Gene Symbol: COX6B
Description: Cytochrome c oxidase subunit 6B
Alias: CG14235, COXG, CcoVIb, CoVIb, Cox6b, Dmel\CG14235, VIb, cytochrome c oxidase subunit 6B, CG14235-PA, CG14235-PB, CG14235-PC, CG14235-PD, COX6B-PA, COX6B-PB, COX6B-PC, COX6B-PD, cytochrome c oxidase VIb, cytochrome c oxidase polypeptide VIb, cytochrome c oxidase subunit VIb, cytochrome c oxidase subunitVIb, subunit VIb
Species: fruit fly

Top Publications

  1. Szuplewski S, Terracol R. The cyclope gene of Drosophila encodes a cytochrome c oxidase subunit VIc homolog. Genetics. 2001;158:1629-43 pubmed
    ..A search in the Genome Annotation Database of Drosophila revealed the absence of subunit VIIb and the presence of 9 putative nuclear cytochrome c oxidase subunits with high identity scores when compared to the 10 human subunits. ..
  2. Porcelli D, Oliva M, Duchi S, Latorre D, Cavaliere V, Barsanti P, et al. Genetic, functional and evolutionary characterization of scox, the Drosophila melanogaster ortholog of the human SCO1 gene. Mitochondrion. 2010;10:433-48 pubmed publisher
  3. Ren J, Rebrin I, Klichko V, Orr W, Sohal R. Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster. Biochem Biophys Res Commun. 2010;401:64-8 pubmed publisher
    ..Western blot analysis, using antibodies specific to Drosophila CcO subunits IV, Va, Vb, VIb, VIc, VIIc, and VIII, indicated that the abundance these polypeptides decreased, ranging from 11% to 40%, during ..
  4. Peng C, Chan H, Huang Y, Yu H, Chen Z. Apple polyphenols extend the mean lifespan of Drosophila melanogaster. J Agric Food Chem. 2011;59:2097-106 pubmed publisher
    ..dismutase (SOD), catalase (CAT), methuselah (MTH), Rpn11, and cytochrome c oxidase (CcO) subunits III and VIb. Results showed the mean lifespan was significantly extended by 10% in fruit flies fed the AP diet...
  5. Kemppainen K, Rinne J, Sriram A, Lakanmaa M, Zeb A, Tuomela T, et al. Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency. Hum Mol Genet. 2014;23:2078-93 pubmed publisher
    ..These findings confirm the potential utility of alternative respiratory chain enzymes as tools to combat mitochondrial disease, while indicating important limitations thereof. ..