Gene Symbol: Cyp4d2
Description: Cytochrome P450-4d2
Alias: 4d2, CG3466, CYP4D2, Cyp4D2, Cyt-P450-4D2, Dmel\CG3466, EG:152A3.4, P-450, P450, cytochrome P450-4d2, CG3466-PA, CG3466-PB, Cyp4d2-PA, Cyp4d2-PB, cytochrome P-450, cytochrome P450, cytochrome P450 4D2
Species: fruit fly

Top Publications

  1. Frolov M, Alatortsev V. Cluster of cytochrome P450 genes on the X chromosome of Drosophila melanogaster. DNA Cell Biol. 1994;13:663-8 pubmed
    A new cytochrome P450 gene was found within the wap1-prune genetic region of the Drosophila melanogaster X chromosome. It encodes a putative cytochrome P450 of subfamily 4D and has been designated CYP4D2...
  2. Dunkov B, Rodriguez Arnaiz R, Pittendrigh B, ffrench Constant R, Feyereisen R. Cytochrome P450 gene clusters in Drosophila melanogaster. Mol Gen Genet. 1996;251:290-7 pubmed
    Twelve cytochrome P450 cDNA fragments were cloned from Drosophila melanogaster by reverse transcriptase/PCR (RT/PCR) using degenerate oligonucleotide primers...
  3. Chavez V, Marques G, Delbecque J, Kobayashi K, Hollingsworth M, Burr J, et al. The Drosophila disembodied gene controls late embryonic morphogenesis and codes for a cytochrome P450 enzyme that regulates embryonic ecdysone levels. Development. 2000;127:4115-26 pubmed
    ..have suggested that production of 20-hydroxyecdysone in Drosophila and other arthropods involves a series of cytochrome P450 catalyzed hydroxylations of cholesterol...
  4. Beisswanger S, Stephan W, De Lorenzo D. Evidence for a selective sweep in the wapl region of Drosophila melanogaster. Genetics. 2006;172:265-74 pubmed
    ..Evidence that this sweep may have originated in an ancestral population in Africa is presented. ..
  5. Wang S, He G, Chen R, Li F, Li G. The involvement of cytochrome P450 monooxygenases in methanol elimination in Drosophila melanogaster larvae. Arch Insect Biochem Physiol. 2012;79:264-75 pubmed publisher
    ..These results reveal that cytochrome P450 monooxygenases (CYPs), rather than catalases, alcohol dehydrogenases, glutathione S-transferases, and ..
  6. Keogh D, Mitchell M, Crooks J, Smith S. Effects of the adenylate cyclase activator forskolin and its inactive derivative 1,9-dideoxyforskolin on insect cytochrome P-450 dependent steroid hydroxylase activity. Experientia. 1992;48:39-41 pubmed
    ..The concentrations of these labdane diterpenes required to elicit a 50% inhibition of the cytochrome P-450 dependent steroid hydroxylase activity in the insect tissues ranged from approximately 5 x 10(-6) to 5 x 10(-4) M. ..
  7. Danielson P, Letman J, Fogleman J. Alkaloid metabolism by cytochrome P-450 enzymes in Drosophila melanogaster. Comp Biochem Physiol B Biochem Mol Biol. 1995;110:683-8 pubmed
    ..Results from larval viability and adult longevity studies indicate that D. melanogaster's in vitro activity does not produce an enhanced in vivo tolerance of alkaloids. ..
  8. Zakharenko L, Zakharov I. [Ethanol inhibits recombination in somatic cells of gamma-irradiated larvae of Drosophila melanogaster]. Genetika. 1998;34:364-7 pubmed
    ..In lines with high activity of cytochrome P450, ethanol did not exhibit the radioprotective effect...
  9. Verni F, Gandhi R, Goldberg M, Gatti M. Genetic and molecular analysis of wings apart-like (wapl), a gene controlling heterochromatin organization in Drosophila melanogaster. Genetics. 2000;154:1693-710 pubmed

More Information


  1. Maïbèche Coisne M, Monti Dedieu L, Aragon S, Dauphin Villemant C. A new cytochrome P450 from Drosophila melanogaster, CYP4G15, expressed in the nervous system. Biochem Biophys Res Commun. 2000;273:1132-7 pubmed
    A novel cytochrome P450 was isolated from Drosophila melanogaster by PCR strategy with primers deduced from the crayfish Orconectes limosus CYP4C15 sequence, which is supposed to be involved in ecdysteroid biosynthesis...
  2. Wang S, Hu X, Meng Q, Muhammad S, Chen R, Li F, et al. The involvement of several enzymes in methanol detoxification in Drosophila melanogaster adults. Comp Biochem Physiol B Biochem Mol Biol. 2013;166:7-14 pubmed publisher
    ..Our previous results showed that cytochrome P450 monooxygenases (CYPs) were associated with methanol detoxification in the larvae...