Genomes and Genes
Gene Symbol: CycB
Description: Cyclin B
Alias: 3510, CG3510, CYC-B, CYCB, Cyc B, Cycb, DmcycB, Dmel\CG3510, chr2R:18312808..18312907, cyc B, cyc-B, cycB, cycb, cyclin B, cyclinB, mAbF2F4, cyclin B, CG3510-PA, CG3510-PB, CG3510-PC, CG3510-PE, CycB-PA, CycB-PB, CycB-PC, CycB-PE, Cyclin-B, cyclin B1, cyclinB, dCyclinB
Species: fruit fly
- Archambault V, D Avino P, Deery M, Lilley K, Glover D. Sequestration of Polo kinase to microtubules by phosphopriming-independent binding to Map205 is relieved by phosphorylation at a CDK site in mitosis. Genes Dev. 2008;22:2707-20 pubmed publisher..We propose that Map205-dependent targeting of Polo to microtubules provides a stable reservoir of Polo that can be rapidly mobilized by the activity of Cdk1 at mitotic entry. ..
- Morris J, Hong A, Lilly M, Lehmann R. twin, a CCR4 homolog, regulates cyclin poly(A) tail length to permit Drosophila oogenesis. Development. 2005;132:1165-74 pubmed..We propose that Twin/Ccr4 functions during early oogenesis to coordinate cyst division, oocyte fate specification and egg chamber maturation. ..
- Maldonado Codina G, Glover D. Cyclins A and B associate with chromatin and the polar regions of spindles, respectively, and do not undergo complete degradation at anaphase in syncytial Drosophila embryos. J Cell Biol. 1992;116:967-76 pubmed..regions of the chromosomes onto the metaphase plate all take place within the surface layer occupied by cyclin B on the apical side of the blastoderm nuclei...
- Swan A, Schupbach T. The Cdc20 (Fzy)/Cdh1-related protein, Cort, cooperates with Fzy in cyclin destruction and anaphase progression in meiosis I and II in Drosophila. Development. 2007;134:891-9 pubmed..cyclin destruction globally in the egg, Cort and Fzy appear to both be required for the local destruction of cyclin B on spindles...
- Knoblich J, Lehner C. Synergistic action of Drosophila cyclins A and B during the G2-M transition. EMBO J. 1993;12:65-74 pubmedA variety of different cyclin proteins have been identified in higher eukaryotes. In the case of cyclin B, functional analyses have clearly demonstrated an important role in the control of entry into mitosis...
- Rangone H, Wegel E, Gatt M, Yeung E, Flowers A, Debski J, et al. Suppression of scant identifies Endos as a substrate of greatwall kinase and a negative regulator of protein phosphatase 2A in mitosis. PLoS Genet. 2011;7:e1002225 pubmed publisher..Together these interactions suggest that Greatwall and Endos act to promote the inactivation of PP2A-Twins/B55 in Drosophila. We discuss the involvement of Polo kinase in such a regulatory loop. ..
- Rimmington G, Dalby B, Glover D. Expression of N-terminally truncated cyclin B in the Drosophila larval brain leads to mitotic delay at late anaphase. J Cell Sci. 1994;107 ( Pt 10):2729-38 pubmedWe have introduced an N-terminally truncated form of cyclin B into the Drosophila germ-line downstream of the yeast upstream activator that responds to GAL4...
- Meyer C, Kramer I, Dittrich R, Marzodko S, Emmerich J, Lehner C. Drosophila p27Dacapo expression during embryogenesis is controlled by a complex regulatory region independent of cell cycle progression. Development. 2002;129:319-28 pubmed..The dacapo regulatory region includes many independent cis-regulatory elements. The elements that control epidermal expression integrate developmental cues that time the arrest of cell proliferation...
- Schaeffer V, Althauser C, Shcherbata H, Deng W, Ruohola Baker H. Notch-dependent Fizzy-related/Hec1/Cdh1 expression is required for the mitotic-to-endocycle transition in Drosophila follicle cells. Curr Biol. 2004;14:630-6 pubmed
- Fischer M, Heeger S, Hacker U, Lehner C. The mitotic arrest in response to hypoxia and of polar bodies during early embryogenesis requires Drosophila Mps1. Curr Biol. 2004;14:2019-24 pubmed..Finally, we show that Mps1 and the mitotic spindle checkpoint are responsible for the developmental cell cycle arrest of the three haploid products of female meiosis that are not used as the female pronucleus. ..
- Hatfield S, Shcherbata H, Fischer K, Nakahara K, Carthew R, Ruohola Baker H. Stem cell division is regulated by the microRNA pathway. Nature. 2005;435:974-8 pubmed..Hence, the miRNA pathway might be part of a mechanism that makes stem cells insensitive to environmental signals that normally stop the cell cycle at the G1/S transition. ..
- Whitfield W, Gonzalez C, Sánchez Herrero E, Glover D. Transcripts of one of two Drosophila cyclin genes become localized in pole cells during embryogenesis. Nature. 1989;338:337-40 pubmed..maternal mRNAs, but whereas the cyclin A mRNA is relatively uniformly distributed before cell formation, the cyclin B mRNA becomes localized to the developing pole cells...
- Cullen C, Brittle A, Ito T, Ohkura H. The conserved kinase NHK-1 is essential for mitotic progression and unifying acentrosomal meiotic spindles in Drosophila melanogaster. J Cell Biol. 2005;171:593-602 pubmed..NHK-1 itself is phosphorylated in mitosis and female meiosis, suggesting that this kinase is part of the regulatory system coordinating progression of mitosis and meiosis. ..
- Kylsten P, Saint R. Imaginal tissues of Drosophila melanogaster exhibit different modes of cell proliferation control. Dev Biol. 1997;192:509-22 pubmed..melanogaster development, but also reveals that at least one additional mechanism is utilized to control G2-phase length and thus cell proliferation in different developmental contexts. ..
- Carmena M, Riparbelli M, Minestrini G, Tavares A, Adams R, Callaini G, et al. Drosophila polo kinase is required for cytokinesis. J Cell Biol. 1998;143:659-71 pubmed..In spite of these defects, cyclin B is degraded and the cells exit M phase...
- Huang J, Raff J. The disappearance of cyclin B at the end of mitosis is regulated spatially in Drosophila cells. EMBO J. 1999;18:2184-95 pubmedWe have followed the behaviour of a cyclin B-green fluorescent protein (GFP) fusion protein in living Drosophila embryos in order to study how the localization and destruction of cyclin B is regulated in space and time...
- Parry D, O Farrell P. The schedule of destruction of three mitotic cyclins can dictate the timing of events during exit from mitosis. Curr Biol. 2001;11:671-83 pubmed..Stable cyclin A prolonged or blocked chromosome disjunction, leading to metaphase arrest. Stable cyclin B allowed the transition to anaphase, but anaphase A chromosome movements were slowed, anaphase B spindle ..
- Lopes C, Sampaio P, Williams B, Goldberg M, Sunkel C. The Drosophila Bub3 protein is required for the mitotic checkpoint and for normal accumulation of cyclins during G2 and early stages of mitosis. J Cell Sci. 2005;118:187-98 pubmed..Altogether, our data support the hypothesis that the mitotic checkpoint protein Bub3 is also required to regulate entry and progression through early stages of mitosis. ..
- Sauer K, Knoblich J, Richardson H, Lehner C. Distinct modes of cyclin E/cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila embryogenesis. Genes Dev. 1995;9:1327-39 pubmed..Observations in cyclin A mutants implicate G2 cyclins in this regulation. Our results suggest molecular explanations for the different rules governing S phase during mitotic and endoreduplication cycles. ..
- Kadyrova L, Habara Y, Lee T, Wharton R. Translational control of maternal Cyclin B mRNA by Nanos in the Drosophila germline. Development. 2007;134:1519-27 pubmed..Both proteins are also required for repression of maternal Cyclin B mRNA in the germline; it has not been clear whether they act directly on Cyclin B mRNA, and if so, whether ..
- Larochelle S, Pandur J, Fisher R, Salz H, Suter B. Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity. Genes Dev. 1998;12:370-81 pubmed..We show that cdk7 activity is required for the activation of both Cdc2/Cyclin A and Cdc2/Cyclin B complexes, and for cell division...
- Vass S, Cotterill S, Valdeolmillos A, Barbero J, Lin E, Warren W, et al. Depletion of Drad21/Scc1 in Drosophila cells leads to instability of the cohesin complex and disruption of mitotic progression. Curr Biol. 2003;13:208-18 pubmed..The observation of SA instability in the absence of Drad21 implies that the expression of cohesin subunits and assembly of the cohesin complex will be tightly regulated. ..
- Jacobs H, Knoblich J, Lehner C. Drosophila Cyclin B3 is required for female fertility and is dispensable for mitosis like Cyclin B. Genes Dev. 1998;12:3741-51 pubmed..Cyclins A, B, and B3 cooperate to regulate mitosis, but surprisingly single mutants reveal that neither Cyclin B3 nor Cyclin B is required for mitosis. However, both are required for female fertility and Cyclin B also for male fertility.
- Leismann O, Herzig A, Heidmann S, Lehner C. Degradation of Drosophila PIM regulates sister chromatid separation during mitosis. Genes Dev. 2000;14:2192-205 pubmed..Whereas these securins are known to form a complex with separins, we show that PIM associates in vivo with THR, which does not contain the conserved separin domain. ..
- Baker N, Yu S. The EGF receptor defines domains of cell cycle progression and survival to regulate cell number in the developing Drosophila eye. Cell. 2001;104:699-708 pubmed..Through proliferation and survival control, such signals couple the total number of uncommitted cells being generated to the neural patterning of the retina. ..
- Deak P, Donaldson M, Glover D. Mutations in mákos, a Drosophila gene encoding the Cdc27 subunit of the anaphase promoting complex, enhance centrosomal defects in polo and are suppressed by mutations in twins/aar, which encodes a regulatory subunit of PP2A. J Cell Sci. 2003;116:4147-58 pubmed..In contrast to metaphase-checkpoint-arrested cells, such mutant neuroblasts contain elevated levels not only of cyclin B but also of cyclin A...
- Royou A, McCusker D, Kellogg D, Sullivan W. Grapes(Chk1) prevents nuclear CDK1 activation by delaying cyclin B nuclear accumulation. J Cell Biol. 2008;183:63-75 pubmed publisher..We injected cyclin B (CycB) into Drosophila melanogaster embryos during interphase of syncytial cycles and monitored effects on ..
- Savvidou E, Cobbe N, Steffensen S, Cotterill S, Heck M. Drosophila CAP-D2 is required for condensin complex stability and resolution of sister chromatids. J Cell Sci. 2005;118:2529-43 pubmed
- Wang Z, Lin H. The division of Drosophila germline stem cells and their precursors requires a specific cyclin. Curr Biol. 2005;15:328-33 pubmed..Moreover, both female and male CycB mutant GSCs fail to be maintained properly. Removing Cyclin B specifically from female GSCs causes the same defect, confirming the direct and cell-autonomous function of ..
- Giet R, Glover D. Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis. J Cell Biol. 2001;152:669-82 pubmed..This is accompanied by a failure to correctly localize the Pavarotti kinesin-like protein, essential for this process. We discuss these conserved functions of Aurora B kinase in chromosome transmission and cytokinesis. ..
- Pimentel A, Venkatesh T. rap gene encodes Fizzy-related protein (Fzr) and regulates cell proliferation and pattern formation in the developing Drosophila eye-antennal disc. Dev Biol. 2005;285:436-46 pubmed..Loss-of-function mutations in rap cause unscheduled accumulation of cyclin B in the developing eye imaginal disc, resulting in additional mitotic cycles and defective patterning of the ..
- Jongens T, Ackerman L, Swedlow J, Jan L, Jan Y. Germ cell-less encodes a cell type-specific nuclear pore-associated protein and functions early in the germ-cell specification pathway of Drosophila. Genes Dev. 1994;8:2123-36 pubmed..We also present evidence indicating that the gcl protein associates specifically with the nuclear pores of the pole cell nuclei. This localization suggests a novel mechanism in the specification of cell fate for the germ line. ..
- Pearson N, Cullen C, Dzhindzhev N, Ohkura H. A pre-anaphase role for a Cks/Suc1 in acentrosomal spindle formation of Drosophila female meiosis. EMBO Rep. 2005;6:1058-63 pubmed..We showed that the second cks gene cks85A, in contrast, has an important role in mitosis. In conclusion, this study describes a new pre-anaphase role for a Cks in acentrosomal meiotic spindle formation. ..
- Jacobs H, Richter D, Venkatesh T, Lehner C. Completion of mitosis requires neither fzr/rap nor fzr2, a male germline-specific Drosophila Cdh1 homolog. Curr Biol. 2002;12:1435-41 pubmed..Moreover, by characterizing fzr alleles, we demonstrate that completion of mitosis including Cyclin B degradation does not require FZR...
- Glover D. Mitosis in the Drosophila embryo--in and out of control. Trends Genet. 1991;7:125-32 pubmed..Such regulation is introduced together with a G2 phase in cycle 14, and the network of universal mitotic regulators comes under the overall control of string, a cdc25 homologue, whose transcription is activated within mitotic domains. ..
- Deshpande G, Calhoun G, Yanowitz J, Schedl P. Novel functions of nanos in downregulating mitosis and transcription during the development of the Drosophila germline. Cell. 1999;99:271-81 pubmed..Supporting the conclusion that Sxl is an important target for nos repression, ectopic, premature expression of Sxl protein in germ cells disrupts migration and stimulates mitotic activity. ..
- Edgar B, Orr Weaver T. Endoreplication cell cycles: more for less. Cell. 2001;105:297-306 pubmed
- Adams R, Maiato H, Earnshaw W, Carmena M. Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation. J Cell Biol. 2001;153:865-80 pubmed..These experiments reveal that INCENP is required for aurora B kinase function and confirm that the chromosomal passengers have essential roles in mitosis. ..
- Ivanovska I, Khandan T, Ito T, Orr Weaver T. A histone code in meiosis: the histone kinase, NHK-1, is required for proper chromosomal architecture in Drosophila oocytes. Genes Dev. 2005;19:2571-82 pubmed..These studies reveal a critical role for histone modifications in chromosome dynamics in meiosis and mitosis. ..
- Benoit B, Mitou G, Chartier A, Temme C, Zaessinger S, Wahle E, et al. An essential cytoplasmic function for the nuclear poly(A) binding protein, PABP2, in poly(A) tail length control and early development in Drosophila. Dev Cell. 2005;9:511-22 pubmed..PABP2, together with the deadenylase CCR4, regulates the poly(A) tails of oskar and cyclin B mRNAs, both of which are also controlled by cytoplasmic polyadenylation...
- Baker C, Fuller M. Translational control of meiotic cell cycle progression and spermatid differentiation in male germ cells by a novel eIF4G homolog. Development. 2007;134:2863-9 pubmed..is required post-transcriptionally for normal accumulation of the core cell cycle regulatory proteins Twine and CycB in mature spermatocytes. Loss of eIF4G2 function also causes widespread defects in spermatid differentiation...
- Donaldson M, Tavares A, Ohkura H, Deak P, Glover D. Metaphase arrest with centromere separation in polo mutants of Drosophila. J Cell Biol. 2001;153:663-76 pubmed..We discuss roles for Polo kinase in recruiting centrosomal proteins and in regulating progression through the metaphase-anaphase checkpoint. ..
- Monk A, Siddall N, Volk T, Fraser B, Quinn L, McLaughlin E, et al. HOW is required for stem cell maintenance in the Drosophila testis and for the onset of transit-amplifying divisions. Cell Stem Cell. 2010;6:348-60 pubmed publisher..Here we demonstrate that the HOW RNA-binding protein is required for maintenance of CycB and therefore mitotic progression in GSCs and gonialblasts as well as determining the timing of the spermatogonial ..
- Li X, Han Y, Xi R. Polycomb group genes Psc and Su(z)2 restrict follicle stem cell self-renewal and extrusion by controlling canonical and noncanonical Wnt signaling. Genes Dev. 2010;24:933-46 pubmed publisher..Given evolutionary conservation of PcG genes from Drosophila to mammals, they could have similar functions in mammalian stem cells and cancer. ..
- Bhat M, Philp A, Glover D, Bellen H. Chromatid segregation at anaphase requires the barren product, a novel chromosome-associated protein that interacts with Topoisomerase II. Cell. 1996;87:1103-14 pubmed..Centromeres move apart at the metaphase-anaphase transition and Cyclin B is degraded, but sister chromatids remain connected, resulting in chromatin bridging...
- Penton A, Selleck S, Hoffmann F. Regulation of cell cycle synchronization by decapentaplegic during Drosophila eye development. Science. 1997;275:203-6 pubmed..DPP may affect cell cycle synchronization by promoting cell cycle progression through the G2-M phases. This synchronization is critical for the precise assembly of the eye. ..
- Reed B, Orr Weaver T. The Drosophila gene morula inhibits mitotic functions in the endo cell cycle and the mitotic cell cycle. Development. 1997;124:3543-53 pubmed..During oogenesis in wild-type Drosophila, nurse cells become polyploid and do not contain cyclin B protein...
- Whitfield W, Gonzalez C, Maldonado Codina G, Glover D. The A- and B-type cyclins of Drosophila are accumulated and destroyed in temporally distinct events that define separable phases of the G2-M transition. EMBO J. 1990;9:2563-72 pubmedWe show that the sequence of Drosophila cyclin B has greater identity with B-type cyclins from other animal phyla than with Drosophila cyclin A, suggesting that the two cyclins have distinct roles that have been maintained in evolution...
- Sigrist S, Jacobs H, Stratmann R, Lehner C. Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3. EMBO J. 1995;14:4827-38 pubmed..Mutations in fzy block both sister chromosome separation and segregation, indicating that fzy plays a crucial role in the metaphase/anaphase transition. ..
- Dawson I, Roth S, Artavanis Tsakonas S. The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae. J Cell Biol. 1995;129:725-37 pubmed..Our data suggest that fzy function is required for normal cell cycle-regulated proteolysis that is necessary for successful progress through mitosis. ..
- Papoulas O, Monzo K, Cantin G, Ruse C, Yates J, Ryu Y, et al. dFMRP and Caprin, translational regulators of synaptic plasticity, control the cell cycle at the Drosophila mid-blastula transition. Development. 2010;137:4201-9 pubmed publisher..Caprin collaborate to control the cell cycle at the MBT by directly mediating the normal repression of maternal Cyclin B mRNA and the activation of zygotic frühstart mRNA...
- Royou A, Sullivan W, Karess R. Cortical recruitment of nonmuscle myosin II in early syncytial Drosophila embryos: its role in nuclear axial expansion and its regulation by Cdc2 activity. J Cell Biol. 2002;158:127-37 pubmed..The cortical myosin cycle does not require microtubules but correlates inversely with Cdc2/cyclinB (mitosis-promoting factor) activity...
- Sun J, Deng W. Notch-dependent downregulation of the homeodomain gene cut is required for the mitotic cycle/endocycle switch and cell differentiation in Drosophila follicle cells. Development. 2005;132:4299-308 pubmed..Our data suggest that Cut functions in regulating both cell differentiation and the cell cycle, and that downregulation of Cut by Notch contributes to the mitotic cycle/endocycle switch and cell differentiation in follicle cells. ..
- Raff J, Jeffers K, Huang J. The roles of Fzy/Cdc20 and Fzr/Cdh1 in regulating the destruction of cyclin B in space and time. J Cell Biol. 2002;157:1139-49 pubmedIn Drosophila cells cyclin B is normally degraded in two phases: (a) destruction of the spindle-associated cyclin B initiates at centrosomes and spreads to the spindle equator; and (b) any remaining cytoplasmic cyclin B is degraded ..
- Pauli A, Althoff F, Oliveira R, Heidmann S, Schuldiner O, Lehner C, et al. Cell-type-specific TEV protease cleavage reveals cohesin functions in Drosophila neurons. Dev Cell. 2008;14:239-51 pubmed publisher..These data demonstrate essential roles for cohesin in nondividing cells and also introduce a powerful tool by which to investigate protein function in metazoa. ..
- Lehner C, O Farrell P. The roles of Drosophila cyclins A and B in mitotic control. Cell. 1990;61:535-47 pubmedWe have cloned, sequenced, and characterized the expression of a Drosophila cyclin B gene. The independent evolutionary conservation of A- and B-type cyclins implies that they have distinct roles...
- Huang J, Raff J. The dynamic localisation of the Drosophila APC/C: evidence for the existence of multiple complexes that perform distinct functions and are differentially localised. J Cell Sci. 2002;115:2847-56 pubmedIn Drosophila cells, the destruction of cyclin B is spatially regulated. In cellularised embryos, cyclin B is initially degraded on the mitotic spindle and is then degraded in the cytoplasm...
- Griffiths R, Hidalgo A. Prospero maintains the mitotic potential of glial precursors enabling them to respond to neurons. EMBO J. 2004;23:2440-50 pubmed..This enables prospero-expressing cells alone to divide further upon elimination of neurons and to adjust glial number to axons during development. ..
- Wakefield J, Huang J, Raff J. Centrosomes have a role in regulating the destruction of cyclin B in early Drosophila embryos. Curr Biol. 2000;10:1367-70 pubmedWe reported previously that the disappearance of cyclin B at the end of mitosis in early Drosophila embryos starts at centrosomes and spreads into the spindle ...
- Thomas B, Gunning D, Cho J, Zipursky L. Cell cycle progression in the developing Drosophila eye: roughex encodes a novel protein required for the establishment of G1. Cell. 1994;77:1003-14 pubmed..e., Ras1 and Star). rux encodes a novel protein of 335 amino acids. We propose that rux functions as a negative regulator of G1 progression in the developing eye. ..
- Stiffler L, Ji J, Trautmann S, Trusty C, Schubiger G. Cyclin A and B functions in the early Drosophila embryo. Development. 1999;126:5505-13 pubmed..b>Cyclin B was predominantly cytoplasmic, and localized within nuclei only during late prophase...
- Buffin E, Emre D, Karess R. Flies without a spindle checkpoint. Nat Cell Biol. 2007;9:565-72 pubmed..divide correctly despite having no SAC and an accelerated 'clock', which is caused by premature degradation of cyclin B. Mitosis in Drosophila does not need the SAC because correct chromosome attachment is achieved very rapidly, ..
- Lane M, Sauer K, Wallace K, Jan Y, Lehner C, Vaessin H. Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development. Cell. 1996;87:1225-35 pubmed..Mutants unable to express the inhibitor fail to arrest cell proliferation after mitosis 16 and progress through an extra division cycle. Conversely, premature dacapo expression in transgenic embryos results in a precocious G1 arrest. ..
- Reber A, Lehner C, Jacobs H. Terminal mitoses require negative regulation of Fzr/Cdh1 by Cyclin A, preventing premature degradation of mitotic cyclins and String/Cdc25. Development. 2006;133:3201-11 pubmed..of Cyclin A, premature Fizzy-related/Cdh1 activity results in the premature degradation of the Cdk1 activators Cyclin B and Cyclin B3, and apparently of String/Cdc25 phosphatase as well...
- Vrailas A, Moses K. Smoothened, thickveins and the genetic control of cell cycle and cell fate in the developing Drosophila eye. Mech Dev. 2006;123:151-65 pubmed..We conclude that both pathways have several, but differing roles in furrow induction and cell fate and survival, but that neither directly affects cell type specification. ..
- Su T, Walker J, Stumpff J. Activating the DNA damage checkpoint in a developmental context. Curr Biol. 2000;10:119-26 pubmed..Delaying cell division has little effect on gastrulation and developmentally regulated string gene expression, supporting the view that development generally dictates cell proliferation and not vice versa. ..
- Onischenko E, Gubanova N, Kiseleva E, Hallberg E. Cdk1 and okadaic acid-sensitive phosphatases control assembly of nuclear pore complexes in Drosophila embryos. Mol Biol Cell. 2005;16:5152-62 pubmed..In agreement recombinant Cdk1/cyclin B was able to induce phosphorylation and dissociation of nucleoporins from the NPCs in vitro...
- Quinn L, Herr A, McGarry T, Richardson H. The Drosophila Geminin homolog: roles for Geminin in limiting DNA replication, in anaphase and in neurogenesis. Genes Dev. 2001;15:2741-54 pubmed..In a partially female-sterile Dm geminin mutant, excessive DNA amplification in the ovarian follicle cells is observed. Our data suggest roles for Dm Geminin in limiting DNA replication, in anaphase and in neural differentiation. ..
- de Nooij J, Letendre M, Hariharan I. A cyclin-dependent kinase inhibitor, Dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesis. Cell. 1996;87:1237-47 pubmed..Thus, dap functions during embryogenesis to achieve a precisely timed exit from the cell cycle. ..
- Ou C, Wang C, Jiang J, Chien C. Suppression of Hedgehog signaling by Cul3 ligases in proliferation control of retinal precursors. Dev Biol. 2007;308:106-19 pubmed..Taken together, these results suggest that Cul3 downregulates Ci levels to modulate Hh signaling activity, thus ensuring proper cell proliferation during retinal development. ..
- McCleland M, O Farrell P. RNAi of mitotic cyclins in Drosophila uncouples the nuclear and centrosome cycle. Curr Biol. 2008;18:245-54 pubmed publisher..We suggest that high mitotic cyclin normally ensures that the centrosome cycle remains entrained to the nuclear cycle. ..
- Pesin J, Orr Weaver T. Developmental role and regulation of cortex, a meiosis-specific anaphase-promoting complex/cyclosome activator. PLoS Genet. 2007;3:e202 pubmed..Our studies reveal the mechanism for developmental regulation of an APC/C activator and suggest it is one strategy for control of the female meiotic cell cycle in a multicellular organism. ..
- Sibon O, Laurencon A, Hawley R, Theurkauf W. The Drosophila ATM homologue Mei-41 has an essential checkpoint function at the midblastula transition. Curr Biol. 1999;9:302-12 pubmed..Cyclins are required for Cdc2 kinase activity, and mutations in cyclin A and cyclin B bypass the requirement for mei-41 at the MBT...
- Irniger S. Cyclin destruction in mitosis: a crucial task of Cdc20. FEBS Lett. 2002;532:7-11 pubmed..Remarkably, a complete inactivation of cyclin-dependent kinases seems to be not essential. This review discusses recent novel insights into cyclin destruction and its implications for the mitotic exit. ..