Cyp4e2

Summary

Gene Symbol: Cyp4e2
Description: Cytochrome P450-4e2
Alias: 4e2, CG2060, CYP4E2, CyP4e2, Cyp4E2, Cyt-P450-4E2, Dmel\CG2060, P-450, P450, cytochrome P450-4e2, CG2060-PA, CG2060-PB, Cyp4e2-PA, Cyp4e2-PB, cytochrome P450
Species: fruit fly

Top Publications

  1. Carareto C, Hernandez E, Vieira C. Genomic regions harboring insecticide resistance-associated Cyp genes are enriched by transposable element fragments carrying putative transcription factor binding sites in two sibling Drosophila species. Gene. 2014;537:93-9 pubmed publisher
    ..These fragments carry putative binding sites for transcription factors, which reinforces the hypothesis that DNAREP1 may influence gene regulation and play a role in the adaptation of the Drosophila species. ..
  2. Wang S, He G, Chen R, Li F, Li G. The involvement of cytochrome P450 monooxygenases in methanol elimination in Drosophila melanogaster larvae. Arch Insect Biochem Physiol. 2012;79:264-75 pubmed publisher
    ..These results reveal that cytochrome P450 monooxygenases (CYPs), rather than catalases, alcohol dehydrogenases, glutathione S-transferases, and ..
  3. Chen S, Li X. Transposable elements are enriched within or in close proximity to xenobiotic-metabolizing cytochrome P450 genes. BMC Evol Biol. 2007;7:46 pubmed
    ..genes, we scanned two alleles per each of the six xenobiotic-metabolizing Helicoverpa zea cytochrome P450 loci, including CYP6B8, CYP6B27, CYP321A1, CYP321A2, CYP9A12v3 and CYP9A14, for the presence of transposon ..
  4. Dunkov B, Rodriguez Arnaiz R, Pittendrigh B, ffrench Constant R, Feyereisen R. Cytochrome P450 gene clusters in Drosophila melanogaster. Mol Gen Genet. 1996;251:290-7 pubmed
    Twelve cytochrome P450 cDNA fragments were cloned from Drosophila melanogaster by reverse transcriptase/PCR (RT/PCR) using degenerate oligonucleotide primers...
  5. Zakharenko L, Zakharov I. [Ethanol inhibits recombination in somatic cells of gamma-irradiated larvae of Drosophila melanogaster]. Genetika. 1998;34:364-7 pubmed
    ..In lines with high activity of cytochrome P450, ethanol did not exhibit the radioprotective effect...
  6. Hooven L, Sherman K, Butcher S, Giebultowicz J. Does the clock make the poison? Circadian variation in response to pesticides. PLoS ONE. 2009;4:e6469 pubmed publisher
    ..Time of day of chemical exposure should be an important consideration in experimental design, use of pesticides, and human risk assessment. ..
  7. Danielson P, Letman J, Fogleman J. Alkaloid metabolism by cytochrome P-450 enzymes in Drosophila melanogaster. Comp Biochem Physiol B Biochem Mol Biol. 1995;110:683-8 pubmed
    ..Results from larval viability and adult longevity studies indicate that D. melanogaster's in vitro activity does not produce an enhanced in vivo tolerance of alkaloids. ..
  8. Terhzaz S, Cabrero P, Brinzer R, Halberg K, Dow J, Davies S. A novel role of Drosophila cytochrome P450-4e3 in permethrin insecticide tolerance. Insect Biochem Mol Biol. 2015;67:38-46 pubmed publisher
    ..This response includes the induction of genes that encode key Cytochrome P450 monooxygenase detoxification enzymes...
  9. Wang S, Hu X, Meng Q, Muhammad S, Chen R, Li F, et al. The involvement of several enzymes in methanol detoxification in Drosophila melanogaster adults. Comp Biochem Physiol B Biochem Mol Biol. 2013;166:7-14 pubmed publisher
    ..Our previous results showed that cytochrome P450 monooxygenases (CYPs) were associated with methanol detoxification in the larvae...

More Information

Publications18

  1. Jünger M, Rintelen F, Stocker H, Wasserman J, Végh M, Radimerski T, et al. The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J Biol. 2003;2:20 pubmed
    ..We propose that in response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, dFOXO is activated and inhibits growth through the action of target genes such as d4E-BP. ..
  2. Greenspan R, Tononi G, Cirelli C, Shaw P. Sleep and the fruit fly. Trends Neurosci. 2001;24:142-5 pubmed
    ..The record of Drosophila in laying the foundations for subsequent studies in mammals argues in favor of the force of this new approach. ..
  3. Shaw P, Cirelli C, Greenspan R, Tononi G. Correlates of sleep and waking in Drosophila melanogaster. Science. 2000;287:1834-7 pubmed
    ..These results implicate the catabolism of monoamines in the regulation of sleep and waking in the fly and suggest that Drosophila may serve as a model system for the genetic dissection of sleep. ..
  4. Pittendrigh B, Mocelin G, Andreev O, ffrench Constant R. The sequence of a Drosophila Cyp4e2 cytochrome P450-encoding cDNA. Gene. 1996;179:295-6 pubmed
    A composite 1458-bp cDNA that encodes cytochrome P450 (P450) Cyp4e2 has been constructed from clones isolated from two Drosophila embryonic cDNA libraries...
  5. Keogh D, Mitchell M, Crooks J, Smith S. Effects of the adenylate cyclase activator forskolin and its inactive derivative 1,9-dideoxyforskolin on insect cytochrome P-450 dependent steroid hydroxylase activity. Experientia. 1992;48:39-41 pubmed
    ..The concentrations of these labdane diterpenes required to elicit a 50% inhibition of the cytochrome P-450 dependent steroid hydroxylase activity in the insect tissues ranged from approximately 5 x 10(-6) to 5 x 10(-4) M. ..
  6. Daborn P, Boundy S, Yen J, Pittendrigh B, ffrench Constant R. DDT resistance in Drosophila correlates with Cyp6g1 over-expression and confers cross-resistance to the neonicotinoid imidacloprid. Mol Genet Genomics. 2001;266:556-63 pubmed
    ..The genomic sequence in this interval shows a cluster of cytochrome P450 genes, one of which, Cyp6g1, is over-expressed in all resistant strains examined...
  7. Maïbèche Coisne M, Monti Dedieu L, Aragon S, Dauphin Villemant C. A new cytochrome P450 from Drosophila melanogaster, CYP4G15, expressed in the nervous system. Biochem Biophys Res Commun. 2000;273:1132-7 pubmed
    A novel cytochrome P450 was isolated from Drosophila melanogaster by PCR strategy with primers deduced from the crayfish Orconectes limosus CYP4C15 sequence, which is supposed to be involved in ecdysteroid biosynthesis...
  8. Chahine S, O Donnell M. Interactions between detoxification mechanisms and excretion in Malpighian tubules of Drosophila melanogaster. J Exp Biol. 2011;214:462-8 pubmed publisher
    ..to the insecticide synergist piperonyl butoxide (PBO) was associated with reduced expression of two P450 genes (Cyp4e2, Cyp4p1) and two GST genes (GstD1, GstD5) in the tubules, as well as increased expression of Cyp12d1 and GstE1...
  9. Berge J, Feyereisen R, Amichot M. Cytochrome P450 monooxygenases and insecticide resistance in insects. Philos Trans R Soc Lond B Biol Sci. 1998;353:1701-5 pubmed
    b>Cytochrome P450 monooxygenases are involved in many cases of resistance of insects to insecticides. Resistance has long been associated with an increase in monooxygenase activities and with an increase in cytochrome P450 content...