Genomes and Genes
Gene Symbol: crq
Alias: CD36, CG31655, CG4280, CRQ, Cd36, Cqr, Crq, D-CD36, Dmel\CG4280, anon-WO0140519.8, cqm, cqr, croquemort, CD36-like, CG4280-PA, CG4280-PB, CG4280-PC, CG4280-PD, CG4280-PE, crq-PA, crq-PB, crq-PC, crq-PD, crq-PE
Species: fruit fly
- Cho N, Keyes L, Johnson E, Heller J, Ryner L, Karim F, et al. Developmental control of blood cell migration by the Drosophila VEGF pathway. Cell. 2002;108:865-76 pubmed..The results suggest that the Drosophila VEGF pathway guides developmental migrations of blood cells, and we speculate that the ancestral function of VEGF pathways was to guide blood cell movement. ..
- Martin D, Baehrecke E. Caspases function in autophagic programmed cell death in Drosophila. Development. 2004;131:275-84 pubmed..These studies suggest that aspects of the cytoskeleton may be required for changes in dying salivary glands. Furthermore, caspases are not only used during apoptosis, but also function in the regulation of autophagic cell death. ..
- Stuart L, Deng J, Silver J, Takahashi K, Tseng A, Hennessy E, et al. Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain. J Cell Biol. 2005;170:477-85 pubmed..In an on-going forward genetic screen, we identify the Drosophila melanogaster scavenger receptor Croquemort as a receptor for Staphylococcus aureus, implicating for the first time the CD36 family as phagocytic receptors ..
- Stramer B, Wood W, Galko M, Redd M, Jacinto A, Parkhurst S, et al. Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration. J Cell Biol. 2005;168:567-73 pubmed..Cdc42 is necessary for maintaining cellular polarity and yet, despite in vitro evidence, is dispensable for sensing and crawling toward wound cues. ..
- Brückner K, Kockel L, Duchek P, Luque C, Rørth P, Perrimon N. The PDGF/VEGF receptor controls blood cell survival in Drosophila. Dev Cell. 2004;7:73-84 pubmed..This function of PVR shows striking conservation with mammalian hematopoiesis and establishes Drosophila as a model to study hematopoietic cell survival in development and disease. ..
- Nichols Z, Vogt R. The SNMP/CD36 gene family in Diptera, Hymenoptera and Coleoptera: Drosophila melanogaster, D. pseudoobscura, Anopheles gambiae, Aedes aegypti, Apis mellifera, and Tribolium castaneum. Insect Biochem Mol Biol. 2008;38:398-415 pubmed publisher..melanogaster emp (epithelial membrane protein). Group 2 includes the previously characterized D. melanogaster croquemort, ninaD, santa maria, and peste...
- Sears H, Kennedy C, Garrity P. Macrophage-mediated corpse engulfment is required for normal Drosophila CNS morphogenesis. Development. 2003;130:3557-65 pubmed..We further find that inhibition of hemocyte development or of Croquemort, a receptor required for macrophage-mediated corpse engulfment, causes similar CNS defects...
- Kurant E, Axelrod S, Leaman D, Gaul U. Six-microns-under acts upstream of Draper in the glial phagocytosis of apoptotic neurons. Cell. 2008;133:498-509 pubmed publisher..Our study introduces an important factor in tissue-resident apoptotic clearance and underscores the prominent role of glia as "semiprofessional" phagocytes in the nervous system. ..
- Honti V, Csordás G, Márkus R, Kurucz E, Jankovics F, Ando I. Cell lineage tracing reveals the plasticity of the hemocyte lineages and of the hematopoietic compartments in Drosophila melanogaster. Mol Immunol. 2010;47:1997-2004 pubmed publisher..This system allowed us to distinguish two major embryonic hemocyte lineages, the crq and Dot lineages, in two, physically separated compartments, the embryonic macrophages and the embryonic lymph ..
- Franc N, Dimarcq J, Lagueux M, Hoffmann J, Ezekowitz R. Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cells. Immunity. 1996;4:431-43 pubmed..We describe a macrophage receptor for apoptotic cells. This receptor, croquemort (catcher of death), is a member of the CD36 superfamily...
- Wood W, Faria C, Jacinto A. Distinct mechanisms regulate hemocyte chemotaxis during development and wound healing in Drosophila melanogaster. J Cell Biol. 2006;173:405-16 pubmed
- Paladi M, Tepass U. Function of Rho GTPases in embryonic blood cell migration in Drosophila. J Cell Sci. 2004;117:6313-26 pubmed..We find eight deletions that cause defects in macrophage migration suggesting the existence of approximately ten zygotic genes essential for macrophage migration. ..
- Meister M. Blood cells of Drosophila: cell lineages and role in host defence. Curr Opin Immunol. 2004;16:10-5 pubmed..Crystal cells and lamellocytes have no clear mammalian homologues. Research into the molecular mechanisms that underlie the various immune functions of Drosophila blood cells, such as non-self recognition, is now taking wing. ..
- Lee C, Wendel D, Reid P, Lam G, Thummel C, Baehrecke E. E93 directs steroid-triggered programmed cell death in Drosophila. Mol Cell. 2000;6:433-43 pubmed..Furthermore, expression of E93 is sufficient to induce programmed cell death. We propose that the steroid induction of E93 determines a programmed cell death response during development. ..
- Waltzer L, Ferjoux G, Bataillé L, Haenlin M. Cooperation between the GATA and RUNX factors Serpent and Lozenge during Drosophila hematopoiesis. EMBO J. 2003;22:6516-25 pubmed..We propose that interaction and cooperation between GATA and RUNX factors may play an important role in regulating blood cell formation from Drosophila to mammals. ..
- Lin Y, Reddy B, Irvine K. Requirement for a core 1 galactosyltransferase in the Drosophila nervous system. Dev Dyn. 2008;237:3703-14 pubmed publisher..Lectin staining and blotting experiments confirmed that C1GalTA contributes to the synthesis of Gal-beta1,3-GalNAc in vivo. Our results identify a role for mucin-type O-glycosylation during neural development in Drosophila. ..
- Charroux B, Royet J. Elimination of plasmatocytes by targeted apoptosis reveals their role in multiple aspects of the Drosophila immune response. Proc Natl Acad Sci U S A. 2009;106:9797-802 pubmed publisher..Finally, we show that plasmatocytes are involved in immune surveillance during pupal development, because they prevent bacterial infection that causes pupal lethality...
- Ulvila J, Parikka M, Kleino A, Sormunen R, Ezekowitz R, Kocks C, et al. Double-stranded RNA is internalized by scavenger receptor-mediated endocytosis in Drosophila S2 cells. J Biol Chem. 2006;281:14370-5 pubmed..Our data provide insight into the mechanism of dsRNA internalization by Drosophila cells. These results have implications for dsRNA delivery into mammalian cells. ..
- Staveley B, Ruel L, Jin J, Stambolic V, Mastronardi F, Heitzler P, et al. Genetic analysis of protein kinase B (AKT) in Drosophila. Curr Biol. 1998;8:599-602 pubmed..These data implicate Dakt1 as a cell survival gene in Drosophila, consistent with cell protection studies in mammals. ..
- Evans C, Banerjee U. Transcriptional regulation of hematopoiesis in Drosophila. Blood Cells Mol Dis. 2003;30:223-8 pubmed..Herein, we describe the Drosophila blood cell types, their physical origin, and the transcriptional regulators that govern this process. ..
- Lee C, Cooksey B, Baehrecke E. Steroid regulation of midgut cell death during Drosophila development. Dev Biol. 2002;250:101-11 pubmed..Dying midguts express the rpr, hid, ark, dronc, and crq cell death genes, suggesting that the core cell death machinery is involved in larval midgut cell death...
- Manaka J, Kuraishi T, Shiratsuchi A, Nakai Y, Higashida H, Henson P, et al. Draper-mediated and phosphatidylserine-independent phagocytosis of apoptotic cells by Drosophila hemocytes/macrophages. J Biol Chem. 2004;279:48466-76 pubmed..The level of Croquemort, a candidate phagocytosis receptor of Drosophila hemocytes/macrophages, increased in l(2)mbn cells after ..
- Myat M, Andrew D. Fork head prevents apoptosis and promotes cell shape change during formation of the Drosophila salivary glands. Development. 2000;127:4217-26 pubmed
- Thummel C. Steroid-triggered death by autophagy. Bioessays. 2001;23:677-82 pubmed..This paper also shows that E93 can direct cell death independently from the known death-inducer genes, defining a novel death pathway in Drosophila. ..
- Ji S, Sun M, Zheng X, Li L, Sun L, Chen D, et al. Cell-surface localization of Pellino antagonizes Toll-mediated innate immune signalling by controlling MyD88 turnover in Drosophila. Nat Commun. 2014;5:3458 pubmed publisher..Collectively, our study uncovers a mechanism by which a feedback regulatory loop involving MyD88 and Pellino controls Toll-mediated signalling, thereby maintaining homeostasis of host innate immunity. ..
- McPhee C, Logan M, Freeman M, Baehrecke E. Activation of autophagy during cell death requires the engulfment receptor Draper. Nature. 2010;465:1093-6 pubmed publisher..Further, Drpr is the first factor that distinguishes autophagy that is associated with cell death from autophagy associated with cell survival...
- Theopold U, Li D, Fabbri M, Scherfer C, Schmidt O. The coagulation of insect hemolymph. Cell Mol Life Sci. 2002;59:363-72 pubmed..Some striking similarities between blood clotting in vertebrates and the reaction of insect cells involved in hemolymph coagulation have implications for a phylogenetic comparison of hemostasis between divergent animal classes. ..
- Vogt R, Miller N, Litvack R, Fandino R, Sparks J, Staples J, et al. The insect SNMP gene family. Insect Biochem Mol Biol. 2009;39:448-56 pubmed publisher..SNMPs are one of three insect gene clades related to the human fatty acid transporter CD36. We previously characterized the CD36 gene family in 4 insect Orders that effectively cover the Holometabola, or ..
- Pirraglia C, Jattani R, Myat M. Rac function in epithelial tube morphogenesis. Dev Biol. 2006;290:435-46 pubmed..Our results demonstrate that regulation of cadherin-based adherens junctions by Rac is critical for salivary gland morphogenesis and that this regulation occurs through dynamin-mediated endocytosis. ..
- Tingvall T, Roos E, Engstrom Y. The GATA factor Serpent is required for the onset of the humoral immune response in Drosophila embryos. Proc Natl Acad Sci U S A. 2001;98:3884-8 pubmed..In addition, the present study shows that signal transduction pathways controlling innate and epithelial defense reactions can be dissected genetically in Drosophila embryos. ..
- Bunt S, Hooley C, Hu N, Scahill C, Weavers H, Skaer H. Hemocyte-secreted type IV collagen enhances BMP signaling to guide renal tubule morphogenesis in Drosophila. Dev Cell. 2010;19:296-306 pubmed publisher..Such regulated interplay between cell-cell and cell-matrix interactions is likely to have wide relevance in organogenesis and congenital disease. ..
- Bernardoni R, Vivancos V, Giangrande A. glide/gcm is expressed and required in the scavenger cell lineage. Dev Biol. 1997;191:118-30 pubmed..These data and our findings on the dual role of glide/gcm indicate that glial cells and hemocytes/macrophages are functionally and molecularly related. ..
- Dearolf C. Fruit fly "leukemia". Biochim Biophys Acta. 1998;1377:M13-23 pubmed
- Kuraishi T, Manaka J, Kono M, Ishii H, Yamamoto N, Koizumi K, et al. Identification of calreticulin as a marker for phagocytosis of apoptotic cells in Drosophila. Exp Cell Res. 2007;313:500-10 pubmed..These results collectively indicate that calreticulin is the first molecule to be identified as a marker for phagocytosis of apoptotic cells by Drosophila phagocytes. ..
- Burden D, Osheroff N. In vitro evolution of preferred topoisomerase II DNA cleavage sites. J Biol Chem. 1999;274:5227-35 pubmed..melanogaster, implying that it may be a site for the physiological action of this enzyme. ..
- Lee C, Simon C, Woodard C, Baehrecke E. Genetic mechanism for the stage- and tissue-specific regulation of steroid triggered programmed cell death in Drosophila. Dev Biol. 2002;252:138-48 pubmed..mutants indicate that these genes regulate stage-specific transcription of the rpr, hid, ark, dronc, and crq cell death genes...
- Vlisidou I, Dowling A, Evans I, Waterfield N, Ffrench Constant R, Wood W. Drosophila embryos as model systems for monitoring bacterial infection in real time. PLoS Pathog. 2009;5:e1000518 pubmed publisher..Together these data show how Drosophila embryos can be used to track bacterial infection in real time and how mutant analysis can be used to genetically dissect the effects of specific bacterial virulence factors. ..
- Dimarcq J, Imler J, Lanot R, Ezekowitz R, Hoffmann J, Janeway C, et al. Treatment of l(2)mbn Drosophila tumorous blood cells with the steroid hormone ecdysone amplifies the inducibility of antimicrobial peptide gene expression. Insect Biochem Mol Biol. 1997;27:877-86 pubmed..We also report that expression of several regulatory molecules thought to be involved in the immune response is up-regulated by ecdysone in l(2)mbn cells. ..
- Franc N, White K. Innate recognition systems in insect immunity and development: new approaches in Drosophila. Microbes Infect. 2000;2:243-50 pubmed..How particles are recognized is not well understood. Studies in insects, and Drosophila in particular, argue that these are powerful model systems to dissect this process. ..
- Igboin C, Tordoff K, Moeschberger M, Griffen A, Leys E. Porphyromonas gingivalis-host interactions in a Drosophila melanogaster model. Infect Immun. 2011;79:449-58 pubmed publisher..gingivalis infection, while the scavenger receptors Eater and Croquemort played no roles in the response to P. gingivalis infection...
- Inamdar M. Drosophila asrij is expressed in pole cells, trachea and hemocytes. Dev Genes Evol. 2003;213:134-7 pubmed..Expression in the blood-cell lineage precedes that of known hematopoietic transcription factors. These results suggest that Drosophila asrij functions in the hematopoietic lineage. ..
- Tung T, Nagaosa K, Fujita Y, Kita A, Mori H, Okada R, et al. Phosphatidylserine recognition and induction of apoptotic cell clearance by Drosophila engulfment receptor Draper. J Biochem. 2013;153:483-91 pubmed publisher..These results indicated that phosphatidylserine serves as an eat-me signal in the phagocytic removal of apoptotic cells in Drosophila and that Draper is a phosphatidylserine-binding receptor for phagocytosis. ..
- Baer M, Bilstein A, Caussinus E, Csiszar A, Affolter M, Leptin M. The role of apoptosis in shaping the tracheal system in the Drosophila embryo. Mech Dev. 2010;127:28-35 pubmed publisher..Extruded cells die and are engulfed by macrophages. Our results suggest that the pattern of cell extrusion and death is not hard-wired, but is determined by environmental cues. ..
- Stofanko M, Kwon S, Badenhorst P. Lineage tracing of lamellocytes demonstrates Drosophila macrophage plasticity. PLoS ONE. 2010;5:e14051 pubmed publisher..Taken together, our data suggest that lamellocytes arise from plasmatocytes and that plasmatocytes may be inherently plastic, possessing the ability to differentiate further into lamellocytes upon appropriate challenge. ..
- Schlotterer C, Agis M. Microsatellite analysis of Drosophila melanogaster populations along a microclimatic contrast at lower Nahel Oren canyon, Mount Carmel, Israel. Mol Biol Evol. 2002;19:563-8 pubmed..melanogaster populations was low (F(ST) = 0.0012). Also a tree of individuals based on the proportion of shared alleles and a model-based clustering method provided no evidence for population substructuring. ..
- Poels J, Spasic M, Callaerts P, Norga K. An appetite for destruction: from self-eating to cell cannibalism as a neuronal survival strategy. Autophagy. 2012;8:1401-3 pubmed publisher..Finally, we uncovered a new survival mechanism in AMPK-deficient neurons--cell cannibalism. ..
- Ghosh S, Singh A, Mandal S, Mandal L. Active hematopoietic hubs in Drosophila adults generate hemocytes and contribute to immune response. Dev Cell. 2015;33:478-88 pubmed publisher..The presence of progenitors and differentiated hemocytes embedded in a functional network of Laminin A and Pericardin within this hematopoietic hub projects it as a simple version of the vertebrate bone marrow. ..
- Guillou A, Troha K, Wang H, Franc N, Buchon N. The Drosophila CD36 Homologue croquemort Is Required to Maintain Immune and Gut Homeostasis during Development and Aging. PLoS Pathog. 2016;12:e1005961 pubmed publisher..Here, we report that Croquemort (Crq), a Drosophila member of the CD36 family of scavenger receptors, is required for microbial phagocytosis and ..
- Braun A, Lemaitre B, Lanot R, Zachary D, Meister M. Drosophila immunity: analysis of larval hemocytes by P-element-mediated enhancer trap. Genetics. 1997;147:623-34 pubmed..We anticipate that this mutation, which we named domino, will prove a useful tool in the analysis of the role of hemocytes during the various aspects of immune response and melanotic tumor formation. ..
- Booth G, Kinrade E, Hidalgo A. Glia maintain follower neuron survival during Drosophila CNS development. Development. 2000;127:237-44 pubmed..This differential requirement of neurons for glia is instructive in patterning and links control of cell number with axon guidance during CNS development. ..
- Han C, Song Y, Xiao H, Wang D, Franc N, Jan L, et al. Epidermal cells are the primary phagocytes in the fragmentation and clearance of degenerating dendrites in Drosophila. Neuron. 2014;81:544-560 pubmed publisher..Using multiple dendritic membrane markers to trace phagocytosis, we show that two members of the CD36 family, croquemort (crq) and debris buster (dsb), act at distinct stages of phagosome maturation for dendrite clearance...
- Nelliot A, Bond N, Hoshizaki D. Fat-body remodeling in Drosophila melanogaster. Genesis. 2006;44:396-400 pubmed..melanogaster is a hemocyte independent process...
- Woodcock K, Kierdorf K, Pouchelon C, Vivancos V, Dionne M, Geissmann F. Macrophage-derived upd3 cytokine causes impaired glucose homeostasis and reduced lifespan in Drosophila fed a lipid-rich diet. Immunity. 2015;42:133-44 pubmed..Drosophila macrophages produced the JAK-STAT-activating cytokine upd3, in a scavenger-receptor (crq) and JNK-dependent manner...
- Dolezal T, Dolezelova E, Zurovec M, Bryant P. A role for adenosine deaminase in Drosophila larval development. PLoS Biol. 2005;3:e201 pubmed..The existence of such an independent mechanism has also been suggested in mammals. ..
- ..Specifically, I discuss recent work on the use of Drosophila to study the transmission of disease by insect vectors and to investigate insecticide function and development. ..
- Hamilos G, Samonis G, Kontoyiannis D. Recent Advances in the Use of Drosophila melanogaster as a Model to Study Immunopathogenesis of Medically Important Filamentous Fungi. Int J Microbiol. 2012;2012:583792 pubmed publisher..In view of recent advances in Drosophila genetics, fruit flies will become an invaluable surrogate model to study immunopathogenesis of fungal diseases. ..
- Davidson C, Tirouvanziam R, Herzenberg L, Lipsick J. Functional evolution of the vertebrate Myb gene family: B-Myb, but neither A-Myb nor c-Myb, complements Drosophila Myb in hemocytes. Genetics. 2005;169:215-29 pubmed..Finally, these experiments demonstrate the utility of genetic complementation in Drosophila to explore the functional evolution of duplicated genes in vertebrates. ..
- Shia A, Glittenberg M, Thompson G, Weber A, Reichhart J, Ligoxygakis P. Toll-dependent antimicrobial responses in Drosophila larval fat body require Spätzle secreted by haemocytes. J Cell Sci. 2009;122:4505-15 pubmed publisher..These results show that in larvae, integration of the two responses in a systemic reaction depend on the production of a cytokine (spz), a process that strongly parallels the mammalian immune response. ..
- Franc N. Phagocytosis of apoptotic cells in mammals, caenorhabditis elegans and Drosophila melanogaster: molecular mechanisms and physiological consequences. Front Biosci. 2002;7:d1298-313 pubmed..Drosophila melanogaster will become the model of choice in genetically dissecting the molecular mechanisms underlying phagocytosis of apoptotic cells by 'professional' phagocytes such as macrophages. ..
- Lavine M, Strand M. Insect hemocytes and their role in immunity. Insect Biochem Mol Biol. 2002;32:1295-309 pubmed..Cross-talk between the immune and nervous system may also play a role in regulating inflammation-like responses in insects during infection. ..
- Cuttell L, Vaughan A, Silva E, Escaron C, Lavine M, Van Goethem E, et al. Undertaker, a Drosophila Junctophilin, links Draper-mediated phagocytosis and calcium homeostasis. Cell. 2008;135:524-34 pubmed publisher..Thus, our results implicate a Junctophilin in phagocytosis and link Draper-mediated phagocytosis to Ca2+ homeostasis, highlighting a previously uncharacterized role for the CED1/6/7 pathway. ..
- Venkatachalam K, Long A, Elsaesser R, Nikolaeva D, Broadie K, Montell C. Motor deficit in a Drosophila model of mucolipidosis type IV due to defective clearance of apoptotic cells. Cell. 2008;135:838-51 pubmed publisher..Since hematopoietic cells in humans are involved in clearance of apoptotic cells, our results raise the possibility that bone marrow transplantation may limit the progression of MLIV...
- Nonaka S, Nagaosa K, Mori T, Shiratsuchi A, Nakanishi Y. Integrin ?PS3/??-mediated phagocytosis of apoptotic cells and bacteria in Drosophila. J Biol Chem. 2013;288:10374-80 pubmed publisher..These results collectively indicated that integrin ?PS3/?? serves as a receptor in the phagocytosis of apoptotic cells and bacteria by Drosophila phagocytes. ..