Gene Symbol: Cyp4d1
Description: Cytochrome P450-4d1
Alias: 4d1, CG3656, CYP4D1, CYP6D1, Cyp4D1, Cyt-P450-4D1, Dmel\CG3656, EG:87B1.1, P-450, P450, cyp4d1, cytochrome P450-4d1, CG3656-PA, CG3656-PB, Cyp4d1-PA, Cyp4d1-PB, P450 CYPD1, cytochrome P450, cytochrome P450 4D1
Species: fruit fly

Top Publications

  1. Dunkov B, Rodriguez Arnaiz R, Pittendrigh B, ffrench Constant R, Feyereisen R. Cytochrome P450 gene clusters in Drosophila melanogaster. Mol Gen Genet. 1996;251:290-7 pubmed
    Twelve cytochrome P450 cDNA fragments were cloned from Drosophila melanogaster by reverse transcriptase/PCR (RT/PCR) using degenerate oligonucleotide primers...
  2. Santos A, Lehmann R. Isoprenoids control germ cell migration downstream of HMGCoA reductase. Dev Cell. 2004;6:283-93 pubmed
    ..The specificity and evolutionary conservation of the HMGCoAr pathway for germ cells suggest that an attractant common to invertebrates and vertebrates guides germ cells in early embryos. ..
  3. Davies L, Williams D, Aguiar Santana I, Pedersen J, Turner P, Rees H. Expression and down-regulation of cytochrome P450 genes of the CYP4 family by ecdysteroid agonists in Spodoptera littoralis and Drosophila melanogaster. Insect Biochem Mol Biol. 2006;36:801-7 pubmed
    ..Similarly, in D. melanogaster, Cyp4ac1, Cyp4ac3, Cyp4ad1 and Cyp4d1 gene expression is drastically down-regulated by ecdysteroid agonist...
  4. Keogh D, Mitchell M, Crooks J, Smith S. Effects of the adenylate cyclase activator forskolin and its inactive derivative 1,9-dideoxyforskolin on insect cytochrome P-450 dependent steroid hydroxylase activity. Experientia. 1992;48:39-41 pubmed
    ..The concentrations of these labdane diterpenes required to elicit a 50% inhibition of the cytochrome P-450 dependent steroid hydroxylase activity in the insect tissues ranged from approximately 5 x 10(-6) to 5 x 10(-4) M. ..
  5. Beisswanger S, Stephan W, De Lorenzo D. Evidence for a selective sweep in the wapl region of Drosophila melanogaster. Genetics. 2006;172:265-74 pubmed
    ..We detect a 60.5-kb stretch of DNA encompassing the genes ph-d, ph-p, CG3835, bcn92, Pgd, wapl, and Cyp4d1, which almost completely lacks variation in the European sample...
  6. Lin G, Kozaki T, Scott J. Hormone receptor-like in 96 and Broad-Complex modulate phenobarbital induced transcription of cytochrome P450 CYP6D1 in Drosophila S2 cells. Insect Mol Biol. 2011;20:87-95 pubmed publisher
    ..Drosophila Schneider (S2) cells, constructs containing variable lengths of the promoter of the PB inducible cytochrome P450 CYP6D1 were evaluated in the presence and absence of PB...
  7. Danielson P, Letman J, Fogleman J. Alkaloid metabolism by cytochrome P-450 enzymes in Drosophila melanogaster. Comp Biochem Physiol B Biochem Mol Biol. 1995;110:683-8 pubmed
    ..Results from larval viability and adult longevity studies indicate that D. melanogaster's in vitro activity does not produce an enhanced in vivo tolerance of alkaloids. ..
  8. Zakharenko L, Zakharov I. [Ethanol inhibits recombination in somatic cells of gamma-irradiated larvae of Drosophila melanogaster]. Genetika. 1998;34:364-7 pubmed
    ..In lines with high activity of cytochrome P450, ethanol did not exhibit the radioprotective effect...
  9. Danielson P, Foster J, McMahill M, Smith M, Fogleman J. Induction by alkaloids and phenobarbital of Family 4 Cytochrome P450s in Drosophila: evidence for involvement in host plant utilization. Mol Gen Genet. 1998;259:54-9 pubmed
    ..Strong barbiturate inducibility of CYP4D10 and two other D. mettleri P450 sequences of the CYP4 family was also observed, suggesting a pattern of xenobiotic responsiveness more similar to ..

More Information


  1. Verni F, Gandhi R, Goldberg M, Gatti M. Genetic and molecular analysis of wings apart-like (wapl), a gene controlling heterochromatin organization in Drosophila melanogaster. Genetics. 2000;154:1693-710 pubmed
  2. Maïbèche Coisne M, Monti Dedieu L, Aragon S, Dauphin Villemant C. A new cytochrome P450 from Drosophila melanogaster, CYP4G15, expressed in the nervous system. Biochem Biophys Res Commun. 2000;273:1132-7 pubmed
    A novel cytochrome P450 was isolated from Drosophila melanogaster by PCR strategy with primers deduced from the crayfish Orconectes limosus CYP4C15 sequence, which is supposed to be involved in ecdysteroid biosynthesis...
  3. Gandhi R, Varak E, Goldberg M. Molecular analysis of a cytochrome P450 gene of family 4 on the Drosophila X chromosome. DNA Cell Biol. 1992;11:397-404 pubmed
    A member of the cytochrome P450 superfamily has been identified within region 2D of the Drosophila X chromosome...
  4. Li H, Sun L, Mittapalli O, Muir W, Xie J, Wu J, et al. Bowman-Birk inhibitor affects pathways associated with energy metabolism in Drosophila melanogaster. Insect Mol Biol. 2010;19:303-13 pubmed publisher
    ..melanogaster. In addition, ultrastructure studies indicate that microvilli are significantly shortened in BBI-fed larvae. These data provide further insights into the complex cellular response of insects to dietary protease inhibitors. ..
  5. Feng S, Huang J, Wang J. Loss of the Polycomb group gene polyhomeotic induces non-autonomous cell overproliferation. EMBO Rep. 2011;12:157-63 pubmed publisher
    ..We propose that PcG misregulation promotes tumorigenesis through several cellular mechanisms. ..