Gene Symbol: Ctr1C
Description: Copper transporter 1C
Alias: BcDNA:AT31946, CG15551, Dmel\CG15551, FBgn0039813, copper transporter 1C, CG15551-PA, Ctr1C-PA
Species: fruit fly
Zhou H, Cadigan K, Thiele D. A copper-regulated transporter required for copper acquisition, pigmentation, and specific stages of development in Drosophila melanogaster. J Biol Chem. 2003;278:48210-8 pubmed
..Three distinct Drosophila Ctr1 genes (Ctr1A, Ctr1B, and Ctr1C) have been identified, which have unique expression patterns over the course of development...
Selvaraj A, Balamurugan K, Yepiskoposyan H, Zhou H, Egli D, Georgiev O, et al
. Metal-responsive transcription factor (MTF-1) handles both extremes, copper load and copper starvation, by activating different genes. Genes Dev. 2005;19:891-6 pubmed
..Thus, a single transcription factor, MTF-1, plays a direct role in both copper detoxification and acquisition by inducing the expression of metallothioneins and of a copper importer, respectively. ..
Hua H, Georgiev O, Schaffner W, Steiger D. Human copper transporter Ctr1 is functional in Drosophila, revealing a high degree of conservation between mammals and insects. J Biol Inorg Chem. 2010;15:107-13 pubmed publisher
..The fruit fly Drosophila has three family members, termed Ctr1A, Ctr1B, and Ctr1C. Ctr1A is expressed throughout development, and a null mutation causes lethality at an early stage...
Lang M, Fan Q, Wang L, Zheng Y, Xiao G, Wang X, et al
. Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates A?42-induced Alzheimer's disease-like symptoms. Neurobiol Aging. 2013;34:2604-12 pubmed publisher
..We found that inhibition of Ctr1C expression by RNAi in A?-expressing flies significantly reduced copper accumulation in the brains of the flies as ..
Southon A, Burke R, Norgate M, Batterham P, Camakaris J. Copper homoeostasis in Drosophila melanogaster S2 cells. Biochem J. 2004;383:303-9 pubmed
..This work is consistent with previous studies in mammalian cells, validating S2 cells as a model system for studying Cu transport and identifying novel Cu regulatory mechanisms. ..
Steiger D, Fetchko M, Vardanyan A, Atanesyan L, Steiner K, Turski M, et al
. The Drosophila copper transporter Ctr1C functions in male fertility. J Biol Chem. 2010;285:17089-97 pubmed publisher
..Drosophila has three Ctr1 homologs: Ctr1A, Ctr1B, and Ctr1C. Earlier work has shown that Ctr1A is an essential gene that is ubiquitously expressed throughout development, ..
Armstrong N, Ramamoorthy M, Lyon D, Jones K, Duttaroy A. Mechanism of silver nanoparticles action on insect pigmentation reveals intervention of copper homeostasis. PLoS ONE. 2013;8:e53186 pubmed publisher
..Finally, we claim that Drosophila, an established genetic model system, can be well utilized for further understanding of the biological effects of nanoparticles. ..