Gene Symbol: CstF-64
Description: Cleavage stimulation factor 64 kilodalton subunit
Alias: CG7697, CStF 64, CstF 64, CstF64, Dmel\CG7697, dCstF64, cleavage stimulation factor 64 kilodalton subunit, CG7697-PA, CstF-64-PA, cleavage stimulation factor
Species: fruit fly
Soller M, White K. ELAV inhibits 3'-end processing to promote neural splicing of ewg pre-mRNA. Genes Dev. 2003;17:2526-38 pubmed
..substrates in UV cross-linking assays suggest that ELAV does not inhibit or redirect binding of cleavage factor dCstF64 at the regulated polyadenylation site on ewg RNA...
Ding Y, Zhao L, Yang S, Jiang Y, Chen Y, Zhao R, et al
. A young Drosophila duplicate gene plays essential roles in spermatogenesis by regulating several Y-linked male fertility genes. PLoS Genet. 2010;6:e1001255 pubmed publisher
Hatton L, Eloranta J, Figueiredo L, Takagaki Y, Manley J, O Hare K. The Drosophila homologue of the 64 kDa subunit of cleavage stimulation factor interacts with the 77 kDa subunit encoded by the suppressor of forked gene. Nucleic Acids Res. 2000;28:520-6 pubmed
During mRNA 3' end formation, cleavage stimulation factor (CstF) binds to a GU-rich sequence downstream from the polyadenylation site and helps to stabilise the binding of cleavage-polyadenylation specificity factor (CPSF) to the ..
Gawande B, Robida M, Rahn A, Singh R. Drosophila Sex-lethal protein mediates polyadenylation switching in the female germline. EMBO J. 2006;25:1263-72 pubmed
..binds to multiple SXL-binding sites, which include the GU-rich poly(A) enhancer, and competes for the binding of CstF64 in vitro...
Salisbury J, Hutchison K, Graber J. A multispecies comparison of the metazoan 3'-processing downstream elements and the CstF-64 RNA recognition motif. BMC Genomics. 2006;7:55 pubmed
The Cleavage Stimulation Factor (CstF) is a required protein complex for eukaryotic mRNA 3'-processing...
Sullivan K, Steiniger M, Marzluff W. A core complex of CPSF73, CPSF100, and Symplekin may form two different cleavage factors for processing of poly(A) and histone mRNAs. Mol Cell. 2009;34:322-32 pubmed publisher
..Depletion of SLBP recruits CstF50 to histone genes. Knockdown of CPSF160 or CstF64 downregulates Symplekin but does not affect histone pre-mRNA processing or association of Symplekin with the ..
Tatomer D, Rizzardi L, Curry K, Witkowski A, Marzluff W, Duronio R. Drosophila Symplekin localizes dynamically to the histone locus body and tricellular junctions. Nucleus. 2014;5:613-25 pubmed publisher
..This localization depends on the RNA binding protein ypsilon schachtel. CPSF-73 and a number of mRNAs are localized at this same site, suggesting that Symplekin participates in cytoplasmic polyadenylation at tricellular junctions. ..