Gene Symbol: Cyp6a9
Description: Cytochrome P450-6a9
Alias: 6a9, CG10246, CYP6A9, CYP6a9, Cyt-P450-rAF4, Dmel\CG10246, P-450, P450, cytochrome P450-6a9, CG10246-PB, Cyp6a9-PB, cytochrome P450 related AF4
Species: fruit fly

Top Publications

  1. Maitra S, Dombrowski S, Waters L, Ganguly R. Three second chromosome-linked clustered Cyp6 genes show differential constitutive and barbital-induced expression in DDT-resistant and susceptible strains of Drosophila melanogaster. Gene. 1996;180:165-71 pubmed
    ..The polypeptides encoded by these two genes, Cyp6a8 and Cyp6a9, show 77 and 75% amino acid sequence similarity, and 60 and 55% identity with Cyp6a2 of D...
  2. Keogh D, Mitchell M, Crooks J, Smith S. Effects of the adenylate cyclase activator forskolin and its inactive derivative 1,9-dideoxyforskolin on insect cytochrome P-450 dependent steroid hydroxylase activity. Experientia. 1992;48:39-41 pubmed
    ..The concentrations of these labdane diterpenes required to elicit a 50% inhibition of the cytochrome P-450 dependent steroid hydroxylase activity in the insect tissues ranged from approximately 5 x 10(-6) to 5 x 10(-4) M. ..
  3. Danielson P, Fogleman J. Isolation and sequence analysis of cytochrome P450 12B1: the first mitochondrial insect P450 with homology to 1 alpha,25 dihydroxy-D3 24-hydroxylase. Insect Biochem Mol Biol. 1997;27:595-604 pubmed
    ..current study, a degenerate polymerase chain reaction (PCR) primer was targeted to the highly conserved region of P450 genes that encodes the heme-binding decapeptide...
  4. Zakharenko L, Zakharov I. [Ethanol inhibits recombination in somatic cells of gamma-irradiated larvae of Drosophila melanogaster]. Genetika. 1998;34:364-7 pubmed
    ..In lines with high activity of cytochrome P450, ethanol did not exhibit the radioprotective effect...
  5. Carareto C, Hernandez E, Vieira C. Genomic regions harboring insecticide resistance-associated Cyp genes are enriched by transposable element fragments carrying putative transcription factor binding sites in two sibling Drosophila species. Gene. 2014;537:93-9 pubmed publisher
    ..These fragments carry putative binding sites for transcription factors, which reinforces the hypothesis that DNAREP1 may influence gene regulation and play a role in the adaptation of the Drosophila species. ..
  6. Daborn P, Boundy S, Yen J, Pittendrigh B, ffrench Constant R. DDT resistance in Drosophila correlates with Cyp6g1 over-expression and confers cross-resistance to the neonicotinoid imidacloprid. Mol Genet Genomics. 2001;266:556-63 pubmed
    ..The genomic sequence in this interval shows a cluster of cytochrome P450 genes, one of which, Cyp6g1, is over-expressed in all resistant strains examined...
  7. Chen S, Li X. Transposable elements are enriched within or in close proximity to xenobiotic-metabolizing cytochrome P450 genes. BMC Evol Biol. 2007;7:46 pubmed
    ..In D. melanogaster, seven out of the eight Drosophila P450s (CYP4E2, CYP6A2, CYP6A8, CYP6A9, CYP6G1, CYP6W1, CYP12A4, CYP12D1) implicated in insecticide resistance are associated with a variety of ..
  8. Danielson P, Letman J, Fogleman J. Alkaloid metabolism by cytochrome P-450 enzymes in Drosophila melanogaster. Comp Biochem Physiol B Biochem Mol Biol. 1995;110:683-8 pubmed
    ..Results from larval viability and adult longevity studies indicate that D. melanogaster's in vitro activity does not produce an enhanced in vivo tolerance of alkaloids. ..
  9. Berge J, Feyereisen R, Amichot M. Cytochrome P450 monooxygenases and insecticide resistance in insects. Philos Trans R Soc Lond B Biol Sci. 1998;353:1701-5 pubmed
    Cytochrome P450 monooxygenases are involved in many cases of resistance of insects to insecticides. Resistance has long been associated with an increase in monooxygenase activities and with an increase in cytochrome P450 content...

More Information


  1. Lu B, Zelle K, Seltzer R, Hefetz A, Ben Shahar Y. Feminization of pheromone-sensing neurons affects mating decisions in Drosophila males. Biol Open. 2014;3:152-60 pubmed publisher
    ..Together, these data indicate that the sexual cellular identity of pheromone sensing GRNs plays a major role in how individual flies interpret their social environment in the context of mating decisions. ..
  2. Rival T, Page R, Chandraratna D, Sendall T, Ryder E, Liu B, et al. Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's disease. Eur J Neurosci. 2009;29:1335-47 pubmed publisher