Gene Symbol: COX5A
Description: Cytochrome c oxidase subunit 5A
Alias: CG14724, COX, COXA, COXA_DROME, CoVa, Cox5a, Dmel\CG14724, cova, tend, cytochrome c oxidase subunit 5A, CG14724-PA, CG14724-PB, CG14724-PC, CG14724-PD, COX5A-PA, COX5A-PB, COX5A-PC, COX5A-PD, cytochrome c oxidase, cytochrome c oxidase Va, cytochrome c oxidase Va, mt precursor, cytochrome c oxidase polypeptide Va, cytochrome c oxidase subunit Va, cytochrome c oxidase subunit Va preprotein, cytochrome oxidase Va, cytochrome oxidase subunit Va, cytochrome-c oxidase subunit Va, subunit Va, subunit Va of complex IV, tenured
Species: fruit fly

Top Publications

  1. Szuplewski S, Terracol R. The cyclope gene of Drosophila encodes a cytochrome c oxidase subunit VIc homolog. Genetics. 2001;158:1629-43 pubmed
    b>Cytochrome c oxidase is the terminal enzyme of the mitochondrial electron transfer chain. In eukaryotes, the enzyme is composed of 3 mitochondrial DNA-encoded subunits and 7-10 (in mammals) nuclear DNA-encoded subunits...
  2. Mandal S, Guptan P, Owusu Ansah E, Banerjee U. Mitochondrial regulation of cell cycle progression during development as revealed by the tenured mutation in Drosophila. Dev Cell. 2005;9:843-54 pubmed
    ..We isolated a mutation, tenured (tend), in a gene encoding cytochrome oxidase subunit Va. This mutation causes a drop in intracellular ATP to levels sufficient to maintain cell survival, ..
  3. Mandal S, Freije W, Guptan P, Banerjee U. Metabolic control of G1-S transition: cyclin E degradation by p53-induced activation of the ubiquitin-proteasome system. J Cell Biol. 2010;188:473-9 pubmed publisher
    ..Our work provides in vivo genetic evidence for p53-mediated integration of metabolic stress signals, which modulate the activity of the ubiquitin-proteasome system to degrade cyclin E protein and thereby impose cell cycle arrest. ..
  4. Owusu Ansah E, Yavari A, Mandal S, Banerjee U. Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint. Nat Genet. 2008;40:356-61 pubmed publisher
    ..Thus, our results indicate that the mitochondrion can use AMP and ROS at sublethal concentrations as independent signaling molecules to modulate cell cycle progression. ..
  5. Liao T, Call G, Guptan P, Cespedes A, Marshall J, Yackle K, et al. An efficient genetic screen in Drosophila to identify nuclear-encoded genes with mitochondrial function. Genetics. 2006;174:525-33 pubmed
    ..These same phenotypes were previously seen in mutants for cytochrome c oxidase subunit Va. We have molecularly characterized six complementation groups and, surprisingly, each encodes a ..
  6. Tiefenböck S, Baltzer C, Egli N, Frei C. The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling. EMBO J. 2010;29:171-83 pubmed publisher
    ..Taken together, our data place Spargel at a nodal point for the integration of mitochondrial activity to tissue and organismal metabolism and growth. ..
  7. Kemppainen K, Rinne J, Sriram A, Lakanmaa M, Zeb A, Tuomela T, et al. Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency. Hum Mol Genet. 2014;23:2078-93 pubmed publisher
    ..These findings confirm the potential utility of alternative respiratory chain enzymes as tools to combat mitochondrial disease, while indicating important limitations thereof. ..
  8. Gordon G, Zhang T, Zhao J, Du W. Deregulated G1-S control and energy stress contribute to the synthetic-lethal interactions between inactivation of RB and TSC1 or TSC2. J Cell Sci. 2013;126:2004-13 pubmed publisher
    ..Decreasing mitochondrial ATP synthesis by inactivating cova or abrogating the energy-stress response by removing the metabolic regulator LKB1 both enhance the elimination of ..
  9. Van Vranken J, Bricker D, Dephoure N, Gygi S, Cox J, Thummel C, et al. SDHAF4 promotes mitochondrial succinate dehydrogenase activity and prevents neurodegeneration. Cell Metab. 2014;20:241-52 pubmed publisher
    ..These studies provide insights into the mechanisms by which SDH is assembled and raise the possibility that some forms of neuromuscular disease may be associated with mutations that affect this SDH assembly factor. ..

More Information


  1. Freije W, Mandal S, Banerjee U. Expression profiling of attenuated mitochondrial function identifies retrograde signals in Drosophila. G3 (Bethesda). 2012;2:843-51 pubmed publisher
    ..Affymetrix microarray-based transcriptional profiling of Drosophila S2 cells knocked down for the gene encoding subunit Va of the complex IV of the mitochondrial electron transport chain...
  2. Choo A, O Keefe L, Lee C, Gregory S, Shaukat Z, Colella A, et al. Tumor suppressor WWOX moderates the mitochondrial respiratory complex. Genes Chromosomes Cancer. 2015;54:745-61 pubmed publisher
    ..Thus, the ability of WWOX to facilitate escape from mitochondrial damage-induced glycolysis (Warburg effect) is, therefore, a plausible mechanism for its tumor suppressor activity. ..
  3. Nakamura M, Ohsawa S, Igaki T. Mitochondrial defects trigger proliferation of neighbouring cells via a senescence-associated secretory phenotype in Drosophila. Nat Commun. 2014;5:5264 pubmed publisher
    ..Our data suggest that mitochondrial defects promote Ras-induced cellular senescence and thereby contribute to tumour progression through SASP. ..
  4. Homem C, Steinmann V, Burkard T, Jais A, Esterbauer H, Knoblich J. Ecdysone and mediator change energy metabolism to terminate proliferation in Drosophila neural stem cells. Cell. 2014;158:874-888 pubmed publisher
    ..Our findings show that cell size control can be modified by systemic hormonal signaling and reveal a unique connection between metabolism and proliferation in stem cells. ..
  5. Walker D, Benzer S. Mitochondrial "swirls" induced by oxygen stress and in the Drosophila mutant hyperswirl. Proc Natl Acad Sci U S A. 2004;101:10290-5 pubmed
    ..The cristae involved in a swirl are deficient in respiratory enzyme cytochrome c oxidase activity, within an otherwise cytochrome c oxidase-positive mitochondrion...
  6. Hill J, Chen Z, Xu H. Selective propagation of functional mitochondrial DNA during oogenesis restricts the transmission of a deleterious mitochondrial variant. Nat Genet. 2014;46:389-92 pubmed publisher
    ..These findings establish a previously uncharacterized developmental mechanism for the selective amplification of wild-type mtDNA, which may be evolutionarily conserved to limit the transmission of deleterious mutations. ..
  7. Barry W, Thummel C. The Drosophila HNF4 nuclear receptor promotes glucose-stimulated insulin secretion and mitochondrial function in adults. elife. 2016;5: pubmed publisher
    ..These findings establish an animal model for MODY1 and define a developmental reprogramming of metabolism to support the energetic needs of the mature animal. ..
  8. Maier D, Farr C, Poeck B, Alahari A, Vogel M, Fischer S, et al. Mitochondrial single-stranded DNA-binding protein is required for mitochondrial DNA replication and development in Drosophila melanogaster. Mol Biol Cell. 2001;12:821-30 pubmed
    ..lopo(1) is the first mtSSB mutant in higher eukaryotes, and its analysis demonstrates the essential function of this gene in development, providing an excellent model to study mitochondrial biogenesis in animals. ..
  9. Wang Y, Cruz T, Irion U, Moussian B. Differentiated muscles are mandatory for gas-filling of the Drosophila airway system. Biol Open. 2015;4:1753-61 pubmed publisher
    ..We think that in analogy to the function of smooth muscles in vertebrate lungs, a balance of physical forces between muscles and the elasticity of tracheal walls may be decisive for tracheal terminal differentiation in Drosophila. ..
  10. Tixier V, Bataillé L, Etard C, Jagla T, Weger M, Daponte J, et al. Glycolysis supports embryonic muscle growth by promoting myoblast fusion. Proc Natl Acad Sci U S A. 2013;110:18982-7 pubmed publisher
  11. Porcelli D, Oliva M, Duchi S, Latorre D, Cavaliere V, Barsanti P, et al. Genetic, functional and evolutionary characterization of scox, the Drosophila melanogaster ortholog of the human SCO1 gene. Mitochondrion. 2010;10:433-48 pubmed publisher
    SCO proteins are copper-donor chaperones involved in the assembly of mitochondrial cytochrome c oxidase (COX)...
  12. Ferguson M, Mockett R, Shen Y, Orr W, Sohal R. Age-associated decline in mitochondrial respiration and electron transport in Drosophila melanogaster. Biochem J. 2005;390:501-11 pubmed
    ..There was also a significant age-related decline in the activity of cytochrome c oxidase (complex IV), but not of the other mitochondrial oxidoreductases examined...
  13. Caggese C, Ragone G, Perrini B, Moschetti R, De Pinto V, Caizzi R, et al. Identification of nuclear genes encoding mitochondrial proteins: isolation of a collection of D. melanogaster cDNAs homologous to sequences in the Human Gene Index database. Mol Gen Genet. 1999;261:64-70 pubmed
    ..Our experimental strategy represents an efficient approach to the identification and interspecies comparison of genes encoding products targeted to the mitochondrion. ..
  14. Ohsawa S, Sato Y, Enomoto M, Nakamura M, Betsumiya A, Igaki T. Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila. Nature. 2012;490:547-51 pubmed publisher
    ..Our findings provide a mechanistic basis for interclonal tumour progression driven by mitochondrial dysfunction and oncogenic Ras...
  15. Ren J, Rebrin I, Klichko V, Orr W, Sohal R. Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster. Biochem Biophys Res Commun. 2010;401:64-8 pubmed publisher
    The hypothesis, that structural deterioration of cytochrome c oxidase (CcO) is a causal factor in the age-related decline in mitochondrial respiratory activity and an increase in H?O? generation, was tested in Drosophila melanogaster...
  16. Kalifa Y, Huang T, Rosen L, Chatterjee S, Gavis E. Glorund, a Drosophila hnRNP F/H homolog, is an ovarian repressor of nanos translation. Dev Cell. 2006;10:291-301 pubmed
    ..These data, together with the analysis of a glorund null mutant, reveal a specific role for an hnRNP in repression of nanos translation during oogenesis. ..