Cp190

Summary

Gene Symbol: Cp190
Description: Centrosomal protein 190kD
Alias: AbS1-4, Bx-63, Bx63, CEN190, CG6384, CP-190, CP-60, CP190, CP190_DROME, Cen185, Cen190, DMAP 190, DMAP-190, DMAP190, Dmap190, Dmel\CG6384, E(mod)4-1, Map190, Rb188, cp190, dmap190, centrosomal protein 190kD, CG6384-PA, CG6384-PB, Cp190-PA, Cp190-PB, E(mod)4-1, centrosomal protein 190, centrosomal protein 190 kD, centrosomal protein 190 kDa, centrosomal protein 90, centrosomal protein of 190 kDa, enhancer of mod(mdg4)4-1
Species: fruit fly

Top Publications

  1. Postner M, Miller K, Wieschaus E. Maternal effect mutations of the sponge locus affect actin cytoskeletal rearrangements in Drosophila melanogaster embryos. J Cell Biol. 1992;119:1205-18 pubmed
    ..Furthermore, the formation of actin caps and metaphase furrows is not a prerequisite for the formation of the hexagonal array of actin instrumental in the conversion of the syncytial embryo into a cellular blastoderm. ..
  2. Ohkura H, Torok T, Tick G, Hoheisel J, Kiss I, Glover D. Mutation of a gene for a Drosophila kinesin-like protein, Klp38B, leads to failure of cytokinesis. J Cell Sci. 1997;110 ( Pt 8):945-54 pubmed
    ..Taken together, we conclude that these Klp38B mutations lead to a failure of cytokinesis resulting in polyploidy, and discuss whether or not this is a direct effect of the mutation. ..
  3. Lei E, Corces V. RNA interference machinery influences the nuclear organization of a chromatin insulator. Nat Genet. 2006;38:936-41 pubmed
    ..Rm62 interacts physically with the DNA-binding insulator protein CP190 in an RNA-dependent manner...
  4. Golovnin A, Mazur A, Kopantseva M, Kurshakova M, Gulak P, Gilmore B, et al. Integrity of the Mod(mdg4)-67.2 BTB domain is critical to insulator function in Drosophila melanogaster. Mol Cell Biol. 2007;27:963-74 pubmed
    ..2 BTB domain with the GAF BTB domain produced a nonfunctional protein. Taken together, these data suggest that the Mod(mdg4)-67.2 BTB domain confers novel activities to gypsy insulator function. ..
  5. Negre N, Brown C, Shah P, Kheradpour P, Morrison C, Henikoff J, et al. A comprehensive map of insulator elements for the Drosophila genome. PLoS Genet. 2010;6:e1000814 pubmed publisher
    ..We studied by ChIP-chip the genome-wide binding sites of 6 insulator-associated proteins-dCTCF, CP190, BEAF-32, Su(Hw), Mod(mdg4), and GAF-to obtain the first comprehensive map of insulator elements in Drosophila ..
  6. Kaltschmidt J, Davidson C, Brown N, Brand A. Rotation and asymmetry of the mitotic spindle direct asymmetric cell division in the developing central nervous system. Nat Cell Biol. 2000;2:7-12 pubmed
    ..This observation contradicts the widely held hypothesis that the cleavage furrow is always placed midway between the two centrosomes. ..
  7. Raff J, Kellogg D, Alberts B. Drosophila gamma-tubulin is part of a complex containing two previously identified centrosomal MAPs. J Cell Biol. 1993;121:823-35 pubmed
    ..complex of Drosophila proteins that contains at least two centrosomal microtubule-associated proteins called DMAP190 and DMAP60...
  8. Donaldson M, Tavares A, Ohkura H, Deak P, Glover D. Metaphase arrest with centromere separation in polo mutants of Drosophila. J Cell Biol. 2001;153:663-76 pubmed
    ..that are associated with Centrosomin and the abnormal spindle protein (Asp), but neither with gamma-tubulin nor CP190. We discuss roles for Polo kinase in recruiting centrosomal proteins and in regulating progression through the ..
  9. Cullen C, Brittle A, Ito T, Ohkura H. The conserved kinase NHK-1 is essential for mitotic progression and unifying acentrosomal meiotic spindles in Drosophila melanogaster. J Cell Biol. 2005;171:593-602 pubmed
    ..NHK-1 itself is phosphorylated in mitosis and female meiosis, suggesting that this kinase is part of the regulatory system coordinating progression of mitosis and meiosis. ..

More Information

Publications69

  1. Kaltschmidt J, Brand A. Asymmetric cell division: microtubule dynamics and spindle asymmetry. J Cell Sci. 2002;115:2257-64 pubmed
    ..In this commentary we discuss recent findings on how the mitotic spindle is positioned and on cleavage site induction and place them in the context of cell size asymmetry in different model organisms. ..
  2. Whitfield W, Chaplin M, Oegema K, Parry H, Glover D. The 190 kDa centrosome-associated protein of Drosophila melanogaster contains four zinc finger motifs and binds to specific sites on polytene chromosomes. J Cell Sci. 1995;108 ( Pt 11):3377-87 pubmed
    Microinjection of a bacterially expressed, TRITC labelled fragment of the centrosome-associated protein CP190 of Drosophila melanogaster, into syncytial Drosophila embryos, shows it to associate with the centrosomes during mitosis, and ..
  3. Kellogg D, Field C, Alberts B. Identification of microtubule-associated proteins in the centrosome, spindle, and kinetochore of the early Drosophila embryo. J Cell Biol. 1989;109:2977-91 pubmed
    ..Very few MAPS seem to be identically localized in the cell, indicating that the microtubule cytoskeleton is remarkably complex. ..
  4. Whitfield W, Millar S, Saumweber H, Frasch M, Glover D. Cloning of a gene encoding an antigen associated with the centrosome in Drosophila. J Cell Sci. 1988;89 ( Pt 4):467-80 pubmed
    The monoclonal antibody Bx63 recognizes a centrosomal antigen of Drosophila melanogaster by indirect immunofluorescence and identifies two proteins, with apparent molecular weights of 185 x 10(3) and 66 x 10(3), on Western blots...
  5. Oliver D, Sheehan B, South H, Akbari O, Pai C. The chromosomal association/dissociation of the chromatin insulator protein Cp190 of Drosophila melanogaster is mediated by the BTB/POZ domain and two acidic regions. BMC Cell Biol. 2010;11:101 pubmed publisher
    ..They regulate gene transcription by interfering with promoter-enhancer communication. The Cp190 protein of Drosophila melanogaster is essential to the function of at least three-types of chromatin insulator ..
  6. Van Bortle K, Ramos E, Takenaka N, Yang J, Wahi J, Corces V. Drosophila CTCF tandemly aligns with other insulator proteins at the borders of H3K27me3 domains. Genome Res. 2012;22:2176-87 pubmed publisher
    ..We reveal an important relationship between dCTCF and other Drosophila insulator proteins and speculate that vertebrate CTCF may also align with other nuclear proteins to accomplish similar functions. ..
  7. Wood A, Van Bortle K, Ramos E, Takenaka N, Rohrbaugh M, Jones B, et al. Regulation of chromatin organization and inducible gene expression by a Drosophila insulator. Mol Cell. 2011;44:29-38 pubmed publisher
    ..Drosophila insulators contain specific DNA-binding proteins plus common components, such as CP190, that facilitate these interactions...
  8. Chodagam S, Royou A, Whitfield W, Karess R, Raff J. The centrosomal protein CP190 regulates myosin function during early Drosophila development. Curr Biol. 2005;15:1308-13 pubmed
    ..The Drosophila CP190 protein is nuclear in interphase, interacts with centrosomes during mitosis, and binds to MTs directly in vitro...
  9. Adams R, Tavares A, Salzberg A, Bellen H, Glover D. pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis. Genes Dev. 1998;12:1483-94 pubmed
    ..We suggest that PAV-KLP is required both to establish the structure of the telophase spindle to provide a framework for the assembly of the contractile ring, and to mobilize mitotic regulator proteins. ..
  10. Akbari O, Oliver D, Eyer K, Pai C. An Entry/Gateway cloning system for general expression of genes with molecular tags in Drosophila melanogaster. BMC Cell Biol. 2009;10:8 pubmed publisher
    ..The vectors were used to generate fluorescent CP190 which is a component of the gypsy chromatin insulator...
  11. Moshkovich N, Nisha P, Boyle P, Thompson B, Dale R, Lei E. RNAi-independent role for Argonaute2 in CTCF/CP190 chromatin insulator function. Genes Dev. 2011;25:1686-701 pubmed publisher
    ..Intriguingly, AGO2 colocalizes extensively with CTCF/CP190 chromatin insulators but not with genomic regions corresponding to endogenous siRNA production...
  12. Gerasimova T, Lei E, Bushey A, Corces V. Coordinated control of dCTCF and gypsy chromatin insulators in Drosophila. Mol Cell. 2007;28:761-72 pubmed
    ..dCTCF colocalizes with CP190, which is required for proper binding of dCTCF to chromatin, but not with the other gypsy insulator proteins Su(Hw)..
  13. Rogers G, Rusan N, Peifer M, Rogers S. A multicomponent assembly pathway contributes to the formation of acentrosomal microtubule arrays in interphase Drosophila cells. Mol Biol Cell. 2008;19:3163-78 pubmed publisher
    ..Taken together, these results modify our view of the cycle of centrosome function and reveal a multi-component acentrosomal microtubule assembly pathway to establish interphase microtubule arrays in Drosophila. ..
  14. Baxley R, Soshnev A, Koryakov D, Zhimulev I, Geyer P. The role of the Suppressor of Hairy-wing insulator protein in Drosophila oogenesis. Dev Biol. 2011;356:398-410 pubmed publisher
    ..2 (Mod67.2) and Centrosomal Protein of 190kDa (CP190). Accumulation of these proteins is distinct from Su(Hw), with Mod67...
  15. Capelson M, Corces V. SUMO conjugation attenuates the activity of the gypsy chromatin insulator. EMBO J. 2006;25:1906-14 pubmed
    ..2 and CP190, are sumoylated, and that SUMO is associated with a subset of genomic insulator sites...
  16. Lim S, Boyle P, Chinen M, Dale R, Lei E. Genome-wide localization of exosome components to active promoters and chromatin insulators in Drosophila. Nucleic Acids Res. 2013;41:2963-80 pubmed publisher
    ..the exosome, the highly conserved major cellular 3' to 5' RNA degradation machinery, as a physical interactor of CP190-dependent chromatin insulator complexes in Drosophila...
  17. Gopalakrishnan J, Mennella V, Blachon S, Zhai B, Smith A, Megraw T, et al. Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome. Nat Commun. 2011;2:359 pubmed publisher
    ..In summary, PCM assembly begins in the cytosol where Sas-4 provides a scaffold for pre-assembled cytoplasmic complexes before tethering of the complexes in a centrosome. ..
  18. Hou C, Li L, Qin Z, Corces V. Gene density, transcription, and insulators contribute to the partition of the Drosophila genome into physical domains. Mol Cell. 2012;48:471-84 pubmed publisher
    ..These results suggest that the higher-order physical organization of chromatin may impose an additional level of regulation over classical epigenetic marks. ..
  19. Feller C, Prestel M, Hartmann H, Straub T, Söding J, Becker P. The MOF-containing NSL complex associates globally with housekeeping genes, but activates only a defined subset. Nucleic Acids Res. 2012;40:1509-22 pubmed publisher
    ..We conclude that the regulatory capacity of the NSL complex is highly context-dependent. Activation by the NSL complex requires a particular promoter architecture defined by combinations of chromatin regulators and core promoter motifs. ..
  20. Oegema K, Marshall W, Sedat J, Alberts B. Two proteins that cycle asynchronously between centrosomes and nuclear structures: Drosophila CP60 and CP190. J Cell Sci. 1997;110 ( Pt 14):1573-83 pubmed
    ..b>CP190 and CP60 are two Drosophila proteins of unknown function that shuttle between centrosomes and nuclei in a cell ..
  21. Lemos C, Sampaio P, Maiato H, Costa M, Omel yanchuk L, Liberal V, et al. Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization. EMBO J. 2000;19:3668-82 pubmed
    ..The defects observed in the mutant alleles and the intracellular localization of the protein suggest that Mast plays an essential role in centrosome separation and organization of the bipolar mitotic spindle. ..
  22. Kellogg D, Alberts B. Purification of a multiprotein complex containing centrosomal proteins from the Drosophila embryo by chromatography with low-affinity polyclonal antibodies. Mol Biol Cell. 1992;3:1-11 pubmed
    ..We present evidence that these KCl-eluted proteins represent additional centrosomal components that interact with the 190-kDa protein to form a multiprotein complex within the cell. ..
  23. Li K, Kaufman T. The homeotic target gene centrosomin encodes an essential centrosomal component. Cell. 1996;85:585-96 pubmed
    ..We propose that cnn provides an example of homeotic genes directly regulating the accumulation of essential cellular proteins to carry out segment-specific morphogenetic functions. ..
  24. Pai C, Lei E, Ghosh D, Corces V. The centrosomal protein CP190 is a component of the gypsy chromatin insulator. Mol Cell. 2004;16:737-48 pubmed
    ..A genetic screen for dominant enhancers of the mod(mdg4) phenotype identified the Centrosomal Protein 190 (CP190) as an essential constituent of the gypsy insulator...
  25. Capelson M, Corces V. The ubiquitin ligase dTopors directs the nuclear organization of a chromatin insulator. Mol Cell. 2005;20:105-16 pubmed
    ..2, and CP190. We have identified a factor, Drosophila Topoisomerase I-interacting RS protein (dTopors) that interacts with the ..
  26. Mohan M, Bartkuhn M, Herold M, Philippen A, Heinl N, Bardenhagen I, et al. The Drosophila insulator proteins CTCF and CP190 link enhancer blocking to body patterning. EMBO J. 2007;26:4203-14 pubmed
    ..In contrast, the Su(Hw) interacting factor CP190 largely overlapped with dCTCF binding sites and interacts with dCTCF...
  27. Rach E, Winter D, Benjamin A, Corcoran D, Ni T, Zhu J, et al. Transcription initiation patterns indicate divergent strategies for gene regulation at the chromatin level. PLoS Genet. 2011;7:e1001274 pubmed publisher
  28. Glover D, Hagan I, Tavares A. Polo-like kinases: a team that plays throughout mitosis. Genes Dev. 1998;12:3777-87 pubmed
  29. Butcher R, Chodagam S, Basto R, Wakefield J, Henderson D, Raff J, et al. The Drosophila centrosome-associated protein CP190 is essential for viability but not for cell division. J Cell Sci. 2004;117:1191-9 pubmed
    The Drosophila CP190 and CP60 proteins interact with each other and shuttle between the nucleus in interphase and the centrosome in mitosis...
  30. Kellogg D, Oegema K, Raff J, Schneider K, Alberts B. CP60: a microtubule-associated protein that is localized to the centrosome in a cell cycle-specific manner. Mol Biol Cell. 1995;6:1673-84 pubmed
    b>DMAP190 is a microtubule-associated protein from Drosophila that is localized to the centrosome...
  31. Schoborg T, Labrador M. The phylogenetic distribution of non-CTCF insulator proteins is limited to insects and reveals that BEAF-32 is Drosophila lineage specific. J Mol Evol. 2010;70:74-84 pubmed publisher
  32. Erokhin M, Davydova A, Kyrchanova O, Parshikov A, Georgiev P, Chetverina D. Insulators form gene loops by interacting with promoters in Drosophila. Development. 2011;138:4097-106 pubmed publisher
    ..Both insulators support basal activity of the yellow and white promoters in eyes. Thus, the ability of insulators to interact with promoters might play an important role in the regulation of basal gene transcription...
  33. Liang J, Lacroix L, Gamot A, Cuddapah S, Queille S, Lhoumaud P, et al. Chromatin immunoprecipitation indirect peaks highlight long-range interactions of insulator proteins and Pol II pausing. Mol Cell. 2014;53:672-81 pubmed publisher
    ..Indirect peaks depend on protein-protein interactions among multiple IBPs and their common cofactors, including CP190, as confirmed by high-resolution analyses of long-range contacts...
  34. Giet R, McLean D, Descamps S, Lee M, Raff J, Prigent C, et al. Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules. J Cell Biol. 2002;156:437-51 pubmed
  35. Cullen C, Deak P, Glover D, Ohkura H. mini spindles: A gene encoding a conserved microtubule-associated protein required for the integrity of the mitotic spindle in Drosophila. J Cell Biol. 1999;146:1005-18 pubmed
    ..The absence of centrosomal staining in interphase of the cellularized embryos suggests that the interactions between Msps protein and microtubules or centrosomes may be regulated during the cell cycle. ..
  36. Inoue Y, do Carmo Avides M, Shiraki M, Deak P, Yamaguchi M, Nishimoto Y, et al. Orbit, a novel microtubule-associated protein essential for mitosis in Drosophila melanogaster. J Cell Biol. 2000;149:153-66 pubmed
  37. Golovnin A, Volkov I, Georgiev P. SUMO conjugation is required for the assembly of Drosophila Su(Hw) and Mod(mdg4) into insulator bodies that facilitate insulator complex formation. J Cell Sci. 2012;125:2064-74 pubmed publisher
    ..in Drosophila require Suppressor of Hairy Wing [Su(Hw)], Modifier of mdg4 [Mod(mdg4)] and centrosomal 190 kDa (CP190) proteins to be functional. These insulator proteins are colocalized in nuclear speckles named insulator bodies...
  38. Matzat L, Dale R, Moshkovich N, Lei E. Tissue-specific regulation of chromatin insulator function. PLoS Genet. 2012;8:e1003069 pubmed publisher
    ..Taken together, these data reveal a novel, tissue-specific mode of regulation of a chromatin insulator. ..
  39. Bonchuk A, Denisov S, Georgiev P, Maksimenko O. Drosophila BTB/POZ domains of "ttk group" can form multimers and selectively interact with each other. J Mol Biol. 2011;412:423-36 pubmed publisher
    ..The BTB domain of Drosophila CP190 protein does not belong to the ttk group...
  40. Vaizel Ohayon D, Schejter E. Mutations in centrosomin reveal requirements for centrosomal function during early Drosophila embryogenesis. Curr Biol. 1999;9:889-98 pubmed
    ..Centrosomin is an essential core component of early embryonic centrosomes in Drosophila. Microtubule-dependent events of early embryogenesis display differential requirements for centrosomal function. ..
  41. Barbosa V, Yamamoto R, Henderson D, Glover D. Mutation of a Drosophila gamma tubulin ring complex subunit encoded by discs degenerate-4 differentially disrupts centrosomal protein localization. Genes Dev. 2000;14:3126-39 pubmed
    ..The centrosome associated protein CP190 is partially lost from the spindle poles in dd4 cells supporting a weak interaction with gamma-tubulin, and the ..
  42. van Bemmel J, Pagie L, Braunschweig U, Brugman W, Meuleman W, Kerkhoven R, et al. The insulator protein SU(HW) fine-tunes nuclear lamina interactions of the Drosophila genome. PLoS ONE. 2010;5:e15013 pubmed publisher
    ..Our results provide insights into the evolution of LAD organization and identify SU(HW) as a fine-tuner of genome - NL interactions...
  43. Ong C, Van Bortle K, Ramos E, Corces V. Poly(ADP-ribosyl)ation regulates insulator function and intrachromosomal interactions in Drosophila. Cell. 2013;155:148-59 pubmed publisher
    ..However, poly(ADP-ribosyl)ation of K566 in CP190 promotes protein-protein interactions with other insulator proteins, association with the nuclear lamina, and ..
  44. Lee M, Gergely F, Jeffers K, Peak Chew S, Raff J. Msps/XMAP215 interacts with the centrosomal protein D-TACC to regulate microtubule behaviour. Nat Cell Biol. 2001;3:643-9 pubmed
    ..We propose that D-TACC and Msps normally cooperate to stabilize centrosomal microtubules by binding to their minus ends and binding to their plus ends as they grow out from the centrosome. ..
  45. Bushey A, Ramos E, Corces V. Three subclasses of a Drosophila insulator show distinct and cell type-specific genomic distributions. Genes Dev. 2009;23:1338-50 pubmed publisher
    ..loci throughout the Drosophila melanogaster genome and function by recruiting an additional protein, Centrosomal Protein 190 (CP190)...
  46. Matthies H, McDonald H, Goldstein L, Theurkauf W. Anastral meiotic spindle morphogenesis: role of the non-claret disjunctional kinesin-like protein. J Cell Biol. 1996;134:455-64 pubmed
    ..Based on these observations, we propose that microtubule bundling by the NCD kinesin-like protein promotes assembly of a stable bipolar spindle in the absence of typical MTOCs. ..
  47. Moritz M, Zheng Y, Alberts B, Oegema K. Recruitment of the gamma-tubulin ring complex to Drosophila salt-stripped centrosome scaffolds. J Cell Biol. 1998;142:775-86 pubmed
    ..isolated Drosophila centrosomes with 2 M KI generates salt-resistant scaffolds that lack the centrosomal proteins CP190, CP60, centrosomin, and gamma-tubulin...
  48. Glover D, Leibowitz M, McLean D, Parry H. Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Cell. 1995;81:95-105 pubmed
    ..The size of the single centrosomal body in these circular figures suggests that loss of function of the serine-threonine protein kinase encoded by aur leads to a failure of the centrosomes to separate and form a bipolar spindle. ..
  49. Ahanger S, Shouche Y, Mishra R. Functional sub-division of the Drosophila genome via chromatin looping: the emerging importance of CP190. Nucleus. 2013;4:115-22 pubmed publisher
    ..Important to such processes in Drosophila is CP190, a common co-factor of insulator complexes...
  50. Gurudatta B, Yang J, Van Bortle K, Donlin Asp P, Corces V. Dynamic changes in the genomic localization of DNA replication-related element binding factor during the cell cycle. Cell Cycle. 2013;12:1605-15 pubmed publisher
    ..persists bound to chromatin during mitosis at a subset of sites where it also co-localizes with dCTCF, BEAF-32 and CP190. These sites are highly enriched for sites where Orc2 and Mcm2 are present during interphase and at the borders of ..
  51. Megraw T, Li K, Kao L, Kaufman T. The centrosomin protein is required for centrosome assembly and function during cleavage in Drosophila. Development. 1999;126:2829-39 pubmed
    ..Spindle poles in the mutants contain little or no detectable amounts of the centrosomal proteins CP60, CP190 and (gamma)-tubulin and late stage embryos often do not have astral microtubules at their spindle poles...
  52. Wallace H, Plata M, Kang H, Ross M, Labrador M. Chromatin insulators specifically associate with different levels of higher-order chromatin organization in Drosophila. Chromosoma. 2010;119:177-94 pubmed publisher
    ..In addition, clusters of coexpressed genes in this region form bands characterized by the lack of CP190 and BEAF-32 insulator proteins...
  53. Ramos E, Torre E, Bushey A, Gurudatta B, Corces V. DNA topoisomerase II modulates insulator function in Drosophila. PLoS ONE. 2011;6:e16562 pubmed publisher
    ..2 protein and its binding to polytene chromosomes are restored. Thus, Topo II is required to prevent Mod(mdg4)2.2 degradation and, consequently, to stabilize Su(Hw) insulator-mediated chromatin organization. ..
  54. Cullen C, Ohkura H. Msps protein is localized to acentrosomal poles to ensure bipolarity of Drosophila meiotic spindles. Nat Cell Biol. 2001;3:637-42 pubmed
    ..We propose that the polar localization of Msps mediated by D-TACC and Ncd may be crucial for the stabilization of meiotic spindle bipolarity. ..
  55. Kyrchanova O, Maksimenko O, Stakhov V, Ivlieva T, Parshikov A, Studitsky V, et al. Effective blocking of the white enhancer requires cooperation between two main mechanisms suggested for the insulator function. PLoS Genet. 2013;9:e1003606 pubmed publisher
  56. Megraw T, Kilaru S, Turner F, Kaufman T. The centrosome is a dynamic structure that ejects PCM flares. J Cell Sci. 2002;115:4707-18 pubmed
    ..We propose that flare particles play a role in organizing the actin cytoskeleton during syncytial cleavage. ..
  57. do Carmo Avides M, Glover D. Abnormal spindle protein, Asp, and the integrity of mitotic centrosomal microtubule organizing centers. Science. 1999;283:1733-5 pubmed
    ..This was corrected by addition of purified Asp protein. Thus, Asp appears to hold together the microtubule-nucleating gamma-tubulin ring complexes that organize the mitotic centrosome. ..
  58. Schwartz Y, Linder Basso D, Kharchenko P, Tolstorukov M, Kim M, Li H, et al. Nature and function of insulator protein binding sites in the Drosophila genome. Genome Res. 2012;22:2188-98 pubmed publisher
    ..of insulator proteins to different classes of sites and uncover a novel type of insulator element that binds CP190 but not any other known insulator proteins...
  59. Oegema K, Whitfield W, Alberts B. The cell cycle-dependent localization of the CP190 centrosomal protein is determined by the coordinate action of two separable domains. J Cell Biol. 1995;131:1261-73 pubmed
    b>CP190, a protein of 1,096 amino acids from Drosophila melanogaster, oscillates in a cell cycle-specific manner between the nucleus during interphase, and the centrosome during mitosis...
  60. Basto R, Lau J, Vinogradova T, Gardiol A, Woods C, Khodjakov A, et al. Flies without centrioles. Cell. 2006;125:1375-86 pubmed
    ..Thus, centrioles are essential for the formation of centrosomes, cilia, and flagella, but, remarkably, they are not essential for most aspects of Drosophila development. ..