675 pubmed publisher
    ..As this Derlin-1-dependent cell death is negated by TER94 overexpression, we propose that while Derlin-1 and VCP work cooperatively in ER stress response, their imbalance has a role in removing cells suffering prolonged ER stress. ..