Gene Symbol: Cyp12d1-p
Description: Cyp12d1-p
Alias: 12D1, 12d1, CG18240, CG30489, CYP12D1, CYP12d1-p, Cyp 12d1, Cyp12d1, Dmel\CG30489, Cyp12d1-p, CG30489-PA, CG30489-PB, Cyp12d1-p-PA, Cyp12d1-p-PB, cytochrome P450, cytochrome P450-12d1
Species: fruit fly

Top Publications

  1. Moskalev A, Shaposhnikov M, Snezhkina A, Kogan V, Plyusnina E, Peregudova D, et al. Mining gene expression data for pollutants (dioxin, toluene, formaldehyde) and low dose of gamma-irradiation. PLoS ONE. 2014;9:e86051 pubmed publisher
    ..Females and, to a lesser extent, males actively metabolize xenobiotics by the action of cytochrome P450 when under the influence of dioxin and toluene...
  2. Ffrench Constant R, Daborn P, Le Goff G. The genetics and genomics of insecticide resistance. Trends Genet. 2004;20:163-70 pubmed
    ..These studies enable us to address three fundamental questions in the evolution of resistance. How many genes are involved? How many mutations are there within these genes? How often do these mutations arise in natural populations? ..
  3. Daborn P, Lumb C, Boey A, Wong W, Ffrench Constant R, Batterham P. Evaluating the insecticide resistance potential of eight Drosophila melanogaster cytochrome P450 genes by transgenic over-expression. Insect Biochem Mol Biol. 2007;37:512-9 pubmed
    ..Drosophila over-expressing Cyp6g1, Cyp6g2, Cyp6t3, Cyp6a2, Cyp6a8, Cyp6a19, Cyp6a23 and Cyp12d1 were screened for resistance to four insecticides--DDT, nitenpyram, dicyclanil and diazinon...
  4. Willoughby L, Chung H, Lumb C, Robin C, Batterham P, Daborn P. A comparison of Drosophila melanogaster detoxification gene induction responses for six insecticides, caffeine and phenobarbital. Insect Biochem Mol Biol. 2006;36:934-42 pubmed
    ..Mutations leading to changes in expression levels or substrate specificities of cytochrome P450 (P450), glutathione-S-transferase (GST) and esterase genes have been linked to many cases of resistance with ..
  5. Brandt A, Scharf M, Pedra J, Holmes G, Dean A, Kreitman M, et al. Differential expression and induction of two Drosophila cytochrome P450 genes near the Rst(2)DDT locus. Insect Mol Biol. 2002;11:337-41 pubmed
    ..Six cytochrome P450 genes exist in this region...
  6. Le Goff G, Boundy S, Daborn P, Yen J, Sofer L, Lind R, et al. Microarray analysis of cytochrome P450 mediated insecticide resistance in Drosophila. Insect Biochem Mol Biol. 2003;33:701-8 pubmed
    ..Using microarray analysis of all Drosophila P450 genes, here we show that different P450 genes such as Cyp12d1 and Cyp6a8 can also be selected using DDT in the laboratory...
  7. McDonnell C, King D, Comeron J, Li H, Sun W, Berenbaum M, et al. Evolutionary toxicogenomics: diversification of the Cyp12d1 and Cyp12d3 genes in Drosophila species. J Mol Evol. 2012;74:281-96 pubmed publisher
    Gene duplication and divergence are overwhelmingly considered to be the primary mechanisms by which cytochrome P450 monooxygenases (P450s) have radiated into a large and diverse gene superfamily...
  8. Ranson H, Claudianos C, Ortelli F, Abgrall C, Hemingway J, Sharakhova M, et al. Evolution of supergene families associated with insecticide resistance. Science. 2002;298:179-81 pubmed
    ..The analyses also provide the means for identifying previously unknown molecules involved in fundamental biological processes such as development. ..
  9. Festucci Buselli R, Carvalho Dias A, de Oliveira Andrade M, Caixeta Nunes C, Li H, Stuart J, et al. Expression of Cyp6g1 and Cyp12d1 in DDT resistant and susceptible strains of Drosophila melanogaster. Insect Mol Biol. 2005;14:69-77 pubmed
    The Rst(2)DDT locus (loci) in Drosophila is associated with the over-expression of two cytochrome P450 genes, Cyp6g1 and Cyp12d1...

More Information


  1. Najarro M, Hackett J, Smith B, Highfill C, King E, Long A, et al. Identifying Loci Contributing to Natural Variation in Xenobiotic Resistance in Drosophila. PLoS Genet. 2015;11:e1005663 pubmed publisher
    ..5-14.4% of the broad-sense heritability for caffeine resistance. Four QTL harbor members of the cytochrome P450 family of detoxification enzymes, which represent strong a priori candidate genes...
  2. Rand M, Lowe J, Mahapatra C. Drosophila CYP6g1 and its human homolog CYP3A4 confer tolerance to methylmercury during development. Toxicology. 2012;300:75-82 pubmed publisher
    ..brains of MeHg tolerant and susceptible strains of Drosophila, we previously identified members of the cytochrome p450 (CYP) family of monooxygenases/oxidoreductases as candidate MeHg tolerance genes...
  3. Chen S, Li X. Transposable elements are enriched within or in close proximity to xenobiotic-metabolizing cytochrome P450 genes. BMC Evol Biol. 2007;7:46 pubmed
    ..genes, we scanned two alleles per each of the six xenobiotic-metabolizing Helicoverpa zea cytochrome P450 loci, including CYP6B8, CYP6B27, CYP321A1, CYP321A2, CYP9A12v3 and CYP9A14, for the presence of transposon ..
  4. Gellatly K, Yoon K, Doherty J, Sun W, Pittendrigh B, Clark J. RNAi validation of resistance genes and their interactions in the highly DDT-resistant 91-R strain of Drosophila melanogaster. Pestic Biochem Physiol. 2015;121:107-15 pubmed publisher
    ..involved in DDT resistance and has validated the role of several cuticular proteins (Cyp4g1 and Lcp1), cytochrome P450 monooxygenases (Cyp6g1 and Cyp12d1), and ATP binding cassette transporters (Mdr50, Mdr65, and Mrp1) involved ..
  5. Sun W, Valero M, Seong K, Steele L, Huang I, Lee C, et al. A glycine insertion in the estrogen-related receptor (ERR) is associated with enhanced expression of three cytochrome P450 genes in transgenic Drosophila melanogaster. PLoS ONE. 2015;10:e0118779 pubmed publisher
    ..melanogaster strains represent a resource for the discovery of the underlying molecular mechanisms of cytochrome P450 constitutive over-expression, even if some of these P450s are not directly involved in the resistance ..
  6. Schrider D, Begun D, Hahn M. Detecting highly differentiated copy-number variants from pooled population sequencing. Pac Symp Biocomput. 2013;:344-55 pubmed
    ..Using novel pooled sequence data from two populations of Drosophila melanogaster along a latitudinal cline, we demonstrate the utility of our method for identifying CNVs involved in local adaptation. ..
  7. Deng H, Kerppola T. Visualization of the Drosophila dKeap1-CncC interaction on chromatin illumines cooperative, xenobiotic-specific gene activation. Development. 2014;141:3277-88 pubmed publisher
  8. Li T, Cao C, Yang T, Zhang L, He L, Xi Z, et al. A G-protein-coupled receptor regulation pathway in cytochrome P450-mediated permethrin-resistance in mosquitoes, Culex quinquefasciatus. Sci Rep. 2015;5:17772 pubmed publisher
    ..reducing the expression of two cAMP-dependent protein kinase A genes (PKAs) and four resistance related cytochrome P450 genes...
  9. Hamby K, Kwok R, Zalom F, Chiu J. Integrating circadian activity and gene expression profiles to predict chronotoxicity of Drosophila suzukii response to insecticides. PLoS ONE. 2013;8:e68472 pubmed publisher
    ..However, field research is necessary for extrapolation to agricultural settings. ..
  10. Jones R, Bakker S, Stone D, Shuttleworth S, Boundy S, McCart C, et al. Homology modelling of Drosophila cytochrome P450 enzymes associated with insecticide resistance. Pest Manag Sci. 2010;66:1106-15 pubmed publisher
    Overexpression of the cytochrome P450 gene Cyp6g1 confers resistance against DDT and a broad range of other insecticides in Drosophila melanogaster Meig...
  11. Mitchell C, Saul M, Lei L, Wei H, Werner T. The mechanisms underlying α-amanitin resistance in Drosophila melanogaster: a microarray analysis. PLoS ONE. 2014;9:e93489 pubmed publisher
    ..We speculate that the resistance to mushroom toxins in D. melanogaster and perhaps in mycophagous Drosophila species has evolved as cross-resistance to pesticides, other xenobiotic substances, or environmental stress factors. ..
  12. Schmidt J, Good R, Appleton B, Sherrard J, Raymant G, Bogwitz M, et al. Copy number variation and transposable elements feature in recent, ongoing adaptation at the Cyp6g1 locus. PLoS Genet. 2010;6:e1000998 pubmed publisher
    ..In contrast, copy number variation for another candidate resistance gene, Cyp12d1, is not associated with resistance...
  13. Jensen H, Scott I, Sims S, Trudeau V, Arnason J. The effect of a synergistic concentration of a Piper nigrum extract used in conjunction with pyrethrum upon gene expression in Drosophila melanogaster. Insect Mol Biol. 2006;15:329-39 pubmed
    ..melanogaster treated with at least two of the following treatments: P. nigrum, pyrethrum or P. nigrum plus pyrethrum. These are likely implicated in Drosophila defence responses to toxins...
  14. Carareto C, Hernandez E, Vieira C. Genomic regions harboring insecticide resistance-associated Cyp genes are enriched by transposable element fragments carrying putative transcription factor binding sites in two sibling Drosophila species. Gene. 2014;537:93-9 pubmed publisher
    ..These fragments carry putative binding sites for transcription factors, which reinforces the hypothesis that DNAREP1 may influence gene regulation and play a role in the adaptation of the Drosophila species. ..
  15. Chahine S, O Donnell M. Interactions between detoxification mechanisms and excretion in Malpighian tubules of Drosophila melanogaster. J Exp Biol. 2011;214:462-8 pubmed publisher
    ..P450 genes (Cyp4e2, Cyp4p1) and two GST genes (GstD1, GstD5) in the tubules, as well as increased expression of Cyp12d1 and GstE1...
  16. Kasai S, Tomita T. Male specific expression of a cytochrome P450 (Cyp312a1) in Drosophila melanogaster. Biochem Biophys Res Commun. 2003;300:894-900 pubmed
    Using cDNA array techniques, the transcriptional levels of Drosophila cytochrome P450 (P450) genes were compared between male and female flies...