CrebB-17A

Summary

Gene Symbol: CrebB-17A
Description: Cyclic-AMP response element binding protein B at 17A
Alias: CG6103, CRE-BP, CREB, CREB-B, CREB-b, CREB2, CREB2a, CREB2b, Creb, Creb17A, Creb2, Creb2-b, Creb2.b, Creb2b, CrebB, CrebB17-A, Dmel\CG6103, S162, dCREB, dCREB-2, dCREB-2a, dCREB-B, dCREB2, dCREB2-a, dCREB2-b, dCREB2a, dCREB2b, dCbz, dCreb2, dCreb2-b, dCrebB2, dcreb2-b, l(1)17Af, CG6103-PD, CG6103-PE, CG6103-PF, CG6103-PG, CG6103-PH, CG6103-PI, CG6103-PJ, CG6103-PK, CG6103-PL, CG6103-PM, CG6103-PN, CG6103-PO, CrebB-17A-PD, CrebB-17A-PE, CrebB-17A-PF, CrebB-17A-PG, CrebB-17A-PH, CrebB-17A-PI, CrebB-17A-PJ, CrebB-17A-PK, CrebB-17A-PL, CrebB-17A-PM, CrebB-17A-PN, CrebB-17A-PO, activator, blocker, cAMP response element-binding protein, cAMP-regulated enhancer-binding protein, cAMP-response element binding protein, cAMP-response element-binding protein, cyclic AMP response element binding protein, dCREB2, lethal(1)17Af
Species: fruit fly

Top Publications

  1. pmc Regulation of feeding and metabolism by neuronal and peripheral clocks in Drosophila
    Kanyan Xu
    Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell Metab 8:289-300. 2008
  2. doi cAMP signalling in mushroom bodies modulates temperature preference behaviour in Drosophila
    Sung Tae Hong
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Guseong Dong, Yusong gu, Daejeon, 305 701, Korea
    Nature 454:771-5. 2008
  3. pmc Autoregulatory and paracrine control of synaptic and behavioral plasticity by octopaminergic signaling
    Alex C Koon
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Neurosci 14:190-9. 2011
  4. ncbi A non-circadian role for cAMP signaling and CREB activity in Drosophila rest homeostasis
    J C Hendricks
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, 991 Maloney Building, 3600 Spruce St, Philadelphia, Pennsylvania, 19104 USA
    Nat Neurosci 4:1108-15. 2001
  5. ncbi CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila
    J C Yin
    Cold Spring Harbor Laboratory, New York 11724, USA
    Cell 81:107-15. 1995
  6. ncbi Phosphorylation of conserved casein kinase sites regulates cAMP-response element-binding protein DNA binding in Drosophila
    Junjiro Horiuchi
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    J Biol Chem 279:12117-25. 2004
  7. ncbi Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila
    J C Yin
    Cold Spring Harbor Laboratory, New York 11724
    Cell 79:49-58. 1994
  8. pmc Overexpression of neprilysin reduces alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and prem
    Kanae Iijima-Ando
    Laboratory of Neurogenetics and Pathobiology, Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 283:19066-76. 2008
  9. pmc cAMP-response element-binding protein and heat-shock protein 70 additively suppress polyglutamine-mediated toxicity in Drosophila
    Kanae Iijima-Ando
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 102:10261-6. 2005
  10. pmc The insulin-regulated CREB coactivator TORC promotes stress resistance in Drosophila
    Biao Wang
    Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA 92037, USA
    Cell Metab 7:434-44. 2008

Research Grants

Scientific Experts

  • Ralf Stanewsky
  • Takaomi Sakai
  • R Lamprecht
  • M Mayford
  • J C Yin
  • Magdalena A Walkiewicz
  • John A Kiger
  • Joshua T Dubnau
  • Paul J Shaw
  • B D Burrell
  • R S Hewes
  • J C Hendricks
  • Mary Packard
  • Carl A Stratton
  • A Brunner
  • C M Alberini
  • Edward Korzus
  • Kanae Iijima-Ando
  • Koichi Iijima
  • Ken Honjo
  • Christopher Shenton
  • Anne K Tanenhaus
  • T Tully
  • Sekyu Choi
  • Alex C Koon
  • Scott Waddell
  • Jongkyeong Chung
  • Lijuan Zhao
  • R L Davis
  • Y Wang
  • Feng Tie
  • Stephen A Hearn
  • Anthony Gatt
  • Biao Wang
  • Kanyan Xu
  • Sung Tae Hong
  • Michael J Krashes
  • Chunghun Lim
  • Katsuo Furukubo-Tokunaga
  • Yan Wang
  • M P Belvin
  • Dinghui Yu
  • Srividya Bhaskara
  • Indrani Ganguly-Fitzgerald
  • M Bienz
  • Ronald L Davis
  • Amita Sehgal
  • Priscilla Wu
  • Junjiro Horiuchi
  • Christopher J Mee
  • Bastianella Perazzona
  • Jeroen Poels
  • Aurelie Grienenberger
  • Subhabrata Sanyal
  • Thomas C Dockendorff
  • K Roxström-Lindquist
  • S Eresh
  • Jiabin Zhang
  • Vivian Budnik
  • Shamik Dasgupta
  • James Ashley
  • J Riese
  • Romina Barria
  • Wonho Kim
  • Ruth Brain
  • Mark J Alkema
  • Andrei Zlobin
  • N S Atkinson
  • A Ghezzi
  • Peter J Harte
  • Rakhee Banerjee
  • Jayashree Prasad-Sinha
  • Manuel O Diaz
  • Vincent Stepanik
  • Peter C Scacheri
  • Kyunghwa Jeong
  • Seogang Hyun
  • John B Thomas
  • Jian Chen
  • Yi Zhong
  • Marc Montminy
  • Linda Granger
  • Sunhoe Bang
  • Donggi Paik
  • Jodi Meltzer
  • Inessa Hakker
  • O Stork
  • D De Cesare
  • Jongkyun Kang
  • Pablo E Schilman

Detail Information

Publications77

  1. pmc Regulation of feeding and metabolism by neuronal and peripheral clocks in Drosophila
    Kanyan Xu
    Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell Metab 8:289-300. 2008
    ..We propose that the input of neuronal clocks and clocks in metabolic tissues is coordinated to provide effective energy homeostasis...
  2. doi cAMP signalling in mushroom bodies modulates temperature preference behaviour in Drosophila
    Sung Tae Hong
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Guseong Dong, Yusong gu, Daejeon, 305 701, Korea
    Nature 454:771-5. 2008
    ..Preferred temperatures were affected by the level of cAMP and PKA activity in the MBs in various PKA pathway mutants...
  3. pmc Autoregulatory and paracrine control of synaptic and behavioral plasticity by octopaminergic signaling
    Alex C Koon
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Neurosci 14:190-9. 2011
    ..Growth of octopaminergic arbors was controlled by a cAMP- and CREB-dependent positive-feedback mechanism that required Octβ2R octopamine autoreceptors...
  4. ncbi A non-circadian role for cAMP signaling and CREB activity in Drosophila rest homeostasis
    J C Hendricks
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, 991 Maloney Building, 3600 Spruce St, Philadelphia, Pennsylvania, 19104 USA
    Nat Neurosci 4:1108-15. 2001
    ..of sleep-like rest, we investigated the involvement of a candidate gene, cAMP response-element binding protein (CREB). The duration of rest was inversely related to cAMP signaling and CREB activity...
  5. ncbi CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila
    J C Yin
    Cold Spring Harbor Laboratory, New York 11724, USA
    Cell 81:107-15. 1995
    ..Here, we report an enhancement of LTM formation after induced expression of an activator isoform of dCREB2...
  6. ncbi Phosphorylation of conserved casein kinase sites regulates cAMP-response element-binding protein DNA binding in Drosophila
    Junjiro Horiuchi
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    J Biol Chem 279:12117-25. 2004
    The Drosophila homolog of cAMP-response element-binding protein (CREB), dCREB2, exists with serine 231, equivalent to mammalian serine 133, in a predominantly phosphorylated state...
  7. ncbi Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila
    J C Yin
    Cold Spring Harbor Laboratory, New York 11724
    Cell 79:49-58. 1994
    ..Using an inducible transgene that expresses a dominant negative member of the fly CREB family, LTM was specifically and completely blocked only after induction, while ARM and learning were unaffected...
  8. pmc Overexpression of neprilysin reduces alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and prem
    Kanae Iijima-Ando
    Laboratory of Neurogenetics and Pathobiology, Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 283:19066-76. 2008
    ..Down-regulation of NEP activity in aging brains may be an evolutionarily conserved phenomenon, which could predispose humans to developing late-onset AD...
  9. pmc cAMP-response element-binding protein and heat-shock protein 70 additively suppress polyglutamine-mediated toxicity in Drosophila
    Kanae Iijima-Ando
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 102:10261-6. 2005
    ..A mutation in the Drosophila homolog of CREB, dCREB2, enhances lethality due to polyglutamine peptides (polyQ), and an additional copy of dCREB2 partially rescues this ..
  10. pmc The insulin-regulated CREB coactivator TORC promotes stress resistance in Drosophila
    Biao Wang
    Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA 92037, USA
    Cell Metab 7:434-44. 2008
    In fasted mammals, glucose homeostasis is maintained through induction of the cAMP response element-binding protein (CREB) coactivator transducer of regulated CREB activity 2 (TORC2), which stimulates the gluconeogenic program in concert ..
  11. pmc A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist
    J C Yin
    Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge 02139, USA
    Mol Cell Biol 15:5123-30. 1995
    ..Uniquely among Drosophila genes characterized to date, it codes for a cAMP-responsive transcriptional activator. An alternatively spliced product of the same gene is a specific antagonist of cAMP-inducible transcription...
  12. pmc A CREB-binding site as a target for decapentaplegic signalling during Drosophila endoderm induction
    S Eresh
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 16:2014-22. 1997
    ..Furthermore, the Drosophila CRE-binding protein dCREB-B binds to the Ultrabithorax CRE, and ubiquitous expression of a dominant-negative form of dCREB-B suppresses CRE-..
  13. ncbi The Drosophila dCREB2 gene affects the circadian clock
    M P Belvin
    Cold Spring Harbor Laboratory, New York 11724, USA
    Neuron 22:777-87. 1999
    We report the role of dCREB2, the Drosophila homolog of CREB/CREM, in circadian rhythms. dCREB2 activity cycles with a 24 hr rhythm in flies, both in a light:dark cycle and in constant darkness...
  14. ncbi Genetic dissection of structural and functional components of synaptic plasticity. III. CREB is necessary for presynaptic functional plasticity
    G W Davis
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Neuron 17:669-79. 1996
    ..Expression of the CREB activator (dCREB2-a) increases synaptic strength only in FasII mutants that increase bouton number...
  15. doi Distinctive neuronal networks and biochemical pathways for appetitive and aversive memory in Drosophila larvae
    Ken Honjo
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    J Neurosci 29:852-62. 2009
    ..produced in this paradigm depends on intact cAMP signaling, but neither mutation of amnesiac nor suppression of CREB activity affects its kinetics...
  16. ncbi The role of cAMP response element-binding protein in Drosophila long-term memory
    Bastianella Perazzona
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 24:8823-8. 2004
    ..dCREB2-b) under the control of a heat-shock promoter was reported to block LTM, whereas overexpression of an activator isoform (dCREB2-a) was reported to enhance LTM...
  17. pmc CREB regulation of BK channel gene expression underlies rapid drug tolerance
    Y Wang
    Section of Neurobiology, The University of Texas at Austin, Austin, TX 78712 0248, USA
    Genes Brain Behav 8:369-76. 2009
    ..Here, we show that benzyl alcohol sedation alters expression of both dCREB-A and dCREB2-b genes to increase production of positively acting CREB isoforms and to reduce expression of negatively acting ..
  18. pmc Drosophila salt-inducible kinase (SIK) regulates starvation resistance through cAMP-response element-binding protein (CREB)-regulated transcription coactivator (CRTC)
    Sekyu Choi
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 335 Gwahangno, Yuseong Gu, Daejeon 305 701, Republic of Korea
    J Biol Chem 286:2658-64. 2011
    ..to play important functions in glucose homeostasis by inhibiting the cAMP-response element-binding protein (CREB)-regulated transcription coactivator (CRTC)...
  19. pmc In vivo circadian oscillation of dCREB2 and NF-κB activity in the Drosophila nervous system
    Anne K Tanenhaus
    Neuroscience Training Program, University of Wisconsin Madison, Madison, WI 53706, USA
    PLoS ONE 7:e45130. 2012
    ..Using a luciferase-based reporter, we show in vivo that Drosophila dCREB2- and NF-κB-mediated transcription oscillates in neuronal cells, glia, and in the mushroom body, a higher-order ..
  20. ncbi An intron enhancer activates the immunoglobulin-related Hemolin gene in Hyalophora cecropia
    K Roxström-Lindquist
    Department of Genetics, Stockholm University, Stockholm, Sweden
    Insect Mol Biol 11:505-15. 2002
    ..This is the first report of an insect immune-related gene that is up-regulated by an enhancer activity conferred through an intron...
  21. ncbi Isoforms of cyclic AMP response element binding proteins in Drosophila S2 cells
    Jeroen Poels
    Laboratory for Developmental Physiology, Genomics and Proteomics, Naamsestraat 59, B 3000 Leuven, Belgium
    Biochem Biophys Res Commun 320:318-24. 2004
    ..In this context, we have now investigated the presence of different dCREB transcripts in a stable, embryonic insect cell line, i.e., Drosophila Schneider 2 (S2) cells...
  22. ncbi Overexpression of a CREB repressor isoform enhances the female sexual receptivity in Drosophila
    Takaomi Sakai
    Institute for Behavioral Sciences, Gunma University School of Medicine, 3 39 22, Maebashi, 371 8511, Japan
    Behav Genet 32:413-22. 2002
    ..Drosophila melanogaster, one of alternatively spliced products of the CREB gene, dCREB2-a, is a transcriptional activator, while another isoform, dCREB2-b, is a repressor of dCREB2-a...
  23. ncbi FASt remodeling of synapses in Drosophila
    Mary Packard
    Department of Neurobiology, University of Massachusetts Medical School, Aaron Lazare Medical Research Building, 364 Plantation Street, Worcester, MA 01605 2324, USA
    Curr Opin Neurobiol 13:527-34. 2003
    ..These studies offer convincing evidence that synaptic cell adhesion brings about both negative and positive forces that stabilize synapses, while maintaining their ability to change in an activity-dependent manner...
  24. ncbi The relation of transcription to memory formation
    Edward Korzus
    University of California San Diego, Department of Neurosciences, 9500 Gilman Drive M C 0986, La Jolla, CA 92093 0986, USA
    Acta Biochim Pol 50:775-82. 2003
    ..in Drosophila and Aplysia indicate that the transcription factor cAMP/Ca(2+) response element binding protein (CREB) is critical in mediating the conversion from short- to long-term memory...
  25. ncbi Genetic analysis of the circadian system in Drosophila melanogaster and mammals
    Ralf Stanewsky
    Universitat Regensburg, Institut fur Zoologie, Lehrstuhl für Entwicklungsbiologie, Universitatsstrasse 31, 93040 Regensburg, Germany
    J Neurobiol 54:111-47. 2003
    ..This review will try to give a comparative overview about the two systems, highlighting similarities as well as specifics of both insect and murine clocks...
  26. ncbi Tgfbeta signaling acts on a Hox response element to confer specificity and diversity to Hox protein function
    Aurelie Grienenberger
    Laboratoire de Génétique et Biologie du Développement, IBDM, CNRS, Universite de la Mediterranee, Parc Scientifique de Luminy, Case 907, 13288 Marseille Cedex 9, France
    Development 130:5445-55. 2003
    ..The signal, acting through Mad and Creb, provides spatial information that subdivides the domain of Abdominal A function through direct combinatorial ..
  27. ncbi Perchance to dream: solving the mystery of sleep through genetic analysis
    Paul J Shaw
    The Neurosciences Institute, 10640 John J Hopkins Dr, San Diego, California 92121, USA
    J Neurobiol 54:179-202. 2003
    ..In this article we will review recent studies that have used genetic techniques to evaluate sleep in the fruit fly and the mouse...
  28. ncbi Neural substrates of memory: from synapse to system
    Josh Dubnau
    Cold Spring Harbor Laboratories, 1 Bungtown Rd, Cold Spring Harbor, New York 11724, USA
    J Neurobiol 54:238-53. 2003
    ..Our objective here is to offer a conceptually unifying perspective and to discuss this perspective in relation to an experiment analysis of memory in Drosophila...
  29. pmc A clock gene, period, plays a key role in long-term memory formation in Drosophila
    Takaomi Sakai
    Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi 371 8511, Japan
    Proc Natl Acad Sci U S A 101:16058-63. 2004
    The cAMP-responsive transcription factor, CREB, is required for formation of long-term memory (LTM) in Drosophila melanogaster and regulates transcription of a circadian clock gene, period (per)...
  30. pmc Mitochondrial mislocalization underlies Abeta42-induced neuronal dysfunction in a Drosophila model of Alzheimer's disease
    Kanae Iijima-Ando
    Laboratory of Neurogenetics and Pathobiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    PLoS ONE 4:e8310. 2009
    ..These results demonstrate that mislocalization of mitochondria underlies the pathogenic effects of Abeta42 in vivo...
  31. ncbi Induction of two cytochrome P450 genes, Cyp6a2 and Cyp6a8, of Drosophila melanogaster by caffeine in adult flies and in cell culture
    Srividya Bhaskara
    Department of Biochemistry, Cellular and Molecular Biology, University of Tennessee, Knoxville, 37996, USA
    Gene 377:56-64. 2006
    ..of Cyp6a2 and Cyp6a8 genes which also contain many binding sites for activator protein 1 (AP1) and cyclic AMP response element binding protein (CRE-BP). Significance of these binding sites in caffeine-inducibility has been discussed.
  32. pmc CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing
    Feng Tie
    Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA
    Development 136:3131-41. 2009
    ..We propose that TRX-dependent acetylation of H3K27 by CBP prevents H3K27me3 at Polycomb target genes and constitutes a key part of the molecular mechanism by which TRX antagonizes or prevents Polycomb silencing...
  33. pmc Increased insulin/insulin growth factor signaling advances the onset of metamorphosis in Drosophila
    Magdalena A Walkiewicz
    Department of Biochemistry and Cell Biology, Rice University, Houston, Texas, United States of America
    PLoS ONE 4:e5072. 2009
    ....
  34. ncbi Molecular enhancement of memory formation
    T J Carew
    Department of Psychology, Yale University, New Haven, Connecticut 06520, USA
    Neuron 16:5-8. 1996
  35. pmc Rapid consolidation to a radish and protein synthesis-dependent long-term memory after single-session appetitive olfactory conditioning in Drosophila
    Michael J Krashes
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Neurosci 28:3103-13. 2008
    ..Appetitive LTM has some mechanistic similarity to aversive LTM in that it can be disrupted by cycloheximide, the dCreb2-b transcriptional repressor, and the crammer and tequila LTM-specific mutations...
  36. pmc Drug-induced epigenetic changes produce drug tolerance
    Yan Wang
    Section of Neurobiology, The University of Texas at Austin, Austin, Texas, USA
    PLoS Biol 5:e265. 2007
    ..The cAMP response element binding protein (CREB) is an important transcription factor mediating experience-based neuroadaptations...
  37. pmc Functional role of CREB-binding protein in the circadian clock system of Drosophila melanogaster
    Chunghun Lim
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, South Korea
    Mol Cell Biol 27:4876-90. 2007
    ..Here, using transgenic fly models, we show that CREB-binding protein (CBP) participates in the transcriptional regulation of the Drosophila CLOCK/CYCLE (dCLK/CYC) ..
  38. pmc Drosophila alpha/beta mushroom body neurons form a branch-specific, long-term cellular memory trace after spaced olfactory conditioning
    Dinghui Yu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Neuron 52:845-55. 2006
    ..and was blocked by mutation of the amnesiac gene, inhibition of protein synthesis, or the expression of a protein blocker of the transcription factor Creb...
  39. ncbi Waking experience affects sleep need in Drosophila
    Indrani Ganguly-Fitzgerald
    Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92101, USA
    Science 313:1775-81. 2006
    ..Furthermore, this experience-dependent plasticity in sleep need is subserved by the dopaminergic and adenosine 3',5'-monophosphate signaling pathways and a particular subset of 17 long-term memory genes...
  40. ncbi Induction of cAMP response element-binding protein-dependent medium-term memory by appetitive gustatory reinforcement in Drosophila larvae
    Ken Honjo
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305 8572, Japan
    J Neurosci 25:7905-13. 2005
    ..appetitive conditioning lasts medium term and depends on both amnesiac and cAMP response element-binding protein (CREB)...
  41. pmc Regulation of energy stores and feeding by neuronal and peripheral CREB activity in Drosophila
    Koichi Iijima
    Laboratory of Neurodegenerative and Metabolic Diseases, Farber Institute for Neurosciences, Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 4:e8498. 2009
    ..While Drosophila has a homolog of mammalian CREB, dCREB2, its role in energy metabolism is not fully understood...
  42. ncbi Clock mechanisms in Drosophila
    Ralf Stanewsky
    Universitat Regensburg, Institut fur Zoologie, Lehrstuhl für Entwicklungsbiologie, Universitatsstrasse 31, 93040 Regensburg, Germany
    Cell Tissue Res 309:11-26. 2002
    ..Although their regulation depends on the major clock genes, the majority of the clock-controlled genes are not direct targets of clock factors...
  43. ncbi Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest
    Thomas C Dockendorff
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuron 34:973-84. 2002
    ..Molecular analysis fails to reveal any defects in the expression of clock components; however, the CREB output is affected...
  44. ncbi Drosophila learning and memory: recent progress and new approaches
    M P Belvin
    Cold Spring Harbor Laboratory, NY 11724, USA
    Bioessays 19:1083-9. 1997
    ..This made possible experiments that implicated the Drosophila CREB gene as a critical component in the consolidation of long-term memory, and paves the way for future experiments ..
  45. ncbi D-Fos, a target gene of Decapentaplegic signalling with a critical role during Drosophila endoderm induction
    J Riese
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Development 124:3353-61. 1997
    ....
  46. ncbi The fascination of the Drosophila NMJ
    A Brunner
    Department of Genetics, University of Cambridge, UK
    Trends Genet 13:85-7. 1997
  47. ncbi The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing
    T Kadowaki
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 10:3116-28. 1996
    ..We identified a human sequence related to Porc suggesting the existence of a family of proteins involved in processing of Wnts...
  48. ncbi The supple synapse: an affair that remembers
    W Roush
    Science 274:1102-3. 1996
  49. pmc Discovery of genes involved with learning and memory: an experimental synthesis of Hirschian and Benzerian perspectives
    T Tully
    Cold Spring Harbor Laboratory, NY 11724, USA
    Proc Natl Acad Sci U S A 93:13460-7. 1996
    ..In addition, more specific conclusions will be obtained from reverse-genetic experiments, in which gene disruptions are restricted in time and/or space...
  50. ncbi Biochemistry of insect learning: lessons from bees and flies
    V H Meller
    Department of Cell Biology and Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Insect Biochem Mol Biol 26:327-35. 1996
    ..In spite of similarities, temporal, and possibly biochemical aspects of learning differ markedly between these organisms...
  51. ncbi CREB and the formation of long-term memory
    J C Yin
    Cold Spring Harbor Laboratory, New York 11724, USA
    Curr Opin Neurobiol 6:264-8. 1996
    b>Cyclic AMP response element binding protein (CREB)-responsive transcription plays a central role in the formation of long-term memory in Drosophila, Aplysia and mice...
  52. ncbi Physiology and biochemistry of Drosophila learning mutants
    R L Davis
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas, USA
    Physiol Rev 76:299-317. 1996
    ..activating peptides), dunce (cAMP phosophodiesterase), rutabaga (adenylyl cyclase), DCO (protein kinase A), and dCREB2 (cAMP-response element binding protein), have proven important for normal learning...
  53. ncbi Isolation of Drosophila CREB-B: a novel CRE-binding protein
    T Usui
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201
    DNA Cell Biol 12:589-95. 1993
    ..However, the putative DNA binding domains for all three proteins are highly conserved. The activator region of dCREB-B is completely different from that of both mammalian CREB and dCREB-A...
  54. ncbi Drosophila mushroom body subdomains: innate or learned representations of odor preference and sexual orientation?
    J S de Belle
    Max Planck Institut für biologische Kybernetik, Tubingen, Federal Republic of Germany
    Neuron 15:245-7. 1995
  55. ncbi Dissection of memory formation: from behavioral pharmacology to molecular genetics
    J DeZazzo
    Cold Spring Harbor Laboratory, Harbor, NY 11724, USA
    Trends Neurosci 18:212-8. 1995
    ..These studies support the application of reverse-genetic strategies, including the use of temporally specific agonists and antagonists, to advance the functional dissection of memory formation...
  56. ncbi Memory mechanisms. Photographic memory in flies
    Y Goda
    Molecular Neurobiology Laboratory, Salk Institute, La Jolla, California 92037, USA
    Curr Biol 5:852-3. 1995
    A new study of olfactory memory formation in Drosophila shows that a delicate balance of CREB transcription factor activity may play a decisive role in triggering long-term memory.
  57. ncbi Flies, genes, learning, and memory
    R J Greenspan
    Department of Biology, New York University, New York 10003, USA
    Neuron 15:747-50. 1995
  58. ncbi Gene discovery in Drosophila: new insights for learning and memory
    J Dubnau
    Cold Spring Harbor Laboratory, New York 11724, USA
    Annu Rev Neurosci 21:407-44. 1998
    ..Second, because core cellular mechanisms of simple forms of learning are evolutionarily conserved, biological pathways discovered in invertebrates are likely to be conserved in vertebrate systems as well...
  59. ncbi Shaping animal body plans in development and evolution by modulation of Hox expression patterns
    G Gellon
    Department of Biology, Yale University, New Haven, CT, USA
    Bioessays 20:116-25. 1998
    ....
  60. pmc Regulation of gene expression and its role in long-term memory and synaptic plasticity
    T Tully
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 94:4239-41. 1997
  61. ncbi AP-1 functions upstream of CREB to control synaptic plasticity in Drosophila
    Subhabrata Sanyal
    Department of Molecular and Cellular Biology, University of Arizona, Tucson 85721, USA
    Nature 416:870-4. 2002
    ..activity causes kinase-mediated activation of the transcription factor cyclic AMP response-element-binding protein, CREB. Together with appropriate cofactors, CREB then transcriptionally induces a group of 'immediate early' ..
  62. ncbi Learning in simple systems
    B D Burrell
    Department of Biological Sciences, 1392 Lilly Hall of Life Sciences, West Lafayette, IN 47907 1392, USA
    Curr Opin Neurobiol 11:757-64. 2001
    ..Some pathways contribute to a single stage of memory formation, whereas others impact on multiple stages of memory development. Distinct cellular pathways may also act in series or in parallel during various stages of memory formation...
  63. pmc The cryptocephal gene (ATF4) encodes multiple basic-leucine zipper proteins controlling molting and metamorphosis in Drosophila
    R S Hewes
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Genetics 155:1711-23. 2000
    ..Here we report that crc encodes a Drosophila homolog of vertebrate ATF4, a member of the CREB/ATF family of basic-leucine zipper (bZIP) transcription factors. We identified three putative protein isoforms...
  64. ncbi Genetic approaches to memory storage
    M Mayford
    University of California, San Diego, Department of Neurosciences, La Jolla, CA 92093 0691, USA
    Trends Genet 15:463-70. 1999
    ..In these organisms, the effectiveness of genetic approaches in the study of memory has improved significantly in the past five years. Below we review these advances...
  65. ncbi Genes to remember
    C M Alberini
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    J Exp Biol 202:2887-91. 1999
    ..Here, we review the studies showing that conserved molecules and biological mechanisms are engaged in simple and complex forms of memory...
  66. ncbi Signaling routes to CREM and CREB: plasticity in transcriptional activation
    D De Cesare
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, B P 163, 67404 Illkirch Strasbourg, France
    Trends Biochem Sci 24:281-5. 1999
    ..Phosphorylation allows recruitment of CREB-binding protein (CBP), a large co-activator that contacts the general transcriptional machinery...
  67. ncbi Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling
    L Waltzer
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Nature 395:521-5. 1998
    ..Here we report that Drosophila CREB-binding protein (dCBP) binds to dTCF. dCBP mutants show mild Wingless overactivation phenotypes in various tissues...
  68. ncbi Invited review: Sleeping flies don't lie: the use of Drosophila melanogaster to study sleep and circadian rhythms
    Joan C Hendricks
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Appl Physiol (1985) 94:1660-72; discussion 1673. 2003
    ..Nonetheless, studies have already established that two transcription factors alter rest and rest homeostasis. The implications of these advances for the future of sleep research are summarized...
  69. pmc Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway
    D A Harrison
    Department of Genetics, Boston, Massachusetts 02115 USA
    Genes Dev 12:3252-63. 1998
    ..We propose that Upd is a ligand that relies on JAK signaling to stimulate transcription of pair-rule genes in a segmentally restricted manner in the early Drosophila embryo...
  70. ncbi Memory formation and the regulation of gene expression
    O Stork
    Laboratory of Neurochemistry, National Institute for Physiological Sciences, Myodaiji, Okazaki, Japan
    Cell Mol Life Sci 55:575-92. 1999
    ..It is expected that the new molecular methods will help to identify and characterize molecules whose expression changes during LTM formation even in complex vertebrate learning paradigms...
  71. pmc Hemocytes are essential for wing maturation in Drosophila melanogaster
    J A Kiger
    Molecular and Cellular Biology, University of California, 1 Shields Avenue, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 98:10190-5. 2001
    ..We propose that batone is required for the release of a hormone necessary for wing expansion and tissue remodeling by hemocytes in the wing...
  72. ncbi A return to genetic dissection of memory in Drosophila
    T Tully
    Cold Spring Harbor Laboratory, New York 11724, USA
    Cold Spring Harb Symp Quant Biol 61:207-18. 1996
  73. ncbi CREB: a message to remember
    R Lamprecht
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
    Cell Mol Life Sci 55:554-63. 1999
    ..most salient results consonant with this hypothesis is that the transcription factor cAMP response element binding (CREB) is involved in the formation of memory in organisms with diverse phylogenetic background from mollusks to mammals...
  74. ncbi Neurofibromin progress on the fly
    R L Davis
    Nature 403:846-7. 2000
  75. pmc Genetic and developmental analysis of polytene section 17 of the X chromosome of Drosophila melanogaster
    D F Eberl
    Department of Molecular Biology and Genetics, University of Guelph, Ontario, Canada
    Genetics 130:569-83. 1992
    ..In this interval of 37 to 43 polytene chromosome bands we have defined 17 genes, 12 (71%) of which are of significance to oogenesis or embryogenesis...
  76. ncbi Regulation of neuronal excitability through pumilio-dependent control of a sodium channel gene
    Christopher J Mee
    Neuroscience Group, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom
    J Neurosci 24:8695-703. 2004
    ..We show, through use of anemone toxin (ATX II), that alteration in persistent I(Na) is sufficient to regulate membrane excitability in these two motoneurons...
  77. pmc Functional intertwining of Dpp and EGFR signaling during Drosophila endoderm induction
    D Szuts
    Medical Research Council MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, UK
    Genes Dev 12:2022-35. 1998
    ..We discuss the potential significance of why an inductive process might use a secondary signal whose function is intertwined with that of the primary signal...

Research Grants8

  1. GENETIC INTERFERENCE WITH MEMORY CONSOLIDATION
    Edward Korzus; Fiscal Year: 2003
    ..It has been previously shown that cAMP response element binding protein (CREB)-mediated transcription is required in long-term plasticity and this phenomenon is conserved ..
  2. Functional Anatomy of Learning and Memory in Drosophila
    JOSHUA DUBNAU; Fiscal Year: 2007
    ..As a result, an understanding of the "logic" of how information is processed in relatively simple nervous systems can greatly inform future investigations of human cognition. ..
  3. Genome-wide regulatory network governing neuronal mRNA translation.
    Joshua T Dubnau; Fiscal Year: 2010
    ..This proposal describes a method that can provide individual reporters of the regulation of protein synthesis for each gene in the genome, and can identify the regulatory mechanisms controlling each one. ..