Research Topics

Genomes and Genes

Gene Symbol: Cyp301a1

Description: Cyp301a1

Alias: 301a1, CG8587, Cyp301A1, Dmel\CG8587, Cyp301a1, CG8587-PA, Cyp301a1-PA, cytochrome P450

Species: fruit fly

Najarro M, Hackett J, Smith B, Highfill C, King E, Long A, et al. Identifying Loci Contributing to Natural Variation in Xenobiotic Resistance in Drosophila. PLoS Genet. 2015;11:e1005663 pubmed publisher

..5-14.4% of the broad-sense heritability for caffeine resistance. Four QTL harbor members of the cytochrome P450 family of detoxification enzymes, which represent strong a priori candidate genes...
Brandt A, Scharf M, Pedra J, Holmes G, Dean A, Kreitman M, et al. Differential expression and induction of two Drosophila cytochrome P450 genes near the Rst(2)DDT locus. Insect Mol Biol. 2002;11:337-41 pubmed

..Six cytochrome P450 genes exist in this region...
Ranson H, Claudianos C, Ortelli F, Abgrall C, Hemingway J, Sharakhova M, et al. Evolution of supergene families associated with insecticide resistance. Science. 2002;298:179-81 pubmed

..The analyses also provide the means for identifying previously unknown molecules involved in fundamental biological processes such as development. ..
Sztal T, Chung H, Berger S, Currie P, Batterham P, Daborn P. A cytochrome p450 conserved in insects is involved in cuticle formation. PLoS ONE. 2012;7:e36544 pubmed publisher

The sequencing of numerous insect genomes has revealed dynamic changes in the number and identity of cytochrome P450 genes in different insects...