Gene Symbol: Cul1
Description: Cullin 1
Alias: CG1877, CUL1, Cul-1, Cul1[Ex], Cullin-1, Cullin1, Dmel\CG1877, Lin-19, Lin19, Q9V312, cul-1, cul1, dCUL1, dCul-1, dCul1, dmCUL1, l(2)02074, l(2)k01207, lin 19, lin-19/cul-1, lin19, lin19-like, cullin 1, CG1877-PA, CG1877-PB, CG1877-PC, CG1877-PD, Cul1-PA, Cul1-PB, Cul1-PC, Cul1-PD, cullin, cullin-1, cullin1, dCullin, dCullin1, lin-19-like, lin19-like
Species: fruit fly

Top Publications

  1. Bocca S, Muzzopappa M, Silberstein S, Wappner P. Occurrence of a putative SCF ubiquitin ligase complex in Drosophila. Biochem Biophys Res Commun. 2001;286:357-64 pubmed
    ..Our results suggest that dRbx1, dSkpA, dCullin1, and Slimb proteins are components of a Drosophila SCF complex that functions in combination with the ubiquitin ..
  2. Chan Y, Yoon J, Wu J, Kim H, Pan K, Yim J, et al. DEN1 deneddylates non-cullin proteins in vivo. J Cell Sci. 2008;121:3218-23 pubmed publisher
    The ubiquitin-like protein Nedd8/Rub1 covalently modifies and activates cullin ubiquitin ligases. However, the repertoire of Nedd8-modified proteins and the regulation of protein neddylation status are not clear...
  3. Djagaeva I, Doronkin S. Dual regulation of dendritic morphogenesis in Drosophila by the COP9 signalosome. PLoS ONE. 2009;4:e7577 pubmed publisher
    ..In particular, CSN stimulates dendritic branching through Cullin1, and inhibits it via control of Cullin3 function...
  4. Zhou D, Xue J, Chen J, Morcillo P, Lambert J, White K, et al. Experimental selection for Drosophila survival in extremely low O(2) environment. PLoS ONE. 2007;2:e490 pubmed
    ..We found that down-regulation of several candidate genes including Best1, broad, CG7102, dunce, lin19-like and sec6 conferred severe hypoxia tolerance in Drosophila...
  5. Zhu S, Perez R, Pan M, Lee T. Requirement of Cul3 for axonal arborization and dendritic elaboration in Drosophila mushroom body neurons. J Neurosci. 2005;25:4189-97 pubmed
    Cul3 belongs to the family of cullin proteins, which function as scaffold proteins of E3 ubiquitin ligase complexes...
  6. Donaldson T, Noureddine M, Reynolds P, Bradford W, Duronio R. Targeted disruption of Drosophila Roc1b reveals functional differences in the Roc subunit of Cullin-dependent E3 ubiquitin ligases. Mol Biol Cell. 2004;15:4892-903 pubmed
    b>Cullin-dependent ubiquitin ligases regulate a variety of cellular and developmental processes by recruiting specific proteins for ubiquitin-mediated degradation...
  7. Kim S, Kim H, Kim S, Yim J. Drosophila Cand1 regulates Cullin3-dependent E3 ligases by affecting the neddylation of Cullin3 and by controlling the stability of Cullin3 and adaptor protein. Dev Biol. 2010;346:247-57 pubmed publisher
    ..and neddylation-dissociated 1 (Cand1) is known to negatively regulate CRL activity by sequestering unneddylated Cullin1 (Cul1) in biochemical studies...
  8. Rencus Lazar S, Amir Y, Wu J, Chien C, Chamovitz D, Segal D. The proto-oncogene Int6 is essential for neddylation of Cul1 and Cul3 in Drosophila. PLoS ONE. 2008;3:e2239 pubmed publisher
    ..pombe, and the COP9 signalosome. The COP9 signalosome regulates the activity of Cullin-Ring Ubiquitin Ligases via deneddylation of their cullin subunit...
  9. Wu J, Lin H, Hu Y, Chien C. Neddylation and deneddylation regulate Cul1 and Cul3 protein accumulation. Nat Cell Biol. 2005;7:1014-20 pubmed
    ..Here we show that in cells deficient for CSN activity, cullin1 (Cul1) and cullin3 (Cul3) proteins are unstable, and that to preserve their normal cellular levels, CSN ..

More Information


  1. Hériché J, Ang D, Bier E, O Farrell P. Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila. BMC Genet. 2003;4:9 pubmed
    b>Cul1 is a core component of the evolutionarily conserved SCF-type ubiquitin ligases that target specific proteins for destruction...
  2. Filippov V, Filippova M, Sehnal F, Gill S. Temporal and spatial expression of the cell-cycle regulator cul-1 in Drosophila and its stimulation by radiation-induced apoptosis. J Exp Biol. 2000;203:2747-56 pubmed
    ..Zygotic transcription of the gene, however, resumes at early stages of embryogenesis. We also found an increase in cul-1 transcription in cultured cells treated with a lethal dose of gamma-irradiation. ..
  3. Ou C, Lin Y, Chen Y, Chien C. Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development. Genes Dev. 2002;16:2403-14 pubmed
    The ubiquitin-like protein, Nedd8, covalently modifies members of the Cullin family. Cullins are the major components of a series of ubiquitin ligases that control the degradation of a broad range of proteins...
  4. Watts R, Hoopfer E, Luo L. Axon pruning during Drosophila metamorphosis: evidence for local degeneration and requirement of the ubiquitin-proteasome system. Neuron. 2003;38:871-85 pubmed
    ..Our findings suggest that some forms of axon pruning during development may share similarities with degeneration of axons in response to injury. ..
  5. Djagaeva I, Doronkin S. COP9 limits dendritic branching via Cullin3-dependent degradation of the actin-crosslinking BTB-domain protein Kelch. PLoS ONE. 2009;4:e7598 pubmed publisher
    ..In particular, we have reported that CSN stimulates dendritic branching via Cullin1-mediated proteolysis...
  6. Doronkin S, Djagaeva I, Beckendorf S. The COP9 signalosome promotes degradation of Cyclin E during early Drosophila oogenesis. Dev Cell. 2003;4:699-710 pubmed
    ..Using CSN4 and CSN5/Jab1 mutants, we show that the CSN acts during Drosophila oogenesis to remove Nedd8 from Cullin1, a subunit of the SCF ubiquitin ligase...
  7. Higa L, Yang X, Zheng J, Banks D, Wu M, Ghosh P, et al. Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo/p27Kip1 and cyclin E degradation. Cell Cycle. 2006;5:71-7 pubmed
    The CUL4 (cullin 4) proteins are the core components of a new class of ubiquitin E3 ligases that regulate replication and transcription...
  8. Kim H, Kim S, Shim S, Park E, Kim C, Kim K, et al. Drosophila homolog of APP-BP1 (dAPP-BP1) interacts antagonistically with APPL during Drosophila development. Cell Death Differ. 2007;14:103-15 pubmed
    ..APPL overexpression is shown to inhibit the NEDD8 conjugation pathway. APPL-induced apoptosis is rescued by overexpression of dAPP-BP1. Our data suggest that APPL and dAPP-BP1 interact antagonistically during Drosophila development. ..
  9. Rogers G, Rusan N, Roberts D, Peifer M, Rogers S. The SCF Slimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication. J Cell Biol. 2009;184:225-39 pubmed publisher
    ..Genetic analyses have suggested an involvement for Skp/Cullin/F box (SCF)-class ubiquitin ligases in this process...
  10. Cope G, Suh G, Aravind L, Schwarz S, Zipursky S, Koonin E, et al. Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Science. 2002;298:608-11 pubmed
    COP9 signalosome (CSN) cleaves the ubiquitin-like protein Nedd8 from the Cul1 subunit of SCF ubiquitin ligases...
  11. Ou C, Wang C, Jiang J, Chien C. Suppression of Hedgehog signaling by Cul3 ligases in proliferation control of retinal precursors. Dev Biol. 2007;308:106-19 pubmed
    b>Cullin-RING ubiquitin ligases ubiquitinate protein substrates and control their levels through degradation...
  12. Muzzopappa M, Wappner P. Multiple roles of the F-box protein Slimb in Drosophila egg chamber development. Development. 2005;132:2561-71 pubmed
    ..These complexes are composed of three constant polypeptides--Skp1, Cullin1/3 and Roc1/Rbx1--and a fourth variable adapter, the F-box protein...
  13. Kugler J, Woo J, Oh B, Lasko P. Regulation of Drosophila vasa in vivo through paralogous cullin-RING E3 ligase specificity receptors. Mol Cell Biol. 2010;30:1769-82 pubmed publisher
    ..Here, we found that Gustavus (Gus) and Fsn, two ubiquitin Cullin-RING E3 ligase specificity receptors, bind to the same motif on Vasa through their paralogous B30.2/SPRY domains...
  14. Elmore T, Smith D. Putative Drosophila odor receptor OR43b localizes to dendrites of olfactory neurons. Insect Biochem Mol Biol. 2001;31:791-8 pubmed
  15. Huang Y, Lu Y, Wu J, Chien C, Pi H. The COP9 signalosome converts temporal hormone signaling to spatial restriction on neural competence. PLoS Genet. 2014;10:e1004760 pubmed publisher
    ..We propose a model in which nuclear hormone receptors cooperate with the deneddylation machinery to temporally shutdown downstream target gene expression, conferring a spatial restriction on neural competence at the PWM. ..
  16. Bader M, Arama E, Steller H. A novel F-box protein is required for caspase activation during cellular remodeling in Drosophila. Development. 2010;137:1679-88 pubmed publisher
    ..Nutcracker interacts through its F-box domain with members of a Cullin-1-based ubiquitin ligase complex (SCF): Cullin-1 and SkpA...
  17. Li S, Wang C, Sandanaraj E, Aw S, Koe C, Wong J, et al. The SCFSlimb E3 ligase complex regulates asymmetric division to inhibit neuroblast overgrowth. EMBO Rep. 2014;15:165-74 pubmed publisher
    ..Here, we demonstrate that the SCF(Slimb) E3 ubiquitin ligase complex, which is composed of Cul1, SkpA, Roc1a and the F-box protein Supernumerary limbs (Slimb), inhibits ectopic neuroblast formation and regulates ..
  18. Bhutani S, Das A, Maheshwari M, Lakhotia S, Jana N. Dysregulation of core components of SCF complex in poly-glutamine disorders. Cell Death Dis. 2012;3:e428 pubmed publisher
    ..We found that Cullin1 (Cul1) and Skp1, core components of the SCF complex, are reduced in HD mice brain...
  19. Bosch J, Sumabat T, Hafezi Y, Pellock B, Gandhi K, Hariharan I. The Drosophila F-box protein Fbxl7 binds to the protocadherin fat and regulates Dachs localization and Hippo signaling. elife. 2014;3:e03383 pubmed publisher
    ..Fbxl7 can also regulate the trafficking of proteins between the apical membrane and intracellular vesicles. Thus Fbxl7 functions in a subset of pathways downstream of Ft and links Ft to D localization. ..
  20. Jiang J. Degrading Ci: who is Cul-pable?. Genes Dev. 2002;16:2315-21 pubmed
  21. Oren Giladi P, Krieger O, Edgar B, Chamovitz D, Segal D. Cop9 signalosome subunit 8 (CSN8) is essential for Drosophila development. Genes Cells. 2008;13:221-31 pubmed publisher
    ..CSN8 is present exclusively as part of the CSN holo-complex, and lack of CSN8 in the mutants leads to CSN instability. Consistent with this, Cullin deneddylation is impaired in the csn8(null) mutants.
  22. Gemmill R, Lee J, Chamovitz D, Segal D, Hooper J, Drabkin H. Growth suppression induced by the TRC8 hereditary kidney cancer gene is dependent upon JAB1/CSN5. Oncogene. 2005;24:3503-11 pubmed
    ..While there was no obvious influence on CSN deneddylation activity, the increase in CSN subunits and holocomplex suggests that TRC8 modulates signalosome levels or compartmentalization. ..
  23. Buster D, Daniel S, Nguyen H, Windler S, Skwarek L, Peterson M, et al. SCFSlimb ubiquitin ligase suppresses condensin II-mediated nuclear reorganization by degrading Cap-H2. J Cell Biol. 2013;201:49-63 pubmed publisher
    ..Therefore, SCF(Slimb)-mediated down-regulation of condensin II is required to maintain proper organization and morphology of the interphase nucleus. ..
  24. Ribeiro P, Holder M, Frith D, Snijders A, Tapon N. Crumbs promotes expanded recognition and degradation by the SCF(Slimb/?-TrCP) ubiquitin ligase. Proc Natl Acad Sci U S A. 2014;111:E1980-9 pubmed publisher
    ..We identify Skp/Cullin/F-box(Slimb/?-transducin repeats-containing protein) (SCF(Slimb/?-TrCP)) as the E3 ubiquitin ligase complex ..
  25. Li T, Giagtzoglou N, Eberl D, Jaiswal S, Cai T, Godt D, et al. The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals. elife. 2016;5: pubmed publisher
    ..Our work reveals a novel mechanism that regulates protein complexes affected in two forms of syndromic deafness and suggests a molecular function for Myosin IIa in auditory organs. ..
  26. Jin J, Harper J. RING finger specificity in SCF-driven protein destruction. Dev Cell. 2002;2:685-7 pubmed
    SCF ubiquitin ligases contain an E3 core composed of Skp1, Cul1, a member of the Rbx1/Roc1 family of RING finger proteins, and a modular F box protein that functions in substrate targeting...
  27. Smelkinson M, Zhou Q, Kalderon D. Regulation of Ci-SCFSlimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation. Dev Cell. 2007;13:481-95 pubmed
    ..We also show that when Ci proteolysis is compromised, its specific activity is limited principally by Su(fu), and not by Cos2 cytoplasmic tethering or PKA phosphorylation. ..
  28. Kroeger P, Shoue D, Mezzacappa F, Gerlach G, Wingert R, Schulz R. Knockdown of SCF(Skp2) function causes double-parked accumulation in the nucleus and DNA re-replication in Drosophila plasmatocytes. PLoS ONE. 2013;8:e79019 pubmed publisher
  29. Glatter T, Schittenhelm R, Rinner O, Roguska K, Wepf A, Jünger M, et al. Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome. Mol Syst Biol. 2011;7:547 pubmed publisher
    ..Subsequent genetic studies in flies suggest a role for dTTT in controlling cell growth via a dTORC1- and dTORC2-dependent mechanism. ..
  30. Rumpf S, Bagley J, Thompson Peer K, Zhu S, Gorczyca D, Beckstead R, et al. Drosophila Valosin-Containing Protein is required for dendrite pruning through a regulatory role in mRNA metabolism. Proc Natl Acad Sci U S A. 2014;111:7331-6 pubmed publisher
    ..Thus, our results highlight a proteolysis-independent function of the UPS during class IV dendritic arborization neuron dendrite pruning and link the UPS to the control of mRNA metabolism...
  31. Sarikas A, Hartmann T, Pan Z. The cullin protein family. Genome Biol. 2011;12:220 pubmed publisher
    b>Cullin proteins are molecular scaffolds that have crucial roles in the post-translational modification of cellular proteins involving ubiquitin...
  32. Hall J, Lee H, Bunker B, Dorn E, Rogers G, Duronio R, et al. Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage. J Biol Chem. 2008;283:25356-63 pubmed publisher
    ..We conclude that rereplication-associated DNA damage triggers Cdt1 and Cdc6 ubiquitination and destruction, and propose that this pathway represents an evolutionarily conserved mechanism that minimizes the extent of rereplication. ..
  33. Qian Y, Ng C, Schulz C. CSN maintains the germline cellular microenvironment and controls the level of stem cell genes via distinct CRLs in testes of Drosophila melanogaster. Dev Biol. 2015;398:68-79 pubmed publisher
    ..Reducing cullin2 (cul2) from the somatic support cells disrupted germline enclosure, while reducing cullin1 (cul1) from the somatic support cells led to a low level of Chinmo...
  34. Higa L, Mihaylov I, Banks D, Zheng J, Zhang H. Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint. Nat Cell Biol. 2003;5:1008-15 pubmed
    ..Our study reveals an evolutionarily conserved and uncharacterized G1 checkpoint that induces CDT1 proteolysis by the CUL4-ROC1 ubiquitin E3 ligase and CSN complexes in response to DNA damage. ..
  35. Christiansen A, Ding T, Fan Y, Graves H, Herz H, Lindblad J, et al. Non-cell autonomous control of apoptosis by ligand-independent Hedgehog signaling in Drosophila. Cell Death Differ. 2013;20:302-11 pubmed publisher
    ..This non-cell autonomous control of apoptosis highlights an underappreciated function of deregulated Hh signaling, which may help to generate a supportive micro-environment for tumor development. ..
  36. Li T, Fan J, Blanco Sanchez B, Giagtzoglou N, Lin G, Yamamoto S, et al. Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination. PLoS Genet. 2016;12:e1006054 pubmed publisher
    ..Finally, loss of UBR3 up-regulates Kif7 protein levels and decreases Hh signaling in cultured cells. In summary, our work identifies Ubr3 as a novel, evolutionarily conserved modulator of Hh signaling that boosts Hh in some tissues. ..
  37. Strutt H, Thomas MacArthur V, Strutt D. Strabismus promotes recruitment and degradation of farnesylated prickle in Drosophila melanogaster planar polarity specification. PLoS Genet. 2013;9:e1003654 pubmed publisher
    ..proximal cell ends, and we report here that it also promotes proteasomal degradation of excess Pk, probably via a Cullin-1 dependent process...
  38. Fereres S, Simón R, Busturia A. A novel dRYBP-SCF complex functions to inhibit apoptosis in Drosophila. Apoptosis. 2013;18:1500-12 pubmed publisher
    ..Binding Protein (dRYBP) protein interacts both genetically and biochemically with the E3 ubiquitin ligase SKPA, dCULLIN, F-box (SCF) complex to synergistically inhibit apoptosis in Drosophila...
  39. Zielke N, Querings S, Grosskortenhaus R, Reis T, Sprenger F. Molecular dissection of the APC/C inhibitor Rca1 shows a novel F-box-dependent function. EMBO Rep. 2006;7:1266-72 pubmed
    ..Rca1/Emi proteins contain a conserved F-box and interact with components of the Skp-Cullin-F-box (SCF) complex. So far, no function has been ascribed to this domain...
  40. Cho B, Pierre Louis G, Sagner A, Eaton S, Axelrod J. Clustering and negative feedback by endocytosis in planar cell polarity signaling is modulated by ubiquitinylation of prickle. PLoS Genet. 2015;11:e1005259 pubmed publisher
    ..We find that the E3 ubiquitin ligase complex Cullin1(Cul1)/SkpA/Supernumerary limbs(Slimb) regulates the stability of one of the peripheral membrane components, ..
  41. Szuplewski S, Sandmann T, Hietakangas V, Cohen S. Drosophila Minus is required for cell proliferation and influences Cyclin E turnover. Genes Dev. 2009;23:1998-2003 pubmed publisher
    ..Minus does not affect dMyc, another known SCF(Ago) substrate in Drosophila. We propose that Minus contributes to cell cycle regulation in part by selectively controlling turnover of Cyclin E. ..
  42. Stavropoulos N, Young M. insomniac and Cullin-3 regulate sleep and wakefulness in Drosophila. Neuron. 2011;72:964-76 pubmed publisher
    ..insomniac is a member of the BTB/POZ superfamily, which includes many proteins that function as adaptors for the Cullin-3 (Cul3) ubiquitin ligase complex...
  43. Zhang Z, Lv X, Yin W, Zhang X, Feng J, Wu W, et al. Ter94 ATPase complex targets k11-linked ubiquitinated ci to proteasomes for partial degradation. Dev Cell. 2013;25:636-44 pubmed publisher
    ..Ter94 regulates the partial degradation of ubiquitinated Ci by Cul1-Slimb-based E3 ligase through its adaptors Ufd1-like and dNpl4...
  44. Shibutani S, de la Cruz A, Tran V, Turbyfill W, Reis T, Edgar B, et al. Intrinsic negative cell cycle regulation provided by PIP box- and Cul4Cdt2-mediated destruction of E2f1 during S phase. Dev Cell. 2008;15:890-900 pubmed publisher
    ..We propose that pRb-independent inhibition of E2F during S phase is an evolutionarily conserved feature of the metazoan cell cycle that is necessary for development. ..
  45. Reynolds P, Simms J, Duronio R. Identifying determinants of cullin binding specificity among the three functionally different Drosophila melanogaster Roc proteins via domain swapping. PLoS ONE. 2008;3:e2918 pubmed publisher
    b>Cullin-dependent E3 ubiquitin ligases (CDL) are key regulators of protein destruction that participate in a wide range of cell biological processes...
  46. Zhang Y, Wang X, Matakatsu H, Fehon R, Blair S. The novel SH3 domain protein Dlish/CG10933 mediates fat signaling in Drosophila by binding and regulating Dachs. elife. 2016;5: pubmed publisher
    ..Dlish tethers Dachs to the subapical cell cortex, an effect partly mediated by the palmitoyltransferase Approximated under the control of Fat. Conversely, Dlish promotes the Fat-mediated degradation of Dachs. ..
  47. Ayyub C. Cullin-5 and cullin-2 play a role in the development of neuromuscular junction and the female germ line of Drosophila. J Genet. 2011;90:239-49 pubmed
    ..There are six cullin genes in Drosophila melanogaster...
  48. Mandal S, Freije W, Guptan P, Banerjee U. Metabolic control of G1-S transition: cyclin E degradation by p53-induced activation of the ubiquitin-proteasome system. J Cell Biol. 2010;188:473-9 pubmed publisher
    ..Our work provides in vivo genetic evidence for p53-mediated integration of metabolic stress signals, which modulate the activity of the ubiquitin-proteasome system to degrade cyclin E protein and thereby impose cell cycle arrest. ..
  49. Cunha Ferreira I, Rodrigues Martins A, Bento I, Riparbelli M, Zhang W, Laue E, et al. The SCF/Slimb ubiquitin ligase limits centrosome amplification through degradation of SAK/PLK4. Curr Biol. 2009;19:43-9 pubmed publisher
    ..Because the SCF/beta-Trcp complex plays an important role in cell-cycle progression, our results lead to new understanding of the control of centrosome number and how it may go awry in human disease. ..
  50. Khush R, Cornwell W, Uram J, Lemaitre B. A ubiquitin-proteasome pathway represses the Drosophila immune deficiency signaling cascade. Curr Biol. 2002;12:1728-37 pubmed substrates to the 26S proteasome, and mutations affecting either the Drosophila SCF components, Slimb and dCullin1, or the proteasome also induce Diptericin expression...
  51. Du J, Zhang J, Su Y, Liu M, Ospina J, Yang S, et al. In vivo RNAi screen reveals neddylation genes as novel regulators of Hedgehog signaling. PLoS ONE. 2011;6:e24168 pubmed publisher
    ..of the neddylation pathway; they function in an enzyme cascade to conjugate the ubiquitin-like NEDD8 modifier to Cullin proteins...
  52. Swarup S, Verheyen E. Drosophila homeodomain-interacting protein kinase inhibits the Skp1-Cul1-F-box E3 ligase complex to dually promote Wingless and Hedgehog signaling. Proc Natl Acad Sci U S A. 2011;108:9887-92 pubmed publisher
    ..Hipk acts to stabilize Armadillo by impeding the function of the E3 ubiquitin ligase Skp1-Cul1-F-box (SCF)(Slimb), thereby inhibiting Armadillo ubiquitination and subsequent degradation...
  53. Kuo C, Zhu S, Younger S, Jan L, Jan Y. Identification of E2/E3 ubiquitinating enzymes and caspase activity regulating Drosophila sensory neuron dendrite pruning. Neuron. 2006;51:283-90 pubmed
    ..Thus, in addition to uncovering E2/E3 ubiquitinating enzymes for dendrite pruning, this study provides a mechanistic link between UPS and the apoptotic machinery in regulating neuronal process remodeling. ..
  54. Ohlmeyer J, Schupbach T. Encore facilitates SCF-Ubiquitin-proteasome-dependent proteolysis during Drosophila oogenesis. Development. 2003;130:6339-49 pubmed
    ..Mutations in genes coding for components of the SCF pathway such as cul1, UbcD2 and effete enhance the extra division phenotype of encore...
  55. Han Y, Kwok B, Kernan M. Intraflagellar transport is required in Drosophila to differentiate sensory cilia but not sperm. Curr Biol. 2003;13:1679-86 pubmed
    ..NOMPB, the Drosophila homolog of IFT88, is required for the assembly of sensory cilia but not for the extension or function of the sperm flagellum. Assembly of this extremely long axoneme is therefore independent of IFT. ..