Gene Symbol: cryptocephal
Description: cryptocephal
Alias: 929, ATF-4, ATF4, ATF4/crc, Atf4, CG8669, DM6, Dmel\CG8669, Ire1, dATF-4, dATF4, l(2)crc, cryptocephal, CG8669-PA, CG8669-PB, CG8669-PE, CG8669-PF, crc-PA, crc-PB, crc-PE, crc-PF
Species: fruit fly
Products:     cryptocephal

Top Publications

  1. Gauthier S, Hewes R. Transcriptional regulation of neuropeptide and peptide hormone expression by the Drosophila dimmed and cryptocephal genes. J Exp Biol. 2006;209:1803-15 pubmed
    ..factor genes, the basic helix-loop-helix (bHLH) gene dimmed (dimm) and the basic-leucine zipper (bZIP) gene cryptocephal (crc), control expression of diverse neuropeptides and peptide hormones in Drosophila...
  2. Hewes R, Schaefer A, Taghert P. The cryptocephal gene (ATF4) encodes multiple basic-leucine zipper proteins controlling molting and metamorphosis in Drosophila. Genetics. 2000;155:1711-23 pubmed
    The cryptocephal (crc) mutation causes pleiotropic defects in ecdysone-regulated events during Drosophila molting and metamorphosis...
  3. Hewes R, Park D, Gauthier S, Schaefer A, Taghert P. The bHLH protein Dimmed controls neuroendocrine cell differentiation in Drosophila. Development. 2003;130:1771-81 pubmed
    ..We propose that dimmed encodes an integral component of a novel mechanism by which diverse neuroendocrine lineages differentiate and maintain the pro-secretory state. ..
  4. Ryoo H. Drosophila as a model for unfolded protein response research. BMB Rep. 2015;48:445-53 pubmed
    ..The fact that the basic UPR pathways are conserved, together with the availability of many human disease models in this organism, makes Drosophila a powerful tool for studying human disease mechanisms. ..
  5. Gauthier S, VanHaaften E, Cherbas L, Cherbas P, Hewes R. Cryptocephal, the Drosophila melanogaster ATF4, is a specific coactivator for ecdysone receptor isoform B2. PLoS Genet. 2012;8:e1002883 pubmed publisher
    ..Here we show that Cryptocephal (CRC), the Drosophila homolog of ATF4, is an ecdysone receptor coactivator that is specific for isoform B2...
  6. Shafer O, Taghert P. RNA-interference knockdown of Drosophila pigment dispersing factor in neuronal subsets: the anatomical basis of a neuropeptide's circadian functions. PLoS ONE. 2009;4:e8298 pubmed publisher
    ..These results reveal the neuroanatomical basis PDF's various circadian functions and refine our understanding of the clock neuron circuitry of Drosophila. ..
  7. Kang K, Ryoo H, Park J, Yoon J, Kang M. A Drosophila Reporter for the Translational Activation of ATF4 Marks Stressed Cells during Development. PLoS ONE. 2015;10:e0126795 pubmed publisher
    ..b>ATF4 is a transcription factor whose mRNA translation is stimulated in response to stress-activated eIF2alpha kinases...
  8. Demay Y, Perochon J, Szuplewski S, Mignotte B, Gaumer S. The PERK pathway independently triggers apoptosis and a Rac1/Slpr/JNK/Dilp8 signaling favoring tissue homeostasis in a chronic ER stress Drosophila model. Cell Death Dis. 2014;5:e1452 pubmed publisher
    ..We observed, in this novel model of chronic ER-stress, a PERK/ATF4-dependent apoptosis requiring downregulation of the antiapoptotic diap1 gene...
  9. Nelson H, Heiman R, Bolduc C, Kovalick G, Whitley P, Stern M, et al. Calmodulin point mutations affect Drosophila development and behavior. Genetics. 1997;147:1783-98 pubmed

More Information


  1. Fristrom J. Development of the morphological mutant cryptocephal of Drosophila melanogaster. Genetics. 1965;52:297-318 pubmed
  2. Ganetzky B. On the components of segregation distortion in Drosophila melanogaster. Genetics. 1977;86:321-55 pubmed
    ..The results of these studies allow a reinterpretation of results from earlier analyses of the SD system and serve to limit the possible mechanisms to account for segregation distortion. ..
  3. Brittnacher J, Ganetzky B. On the Components of Segregation Distortion in DROSOPHILA MELANOGASTER. II. Deletion Mapping and Dosage Analysis of the SD Locus. Genetics. 1983;103:659-73 pubmed
    ..The Sd product appears to act preferentially at Rsp(s) (sensitive-Responder) but may also act at Rsp(i) (insensitive-Responder). ..
  4. Kang M, Vasudevan D, Kang K, Kim K, Park J, Zhang N, et al. 4E-BP is a target of the GCN2-ATF4 pathway during Drosophila development and aging. J Cell Biol. 2017;216:115-129 pubmed publisher
    ..Here, we show that GCN2 and its downstream transcription factor, ATF4, mediate 4E-BP induction, and GCN2 is required for lifespan extension in response to dietary restriction of amino ..
  5. Kang M, Chung J, Ryoo H. CDK5 and MEKK1 mediate pro-apoptotic signalling following endoplasmic reticulum stress in an autosomal dominant retinitis pigmentosa model. Nat Cell Biol. 2012;14:409-15 pubmed publisher
    ..These findings establish a previously unrecognized branch of ER-stress response signalling involved in degenerative diseases. ..
  6. Abramov Y, Shatskikh A, Maksimenko O, Bonaccorsi S, Gvozdev V, Lavrov S. The Differences Between Cis- and Trans-Gene Inactivation Caused by Heterochromatin in Drosophila. Genetics. 2016;202:93-106 pubmed publisher
    ..We demonstrate that trans-inactivation is followed by de novo HP1a accumulation in the affected transgene; trans-inactivation is specifically favored by the chromatin remodeler SAYP and prevented by Argonaute AGO2. ..
  7. Diao F, Ironfield H, Luan H, Diao F, Shropshire W, Ewer J, et al. Plug-and-play genetic access to drosophila cell types using exchangeable exon cassettes. Cell Rep. 2015;10:1410-21 pubmed publisher
    ..We also introduce an exchangeable, MiMIC-like Trojan exon construct that can be targeted to coding introns using the Crispr/Cas system. ..
  8. Hilliker A, Holm D. Genetic analysis of the proximal region of chromosome 2 of Drosophila melanogaster. I. Detachment products of compound autosomes. Genetics. 1975;81:705-21 pubmed
    ..The data further demonstrate that rolled, and probably light, are located within the proximal heterochromatin. Thus, functional genetic loci are found in heterochromatin, albeit at low density. ..
  9. Bjordal M, Arquier N, Kniazeff J, Pin J, Leopold P. Sensing of amino acids in a dopaminergic circuitry promotes rejection of an incomplete diet in Drosophila. Cell. 2014;156:510-21 pubmed publisher
    ..Taken together, these data identify a central amino-acid-sensing mechanism operating in specific DA neurons and controlling food intake. ..
  10. Seo J, Fortuno E, Suh J, Stenesen D, Tang W, Parks E, et al. Atf4 regulates obesity, glucose homeostasis, and energy expenditure. Diabetes. 2009;58:2565-73 pubmed publisher
    We evaluate a potential role of activating transcription factor 4 (Atf4) in invertebrate and mammalian metabolism. With two parallel approaches-a fat body-specific green fluorescent protein enhancer trap screen in D...
  11. Yapici N, Zimmer M, Domingos A. Cellular and molecular basis of decision-making. EMBO Rep. 2014;15:1023-35 pubmed publisher
    ..These studies interrogate decision-making about food, sexual behaviour, aggression or foraging strategies, and add molecular and cell biology understanding onto the consilience of brain and decision. ..
  12. Hoskins R, Landolin J, Brown J, Sandler J, Takahashi H, Lassmann T, et al. Genome-wide analysis of promoter architecture in Drosophila melanogaster. Genome Res. 2011;21:182-92 pubmed publisher
    ..Our results contribute to the emerging view that core promoters are functionally diverse and control patterning of gene expression in Drosophila and mammals. ..
  13. Zhang Y, Cui C, Lai Z. The defender against apoptotic cell death 1 gene is required for tissue growth and efficient N-glycosylation in Drosophila melanogaster. Dev Biol. 2016;420:186-195 pubmed publisher
    ..Furthermore, Perk-Atf4 signaling, one branch of UPR pathways, appears to play a dual role in inducing cell apoptosis and mediating ..
  14. Celardo I, Lehmann S, Costa A, Loh S, Miguel Martins L. dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective. Cell Death Differ. 2017;24:638-648 pubmed publisher
    ..Here we uncover that this branch is triggered by the activating transcription factor 4 (ATF4)...
  15. Hatsuda H. Finding differentially expressed regions of arbitrary length in quantitative genomic data based on marked point process model. Bioinformatics. 2012;28:i633-i639 pubmed publisher
    ..The program used in this study is available at ..
  16. Lee J, Oney M, Frizzell K, Phadnis N, Hollien J. Drosophila melanogaster activating transcription factor 4 regulates glycolysis during endoplasmic reticulum stress. G3 (Bethesda). 2015;5:667-75 pubmed publisher
    ..The unfolded protein response transcription factor Atf4 was necessary for the up-regulation of glycolytic enzymes and Lactate dehydrogenase (Ldh)...
  17. Sparrow J. The recovery and preliminary examination of a temperature sensitive suppressor of the cryptocephal mutant of Drosophila melanogaster. Genet Res. 1981;38:297-314 pubmed
  18. Siegel J. Genetic characterization of the region of the Drosophila genome known to include the histone structural gene sequences. Genetics. 1981;98:505-27 pubmed
    ..The salivary map positions of certain of the complementation groups suggest that the mutants in these groups may affect histone gene functions. ..
  19. Lindström R, Lindholm P, Kallijärvi J, Palgi M, Saarma M, Heino T. Exploring the Conserved Role of MANF in the Unfolded Protein Response in Drosophila melanogaster. PLoS ONE. 2016;11:e0151550 pubmed publisher
    ..Our data suggest a role for Manf in the regulation of Drosophila UPR. ..
  20. Wright T, Hodgetts R, Sherald A. The genetics of dopa decarboxylase in Drosophila melanogaster. I. Isolation and characterization of deficiencies that delete the dopa-decarboxylase-dosage-sensitive region and the alpha-methyl-dopa-hypersensitive locus. Genetics. 1976;84:267-85 pubmed
    ..These deficiencies permit a localization of both the dopa-decarboxylase-dosage-sensitive region and the alpha-methyl-dopa-hypersensitive locus, l(2) amd, to the same region, 37B10-37C7. ..