Gene Symbol: COX4
Description: Cytochrome c oxidase subunit 4
Alias: C-IV s.4, CG10664, COX, COX IV, COXIV, CX41, CX42, CcO IV, CoIV, Cox4, CoxIV, Dmel\CG10664, cox4, dCOX-IV, cytochrome c oxidase subunit 4, CG10664-PA, CG10664-PB, CG10664-PC, CG10664-PD, COX4-PA, COX4-PB, COX4-PC, COX4-PD, cytochrome c oxidase, cytochrome c oxidase IV, cytochrome c oxidase polypeptide IV, cytochrome c oxidase subunit IV, subunit IV
Species: fruit fly

Top Publications

  1. Klichko V, Sohal B, Radyuk S, Orr W, Sohal R. Decrease in cytochrome c oxidase reserve capacity diminishes robustness of Drosophila melanogaster and shortens lifespan. Biochem J. 2014;459:127-35 pubmed publisher
    The phenotypic effects of under- and over-expression of CcO (cytochrome c oxidase) regulatory subunits IV and Vb were examined in Drosophila melanogaster in order to test further the hypothesis that suppression of the activities of ..
  2. Scialò F, Sriram A, Fernández Ayala D, Gubina N, Lõhmus M, Nelson G, et al. Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan. Cell Metab. 2016;23:725-34 pubmed publisher
    ..These results illustrate that the source of a ROS signal is vital in determining its effects on cellular physiology and establish that manipulation of ubiquinone redox state is a valid strategy to delay aging. ..
  3. Brown A, Baumbach J, Cook P, Ligoxygakis P. Short-term starvation of immune deficient Drosophila improves survival to gram-negative bacterial infections. PLoS ONE. 2009;4:e4490 pubmed publisher
    ..Our results show that NO release through STS may reflect an evolutionary conserved process. Moreover, STS could be explored to address immune phenotypes related to infection and may offer ways to boost natural immunity. ..
  4. Sieber M, Thomsen M, Spradling A. Electron Transport Chain Remodeling by GSK3 during Oogenesis Connects Nutrient State to Reproduction. Cell. 2016;164:420-32 pubmed publisher
    ..Our studies reveal an important link between metabolism and oocyte maturation. ..
  5. Banerjee K, Ayyub C, Sengupta S, Kolthur Seetharam U. Fat body dSir2 regulates muscle mitochondrial physiology and energy homeostasis nonautonomously and mimics the autonomous functions of dSir2 in muscles. Mol Cell Biol. 2013;33:252-64 pubmed publisher
    ..In summary, we show that fat body dSir2 is a master regulator of organismal energy homeostasis and is required for maintaining the metabolic regulatory network across tissues. ..
  6. Homem C, Steinmann V, Burkard T, Jais A, Esterbauer H, Knoblich J. Ecdysone and mediator change energy metabolism to terminate proliferation in Drosophila neural stem cells. Cell. 2014;158:874-888 pubmed publisher
    ..Our findings show that cell size control can be modified by systemic hormonal signaling and reveal a unique connection between metabolism and proliferation in stem cells. ..
  7. Teixeira F, Sanchez C, Hurd T, Seifert J, Czech B, Preall J, et al. ATP synthase promotes germ cell differentiation independent of oxidative phosphorylation. Nat Cell Biol. 2015;17:689-96 pubmed publisher
    ..Taken together, our results suggest that ATP synthase-dependent crista maturation is a key developmental process required for differentiation independent of oxidative phosphorylation. ..
  8. Szuplewski S, Terracol R. The cyclope gene of Drosophila encodes a cytochrome c oxidase subunit VIc homolog. Genetics. 2001;158:1629-43 pubmed
    b>Cytochrome c oxidase is the terminal enzyme of the mitochondrial electron transfer chain. In eukaryotes, the enzyme is composed of 3 mitochondrial DNA-encoded subunits and 7-10 (in mammals) nuclear DNA-encoded subunits...
  9. Wang B, Goode J, Best J, Meltzer J, Schilman P, Chen J, et al. The insulin-regulated CREB coactivator TORC promotes stress resistance in Drosophila. Cell Metab. 2008;7:434-44 pubmed publisher
    ..As disruption of insulin signaling also augmented TORC activity in adult flies, our results illustrate the importance of an insulin-regulated pathway that functions in the brain to maintain energy balance. ..

More Information


  1. Porcelli D, Oliva M, Duchi S, Latorre D, Cavaliere V, Barsanti P, et al. Genetic, functional and evolutionary characterization of scox, the Drosophila melanogaster ortholog of the human SCO1 gene. Mitochondrion. 2010;10:433-48 pubmed publisher
    SCO proteins are copper-donor chaperones involved in the assembly of mitochondrial cytochrome c oxidase (COX)...
  2. Kemppainen K, Rinne J, Sriram A, Lakanmaa M, Zeb A, Tuomela T, et al. Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency. Hum Mol Genet. 2014;23:2078-93 pubmed publisher
    ..These findings confirm the potential utility of alternative respiratory chain enzymes as tools to combat mitochondrial disease, while indicating important limitations thereof. ..
  3. Dijkers P, O Farrell P. Dissection of a hypoxia-induced, nitric oxide-mediated signaling cascade. Mol Biol Cell. 2009;20:4083-90 pubmed publisher
    ..These findings reveal the use of unconventional steps in an NO pathway involved in sensing hypoxia and initiating signaling. ..
  4. Ren J, Rebrin I, Klichko V, Orr W, Sohal R. Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster. Biochem Biophys Res Commun. 2010;401:64-8 pubmed publisher
    The hypothesis, that structural deterioration of cytochrome c oxidase (CcO) is a causal factor in the age-related decline in mitochondrial respiratory activity and an increase in H?O? generation, was tested in Drosophila melanogaster...
  5. Lim D, Lee L, Oh C, Kim N, Hwang S, Han S, et al. Microarray analysis of Drosophila dicer-2 mutants reveals potential regulation of mitochondrial metabolism by endogenous siRNAs. J Cell Biochem. 2013;114:418-27 pubmed publisher
    ..Our data support a potential role for the endo-siRNA pathway in energy homeostasis through regulation of mitochondrial metabolism. ..