Gene Symbol: Cpsf160
Description: Cleavage and polyadenylation specificity factor 160
Alias: CG10110, CPSF, CPSF-160, CPSF160, Cpsf, Dmel\CG10110, anon-WO0118547.217, cpsf, dCPSF-160, cleavage and polyadenylation specificity factor 160, CG10110-PA, CG10110-PB, Cpsf160-PA, Cpsf160-PB, cleavage and polyadenylation specificity factor, drosophila cleavage and polyadenylation stimulation factor-160
Species: fruit fly

Top Publications

  1. Sinclair D, Milne T, Hodgson J, Shellard J, Salinas C, Kyba M, et al. The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes. Development. 1998;125:1207-16 pubmed
    ..The differences in target site recognition may account for some of the differences in Asx phenotypes relative to other members of the Polycomb group. ..
  2. Salinas C, Sinclair D, O Hare K, Brock H. Characterization of a Drosophila homologue of the 160-kDa subunit of the cleavage and polyadenylation specificity factor CPSF. Mol Gen Genet. 1998;257:672-80 pubmed
    Processing of the 3' end of mRNA precursors depends on several proteins. The multisubunit cleavage and polyadenylation specificity factor (CPSF) is required for cleavage of the mRNA precursor as well as polyadenylation...
  3. Chern J, Choi K. Lobe mediates Notch signaling to control domain-specific growth in the Drosophila eye disc. Development. 2002;129:4005-13 pubmed
    ..Our data suggest that the control of ventral Ser expression by L represents a molecular mechanism that governs asymmetrical eye growth. ..
  4. Sullivan K, Steiniger M, Marzluff W. A core complex of CPSF73, CPSF100, and Symplekin may form two different cleavage factors for processing of poly(A) and histone mRNAs. Mol Cell. 2009;34:322-32 pubmed publisher
    ..Depletion of SLBP recruits CstF50 to histone genes. Knockdown of CPSF160 or CstF64 downregulates Symplekin but does not affect histone pre-mRNA processing or association of Symplekin ..
  5. Mensch J, Serra F, Lavagnino N, Dopazo H, Hasson E. Positive selection in nucleoporins challenges constraints on early expressed genes in Drosophila development. Genome Biol Evol. 2013;5:2231-41 pubmed publisher
    ..Understanding these exceptions to the broad evolutionary conservation of early expressed developmental genes can shed light into relevant processes driving the evolution of species divergence. ..
  6. Soller M, White K. ELAV inhibits 3'-end processing to promote neural splicing of ewg pre-mRNA. Genes Dev. 2003;17:2526-38 pubmed
    ..These data indicate that binding of 3'-end processing factors, together with ELAV, can regulate alternative splicing. ..
  7. Milne T, Sinclair D, Brock H. The Additional sex combs gene of Drosophila is required for activation and repression of homeotic loci, and interacts specifically with Polycomb and super sex combs. Mol Gen Genet. 1999;261:753-61 pubmed
    ..ASX may interact with a PcG complex containing PC and SXC and mediate activation versus repression at target loci, perhaps by interacting directly with the TRX protein. ..