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Genomes and Genes | crqSummaryGene Symbol: crq Description: croquemort Alias: CD36, CG31655, CG4280, CRQ, Cd36, Cqr, Crq, D-CD36, Dmel\CG4280, anon-WO0140519.8, cqm, cqr, CD36-like, CG4280-PA, CG4280-PB, CG4280-PC, CG4280-PD, CG4280-PE, crq-PA, crq-PB, crq-PC, crq-PD, crq-PE Species: fruit fly Top Publications
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Publications
Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migrationBrian Stramer
Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK
J Cell Biol 168:567-73. 2005..Cdc42 is necessary for maintaining cellular polarity and yet, despite in vitro evidence, is dispensable for sensing and crawling toward wound cues...
The PDGF/VEGF receptor controls blood cell survival in DrosophilaKatja Brückner
Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Dev Cell 7:73-84. 2004..This function of PVR shows striking conservation with mammalian hematopoiesis and establishes Drosophila as a model to study hematopoietic cell survival in development and disease...- Requirement for croquemort in phagocytosis of apoptotic cells in DrosophilaN C Franc
Cutaneous Biology Research Center, Laboratory of Developmental Immunology, and Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School Charlestown, MA 02129, USA
Science 284:1991-4. 1999..Croquemort (CRQ) is a CD36-related receptor expressed exclusively on these macrophages... - Developmental control of blood cell migration by the Drosophila VEGF pathwayNam K Cho
Howard Hughes Medical Institute, Department of Biochemistry, Stanford University, Stanford, CA 94305, USA
Cell 108:865-76. 2002..The results suggest that the Drosophila VEGF pathway guides developmental migrations of blood cells, and we speculate that the ancestral function of VEGF pathways was to guide blood cell movement... - Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domainLynda M Stuart
Laboratory of Developmental Immunology, Department of Pediatrics, Harvard Medical School, Boston, MA 02114, USA
J Cell Biol 170:477-85. 2005..scavenger receptor Croquemort as a receptor for Staphylococcus aureus, implicating for the first time the CD36 family as phagocytic receptors for bacteria... - Macrophage-mediated corpse engulfment is required for normal Drosophila CNS morphogenesisHeather C Sears
Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue 68 230B, Cambridge, MA 02139, USA
Development 130:3557-65. 2003..These data indicate that macrophage-mediated clearance of cell corpses is required for proper morphogenesis of the Drosophila CNS... - Requirement for a core 1 galactosyltransferase in the Drosophila nervous systemYuh Ru Lin
Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, New Jersey 08854, USA
Dev Dyn 237:3703-14. 2008..Lectin staining and blotting experiments confirmed that C1GalTA contributes to the synthesis of Gal-beta1,3-GalNAc in vivo. Our results identify a role for mucin-type O-glycosylation during neural development in Drosophila... - Condensation of the central nervous system in embryonic Drosophila is inhibited by blocking hemocyte migration or neural activityBirgitta Olofsson
Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
Dev Biol 279:233-43. 2005.... - A role for adenosine deaminase in Drosophila larval developmentTomas Dolezal
Developmental Biology Center, University of California, Irvine, California, USA
PLoS Biol 3:e201. 2005..The existence of such an independent mechanism has also been suggested in mammals... - gcm2 promotes glial cell differentiation and is required with glial cells missing for macrophage development in DrosophilaTeresa B Alfonso
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
Dev Biol 248:369-83. 2002..Our results suggest that both gcm and gcm2 are required together for the proliferation of plasmatocyte precursors, the expression of Croquemort protein, and the ability of plasmatocytes to convert into macrophages... - Functional evolution of the vertebrate Myb gene family: B-Myb, but neither A-Myb nor c-Myb, complements Drosophila Myb in hemocytesColin J Davidson
Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
Genetics 169:215-29. 2005..Finally, these experiments demonstrate the utility of genetic complementation in Drosophila to explore the functional evolution of duplicated genes in vertebrates... - Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in DrosophilaChristine Kocks
Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Cell 123:335-46. 2005..Our results suggest that Eater is a major phagocytic receptor for a broad range of bacterial pathogens in Drosophila and provide a powerful model to address the role of phagocytosis in vivo... - Draper-mediated and phosphatidylserine-independent phagocytosis of apoptotic cells by Drosophila hemocytes/macrophagesJunko Manaka
Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa 920 1192, Japan
J Biol Chem 279:48466-76. 2004..These results indicate that Drosophila hemocytes/macrophages execute Draper-mediated phagocytosis to eliminate apoptotic cells... - Rac function in epithelial tube morphogenesisCarolyn Pirraglia
Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
Dev Biol 290:435-46. 2006..Our results demonstrate that regulation of cadherin-based adherens junctions by Rac is critical for salivary gland morphogenesis and that this regulation occurs through dynamin-mediated endocytosis... - Double-stranded RNA is internalized by scavenger receptor-mediated endocytosis in Drosophila S2 cellsJohanna Ulvila
Department of Pediatrics and Biocenter Oulu, University of Oulu, FIN 90014, Oulu, Finland
J Biol Chem 281:14370-5. 2006..Our data provide insight into the mechanism of dsRNA internalization by Drosophila cells. These results have implications for dsRNA delivery into mammalian cells... - Fat-body remodeling in Drosophila melanogasterArchana Nelliot
Genesis 44:396-400. 2006..melanogaster is a hemocyte independent process... - An essential role for a CD36-related receptor in pheromone detection in DrosophilaRichard Benton
Laboratory of Neurogenetics and Behaviour, The Rockefeller University, 1230 York Avenue, Box 63, New York, New York 10065, USA
Nature 450:289-93. 2007The CD36 family of transmembrane receptors is present across metazoans and has been implicated biochemically in lipid binding and transport... - Activation of autophagy during cell death requires the engulfment receptor DraperChristina K McPhee
Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nature 465:1093-6. 2010..Further, Drpr is the first factor that distinguishes autophagy that is associated with cell death from autophagy associated with cell survival... 
The role of apoptosis in shaping the tracheal system in the Drosophila embryoMagdalena M Baer
Institute of Genetics, University of Cologne, Cologne, Germany
Mech Dev 127:28-35. 2010..Extruded cells die and are engulfed by macrophages. Our results suggest that the pattern of cell extrusion and death is not hard-wired, but is determined by environmental cues...- Toll-dependent antimicrobial responses in Drosophila larval fat body require Spätzle secreted by haemocytesAlice K H Shia
Department of Biochemistry, University of Oxford, Oxford, UK
J Cell Sci 122:4505-15. 2009..These results show that in larvae, integration of the two responses in a systemic reaction depend on the production of a cytokine (spz), a process that strongly parallels the mammalian immune response... - Drosophila embryos as model systems for monitoring bacterial infection in real timeIsabella Vlisidou
Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
PLoS Pathog 5:e1000518. 2009..Together these data show how Drosophila embryos can be used to track bacterial infection in real time and how mutant analysis can be used to genetically dissect the effects of specific bacterial virulence factors... - A Drosophila model identifies calpains as modulators of the human leukemogenic fusion protein AML1-ETODani Osman
Unite Mixte de Recherche 5547, Centre National de Recherche Scientifique, Centre de Biologie du Developpement, Universite de Toulouse, Bat4R3, 1118 route de Narbonne, 31062 Toulouse, France
Proc Natl Acad Sci U S A 106:12043-8. 2009..Therefore Drosophila provides a promising genetically tractable model to investigate the conserved basis of leukemogenesis and to open avenues in AML therapy... - Elimination of plasmatocytes by targeted apoptosis reveals their role in multiple aspects of the Drosophila immune responseBernard Charroux
Institut de Biologie du Developpement de Marseille Luminy, Unite Mixte de Recherche 6216, Centre National de la Recherche Scientifique, Université de la Méditerrannée Aix Marseille II, 13288 Marseille Cedex 9, France
Proc Natl Acad Sci U S A 106:9797-802. 2009..Finally, we show that plasmatocytes are involved in immune surveillance during pupal development, because they prevent bacterial infection that causes pupal lethality... - Motor deficit in a Drosophila model of mucolipidosis type IV due to defective clearance of apoptotic cellsKartik Venkatachalam
Departments of Biological Chemistry and Neuroscience, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cell 135:838-51. 2008..Since hematopoietic cells in humans are involved in clearance of apoptotic cells, our results raise the possibility that bone marrow transplantation may limit the progression of MLIV... - Distinct mechanisms regulate hemocyte chemotaxis during development and wound healing in Drosophila melanogasterWill Wood
Instituto Gulbenkian de Ciencia, 2780 156 Oeiras, Portugal
J Cell Biol 173:405-16. 2006.... - Undertaker, a Drosophila Junctophilin, links Draper-mediated phagocytosis and calcium homeostasisLeigh Cuttell
Medical Research Council Cell Biology Unit, MRC Laboratory for Molecular Cell Biology and Cell and Developmental Biology Department, University College London, Gower Street, London WC1E 6BT, UK
Cell 135:524-34. 2008..Thus, our results implicate a Junctophilin in phagocytosis and link Draper-mediated phagocytosis to Ca2+ homeostasis, highlighting a previously uncharacterized role for the CED1/6/7 pathway... - The active role of corpse engulfment pathways during cell competitionWei Li
Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Fly (Austin) 1:274-8. 2007..We also speculate about how cell interactions at clone boundaries may initiate cell competition... - Six-microns-under acts upstream of Draper in the glial phagocytosis of apoptotic neuronsEstee Kurant
Laboratory of Developmental Neurogenetics, Rockefeller University, 1230 York Avenue, New York, NY 10065 6399, USA
Cell 133:498-509. 2008..Our study introduces an important factor in tissue-resident apoptotic clearance and underscores the prominent role of glia as "semiprofessional" phagocytes in the nervous system... - The SNMP/CD36 gene family in Diptera, Hymenoptera and Coleoptera: Drosophila melanogaster, D. pseudoobscura, Anopheles gambiae, Aedes aegypti, Apis mellifera, and Tribolium castaneumZachary Nichols
Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA
Insect Biochem Mol Biol 38:398-415. 2008..thought to play a role in odor detection; SNMPs belong to a larger gene family characterized by the human protein CD36. We have identified 12-14 candidate SNMP/CD36 homologs from each of the genomes of Drosophila melanogaster, D... - Blood cells of Drosophila: cell lineages and role in host defenceMarie Meister
Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, 67084 Strasbourg, France
Curr Opin Immunol 16:10-5. 2004..Crystal cells and lamellocytes have no clear mammalian homologues. Research into the molecular mechanisms that underlie the various immune functions of Drosophila blood cells, such as non-self recognition, is now taking wing... - Caspases function in autophagic programmed cell death in DrosophilaDamali N Martin
Center for Biosystems Research, University of Maryland Biotechnology Institute, and Department of Cell Biology, University of Maryland, College Park, Maryland 20742, USA
Development 131:275-84. 2004..These studies suggest that aspects of the cytoskeleton may be required for changes in dying salivary glands. Furthermore, caspases are not only used during apoptosis, but also function in the regulation of autophagic cell death... - Cooperation between the GATA and RUNX factors Serpent and Lozenge during Drosophila hematopoiesisLucas Waltzer
Centre de Biologie du Developpement, CNRS UMR 5547, 118 route de Narbonne, 31062 Toulouse, France
EMBO J 22:6516-25. 2003..We propose that interaction and cooperation between GATA and RUNX factors may play an important role in regulating blood cell formation from Drosophila to mammals... - Using Drosophila as a model insectD Schneider
Whitehead Institute, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nat Rev Genet 1:218-26. 2000..Specifically, I discuss recent work on the use of Drosophila to study the transmission of disease by insect vectors and to investigate insecticide function and development... - Steroid regulation of programmed cell death during Drosophila developmentE H Baehrecke
Center for Agricultural Biotechnology, University of Maryland Biotechnology Institute, College Park, Maryland, MD 20742, USA
Cell Death Differ 7:1057-62. 2000..This article reviews the current knowledge of steroid signaling and the regulation of programmed cell death during development of Drosophila... - E93 directs steroid-triggered programmed cell death in DrosophilaC Y Lee
Center for Agricultural Biotechnology, University of Maryland Biotechnology Institute, College Park 20742, USA
Mol Cell 6:433-43. 2000..Furthermore, expression of E93 is sufficient to induce programmed cell death. We propose that the steroid induction of E93 determines a programmed cell death response during development... - Fork head prevents apoptosis and promotes cell shape change during formation of the Drosophila salivary glandsM M Myat
Department of Cell Biology and Anatomy, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2196, USA
Development 127:4217-26. 2000.... - Innate recognition systems in insect immunity and development: new approaches in DrosophilaN C Franc
Cutaneous Biology Research Center, Massachusetts General Hospital, Department of Dermatology, Harvard Medical School, 13th Street, Building 149, Charlestown, MA 02129, USA
Microbes Infect 2:243-50. 2000..How particles are recognized is not well understood. Studies in insects, and Drosophila in particular, argue that these are powerful model systems to dissect this process... - Specification of Drosophila hematopoietic lineage by conserved transcription factorsT Lebestky
Molecular Biology Institute, Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095, USA
Science 288:146-9. 2000..Given the similarities of Srp and Lz to mammalian GATA and AML1 proteins, observations in Drosophila are likely to have broad implications for understanding mammalian hematopoiesis and leukemias... - In vitro evolution of preferred topoisomerase II DNA cleavage sitesD A Burden
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
J Biol Chem 274:5227-35. 1999..melanogaster, implying that it may be a site for the physiological action of this enzyme... - Genetic analysis of protein kinase B (AKT) in DrosophilaB E Staveley
Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Canada
Curr Biol 8:599-602. 1998..These data implicate Dakt1 as a cell survival gene in Drosophila, consistent with cell protection studies in mammals... - Fruit fly "leukemia"C R Dearolf
Department of Pediatrics, Massachusetts General Hospital, Boston 02114, USA
Biochim Biophys Acta 1377:M13-23. 1998 - Treatment of l(2)mbn Drosophila tumorous blood cells with the steroid hormone ecdysone amplifies the inducibility of antimicrobial peptide gene expressionJ L Dimarcq
UPR 9022 du CNRS, Institut de Biologie Moleculaire et Cellulaire, Strasbourg, France
Insect Biochem Mol Biol 27:877-86. 1997..We also report that expression of several regulatory molecules thought to be involved in the immune response is up-regulated by ecdysone in l(2)mbn cells... - glide/gcm is expressed and required in the scavenger cell lineageR Bernardoni
Institut de Génétique et Biologie Moléculaire et Cellulaire, IGBMC CNRS ULP, BP 163 67404 Illkirch, C U de Strasbourg, France
Dev Biol 191:118-30. 1997..These data and our findings on the dual role of glide/gcm indicate that glial cells and hemocytes/macrophages are functionally and molecularly related... - Steroid regulation of autophagic programmed cell death during developmentC Y Lee
Center for Agricultural Biotechnology, University of Maryland Biotechnology Institute, College Park, Maryland 20742, USA
Development 128:1443-55. 2001..In contrast, E93 expression is sufficient to induce the removal of cells by phagocytes in the absence of the H99 genes. These studies indicate that apoptosis and autophagy utilize some common regulatory mechanisms... - The GATA factor Serpent is required for the onset of the humoral immune response in Drosophila embryosT O Tingvall
Department of Molecular Biology and Functional Genomics, Arrhenius Laboratories for Natural Sciences, Stockholm University, S 106 91 Stockholm, Sweden
Proc Natl Acad Sci U S A 98:3884-8. 2001..In addition, the present study shows that signal transduction pathways controlling innate and epithelial defense reactions can be dissected genetically in Drosophila embryos... - Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cellsN C Franc
Division of Hematology, Children s Hospital, Boston, Massachusetts 02115, USA
Immunity 4:431-43. 1996..This receptor, croquemort (catcher of death), is a member of the CD36 superfamily... - Transcriptional regulation of hematopoiesis in DrosophilaCory J Evans
Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA
Blood Cells Mol Dis 30:223-8. 2003..Herein, we describe the Drosophila blood cell types, their physical origin, and the transcriptional regulators that govern this process... - Drosophila asrij is expressed in pole cells, trachea and hemocytesManeesha S Inamdar
Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, 560 064, Bangalore, India
Dev Genes Evol 213:134-7. 2003..Expression in the blood-cell lineage precedes that of known hematopoietic transcription factors. These results suggest that Drosophila asrij functions in the hematopoietic lineage... - Genetic mechanism for the stage- and tissue-specific regulation of steroid triggered programmed cell death in DrosophilaCheng Yu Lee
Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, 20742, USA
Dev Biol 252:138-48. 2002..mutants indicate that these genes regulate stage-specific transcription of the rpr, hid, ark, dronc, and crq cell death genes... - Two isoforms of Serpent containing either one or two GATA zinc fingers have different roles in Drosophila haematopoiesisLucas Waltzer
Centre de Biologie du Développement CNRS, 31062 Toulouse, France
EMBO J 21:5477-86. 2002..Our results suggest that the inclusion or exclusion of the N-finger in the naturally occurring isoforms of Srp can provide an effective means of extending the versatility of srp function during development... - Steroid regulation of midgut cell death during Drosophila developmentCheng Yu Lee
Center for Biosystems Research, University of Maryland Biotechnology Institute, University of Maryland, College Park, Maryland 20742, USA
Dev Biol 250:101-11. 2002..Dying midguts express the rpr, hid, ark, dronc, and crq cell death genes, suggesting that the core cell death machinery is involved in larval midgut cell death... - Insect hemocytes and their role in immunityM D Lavine
Department of Entomology, University of Georgia, Athens, GA 30602, USA
Insect Biochem Mol Biol 32:1295-309. 2002..Cross-talk between the immune and nervous system may also play a role in regulating inflammation-like responses in insects during infection... - Phagocytosis of apoptotic cells in mammals, caenorhabditis elegans and Drosophila melanogaster: molecular mechanisms and physiological consequencesNathalie C Franc
MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, University College London, Gower Street, London WC1E 6BT, United Kingdom
Front Biosci 7:d1298-313. 2002..Drosophila melanogaster will become the model of choice in genetically dissecting the molecular mechanisms underlying phagocytosis of apoptotic cells by 'professional' phagocytes such as macrophages... - Microsatellite analysis of Drosophila melanogaster populations along a microclimatic contrast at lower Nahel Oren canyon, Mount Carmel, IsraelChristian Schlotterer
Institut fur Tierzucht und Genetik, Vienna University of Veterinary Medicine, Josef Baumann Gasse 1, 1210 Vienna, Austria
Mol Biol Evol 19:563-8. 2002..melanogaster populations was low (F(ST) = 0.0012). Also a tree of individuals based on the proportion of shared alleles and a model-based clustering method provided no evidence for population substructuring... - The coagulation of insect hemolymphU Theopold
Department of Molecular Biology and Functional Genomics, Stockholm University, Sweden
Cell Mol Life Sci 59:363-72. 2002..Some striking similarities between blood clotting in vertebrates and the reaction of insect cells involved in hemolymph coagulation have implications for a phylogenetic comparison of hemostasis between divergent animal classes... - Steroid-triggered death by autophagyC S Thummel
Howard Hughes Medical Institute, Department of Human Genetics, 15 North 2030 East Room 5100, University of Utah, UT 84112 5331, USA
Bioessays 23:677-82. 2001..This paper also shows that E93 can direct cell death independently from the known death-inducer genes, defining a novel death pathway in Drosophila... - Drosophila immunity: analysis of larval hemocytes by P-element-mediated enhancer trapA Braun
Unité Propre de Recherche 9022 du CNRS, Institut de Biologie Moleculaire et Cellulaire, Strasbourg, France
Genetics 147:623-34. 1997..We anticipate that this mutation, which we named domino, will prove a useful tool in the analysis of the role of hemocytes during the various aspects of immune response and melanotic tumor formation...
Research Grants
- Transcriptional Control of Drosophila Detoxification GenesCarl S Thummel; Fiscal Year: 2010..This research will provide new insights into how higher organisms, including humans, cope with toxic compounds in their environment and establish Drosophila as a new model system for characterizing xenobiotic response regulation. ..
- Regulation and Function of Drosophila Nuclear ReceptorsCARL THUMMEL; Fiscal Year: 2009....
- Regulation and Function of Drosophila Nuclear ReceptorsCarl S Thummel; Fiscal Year: 2010....
- Mechanisms of Steroid-Triggered Programmed Cell DeathCARL THUMMEL; Fiscal Year: 2009..Finally, our studies provide a foundation for determining how steroids control cell death in humans, with implications for understanding and treating human disease. ..
- STEROID REGULATION OF PROGRAMMED CELL DEATHCARL THUMMEL; Fiscal Year: 2003..In addition, this study will provide insight into the molecular mechanisms by which systemic hormonal signals are refined into stage- and tissue-specific biological responses during development. ..
- Genetic regulation of autophagic cell deathERIC BAEHRECKE; Fiscal Year: 2007..The recent association of autophagic cell death with neurodegenerative disorders and cancer indicates the importance of investigating this understudied form of programmed cell death. ..
- Regulation and Function of Drosophila Nuclear ReceptorsCarl S Thummel; Fiscal Year: 2010....