Gene Symbol: COX8
Description: Cytochrome c oxidase subunit 8
Alias: 0554/18, BcDNA:GH15688, CG7181, CcO VIIc, CoVIII, Dmel\CG7181, VIII, anon-WO0118547.331, l(3)S055418, cytochrome c oxidase subunit 8, CG7181-PA, CG7181-PB, COX8-PA, COX8-PB, cytochrome c oxidase subunit VIII, lethal (3) S055418, subunit VIII
Species: fruit fly

Top Publications

  1. Klichko V, Sohal B, Radyuk S, Orr W, Sohal R. Decrease in cytochrome c oxidase reserve capacity diminishes robustness of Drosophila melanogaster and shortens lifespan. Biochem J. 2014;459:127-35 pubmed publisher
    ..Our results demonstrate that: (i) the suppression of CcO function exerts deleterious rather than benign effects on fitness and survival, and (ii) the structure/function of CcO, an ETC oxidoreductase, can be 're-engineered' in vivo. ..
  2. Szuplewski S, Terracol R. The cyclope gene of Drosophila encodes a cytochrome c oxidase subunit VIc homolog. Genetics. 2001;158:1629-43 pubmed
    ..A search in the Genome Annotation Database of Drosophila revealed the absence of subunit VIIb and the presence of 9 putative nuclear cytochrome c oxidase subunits with high identity scores when compared to the 10 human subunits. ..
  3. Szlanka T, Haracska L, Kiss I, Deak P, Kurucz E, Ando I, et al. Deletion of proteasomal subunit S5a/Rpn10/p54 causes lethality, multiple mitotic defects and overexpression of proteasomal genes in Drosophila melanogaster. J Cell Sci. 2003;116:1023-33 pubmed
  4. Porcelli D, Oliva M, Duchi S, Latorre D, Cavaliere V, Barsanti P, et al. Genetic, functional and evolutionary characterization of scox, the Drosophila melanogaster ortholog of the human SCO1 gene. Mitochondrion. 2010;10:433-48 pubmed publisher
  5. Ren J, Rebrin I, Klichko V, Orr W, Sohal R. Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster. Biochem Biophys Res Commun. 2010;401:64-8 pubmed publisher
    ..Western blot analysis, using antibodies specific to Drosophila CcO subunits IV, Va, Vb, VIb, VIc, VIIc, and VIII, indicated that the abundance these polypeptides decreased, ranging from 11% to 40%, during aging...
  6. Tsui M, Itoh A, Amgad M, Wang S, Sasaki T. Vectors for Genetically-Encoded Tags for Electron Microscopy Contrast in Drosophila. Biol Proced Online. 2016;18:5 pubmed publisher
    ..The constructed vectors will no doubt be a useful molecular tool for genetic tagging to facilitate high-resolution localization of proteins in Drosophila by electron microscopy. ..