Gene Symbol: CtsB1
Description: Cathepsin B1
Alias: CG-10992, CG10992, CTSB1, Dmel\CG10992, anon-EST:ParkEST132, cathepsin B1, CG10992-PA, CG10992-PC, CtsB1-PA, CtsB1-PC, cathepsin B
Species: fruit fly

Top Publications

  1. Kocks C, Maehr R, Overkleeft H, Wang E, Iyer L, Lennon Dumenil A, et al. Functional proteomics of the active cysteine protease content in Drosophila S2 cells. Mol Cell Proteomics. 2003;2:1188-97 pubmed
    ..In support of this concept, we found CTS activity in phagosomes of Drosophila S2 cells. These results underscore the utility of activity profiling to address the functional role of insect proteases in immunity. ..
  2. Eissenberg J, Ilvarsonn A, Sly W, Waheed A, Krzyzanek V, Pohlmann R, et al. Drosophila GGA model: an ultimate gateway to GGA analysis. Traffic. 2011;12:1821-38 pubmed publisher
    ..This shows that Drosophila provides an excellent whole-animal model to gain new insights into the function of GGA in the physiological environment of a multicellular organism. ..
  3. Tseng T, Cheng C, Chen D, Shih M, Liu Y, Hsu S, et al. A molten globule-to-ordered structure transition of Drosophila melanogaster crammer is required for its ability to inhibit cathepsin. Biochem J. 2012;442:563-72 pubmed publisher
  4. Gruber J, Long A. Cis-regulatory variation is typically polyallelic in Drosophila. Genetics. 2009;181:661-70 pubmed publisher
    ..If standing cis-regulatory variation is actually slightly deleterious, the true mutational target size is larger. ..
  5. Creagh E, Brumatti G, Sheridan C, Duriez P, Taylor R, Cullen S, et al. Bicaudal is a conserved substrate for Drosophila and mammalian caspases and is essential for cell survival. PLoS ONE. 2009;4:e5055 pubmed publisher
    ..These data suggest that bicaudal/betaNAC is essential for cell survival and is a conserved target of caspases from flies to man. ..
  6. Von Ohlen T, Luce Fedrow A, Ortega M, Ganta R, Chapes S. Identification of critical host mitochondrion-associated genes during Ehrlichia chaffeensis infections. Infect Immun. 2012;80:3576-86 pubmed publisher
    ..chaffeensis replication and that it may be important for the provision of CTP, uridine, and cytidine nucleotides. ..
  7. Tseng T, Cheng C, Hsu S, Shih M, He P, Lyu P. Residue-specific annotation of disorder-to-order transition and cathepsin inhibition of a propeptide-like crammer from D. melanogaster. PLoS ONE. 2013;8:e54187 pubmed publisher
    ..E8, R28, R29, and E67 in the salt bridges considerably decrease the ability of crammer to inhibit Drosophila cathepsin B (CTSB)...
  8. Kowalewski Nimmerfall E, Schähs P, Maresch D, Rendic D, KRAMER H, Mach L. Drosophila melanogaster cellular repressor of E1A-stimulated genes is a lysosomal protein essential for fly development. Biochim Biophys Acta. 2014;1843:2900-12 pubmed publisher
    ..melanogaster flies. Ubiquitous depletion of dCREG proved lethal at the late pupal stage once a knock-down efficiency of >95% was achieved. These results demonstrate that dCREG is essential for proper completion of fly development. ..
  9. Kuronen M, Talvitie M, Lehesjoki A, Myllykangas L. Genetic modifiers of degeneration in the cathepsin D deficient Drosophila model for neuronal ceroid lipofuscinosis. Neurobiol Dis. 2009;36:488-93 pubmed publisher
    ..Our results warrant further investigation of these mechanisms in the pathogenesis of cathepsin D deficiency. ..

More Information


  1. Kuhn H, Sopko R, Coughlin M, Perrimon N, Mitchison T. The Atg1-Tor pathway regulates yolk catabolism in Drosophila embryos. Development. 2015;142:3869-78 pubmed publisher
    ..We propose that the conserved Tor metabolic sensing pathway regulates yolk catabolism, similar to Tor-dependent metabolic regulation on the lysosome. ..