Genomes and Genes
Gene Symbol: D1
Description: D1 chromosomal protein
Alias: CG9745, Dmel\CG9745, EP(3)0473, HMGI, RE69409, dD1, dHMGx, D1 chromosomal protein, CG9745-PA, CG9745-PC, CG9745-PD, D1-PA, D1-PC, D1-PD, chromosomal protein D1
Species: fruit fly
- Levinger L, Varshavsky A. Protein D1 preferentially binds A + T-rich DNA in vitro and is a component of Drosophila melanogaster nucleosomes containing A + T-rich satellite DNA. Proc Natl Acad Sci U S A. 1982;79:7152-6 pubmedOur previous work [Levinger, L. & Varshavsky, A. (1982) Cell 28, 375-385] has shown that D1, a 50-kilodalton chromosomal protein of Drosophila melanogaster, is specifically associated with isolated nucleosomes that contain a complex A ..
- Francisco F, Lemos B. How do y-chromosomes modulate genome-wide epigenetic States: genome folding, chromatin sinks, and gene expression. J Genomics. 2014;2:94-103 pubmed publisher..We also discuss how the discovery of this new function impacts the current knowledge about Y chromosome origin, its current dynamics, and future fate. ..
- Belyaeva E, Goncharov F, Demakova O, Kolesnikova T, Boldyreva L, Semeshin V, et al. Late replication domains in polytene and non-polytene cells of Drosophila melanogaster. PLoS ONE. 2012;7:e30035 pubmed publisher..IH regions can thus be defined as a special class of domains with low gene density, which have narrow temporal expression patterns, and so displaying relatively conserved organization. ..
- Smith M, Weiler K. Drosophila D1 overexpression induces ectopic pairing of polytene chromosomes and is deleterious to development. Chromosoma. 2010;119:287-309 pubmed publisher..The D1 protein of Drosophila is an example of a chromosomal protein that has been fairly well characterized biochemically, ..
- Ferree P, Barbash D. Species-specific heterochromatin prevents mitotic chromosome segregation to cause hybrid lethality in Drosophila. PLoS Biol. 2009;7:e1000234 pubmed publisher..These findings demonstrate how divergence of noncoding repetitive sequences between species can directly cause reproductive isolation by altering chromosome segregation. ..
- Grewal S, Elgin S. Transcription and RNA interference in the formation of heterochromatin. Nature. 2007;447:399-406 pubmed..Silencing of chromatin might involve trans-acting sources of the crucial small RNAs that carry out RNA interference, but in some cases, transcription of the region to be silenced seems to be required--an apparent contradiction. ..
- Zhang H, Syu L, Modica V, Yu Z, Von Ohlen T, Mellerick D. The Drosophila homeodomain transcription factor, Vnd, associates with a variety of co-factors, is extensively phosphorylated and forms multiple complexes in embryos. FEBS J. 2008;275:5062-73 pubmed publisher..We identify the high mobility group 1-type protein, D1, and the novel helix-loop-helix protein, Olig, as novel Vnd-interacting proteins using co-immunoprecipitation assays...
- Emberly E, Blattes R, Schuettengruber B, Hennion M, Jiang N, Hart C, et al. BEAF regulates cell-cycle genes through the controlled deposition of H3K9 methylation marks into its conserved dual-core binding sites. PLoS Biol. 2008;6:2896-910 pubmed publisher..Our results reveal a novel role for BEAF chromatin dual-cores in regulating a distinct set of genes involved in chromosome organization/segregation and the cell cycle. ..
- Quiñones Coello A, Petrella L, Ayers K, Melillo A, Mazzalupo S, Hudson A, et al. Exploring strategies for protein trapping in Drosophila. Genetics. 2007;175:1089-104 pubmed..We report a total of 335 genes associated with protein or enhancer traps and a web-accessible database for viewing molecular information and expression data for these genes. ..
- Sun X, Morozova T, Sonnenfeld M. Glial and neuronal functions of the Drosophila homolog of the human SWI/SNF gene ATR-X (DATR-X) and the jing zinc-finger gene specify the lateral positioning of longitudinal glia and axons. Genetics. 2006;173:1397-415 pubmed
- Renner U, Ghidelli S, Schafer M, Wisniewski J. Alterations in titer and distribution of high mobility group proteins during embryonic development of Drosophila melanogaster. Biochim Biophys Acta. 2000;1475:99-108 pubmed..The titers of the HMG proteins HMGD, HMGZ, and D1 are highest in ovaries and at the beginning of embryonic development...
- Wisniewski J, Szewczuk Z, Petry I, Schwanbeck R, Renner U. Constitutive phosphorylation of the acidic tails of the high mobility group 1 proteins by casein kinase II alters their conformation, stability, and DNA binding specificity. J Biol Chem. 1999;274:20116-22 pubmed..As the occurrence of acidic tails containing canonical casein kinase II phosphorylation sites is common to diverse HMG and other chromosomal proteins, our results are probably of general significance. ..
- Rodriguez Alfageme C, Rudkin G, Cohen L. Isolation, properties and cellular distribution of D1, a chromosomal protein of Drosophila. Chromosoma. 1980;78:1-31 pubmedThe protein D1 was obtained from nuclei of Drosophila melanogaster embryos and purified by perchloric acid fractionation and preparative gel electrophoresis. In nuclei its amount is approximately 1% of the amount of DNA by weight...