Gene Symbol: Cpsf73
Description: Cleavage and polyadenylation specificity factor 73
Alias: CG7698, CPSF-73, CPSF73, Dmel\CG7698, cpsf-73, dCPSF-73, cleavage and polyadenylation specificity factor 73, CG7698-PA, Cpsf73-PA, cleavage and polyadenylation specificity factor, 73kD-subunit
Species: fruit fly
Osheim Y, Sikes M, Beyer A. EM visualization of Pol II genes in Drosophila: most genes terminate without prior 3' end cleavage of nascent transcripts. Chromosoma. 2002;111:1-12 pubmed
Yang X, Burch B, Yan Y, Marzluff W, Dominski Z. FLASH, a proapoptotic protein involved in activation of caspase-8, is essential for 3' end processing of histone pre-mRNAs. Mol Cell. 2009;36:267-78 pubmed publisher
..These results demonstrate that FLASH is an essential factor required for 3' end maturation of histone mRNAs in both vertebrates and invertebrates and suggest a potential link between this process and apoptosis. ..
Sullivan K, Steiniger M, Marzluff W. A core complex of CPSF73, CPSF100, and Symplekin may form two different cleavage factors for processing of poly(A) and histone mRNAs. Mol Cell. 2009;34:322-32 pubmed publisher
..We demonstrate that Symplekin, CPSF73, and CPSF100 are present in a stable complex and interact with histone-specific processing factors...
Doumanis J, Wada K, Kino Y, Moore A, Nukina N. RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation. PLoS ONE. 2009;4:e7275 pubmed publisher
..Newly identified modifiers including genes related to nuclear transport, nucleotide processes, and signaling, may be involved in polyglutamine aggregate formation and Huntington disease cascades. ..
Tatomer D, Rizzardi L, Curry K, Witkowski A, Marzluff W, Duronio R. Drosophila Symplekin localizes dynamically to the histone locus body and tricellular junctions. Nucleus. 2014;5:613-25 pubmed publisher
..This localization depends on the RNA binding protein ypsilon schachtel. CPSF-73 and a number of mRNAs are localized at this same site, suggesting that Symplekin participates in cytoplasmic polyadenylation at tricellular junctions. ..
Michalski D, Steiniger M. In vivo characterization of the Drosophila mRNA 3' end processing core cleavage complex. RNA. 2015;21:1404-18 pubmed publisher
A core cleavage complex (CCC) consisting of CPSF73, CPSF100, and Symplekin is required for cotranscriptional 3' end processing of all metazoan pre-mRNAs, yet little is known about the in vivo molecular interactions within this complex...