Gene Symbol: COX4L
Description: Cytochrome c oxidase subunit 4-like
Alias: BcDNA:AT07685, CG10396, COX IV, COXIV, CX41, CX42, Dmel\CG10396, cox4, cytochrome c oxidase subunit 4-like, CG10396-PA, CG10396-PB, COX4L-PA, COX4L-PB, cytochrome c oxidase subunit IV
Species: fruit fly

Top Publications

  1. Brown A, Baumbach J, Cook P, Ligoxygakis P. Short-term starvation of immune deficient Drosophila improves survival to gram-negative bacterial infections. PLoS ONE. 2009;4:e4490 pubmed publisher
    ..Our results show that NO release through STS may reflect an evolutionary conserved process. Moreover, STS could be explored to address immune phenotypes related to infection and may offer ways to boost natural immunity. ..
  2. Dijkers P, O Farrell P. Dissection of a hypoxia-induced, nitric oxide-mediated signaling cascade. Mol Biol Cell. 2009;20:4083-90 pubmed publisher
    ..These findings reveal the use of unconventional steps in an NO pathway involved in sensing hypoxia and initiating signaling. ..
  3. Szuplewski S, Terracol R. The cyclope gene of Drosophila encodes a cytochrome c oxidase subunit VIc homolog. Genetics. 2001;158:1629-43 pubmed
    ..A search in the Genome Annotation Database of Drosophila revealed the absence of subunit VIIb and the presence of 9 putative nuclear cytochrome c oxidase subunits with high identity scores when compared to the 10 human subunits. ..
  4. Klichko V, Sohal B, Radyuk S, Orr W, Sohal R. Decrease in cytochrome c oxidase reserve capacity diminishes robustness of Drosophila melanogaster and shortens lifespan. Biochem J. 2014;459:127-35 pubmed publisher
    ..Our results demonstrate that: (i) the suppression of CcO function exerts deleterious rather than benign effects on fitness and survival, and (ii) the structure/function of CcO, an ETC oxidoreductase, can be 're-engineered' in vivo. ..