CycE

Summary

Gene Symbol: CycE
Description: Cyclin E
Alias: 3938, BG:DS07108.3, CDI7, CG3938, CYCE, Cdi7, Cyc, Cyc E, CycEI, CyclE, CyeE, D-CycE, DmCycE, DmcycE, DmcyclinE, Dmel\CG3938, br37, cdi7, cycE, cyclinE, cycline, dCycE, dm-cycE, fond, l(2)05206, l(2)35Dd, l(2)br37, l(2)k02514, l(2)k02602, l(2)k05007, l35Dd, cyclin E, CG3938-PA, CG3938-PB, CG3938-PC, CG3938-PD, CG3938-PE, CG3938-PF, CycE-PA, CycE-PB, CycE-PC, CycE-PD, CycE-PE, CycE-PF, Cyclin-dependent kinase interactor 7, cyclin, cyclin-E, cyclinE, cycline E, dCyclinE, fondue
Species: fruit fly

Top Publications

  1. Shibutani S, Swanhart L, Duronio R. Rbf1-independent termination of E2f1-target gene expression during early Drosophila embryogenesis. Development. 2007;134:467-78 pubmed
    ..The initiation of G1(17) arrest requires the developmentally-induced expression of Dacapo, a p27-like Cyclin E-Cdk2 inhibitor...
  2. Jia J, Zhang W, Wang B, Trinko R, Jiang J. The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. Genes Dev. 2003;17:2514-9 pubmed
    ..dMST mutant cells exhibit elevated levels of Cyclin E and DIAP1, increased cell growth and proliferation, and impaired apoptosis...
  3. Sauer K, Knoblich J, Richardson H, Lehner C. Distinct modes of cyclin E/cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila embryogenesis. Genes Dev. 1995;9:1327-39 pubmed
    Drosophila cyclin E (DmcycE) is required in embryos for S phase of mitotic and endoreduplication cycles. Here, we describe regulatory differences characteristic for these two cell cycle types...
  4. Kango Singh M, Nolo R, Tao C, Verstreken P, Hiesinger P, Bellen H, et al. Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila. Development. 2002;129:5719-30 pubmed
    ..Shar-pei is also not required for cell cycle exit during terminal differentiation, indicating that the mechanisms directing cell proliferation arrest during ..
  5. Koepp D, Schaefer L, Ye X, Keyomarsi K, Chu C, Harper J, et al. Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase. Science. 2001;294:173-7 pubmed
    b>Cyclin E binds and activates the cyclin-dependent kinase Cdk2 and catalyzes the transition from the G1 phase to the S phase of the cell cycle...
  6. Avedisov S, Krasnoselskaya I, Mortin M, Thomas B. Roughex mediates G(1) arrest through a physical association with cyclin A. Mol Cell Biol. 2000;20:8220-9 pubmed
    ..The roughex gene product plays a key role in this synchronization by negatively regulating cyclin A protein levels in G(1). We show here that coexpressed Roughex and cyclin A physically interact in vivo...
  7. Royzman I, Austin R, Bosco G, Bell S, Orr Weaver T. ORC localization in Drosophila follicle cells and the effects of mutations in dE2F and dDP. Genes Dev. 1999;13:827-40 pubmed
    ..The effect of the mutations in the heterodimer subunits suggests that E2F controls not only the onset of S phase but also origin activity within S phase. ..
  8. Wang Z, Kalderon D. Cyclin E-dependent protein kinase activity regulates niche retention of Drosophila ovarian follicle stem cells. Proc Natl Acad Sci U S A. 2009;106:21701-6 pubmed publisher
    ..We identified a hypomorphic cyclin E allele WX that strongly impairs the maintenance of follicle stem cells (FSCs) in the Drosophila ovary but does ..
  9. Silva E, Tsatskis Y, Gardano L, Tapon N, McNeill H. The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway. Curr Biol. 2006;16:2081-9 pubmed
    ..and decreased apoptosis, resulting in massive tissue overgrowth through increased expression of targets such as Cyclin E and Diap1...

More Information

Publications95

  1. Wang H, Ouyang Y, Somers W, Chia W, Lu B. Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon. Nature. 2007;449:96-100 pubmed
    ..The localization and function of Numb is cell-cycle-dependent. Here we show that Polo (ref...
  2. Royzman I, Whittaker A, Orr Weaver T. Mutations in Drosophila DP and E2F distinguish G1-S progression from an associated transcriptional program. Genes Dev. 1997;11:1999-2011 pubmed
    ..Although mutations in dDP or dE2F nearly eliminate E2F-dependent G1-S transcription, S-phase still occurs. Cyclin E has been shown to be essential for S-phase in late embryogenesis, but in dDP and dE2F mutants the peaks of G1-S ..
  3. Sprenger F, Yakubovich N, O Farrell P. S-phase function of Drosophila cyclin A and its downregulation in G1 phase. Curr Biol. 1997;7:488-99 pubmed
    b>Cyclin E is the normal inducer of S phase in G1 cells of Drosophila embryos. Stable G1 quiescence requires the downregulation both of cyclin E and of other factors that can bypass the normal regulation of cell cycle progression...
  4. Tseng A, Tapon N, Kanda H, Cigizoglu S, Edelmann L, Pellock B, et al. Capicua regulates cell proliferation downstream of the receptor tyrosine kinase/ras signaling pathway. Curr Biol. 2007;17:728-33 pubmed
    ..Thus, the DNA-binding protein Cic is a key downstream component in the pathway by which Ras regulates growth in imaginal discs. ..
  5. Johnston L, Prober D, Edgar B, Eisenman R, Gallant P. Drosophila myc regulates cellular growth during development. Cell. 1999;98:779-90 pubmed
    ..Our results indicate that dMyc links patterning signals to cell division by regulating primary targets involved in cellular growth and metabolism. ..
  6. Horsfield J, Penton A, Secombe J, Hoffman F, Richardson H. decapentaplegic is required for arrest in G1 phase during Drosophila eye development. Development. 1998;125:5069-78 pubmed
    ..ubiquitous over-expression of Dpp in the eye imaginal disc transiently inhibits S phase without affecting Cyclin E or Cyclin A abundance...
  7. Frolov M, Moon N, Dyson N. dDP is needed for normal cell proliferation. Mol Cell Biol. 2005;25:3027-39 pubmed
    ..Strikingly, the timing of S-phase entry or exit is not delayed in dDP mutant clones, nor is the accumulation of cyclin A or cyclin B...
  8. Higa L, Yang X, Zheng J, Banks D, Wu M, Ghosh P, et al. Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo/p27Kip1 and cyclin E degradation. Cell Cycle. 2006;5:71-7 pubmed
    ..In addition, we found that the Drosophila CUL4 also regulates the protein level of cyclin E independent of Dacapo...
  9. Polesello C, Tapon N. Salvador-warts-hippo signaling promotes Drosophila posterior follicle cell maturation downstream of notch. Curr Biol. 2007;17:1864-70 pubmed
    ..network controls the expression of Hindsight, the downstream effector of Notch, required for follicle cell mitotic cycle-endocycle switch...
  10. Duman Scheel M, Weng L, Xin S, Du W. Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E. Nature. 2002;417:299-304 pubmed
    ..Here we show that Hh signalling promotes transcription of Cyclin E and Cyclin D, two inhibitors of Rb, and principal regulators of the cell cycle during development in Drosophila...
  11. Moberg K, Bell D, Wahrer D, Haber D, Hariharan I. Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines. Nature. 2001;413:311-6 pubmed
    ..embryogenesis, exit from the cell cycle is contingent on tightly controlled downregulation of the activity of Cyclin E-Cdk2 complexes that normally promote the transition from G1 to S phase...
  12. Shaw R, Kohlmaier A, Polesello C, Veelken C, Edgar B, Tapon N. The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration. Development. 2010;137:4147-58 pubmed publisher
    ..Our results suggest that the Hpo pathway is a mediator of the regenerative response in the Drosophila midgut. ..
  13. Betschinger J, Mechtler K, Knoblich J. Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells. Cell. 2006;124:1241-53 pubmed
    ..While Prospero regulates cell-cycle gene transcription, Brat acts as a posttranscriptional inhibitor of dMyc...
  14. Meyer C, Jacobs H, Datar S, Du W, Edgar B, Lehner C. Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression. EMBO J. 2000;19:4533-42 pubmed
    ..In Drosophila, single genes for Cyclin D and Cdk4 have been identified, simplifying genetic analysis...
  15. Lane M, Sauer K, Wallace K, Jan Y, Lehner C, Vaessin H. Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development. Cell. 1996;87:1225-35 pubmed
    ..dacapo encodes an inhibitor of cyclin E/cdk2 complexes with similarity to the vertebrate Cip/Kip inhibitors...
  16. Wodarz A, Gonzalez C. Connecting cancer to the asymmetric division of stem cells. Cell. 2006;124:1121-3 pubmed
    ..This work suggests a mechanism by which loss of polarity in stem cells may lead to tumorigenesis. ..
  17. Willecke M, Hamaratoglu F, Kango Singh M, Udan R, Chen C, Tao C, et al. The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size. Curr Biol. 2006;16:2090-100 pubmed
    ..after wild-type cells stopped proliferating, and fat mutant cells deregulated Hippo target genes such as cyclin E and diap1...
  18. Harvey K, Pfleger C, Hariharan I. The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell. 2003;114:457-67 pubmed
    ..in increased tissue growth and impaired apoptosis characterized by elevated levels of the cell cycle regulator cyclin E and apoptosis inhibitor DIAP1...
  19. Nolo R, Morrison C, Tao C, Zhang X, Halder G. The bantam microRNA is a target of the hippo tumor-suppressor pathway. Curr Biol. 2006;16:1895-904 pubmed
    ..Hippo regulates bantam independently of cyclin E and diap1, two other Hippo targets, and overexpression of bantam mimics overgrowth phenotypes of hippo mutant ..
  20. Hsu H, LaFever L, Drummond Barbosa D. Diet controls normal and tumorous germline stem cells via insulin-dependent and -independent mechanisms in Drosophila. Dev Biol. 2008;313:700-12 pubmed
    ..Here, we report that DILPs specifically control the G2 phase of the GSC cell cycle via phosphoinositide-3 kinase (PI3K) and dFOXO, and that a separate diet mediator regulates the G1 phase...
  21. Hartl T, Boswell C, Orr Weaver T, Bosco G. Developmentally regulated histone modifications in Drosophila follicle cells: initiation of gene amplification is associated with histone H3 and H4 hyperacetylation and H1 phosphorylation. Chromosoma. 2007;116:197-214 pubmed
    ..into cell cycle states during amplification, as H1 kinase activity in follicle cells is responsive to high Cyclin E activity, and it can be abolished by overexpressing the retinoblastoma homolog, Rbf, that represses Cyclin E...
  22. Bowman S, Rolland V, Betschinger J, Kinsey K, Emery G, Knoblich J. The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila. Dev Cell. 2008;14:535-46 pubmed publisher
    ..Our data describe a transit-amplifying lineage in the Drosophila nervous system and suggest that different vulnerabilities in intermediate cell types can affect the outcome of tumor suppressor loss in stem cell lineages. ..
  23. Britton J, Edgar B. Environmental control of the cell cycle in Drosophila: nutrition activates mitotic and endoreplicative cells by distinct mechanisms. Development. 1998;125:2149-58 pubmed
    ..We also show that ectopic expression of Drosophila Cyclin E or the E2F transcription factor can drive quiescent endoreplicating cells, but not quiescent imaginal neuroblasts,..
  24. Du W, Dyson N. The role of RBF in the introduction of G1 regulation during Drosophila embryogenesis. EMBO J. 1999;18:916-25 pubmed
    The first appearance of G1 during Drosophila embryogenesis, at cell cycle 17, is accompanied by the down-regulation of E2F-dependent transcription...
  25. Moberg K, Mukherjee A, Veraksa A, Artavanis Tsakonas S, Hariharan I. The Drosophila F box protein archipelago regulates dMyc protein levels in vivo. Curr Biol. 2004;14:965-74 pubmed
    ..Because archipelago can also regulate Cyclin E levels and Notch activity, these results indicate how a single F box protein can be responsible for the ..
  26. Crack D, Secombe J, Coombe M, Brumby A, Saint R, Richardson H. Analysis of Drosophila cyclin EI and II function during development: identification of an inhibitory zone within the morphogenetic furrow of the eye imaginal disc that blocks the function of cyclin EI but not cyclin EII. Dev Biol. 2002;241:157-71 pubmed
    The Drosophila cyclin E (DmcycE) gene gives rise to two transcripts encoding proteins that differ at their N termini, DmcycEII and DmcycEI. This study presents the first in vivo dissection of Cyclin E function...
  27. Duronio R, O Farrell P. Developmental control of a G1-S transcriptional program in Drosophila. Development. 1994;120:1503-15 pubmed
    ..DNA polymerase alpha, PCNA and the two ribonucleotide reductase subunits) that can be induced by the G1 cyclin, cyclin E. In Drosophila embryos, this program drives an intricate spatial and temporal pattern of gene expression that ..
  28. Maines J, Stevens L, Tong X, Stein D. Drosophila dMyc is required for ovary cell growth and endoreplication. Development. 2004;131:775-86 pubmed
    ..for dm exhibit a profound decrease in their ability to grow and to carry out endoreplication, a modified cell cycle in which DNA replication occurs in the absence of cell division...
  29. Zhang L, Ren F, Zhang Q, Chen Y, Wang B, Jiang J. The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control. Dev Cell. 2008;14:377-87 pubmed publisher
    ..Finally, Sd recruits Yki to the enhancer of the pathway-responsive gene diap1, suggesting that diap1 is a direct transcriptional target of the Hpo pathway. ..
  30. Escudero L, Freeman M. Mechanism of G1 arrest in the Drosophila eye imaginal disc. BMC Dev Biol. 2007;7:13 pubmed
    ..Each of these has distinct, as well as partially overlapping functions, in ensuring that Cyclin E and dE2F1 are kept in check...
  31. Xin S, Weng L, Xu J, Du W. The role of RBF in developmentally regulated cell proliferation in the eye disc and in Cyclin D/Cdk4 induced cellular growth. Development. 2002;129:1345-56 pubmed
    ..form of RBF that has four putative cdk phosphorylation sites mutated, can no longer be regulated by Cyclin D or Cyclin E. Expression of RBF-280 in the developing eye revealed that RBF-280 does not inhibit G1/S transition in the second ..
  32. Bello B, Izergina N, Caussinus E, Reichert H. Amplification of neural stem cell proliferation by intermediate progenitor cells in Drosophila brain development. Neural Dev. 2008;3:5 pubmed publisher
    ..This suggests that key aspects of neural stem cell biology might be conserved in brain development of insects and mammals. ..
  33. Follette P, Duronio R, O Farrell P. Fluctuations in cyclin E levels are required for multiple rounds of endocycle S phase in Drosophila. Curr Biol. 1998;8:235-8 pubmed
    ..Cyclins A and B are lost in cells as they enter endocycles [8,9], and pulses of Cyclin E expression drive endocycle S phases [10-12]...
  34. Bello B, Reichert H, Hirth F. The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila. Development. 2006;133:2639-48 pubmed
    ..Clonal analysis indicates that the brat mutation affects cell proliferation in a cell-autonomous manner and cell cycle marker expression shows that cells of brat mutant clones show uncontrolled proliferation, which persists into ..
  35. Buttitta L, Katzaroff A, Perez C, de la Cruz A, Edgar B. A double-assurance mechanism controls cell cycle exit upon terminal differentiation in Drosophila. Dev Cell. 2007;12:631-43 pubmed
    ..prevented or even reversed in terminally differentiating cells by the simultaneous activation of E2F1 and either Cyclin E/Cdk2 or Cyclin D/Cdk4...
  36. Badenhorst P. Tramtrack controls glial number and identity in the Drosophila embryonic CNS. Development. 2001;128:4093-101 pubmed
    ..of Tramtrack blocks glial development by inhibiting S-phase and repressing expression of the S-phase cyclin, cyclin E. Conversely, in tramtrack mutant embryos, glia are disrupted and undergo additional rounds of replication...
  37. Narbonne Reveau K, Senger S, Pal M, Herr A, Richardson H, Asano M, et al. APC/CFzr/Cdh1 promotes cell cycle progression during the Drosophila endocycle. Development. 2008;135:1451-61 pubmed publisher
    ..activity of APC/C Fzr/Cdh1 during the Drosophila endocycle is driven by the periodic inhibition of Fzr/Cdh1 by Cyclin E/Cdk2...
  38. Mesquita D, Dekanty A, Milan M. A dp53-dependent mechanism involved in coordinating tissue growth in Drosophila. PLoS Biol. 2010;8:e1000566 pubmed publisher
    ..a stress response mechanism involved in the coordination of tissue growth between adjacent cell populations and that tissue size and cell cycle proliferation can be uncoupled and are independently and non-autonomously regulated by dp53.
  39. Johnston L, Edgar B. Wingless and Notch regulate cell-cycle arrest in the developing Drosophila wing. Nature. 1998;394:82-4 pubmed
    ..Here we investigate how Wg coordinates the cell cycle with patterning by studying the regulation of this growth arrest...
  40. Kannan R, Berger C, Myneni S, Technau G, Shashidhara L. Abdominal-A mediated repression of Cyclin E expression during cell-fate specification in the Drosophila central nervous system. Mech Dev. 2010;127:137-45 pubmed publisher
    ..It does so by down regulating the expression of the cell cycle regulator gene Dcyclin E (CycE)...
  41. de Nooij J, Graber K, Hariharan I. Expression of the cyclin-dependent kinase inhibitor Dacapo is regulated by cyclin E. Mech Dev. 2000;97:73-83 pubmed
    ..We show that the accumulation of dacapo RNA and protein requires Cyclin E and that increased expression of Cyclin E can induce dacapo expression...
  42. Vidwans S, Su T. Cycling through development in Drosophila and other metazoa. Nat Cell Biol. 2001;3:E35-9 pubmed
    The cell-division cycle is an orchestrated sequence of events that results in the duplication of a cell...
  43. Pantalacci S, Tapon N, Leopold P. The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila. Nat Cell Biol. 2003;5:921-7 pubmed
    ..salvador (sav) gene, which encodes a scaffold protein, has been shown to restrict cell number by coordinating cell-cycle exit and apoptosis during Drosophila development...
  44. Yu J, Poulton J, Huang Y, Deng W. The hippo pathway promotes Notch signaling in regulation of cell differentiation, proliferation, and oocyte polarity. PLoS ONE. 2008;3:e1761 pubmed publisher
  45. Follette P, O Farrell P. Cdks and the Drosophila cell cycle. Curr Opin Genet Dev. 1997;7:17-22 pubmed
    b>Cyclin-dependent kinases play essential roles in driving the cell cycle. Much progress has been made in Drosophila over the past year in identifying the specific requirements for individual cyclins in particular cell cycle events...
  46. Richardson H, O Keefe L, Marty T, Saint R. Ectopic cyclin E expression induces premature entry into S phase and disrupts pattern formation in the Drosophila eye imaginal disc. Development. 1995;121:3371-9 pubmed
    ..Studies of mammalian tissue culture cells have shown that the G1-specific cyclin, cyclin E, can be rate limiting for progression from G1 to S phase...
  47. Secombe J, Pispa J, Saint R, Richardson H. Analysis of a Drosophila cyclin E hypomorphic mutation suggests a novel role for cyclin E in cell proliferation control during eye imaginal disc development. Genetics. 1998;149:1867-82 pubmed
    We have generated and characterized a Drosophila cyclin E hypomorphic mutation, DmcycEJP, that is homozygous viable and fertile, but results in adults with rough eyes...
  48. Bello B, Holbro N, Reichert H. Polycomb group genes are required for neural stem cell survival in postembryonic neurogenesis of Drosophila. Development. 2007;134:1091-9 pubmed
    ..Moreover, together with data on mammalian PcG genes, they imply that repression of aberrant reactivation of Hox genes may be a general and evolutionarily conserved role for PcG genes in CNS development. ..
  49. Pellock B, Buff E, White K, Hariharan I. The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling. Dev Biol. 2007;304:102-15 pubmed
    ..Though both mer and ex restrict cell and tissue growth, ex clones exhibit delayed cell cycle exit in the developing eye, while mer clones do not...
  50. Grzeschik N, Parsons L, Allott M, Harvey K, Richardson H. Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms. Curr Biol. 2010;20:573-81 pubmed publisher
    ..Thus, our study implicates Lgl, aPKC, and Crumbs as regulators of tissue growth via the SWH pathway. ..
  51. Reber A, Lehner C, Jacobs H. Terminal mitoses require negative regulation of Fzr/Cdh1 by Cyclin A, preventing premature degradation of mitotic cyclins and String/Cdc25. Development. 2006;133:3201-11 pubmed
    ..b>Cyclin E is known to be downregulated during terminal division cycles to allow a timely cell cycle exit after the final ..
  52. Knoblich J, Sauer K, Jones L, Richardson H, Saint R, Lehner C. Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation. Cell. 1994;77:107-20 pubmed
    ..This exit is dependent on the down-regulation of Drosophila cyclin E (DmcycE) during the final mitotic cycle...
  53. Berger C, Pallavi S, Prasad M, Shashidhara L, Technau G. A critical role for cyclin E in cell fate determination in the central nervous system of Drosophila melanogaster. Nat Cell Biol. 2005;7:56-62 pubmed
    ..They specify the NB6-4a lineage by down-regulating levels of the G1 cyclin, DmCycE (CycE)...
  54. Grosskortenhaus R, Sprenger F. Rca1 inhibits APC-Cdh1(Fzr) and is required to prevent cyclin degradation in G2. Dev Cell. 2002;2:29-40 pubmed
    ..Our data reveal a different mode of APC regulation by Rca1 at the G2 stage, when low Cdk activity is unable to inhibit Cdh1(Fzr) interaction. ..
  55. Maqbool S, Mehrotra S, Kolpakas A, Durden C, Zhang B, Zhong H, et al. Dampened activity of E2F1-DP and Myb-MuvB transcription factors in Drosophila endocycling cells. J Cell Sci. 2010;123:4095-106 pubmed publisher
    The endocycle is a variant cell cycle comprised of alternating gap (G) and DNA synthesis (S) phases (endoreplication) without mitosis (M), which results in DNA polyploidy and large cell size...
  56. Richardson H, O Keefe L, Reed S, Saint R. A Drosophila G1-specific cyclin E homolog exhibits different modes of expression during embryogenesis. Development. 1993;119:673-90 pubmed
    We have isolated a Drosophila homolog of the human G1-specific cyclin E gene. Cyclin E proteins thus constitute an evolutionarily conserved subfamily of metazoan cyclins...
  57. Duronio R, O Farrell P. Developmental control of the G1 to S transition in Drosophila: cyclin Eis a limiting downstream target of E2F. Genes Dev. 1995;9:1456-68 pubmed
    ..However, one unstable product could couple S phase to E2F activation. Here we show that cyclin E expression at G1-S requires E2F, that activation of E2F without cyclin E is not sufficient for S phase, and that ..
  58. Hamaratoglu F, Willecke M, Kango Singh M, Nolo R, Hyun E, Tao C, et al. The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol. 2006;8:27-36 pubmed
    ..Our genetic and biochemical data place Merlin and Expanded upstream of Hippo and identify a pathway through which they act as tumour-suppressor genes. ..
  59. Reis T, Edgar B. Negative regulation of dE2F1 by cyclin-dependent kinases controls cell cycle timing. Cell. 2004;117:253-64 pubmed
    ..dE2F1, in turn, positively regulates cyclin E and string/cdc25, which activate the Cdks to drive cell cycle progression...
  60. Tapon N, Ito N, Dickson B, Treisman J, Hariharan I. The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell. 2001;105:345-55 pubmed
    ..This phenotype is modulated by manipulations in cyclin levels. In postmitotic mutant cells, levels of Cyclin E and Cyclin A are elevated...
  61. Zielke N, Kim K, Tran V, Shibutani S, Bravo M, Nagarajan S, et al. Control of Drosophila endocycles by E2F and CRL4(CDT2). Nature. 2011;480:123-7 pubmed publisher
    ..DNA replication in endocycling Drosophila cells is triggered by cyclin E/cyclin dependent kinase 2 (CYCE/CDK2), but this kinase must be inactivated during each G-phase to allow the ..
  62. Simon F, Fichelson P, Gho M, Audibert A. Notch and Prospero repress proliferation following cyclin E overexpression in the Drosophila bristle lineage. PLoS Genet. 2009;5:e1000594 pubmed publisher
    ..we have tested the capacity of post-mitotic cells to re-enter the cell cycle in response to the overexpression of cyclin E. We show that only terminal cells in which the identity is independent of Notch pathway undergo extra divisions ..
  63. Audibert A, Simon F, Gho M. Cell cycle diversity involves differential regulation of Cyclin E activity in the Drosophila bristle cell lineage. Development. 2005;132:2287-97 pubmed
    ..This feature is due to the expression of Cyclin E that precedes each cell division, and the differential expression of the S-transition negative regulator, Dacapo...
  64. Prober D, Edgar B. Ras1 promotes cellular growth in the Drosophila wing. Cell. 2000;100:435-46 pubmed
    ..Ras upregulated the growth driver dMyc, and both Ras and dMyc increased levels of cyclin E posttranscriptionally...
  65. Park Y, Rangel C, Reynolds M, Caldwell M, Johns M, Nayak M, et al. Drosophila perlecan modulates FGF and hedgehog signals to activate neural stem cell division. Dev Biol. 2003;253:247-57 pubmed
    Mutations in the Drosophila trol gene cause cell cycle arrest of neuroblasts in the larval brain...
  66. Wu S, Huang J, Dong J, Pan D. hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell. 2003;114:445-56 pubmed
    ..Loss of hpo results in elevated transcription of the cell cycle regulator cyclin E and the cell-death inhibitor diap1, leading to increased proliferation and reduced apoptosis...
  67. Li L, Vaessin H. Pan-neural Prospero terminates cell proliferation during Drosophila neurogenesis. Genes Dev. 2000;14:147-51 pubmed
    ..Loss of pros results in aberrant expression of multiple cell-cycle regulatory genes and ectopic mitotic activity...
  68. Mitchell N, Cranna N, Richardson H, Quinn L. The Ecdysone-inducible zinc-finger transcription factor Crol regulates Wg transcription and cell cycle progression in Drosophila. Development. 2008;135:2707-16 pubmed publisher
    ..Herein, we delineate a molecular pathway linking Ecdysone signalling to cell cycle regulation in the Drosophila developing wing...
  69. Nicholson S, Gilbert M, Nicolay B, Frolov M, Moberg K. The archipelago tumor suppressor gene limits rb/e2f-regulated apoptosis in developing Drosophila tissues. Curr Biol. 2009;19:1503-10 pubmed publisher
    The Drosophila archipelago gene (ago) encodes the specificity component of a ubiquitin ligase that targets the cyclin E and dMyc proteins for degradation...
  70. Narbonne Reveau K, Lilly M. The Cyclin-dependent kinase inhibitor Dacapo promotes genomic stability during premeiotic S phase. Mol Biol Cell. 2009;20:1960-9 pubmed publisher
    ..In dap(-/-) females, ovarian cysts enter the meiotic cycle with high levels of Cyclin E/cyclin-dependent kinase (Cdk)2 activity and accumulate DNA damage during the premeiotic S phase...
  71. Mortimer N, Moberg K. The Drosophila F-box protein Archipelago controls levels of the Trachealess transcription factor in the embryonic tracheal system. Dev Biol. 2007;312:560-71 pubmed
    ..ago limits mitotic activity by targeting cell cycle and cell growth proteins for ubiquitin-dependent degradation, but the diverse developmental roles of other F-box ..
  72. Thomer M, May N, Aggarwal B, Kwok G, Calvi B. Drosophila double-parked is sufficient to induce re-replication during development and is regulated by cyclin E/CDK2. Development. 2004;131:4807-18 pubmed
    ..We find that phosphorylation and degradation of Dup protein at G1/S requires cyclin E/CDK2...
  73. Duronio R, Brook A, Dyson N, O Farrell P. E2F-induced S phase requires cyclin E. Genes Dev. 1996;10:2505-13 pubmed
    Both the heterodimeric transcription factor, E2F, and the G1 cyclin, cyclin E, are required for the G1-S transition at the start of the metazoan cell cycle. It has been established that cyclin E can act as an upstream activator of E2F...
  74. Sigrist S, Lehner C. Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles. Cell. 1997;90:671-81 pubmed
    ..While Drosophila fizzy has previously been shown to be required for cyclin destruction during M phase, fzr is required for cyclin removal during G1 when the embryonic epidermal cell ..
  75. Edgar B, Lehner C. Developmental control of cell cycle regulators: a fly's perspective. Science. 1996;274:1646-52 pubmed
    ..Analysis of the regulation of cyclin-dependent kinases (Cdks) in Drosophila has provided insights into how this embryonic program of cell proliferation ..
  76. Du W, Vidal M, Xie J, Dyson N. RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev. 1996;10:1206-18 pubmed
    Genetic studies have shown that cyclin E and dE2F are critical regulators of S-phase entry during Drosophila embryogenesis...
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