Gene Symbol: Crtc
Description: CREB-regulated transcription coactivator
Alias: CG6064, CRTC, Dmel\CG6064, ORE-12, TORC, TORC1, cg6064, dTORC, CREB-regulated transcription coactivator, CG6064-PA, CG6064-PB, CG6064-PC, Crtc-PA, Crtc-PB, Crtc-PC, TORC
Species: fruit fly

Top Publications

  1. Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham J, et al. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Proc Natl Acad Sci U S A. 2003;100:12147-52 pubmed
    ..A protein, termed transducer of regulated cAMP response element-binding protein (CREB) (TORC1), was identified that activated expression through the variant CRE and consensus CRE sites...
  2. Bittinger M, McWhinnie E, Meltzer J, Iourgenko V, Latario B, Liu X, et al. Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins. Curr Biol. 2004;14:2156-61 pubmed
    ..Expression of the catalytic subunit of PKA and the calcium channel TRPV6 relocalized TORC1 to the nucleus...
  3. Wang B, Goode J, Best J, Meltzer J, Schilman P, Chen J, et al. The insulin-regulated CREB coactivator TORC promotes stress resistance in Drosophila. Cell Metab. 2008;7:434-44 pubmed publisher
    ..Here we show that starvation also triggers TORC activation in Drosophila, where it maintains energy balance through induction of CREB target genes in the brain...
  4. Xu K, Zheng X, Sehgal A. Regulation of feeding and metabolism by neuronal and peripheral clocks in Drosophila. Cell Metab. 2008;8:289-300 pubmed publisher
    ..We propose that the input of neuronal clocks and clocks in metabolic tissues is coordinated to provide effective energy homeostasis...
  5. Maia R, Valente V, Cunha M, Sousa J, Araujo D, Silva W, et al. Identification of unannotated exons of low abundance transcripts in Drosophila melanogaster and cloning of a new serine protease gene upregulated upon injury. BMC Genomics. 2007;8:249 pubmed
    ..Our results show that the computational identification and manual inspection are not sufficient to annotate a genome in the absence of experimentally derived data. ..
  6. Choi S, Kim W, Chung J. Drosophila salt-inducible kinase (SIK) regulates starvation resistance through cAMP-response element-binding protein (CREB)-regulated transcription coactivator (CRTC). J Biol Chem. 2011;286:2658-64 pubmed publisher
    ..homeostasis by inhibiting the cAMP-response element-binding protein (CREB)-regulated transcription coactivator (CRTC)...
  7. Hirano Y, Masuda T, Naganos S, Matsuno M, Ueno K, Miyashita T, et al. Fasting launches CRTC to facilitate long-term memory formation in Drosophila. Science. 2013;339:443-6 pubmed publisher
    ..fLTM uses the CREB coactivator CRTC, whereas spLTM uses the coactivator CBP. Thus, flies use distinct LTM machinery depending on their hunger state.
  8. Tiebe M, Lutz M, De La Garza A, Buechling T, Boutros M, Teleman A. REPTOR and REPTOR-BP Regulate Organismal Metabolism and Transcription Downstream of TORC1. Dev Cell. 2015;33:272-84 pubmed publisher
    b>TORC1 regulates growth and metabolism, in part, by influencing transcriptional programs...
  9. Deng H, Gerencser A, Jasper H. Signal integration by Ca(2+) regulates intestinal stem-cell activity. Nature. 2015;528:212-7 pubmed publisher
    ..concentrations induce ISC proliferation by regulating Calcineurin and CREB-regulated transcriptional co-activator (Crtc)...

More Information


  1. Iijima K, Zhao L, Shenton C, Iijima Ando K. Regulation of energy stores and feeding by neuronal and peripheral CREB activity in Drosophila. PLoS ONE. 2009;4:e8498 pubmed publisher
    ..This study demonstrates that CREB activity in either neuronal or peripheral tissues regulates energy balance in Drosophila, and that the key signaling pathway regulating CREB activity in peripheral tissue is evolutionarily conserved. ..
  2. Partridge L, Alic N, Bjedov I, Piper M. Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network. Exp Gerontol. 2011;46:376-81 pubmed publisher
    ..Reduced IIS can act acutely to lower death rate, implying that it may ameliorate the effects of ageing-related damage, rather than preventing it. ..
  3. Quan Z, Sun P, Lin G, Xi R. TSC1/2 regulates intestinal stem cell maintenance and lineage differentiation through Rheb-TORC1-S6K but independently of nutritional status or Notch regulation. J Cell Sci. 2013;126:3884-92 pubmed publisher
    ..Loss of either the Tsc1 or Tsc2 gene in ISCs causes rapid ISC loss through TORC1 hyperactivation, because ISCs can be efficiently rescued by mutation of S6k or by rapamycin treatment...