Gene Symbol: CrebB
Description: Cyclic-AMP response element binding protein B
Alias: CG6103, CRE-BP, CREB, CREB-B, CREB-b, CREB2, CREB2a, CREB2b, Creb, Creb B 17A, Creb17A, Creb2, Creb2-b, Creb2.b, Creb2b, CrebB-17A, CrebB-17B, CrebB17-A, DM9, Dmel\CG6103, S162, dCREB, dCREB-2, dCREB-2a, dCREB-B, dCREB2, dCREB2-a, dCREB2-b, dCREB2a, dCREB2b, dCbz, dCreb2, dCreb2-b, dCrebB2, dcreb2-b, l(1)17Af, Cyclic-AMP response element binding protein B, CG6103-PF, CG6103-PG, CG6103-PI, CG6103-PJ, CG6103-PM, CG6103-PN, CG6103-PO, CG6103-PP, CG6103-PQ, CrebB-PF, CrebB-PG, CrebB-PI, CrebB-PJ, CrebB-PM, CrebB-PN, CrebB-PO, CrebB-PP, CrebB-PQ, Cyclic-AMP response element binding protein B at 17A, Cyclic-AMP response element binding protein B at 17B, activator, blocker, cAMP response element-binding protein, cAMP response-element binding protein, cAMP-regulated enhancer-binding protein, cAMP-response element binding protein, cAMP-response element-binding protein, cyclic AMP response element binding protein, dCREB2, lethal(1)17Af
Species: fruit fly
Products:     CrebB

Top Publications

  1. Eresh S, Riese J, Jackson D, Bohmann D, Bienz M. A CREB-binding site as a target for decapentaplegic signalling during Drosophila endoderm induction. EMBO J. 1997;16:2014-22 pubmed
    ..Furthermore, the Drosophila CRE-binding protein dCREB-B binds to the Ultrabithorax CRE, and ubiquitous expression of a dominant-negative form of dCREB-B suppresses CRE-..
  2. Koon A, Ashley J, Barria R, Dasgupta S, Brain R, Waddell S, et al. Autoregulatory and paracrine control of synaptic and behavioral plasticity by octopaminergic signaling. Nat Neurosci. 2011;14:190-9 pubmed publisher
    ..Growth of octopaminergic arbors was controlled by a cAMP- and CREB-dependent positive-feedback mechanism that required Oct?2R octopamine autoreceptors...
  3. Honjo K, Furukubo Tokunaga K. Distinctive neuronal networks and biochemical pathways for appetitive and aversive memory in Drosophila larvae. J Neurosci. 2009;29:852-62 pubmed publisher
    ..produced in this paradigm depends on intact cAMP signaling, but neither mutation of amnesiac nor suppression of CREB activity affects its kinetics...
  4. Yin J, Wallach J, Wilder E, Klingensmith J, Dang D, Perrimon N, et al. A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist. Mol Cell Biol. 1995;15:5123-30 pubmed
    ..Uniquely among Drosophila genes characterized to date, it codes for a cAMP-responsive transcriptional activator. An alternatively spliced product of the same gene is a specific antagonist of cAMP-inducible transcription...
  5. Horiuchi J, Jiang W, Zhou H, Wu P, Yin J. Phosphorylation of conserved casein kinase sites regulates cAMP-response element-binding protein DNA binding in Drosophila. J Biol Chem. 2004;279:12117-25 pubmed
    The Drosophila homolog of cAMP-response element-binding protein (CREB), dCREB2, exists with serine 231, equivalent to mammalian serine 133, in a predominantly phosphorylated state...
  6. Iijima Ando K, Wu P, Drier E, Iijima K, Yin J. cAMP-response element-binding protein and heat-shock protein 70 additively suppress polyglutamine-mediated toxicity in Drosophila. Proc Natl Acad Sci U S A. 2005;102:10261-6 pubmed
    ..A mutation in the Drosophila homolog of CREB, dCREB2, enhances lethality due to polyglutamine peptides (polyQ), and an additional copy of dCREB2 partially rescues this ..
  7. Xu K, Zheng X, Sehgal A. Regulation of feeding and metabolism by neuronal and peripheral clocks in Drosophila. Cell Metab. 2008;8:289-300 pubmed publisher
    ..We propose that the input of neuronal clocks and clocks in metabolic tissues is coordinated to provide effective energy homeostasis...
  8. Iijima Ando K, Hearn S, Granger L, Shenton C, Gatt A, Chiang H, et al. Overexpression of neprilysin reduces alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and. J Biol Chem. 2008;283:19066-76 pubmed publisher
    ..Down-regulation of NEP activity in aging brains may be an evolutionarily conserved phenomenon, which could predispose humans to developing late-onset AD. ..
  9. Chen X, Ganetzky B. A neuropeptide signaling pathway regulates synaptic growth in Drosophila. J Cell Biol. 2012;196:529-43 pubmed publisher
    ..of NMJ growth occurs through the cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA)-cAMP response element binding protein (CREB) pathway...

More Information


  1. Chen C, Wu J, Lin H, Pai T, Fu T, Wu C, et al. Visualizing long-term memory formation in two neurons of the Drosophila brain. Science. 2012;335:678-85 pubmed publisher
    ..synthesis, we have directly visualized cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB)-dependent transcriptional activation of calcium/calmodulin-dependent protein kinase II and period genes in the DAL ..
  2. Yin J, del Vecchio M, Zhou H, Tully T. CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila. Cell. 1995;81:107-15 pubmed
    ..Here, we report an enhancement of LTM formation after induced expression of an activator isoform of dCREB2...
  3. Yin J, Wallach J, del Vecchio M, Wilder E, Zhou H, Quinn W, et al. Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila. Cell. 1994;79:49-58 pubmed
    ..Using an inducible transgene that expresses a dominant negative member of the fly CREB family, LTM was specifically and completely blocked only after induction, while ARM and learning were unaffected...
  4. Belvin M, Zhou H, Yin J. The Drosophila dCREB2 gene affects the circadian clock. Neuron. 1999;22:777-87 pubmed
    We report the role of dCREB2, the Drosophila homolog of CREB/CREM, in circadian rhythms. dCREB2 activity cycles with a 24 hr rhythm in flies, both in a light:dark cycle and in constant darkness...
  5. Hong S, Bang S, Hyun S, Kang J, Jeong K, Paik D, et al. cAMP signalling in mushroom bodies modulates temperature preference behaviour in Drosophila. Nature. 2008;454:771-5 pubmed publisher
    ..Preferred temperatures were affected by the level of cAMP and PKA activity in the MBs in various PKA pathway mutants...
  6. Wang B, Goode J, Best J, Meltzer J, Schilman P, Chen J, et al. The insulin-regulated CREB coactivator TORC promotes stress resistance in Drosophila. Cell Metab. 2008;7:434-44 pubmed publisher
    In fasted mammals, glucose homeostasis is maintained through induction of the cAMP response element-binding protein (CREB) coactivator transducer of regulated CREB activity 2 (TORC2), which stimulates the gluconeogenic program in concert ..
  7. Perazzona B, Isabel G, Preat T, Davis R. The role of cAMP response element-binding protein in Drosophila long-term memory. J Neurosci. 2004;24:8823-8 pubmed
    ..dCREB2-b) under the control of a heat-shock promoter was reported to block LTM, whereas overexpression of an activator isoform (dCREB2-a) was reported to enhance LTM...
  8. Davis G, Schuster C, Goodman C. Genetic dissection of structural and functional components of synaptic plasticity. III. CREB is necessary for presynaptic functional plasticity. Neuron. 1996;17:669-79 pubmed
    ..Expression of the CREB activator (dCREB2-a) increases synaptic strength only in FasII mutants that increase bouton number...
  9. Hendricks J, Williams J, Panckeri K, Kirk D, Tello M, Yin J, et al. A non-circadian role for cAMP signaling and CREB activity in Drosophila rest homeostasis. Nat Neurosci. 2001;4:1108-15 pubmed
    ..of sleep-like rest, we investigated the involvement of a candidate gene, cAMP response-element binding protein (CREB). The duration of rest was inversely related to cAMP signaling and CREB activity...
  10. De Cesare D, Fimia G, Sassone Corsi P. Signaling routes to CREM and CREB: plasticity in transcriptional activation. Trends Biochem Sci. 1999;24:281-5 pubmed
    ..Phosphorylation allows recruitment of CREB-binding protein (CBP), a large co-activator that contacts the general transcriptional machinery...
  11. Poels J, Franssens V, Van Loy T, Martinez A, Suner M, Dunbar S, et al. Isoforms of cyclic AMP response element binding proteins in Drosophila S2 cells. Biochem Biophys Res Commun. 2004;320:318-24 pubmed
    ..In this context, we have now investigated the presence of different dCREB transcripts in a stable, embryonic insect cell line, i.e., Drosophila Schneider 2 (S2) cells...
  12. Walkiewicz M, Stern M. Increased insulin/insulin growth factor signaling advances the onset of metamorphosis in Drosophila. PLoS ONE. 2009;4:e5072 pubmed publisher
  13. Yuan Q, Xiang Y, Yan Z, Han C, Jan L, Jan Y. Light-induced structural and functional plasticity in Drosophila larval visual system. Science. 2011;333:1458-62 pubmed publisher
  14. Miyashita T, Oda Y, Horiuchi J, Yin J, Morimoto T, Saitoe M. Mg(2+) block of Drosophila NMDA receptors is required for long-term memory formation and CREB-dependent gene expression. Neuron. 2012;74:887-98 pubmed publisher
    ..we show that genetic and pharmacological reduction of Mg(2+) block significantly increases expression of a CREB repressor isoform...
  15. Gonzales E, Tanenhaus A, Zhang J, Chaffee R, Yin J. Early-onset sleep defects in Drosophila models of Huntington's disease reflect alterations of PKA/CREB signaling. Hum Mol Genet. 2016;25:837-52 pubmed publisher
    ..In vivo reporters, however, show dCREB2 activity is unchanged, or decreased when sleep/activity patterns are abnormal, suggesting dissociation of PKA and ..
  16. Stork O, Welzl H. Memory formation and the regulation of gene expression. Cell Mol Life Sci. 1999;55:575-92 pubmed
    ..It is expected that the new molecular methods will help to identify and characterize molecules whose expression changes during LTM formation even in complex vertebrate learning paradigms. ..
  17. Hong S, Lee K, Kwak S, Kim A, Bai H, Jung M, et al. Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammals. PLoS Genet. 2012;8:e1002857 pubmed publisher
    ..neuronal cells and mouse hypothalamic cells, sNPF and NPY modulated the mnb and Dyrk1a expression through the PKA-CREB pathway...
  18. Mizrak D, Ruben M, Myers G, Rhrissorrakrai K, Gunsalus K, Blau J. Electrical activity can impose time of day on the circadian transcriptome of pacemaker neurons. Curr Biol. 2012;22:1871-80 pubmed publisher
    ..Bioinformatic and immunocytochemical analyses suggest that CREB family transcription factors link LN(v) electrical state to circadian gene expression...
  19. Korzus E. The relation of transcription to memory formation. Acta Biochim Pol. 2003;50:775-82 pubmed Drosophila and Aplysia indicate that the transcription factor cAMP/Ca(2+) response element binding protein (CREB) is critical in mediating the conversion from short- to long-term memory...
  20. Sanyal S, Sandstrom D, Hoeffer C, Ramaswami M. AP-1 functions upstream of CREB to control synaptic plasticity in Drosophila. Nature. 2002;416:870-4 pubmed
    ..activity causes kinase-mediated activation of the transcription factor cyclic AMP response-element-binding protein, CREB. Together with appropriate cofactors, CREB then transcriptionally induces a group of 'immediate early' ..
  21. Lim C, Lee J, Choi C, Kim J, Doh E, Choe J. Functional role of CREB-binding protein in the circadian clock system of Drosophila melanogaster. Mol Cell Biol. 2007;27:4876-90 pubmed
    ..Here, using transgenic fly models, we show that CREB-binding protein (CBP) participates in the transcriptional regulation of the Drosophila CLOCK/CYCLE (dCLK/CYC) ..
  22. Zhang J, Tanenhaus A, Davis J, Hanlon B, Yin J. Spatio-temporal in vivo recording of dCREB2 dynamics in Drosophila long-term memory processing. Neurobiol Learn Mem. 2015;118:80-8 pubmed publisher
    ..The Drosophila homologue of mammalian CREB, dCREB2, is also important for LTM...
  23. Sakai T, Tamura T, Kitamoto T, Kidokoro Y. A clock gene, period, plays a key role in long-term memory formation in Drosophila. Proc Natl Acad Sci U S A. 2004;101:16058-63 pubmed
    The cAMP-responsive transcription factor, CREB, is required for formation of long-term memory (LTM) in Drosophila melanogaster and regulates transcription of a circadian clock gene, period (per)...
  24. Freeman A, Bowers M, Mortimer A, Timmerman C, Roux S, Ramaswami M, et al. A new genetic model of activity-induced Ras signaling dependent pre-synaptic plasticity in Drosophila. Brain Res. 2010;1326:15-29 pubmed publisher
    ..neurons; b) attenuation of the Ras/ERK signaling cascade; or c) inhibition of the transcription factors Fos and CREB. All of which restrict synaptic properties to near wild type levels...
  25. Shaw P, Franken P. Perchance to dream: solving the mystery of sleep through genetic analysis. J Neurobiol. 2003;54:179-202 pubmed
    ..In this article we will review recent studies that have used genetic techniques to evaluate sleep in the fruit fly and the mouse. ..
  26. Kang J, Kim J, Choi K. Novel cytochrome P450, cyp6a17, is required for temperature preference behavior in Drosophila. PLoS ONE. 2011;6:e29800 pubmed publisher
    ..Taken together, this study reveals a new PKA-Cytochrome P450 pathway that regulates the temperature preference behavior. ..
  27. Choi S, Kim W, Chung J. Drosophila salt-inducible kinase (SIK) regulates starvation resistance through cAMP-response element-binding protein (CREB)-regulated transcription coactivator (CRTC). J Biol Chem. 2011;286:2658-64 pubmed publisher play important functions in glucose homeostasis by inhibiting the cAMP-response element-binding protein (CREB)-regulated transcription coactivator (CRTC)...
  28. Zhang J, Little C, Tremmel D, Yin J, Wesley C. Notch-inducible hyperphosphorylated CREB and its ultradian oscillation in long-term memory formation. J Neurosci. 2013;33:12825-34 pubmed publisher
    ..We report here results of our studies in adult Drosophila melanogaster showing that Notch regulates dCrebB-17A, the CREB protein...
  29. Kiger J, Natzle J, Green M. Hemocytes are essential for wing maturation in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2001;98:10190-5 pubmed
    ..We propose that batone is required for the release of a hormone necessary for wing expansion and tissue remodeling by hemocytes in the wing. ..
  30. Kadowaki T, Wilder E, Klingensmith J, Zachary K, Perrimon N. The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. Genes Dev. 1996;10:3116-28 pubmed
    ..We identified a human sequence related to Porc suggesting the existence of a family of proteins involved in processing of Wnts. ..
  31. Carew T. Molecular enhancement of memory formation. Neuron. 1996;16:5-8 pubmed
  32. Packard M, Mathew D, Budnik V. FASt remodeling of synapses in Drosophila. Curr Opin Neurobiol. 2003;13:527-34 pubmed
    ..These studies offer convincing evidence that synaptic cell adhesion brings about both negative and positive forces that stabilize synapses, while maintaining their ability to change in an activity-dependent manner. ..
  33. Gomes A, Nolasco S, Soares H. Non-coding RNAs: multi-tasking molecules in the cell. Int J Mol Sci. 2013;14:16010-39 pubmed publisher
    ..We also highlighted the implications of biogenesis and gene expression deregulation of sncRNAs and lncRNAs in human diseases like cancer. ..
  34. Stanewsky R. Genetic analysis of the circadian system in Drosophila melanogaster and mammals. J Neurobiol. 2003;54:111-47 pubmed
    ..This review will try to give a comparative overview about the two systems, highlighting similarities as well as specifics of both insect and murine clocks. ..
  35. Sakai T, Kidokoro Y. Overexpression of a CREB repressor isoform enhances the female sexual receptivity in Drosophila. Behav Genet. 2002;32:413-22 pubmed
    ..Drosophila melanogaster, one of alternatively spliced products of the CREB gene, dCREB2-a, is a transcriptional activator, while another isoform, dCREB2-b, is a repressor of dCREB2-a...
  36. Lamprecht R. CREB: a message to remember. Cell Mol Life Sci. 1999;55:554-63 pubmed
    ..most salient results consonant with this hypothesis is that the transcription factor cAMP response element binding (CREB) is involved in the formation of memory in organisms with diverse phylogenetic background from mollusks to mammals...
  37. Greenspan R. Flies, genes, learning, and memory. Neuron. 1995;15:747-50 pubmed
  38. Bendena W, Campbell J, Zara L, Tobe S, Chin Sang I. Select Neuropeptides and their G-Protein Coupled Receptors in Caenorhabditis Elegans and Drosophila Melanogaster. Front Endocrinol (Lausanne). 2012;3:93 pubmed publisher
    ..melanogaster and C. elegans and the behaviors that have been uncovered through genetic manipulation. ..
  39. Yin J, Tully T. CREB and the formation of long-term memory. Curr Opin Neurobiol. 1996;6:264-8 pubmed
    b>Cyclic AMP response element binding protein (CREB)-responsive transcription plays a central role in the formation of long-term memory in Drosophila, Aplysia and mice...
  40. Singh K, Ju J, Walsh M, Diiorio M, Hart A. Deep conservation of genes required for both Drosphila melanogaster and Caenorhabditis elegans sleep includes a role for dopaminergic signaling. Sleep. 2014;37:1439-51 pubmed publisher
    ..Quantitative analysis of various components of quiescence suggests that interdependent or identical cellular and molecular mechanisms are likely to regulate both arousal and sleep entry. ..
  41. Iijima K, Zhao L, Shenton C, Iijima Ando K. Regulation of energy stores and feeding by neuronal and peripheral CREB activity in Drosophila. PLoS ONE. 2009;4:e8498 pubmed publisher
    ..While Drosophila has a homolog of mammalian CREB, dCREB2, its role in energy metabolism is not fully understood...
  42. Dubnau J, Chiang A, Grady L, Barditch J, Gossweiler S, McNeil J, et al. The staufen/pumilio pathway is involved in Drosophila long-term memory. Curr Biol. 2003;13:286-96 pubmed
    ..Particularly, long-term memory requires CREB-dependent transcription, suggesting the regulation of "downstream" genes...
  43. Tully T. Regulation of gene expression and its role in long-term memory and synaptic plasticity. Proc Natl Acad Sci U S A. 1997;94:4239-41 pubmed
  44. Tubon T, Zhang J, Friedman E, Jin H, Gonzales E, Zhou H, et al. dCREB2-mediated enhancement of memory formation. J Neurosci. 2013;33:7475-87 pubmed publisher
    ..This protein is a transcriptional activator and is responsible for memory enhancement...
  45. Riese J, Tremml G, Bienz M. D-Fos, a target gene of Decapentaplegic signalling with a critical role during Drosophila endoderm induction. Development. 1997;124:3353-61 pubmed
  46. Davis R. Neurofibromin progress on the fly. Nature. 2000;403:846-7 pubmed
  47. Stanewsky R. Clock mechanisms in Drosophila. Cell Tissue Res. 2002;309:11-26 pubmed
    ..Although their regulation depends on the major clock genes, the majority of the clock-controlled genes are not direct targets of clock factors. ..
  48. Orian A. Chromatin profiling, DamID and the emerging landscape of gene expression. Curr Opin Genet Dev. 2006;16:157-64 pubmed
    ..The molecular picture that emerges from DamID and similar studies is that genomes integrate inputs from both genetic and epigenetic machineries to dynamically regulate gene expression. ..
  49. DeZazzo J, Tully T. Dissection of memory formation: from behavioral pharmacology to molecular genetics. Trends Neurosci. 1995;18:212-8 pubmed
    ..These studies support the application of reverse-genetic strategies, including the use of temporally specific agonists and antagonists, to advance the functional dissection of memory formation. ..
  50. Tully T. Discovery of genes involved with learning and memory: an experimental synthesis of Hirschian and Benzerian perspectives. Proc Natl Acad Sci U S A. 1996;93:13460-7 pubmed
    ..In addition, more specific conclusions will be obtained from reverse-genetic experiments, in which gene disruptions are restricted in time and/or space. ..
  51. Sha K, Choi S, Im J, Lee G, Loeffler F, Park J. Regulation of ethanol-related behavior and ethanol metabolism by the Corazonin neurons and Corazonin receptor in Drosophila melanogaster. PLoS ONE. 2014;9:e87062 pubmed publisher
    ..Furthermore, inhibition of PKA or cAMP response element binding protein (CREB) in CrzR cells leads to comparable hangover-like phenotype to the CrzR(01) mutant...
  52. Fropf R, Zhang J, Tanenhaus A, Fropf W, Siefkes E, Yin J. Time of day influences memory formation and dCREB2 proteins in Drosophila. Front Syst Neurosci. 2014;8:43 pubmed publisher
    ..The dCREB2 transcription factor shows circadian regulated oscillations in its activity, and has been shown to be important ..
  53. Fropf R, Tubon T, Yin J. Nuclear gating of a Drosophila dCREB2 activator is involved in memory formation. Neurobiol Learn Mem. 2013;106:258-67 pubmed publisher
    ..Overexpression of an activator or blocker isoform has been shown to enhance or block memory formation, but the molecular mechanisms underlying ..
  54. Akalal D, Yu D, Davis R. A late-phase, long-term memory trace forms in the ? neurons of Drosophila mushroom bodies after olfactory classical conditioning. J Neurosci. 2010;30:16699-708 pubmed publisher
    ..These results demonstrate that behavioral long-term olfactory memory is encoded as modifications of calcium influx into distinct MB neurons during overlapping but different windows of time after training. ..
  55. Usui T, Smolik S, Goodman R. Isolation of Drosophila CREB-B: a novel CRE-binding protein. DNA Cell Biol. 1993;12:589-95 pubmed
    ..However, the putative DNA binding domains for all three proteins are highly conserved. The activator region of dCREB-B is completely different from that of both mammalian CREB and dCREB-A...
  56. Davis R. Physiology and biochemistry of Drosophila learning mutants. Physiol Rev. 1996;76:299-317 pubmed
    ..activating peptides), dunce (cAMP phosophodiesterase), rutabaga (adenylyl cyclase), DCO (protein kinase A), and dCREB2 (cAMP-response element binding protein), have proven important for normal learning...
  57. Dubnau J, Tully T. Gene discovery in Drosophila: new insights for learning and memory. Annu Rev Neurosci. 1998;21:407-44 pubmed
    ..Second, because core cellular mechanisms of simple forms of learning are evolutionarily conserved, biological pathways discovered in invertebrates are likely to be conserved in vertebrate systems as well. ..
  58. Hendricks J. Invited review: Sleeping flies don't lie: the use of Drosophila melanogaster to study sleep and circadian rhythms. J Appl Physiol (1985). 2003;94:1660-72; discussion 1673 pubmed
    ..Nonetheless, studies have already established that two transcription factors alter rest and rest homeostasis. The implications of these advances for the future of sleep research are summarized. ..
  59. Alberini C. Genes to remember. J Exp Biol. 1999;202:2887-91 pubmed
    ..Here, we review the studies showing that conserved molecules and biological mechanisms are engaged in simple and complex forms of memory. ..
  60. Harrison D, McCoon P, Binari R, Gilman M, Perrimon N. Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway. Genes Dev. 1998;12:3252-63 pubmed
    ..We propose that Upd is a ligand that relies on JAK signaling to stimulate transcription of pair-rule genes in a segmentally restricted manner in the early Drosophila embryo...
  61. de Belle J. Drosophila mushroom body subdomains: innate or learned representations of odor preference and sexual orientation?. Neuron. 1995;15:245-7 pubmed
  62. Yu D, Akalal D, Davis R. Drosophila alpha/beta mushroom body neurons form a branch-specific, long-term cellular memory trace after spaced olfactory conditioning. Neuron. 2006;52:845-55 pubmed
    ..and was blocked by mutation of the amnesiac gene, inhibition of protein synthesis, or the expression of a protein blocker of the transcription factor Creb...
  63. Brunner A, O Kane C. The fascination of the Drosophila NMJ. Trends Genet. 1997;13:85-7 pubmed
  64. Pai T, Chen C, Lin H, Chin A, Lai J, Lee P, et al. Drosophila ORB protein in two mushroom body output neurons is necessary for long-term memory formation. Proc Natl Acad Sci U S A. 2013;110:7898-903 pubmed publisher
  65. Stafford J, Lynd K, Jung A, Gordon M. Integration of taste and calorie sensing in Drosophila. J Neurosci. 2012;32:14767-74 pubmed publisher
    ..Our results are consistent with the existence of a taste-independent calorie sensor in flies, and suggest that calorie-based reward modifies long-term feeding preferences. ..
  66. Graves J, Markman S, Alegranti Y, Gechtler J, Johnson R, Cagan R, et al. The LH/CG receptor activates canonical signaling pathway when expressed in Drosophila. Mol Cell Endocrinol. 2015;413:145-56 pubmed publisher
    ..In mammals, LHR mainly couples to the PKA signaling pathway, and CREB is the major transcription factor of this pathway...
  67. Goda Y. Memory mechanisms. Photographic memory in flies. Curr Biol. 1995;5:852-3 pubmed
    A new study of olfactory memory formation in Drosophila shows that a delicate balance of CREB transcription factor activity may play a decisive role in triggering long-term memory.
  68. Honjo K, Furukubo Tokunaga K. Induction of cAMP response element-binding protein-dependent medium-term memory by appetitive gustatory reinforcement in Drosophila larvae. J Neurosci. 2005;25:7905-13 pubmed
    ..appetitive conditioning lasts medium term and depends on both amnesiac and cAMP response element-binding protein (CREB)...
  69. Iijima Ando K, Hearn S, Shenton C, Gatt A, Zhao L, Iijima K. Mitochondrial mislocalization underlies Abeta42-induced neuronal dysfunction in a Drosophila model of Alzheimer's disease. PLoS ONE. 2009;4:e8310 pubmed publisher
    ..These results demonstrate that mislocalization of mitochondria underlies the pathogenic effects of Abeta42 in vivo. ..
  70. Roush W. The supple synapse: an affair that remembers. Science. 1996;274:1102-3 pubmed