Genomes and Genes
Gene Symbol: COX1
Description: cytochrome c oxidase subunit I
Alias: cytochrome c oxidase subunit I
Species: fruit fly
- Nunes M, Nolte V, Schlotterer C. Nonrandom Wolbachia infection status of Drosophila melanogaster strains with different mtDNA haplotypes. Mol Biol Evol. 2008;25:2493-8 pubmed publisher..Although it is difficult to identify the evolutionary forces causing the global increase of wMel, the parallel sweep of Wolbachia and an mtDNA haplotype suggests a fitness advantage of the Wolbachia infection. ..
- Clancy D. Variation in mitochondrial genotype has substantial lifespan effects which may be modulated by nuclear background. Aging Cell. 2008;7:795-804 pubmed publisher..The limited mtDNA variation in D. melanogaster makes it an ideal organism for biochemical studies to link genotype and aging phenotype. ..
- Peralta S, Clemente P, Sanchez Martinez A, Calleja M, Hernández Sierra R, Matsushima Y, et al. Coiled coil domain-containing protein 56 (CCDC56) is a novel mitochondrial protein essential for cytochrome c oxidase function. J Biol Chem. 2012;287:24174-85 pubmed publisher..melanogaster. We propose CCDC56 as a candidate factor required for COX biogenesis/assembly. ..
- Shaw P, Cirelli C, Greenspan R, Tononi G. Correlates of sleep and waking in Drosophila melanogaster. Science. 2000;287:1834-7 pubmed..These results implicate the catabolism of monoamines in the regulation of sleep and waking in the fly and suggest that Drosophila may serve as a model system for the genetic dissection of sleep. ..
- Tsai H, Lin R, Hsieh T. Drosophila mitochondrial topoisomerase III alpha affects the aging process via maintenance of mitochondrial function and genome integrity. J Biomed Sci. 2016;23:38 pubmed publisher..The results reported here demonstrate that mitochondrial Top3? ablation results in mitochondrial genome instability and its dysfunction, thereby accelerating the aging process. ..
- Rogers R, Rogina B. Increased mitochondrial biogenesis preserves intestinal stem cell homeostasis and contributes to longevity in Indy mutant flies. Aging (Albany NY). 2014;6:335-50 pubmed..Our data suggest INDY may be a physiological regulator that modulates intermediary metabolism in response to changes in nutrient availability and organismal needs by modulating dPGC-1. ..
- Lee K, Iijima Ando K, Iijima K, Lee W, Lee J, Yu K, et al. JNK/FOXO-mediated neuronal expression of fly homologue of peroxiredoxin II reduces oxidative stress and extends life span. J Biol Chem. 2009;284:29454-61 pubmed publisher..These results support the hypothesis that JNK/FOXO signaling extends life span via amelioration of oxidative damage and mitochondrial dysfunction in neurons. ..
- Hamm C, Begun D, Vo A, Smith C, Saelao P, Shaver A, et al. Wolbachia do not live by reproductive manipulation alone: infection polymorphism in Drosophila suzukii and D. subpulchrella. Mol Ecol. 2014;23:4871-85 pubmed publisher..Such infections, likely to be mutualistic, may be central to understanding the pervasiveness of Wolbachia among arthropods. ..
- Iijima Ando K, Hearn S, Shenton C, Gatt A, Zhao L, Iijima K. Mitochondrial mislocalization underlies Abeta42-induced neuronal dysfunction in a Drosophila model of Alzheimer's disease. PLoS ONE. 2009;4:e8310 pubmed publisher..These results demonstrate that mislocalization of mitochondria underlies the pathogenic effects of Abeta42 in vivo. ..
- Maier D, Farr C, Poeck B, Alahari A, Vogel M, Fischer S, et al. Mitochondrial single-stranded DNA-binding protein is required for mitochondrial DNA replication and development in Drosophila melanogaster. Mol Biol Cell. 2001;12:821-30 pubmed..lopo(1) is the first mtSSB mutant in higher eukaryotes, and its analysis demonstrates the essential function of this gene in development, providing an excellent model to study mitochondrial biogenesis in animals. ..
- Seligmann H. An overlapping genetic code for frameshifted overlapping genes in Drosophila mitochondria: antisense antitermination tRNAs UAR insert serine. J Theor Biol. 2012;298:51-76 pubmed publisher..Parallel genetic systems coded by an additional mitochondrial genetic code in Drosophila confirm similar phenomena in primate mitochondria. ..
- Ilinsky Y. Coevolution of Drosophila melanogaster mtDNA and Wolbachia genotypes. PLoS ONE. 2013;8:e54373 pubmed publisher..melanogaster mtDNA pattern of variation. Finally, we present a comparative analysis of biogeographic distribution of D. melanogaster mitotypes all over the world. ..
- Nigro L, Solignac M, Sharp P. Mitochondrial DNA sequence divergence in the Melanogaster and oriental species subgroups of Drosophila. J Mol Evol. 1991;33:156-62 pubmed..This suggests the existence of different levels of constraints along the sequenced segment. An overall analysis of the types of substitutions showed a decrease in A + T content during the course of evolution of the species. ..
- Cirelli C. Searching for sleep mutants of Drosophila melanogaster. Bioessays. 2003;25:940-9 pubmed..Ultimately, the characterization of these lines should help identifying crucial cellular pathways involved in the regulatory mechanisms of sleep and its functional consequences. ..
- Satta Y, Ishiwa H, Chigusa S. Analysis of nucleotide substitutions of mitochondrial DNAs in Drosophila melanogaster and its sibling species. Mol Biol Evol. 1987;4:638-50 pubmed..We have also shown that the start codon of the COI gene is GTGA in D. simulans and GTAA in D. mauritiana. These codons are different from that of D. melanogaster (ATAA). ..
- Bruni F, Manzari C, Filice M, Loguercio Polosa P, Colella M, Carmone C, et al. D-MTERF5 is a novel factor modulating transcription in Drosophila mitochondria. Mitochondrion. 2012;12:492-9 pubmed publisher..Co-regulation by DREF (DNA Replication-related Element binding Factor) of D-MTERF5 and DmTTF implies that expression of the two factors needs to be co-ordinated to ensure fine modulation of Drosophila mitochondrial transcription. ..
- Stenico M, Nigro L. Differences in evolutionary rates among amino acid classes in the mitochondrial genes cytochrome oxidase I and cytochrome oxidase II in Drosophila. Mol Biol Evol. 1998;15:777-8 pubmed
- Spicer G, Pitnick S. Molecular systematics of the Drosophila hydei subgroup as inferred from mitochondrial DNA sequences. J Mol Evol. 1996;43:281-6 pubmed..bifurca complex is only weakly supported. The evolution of chromosomal change, interspecific crossability, sperm gigantism, and divergence times of the subgroup is discussed in a phylogenetic context. ..
- Galloni M. Bonsaï, a ribosomal protein S15 homolog, involved in gut mitochondrial activity and systemic growth. Dev Biol. 2003;264:482-94 pubmed..Altogether, these observations suggest that mitochondrial activity is regulated at the tissue-specific level and that this regulation has profound implications for growth and development. ..
- Satta Y, Takahata N. Evolution of Drosophila mitochondrial DNA and the history of the melanogaster subgroup. Proc Natl Acad Sci U S A. 1990;87:9558-62 pubmed..simulans. Yet geographic isolation is so weak as to show no evidence for further speciation. Moreover, one type of mtDNA shared by D. simulans and D. mauritiana suggests either recent divergence or ongoing introgression. ..
- Wolff J, Camus M, Clancy D, Dowling D. Complete mitochondrial genome sequences of thirteen globally sourced strains of fruit fly (Drosophila melanogaster) form a powerful model for mitochondrial research. Mitochondrial DNA A DNA Mapp Seq Anal. 2016;27:4672-4674 pubmed..The sequenced fly strains form a powerful model for mitochondrial research, when it comes to elucidating the links between the mitochondrial genotype and the phenotype. ..
- Cooper B, Burrus C, Ji C, Hahn M, Montooth K. Similar Efficacies of Selection Shape Mitochondrial and Nuclear Genes in Both Drosophila melanogaster and Homo sapiens. G3 (Bethesda). 2015;5:2165-76 pubmed publisher..Thus, despite a smaller Ne, mitochondrial loci of both flies and humans appear to experience similar efficacies of purifying selection as do loci in the recombining nuclear genome. ..
- Hatadani L, McInerney J, de Medeiros H, Junqueira A, de Azeredo Espin A, Klaczko L. Molecular phylogeny of the Drosophila tripunctata and closely related species groups (Diptera: Drosophilidae). Mol Phylogenet Evol. 2009;51:595-600 pubmed publisher..Although most of the basal nodes were unresolved we were able to identify four clusters within the tripunctata radiation. These results suggest the collection of additional data before a proper taxonomic revision could be proposed. ..
- Szuplewski S, Terracol R. The cyclope gene of Drosophila encodes a cytochrome c oxidase subunit VIc homolog. Genetics. 2001;158:1629-43 pubmed..A search in the Genome Annotation Database of Drosophila revealed the absence of subunit VIIb and the presence of 9 putative nuclear cytochrome c oxidase subunits with high identity scores when compared to the 10 human subunits. ..
- Chang K, MIN K. Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function. Nat Neurosci. 2005;8:1577-85 pubmed..These results identify nebula/DSCR1 as a regulator of mitochondrial function and integrity and further suggest that an increased level of DSCR1 may contribute to the mitochondrial dysfunction seen in Down syndrome. ..
- Ma H, Xu H, O Farrell P. Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster. Nat Genet. 2014;46:393-7 pubmed publisher..While they are so balanced, these stably transmitted mutations have no detrimental phenotype, but their segregation could contribute to disease phenotypes and somatic aging...
- Oliveira D, Almeida F, O Grady P, Armella M, DeSalle R, Etges W. Monophyly, divergence times, and evolution of host plant use inferred from a revised phylogeny of the Drosophila repleta species group. Mol Phylogenet Evol. 2012;64:533-44 pubmed publisher..Concordant with our proposed timing of host use shifts, these dates are consistent with the suggested times when the Opuntioideae originated in South America. We discuss the generally accepted South American origin of the repleta group. ..
- Sohal R, Toroser D, Bregere C, Mockett R, Orr W. Age-related decrease in expression of mitochondrial DNA encoded subunits of cytochrome c oxidase in Drosophila melanogaster. Mech Ageing Dev. 2008;129:558-61 pubmed publisher..Apparently, the stoichiometry of CcO holoprotein is dynamically altered during the aging process in D. melanogaster. ..
- Dhami M, Kumarasinghe L. A HRM real-time PCR assay for rapid and specific identification of the emerging pest spotted-wing drosophila (Drosophila suzukii). PLoS ONE. 2014;9:e98934 pubmed publisher..Application of this robust and independently validated assay across the spectrum of key food production and border protection industries will allow us to reduce the further spread of this damaging species worldwide. ..
- Kopp A, Barmina O. Evolutionary history of the Drosophila bipectinata species complex. Genet Res. 2005;85:23-46 pubmed..This contrast underscores the importance of understanding the genetic basis of functional differentiation among closely related species. ..
- Ferguson M, Mockett R, Shen Y, Orr W, Sohal R. Age-associated decline in mitochondrial respiration and electron transport in Drosophila melanogaster. Biochem J. 2005;390:501-11 pubmed..Collectively, these results support the hypothesis that impairment of mitochondrial respiration may be a causal factor in the aging process, and that such impairment may result from and contribute to increased H2O2 production in vivo. ..
- Fitzpatrick B. Molecular correlates of reproductive isolation. Evolution. 2002;56:191-8 pubmed..Inasmuch as proteins are more subject to the action of natural selection than are silent DNA polymorphisms, this result provides broad support for a model of selection-mediated allopatric speciation. ..
- Goto S, Kitamura H, Kimura M. Phylogenetic relationships and climatic adaptations in the Drosophila takahashii and montium species subgroups. Mol Phylogenet Evol. 2000;15:147-56 pubmed..Therefore, considerable genetic reformation would be required for both the subtropical highland and the subtropical lowland species to adapt to temperate climates. ..
- Cagin U, Duncan O, Gatt A, Dionne M, Sweeney S, Bateman J. Mitochondrial retrograde signaling regulates neuronal function. Proc Natl Acad Sci U S A. 2015;112:E6000-9 pubmed publisher..Thus, mitochondrial retrograde signaling regulates neuronal activity and can be manipulated to enhance neuronal function, despite mitochondrial impairment. ..
- Clary D, Wahleithner J, Wolstenholme D. Transfer RNA genes in Drosophila mitochondrial DNA: related 5' flanking sequences and comparisons to mammalian mitochondrial tRNA genes. Nucleic Acids Res. 1983;11:2411-25 pubmed..Upstream from this octanucleotide sequence, and separated from it by 3, 4 and 11 nucleotides, respectively, in the 5' flanking regions of the tRNAile, tRNAserUCN and tRNAgly genes occurs the sequence 5'GATGAG...
- Izumitani H, Kusaka Y, Koshikawa S, Toda M, Katoh T. Phylogeography of the Subgenus Drosophila (Diptera: Drosophilidae): Evolutionary History of Faunal Divergence between the Old and the New Worlds. PLoS ONE. 2016;11:e0160051 pubmed publisher..However, our results also indicate that these events took place multiple times over a wider time range than Throckmorton proposed, from the late Oligocene to the Pliocene. ..
- Chen Z, Qi Y, French S, Zhang G, Covian Garcia R, Balaban R, et al. Genetic mosaic analysis of a deleterious mitochondrial DNA mutation in Drosophila reveals novel aspects of mitochondrial regulation and function. Mol Biol Cell. 2015;26:674-84 pubmed publisher..isolated a temperature-lethal mtDNA mutation in Drosophila, mt:CoI(T300I), which affects the cytochrome c oxidase subunit I (CoI) locus...
- Tourmente S, Savre Train I, Berthier F, Renaud M. Expression of six mitochondrial genes during Drosophila oogenesis: analysis by in situ hybridization. Cell Differ Dev. 1990;31:137-49 pubmed..Northern analysis of poly(A)+RNA from ovaries or cultured cells revealed an 1.7 kb extra-mitochondrial RNA, which is probably of nuclear origin. ..
- Barry W, Thummel C. The Drosophila HNF4 nuclear receptor promotes glucose-stimulated insulin secretion and mitochondrial function in adults. elife. 2016;5: pubmed publisher..These findings establish an animal model for MODY1 and define a developmental reprogramming of metabolism to support the energetic needs of the mature animal. ..
- de Paula W, Agip A, Missirlis F, Ashworth R, Vizcay Barrena G, Lucas C, et al. Female and male gamete mitochondria are distinct and complementary in transcription, structure, and genome function. Genome Biol Evol. 2013;5:1969-77 pubmed publisher..Suppressed mitochondrial metabolism in the female germ line may therefore constitute a mechanism for increasing the fidelity of mitochondrial DNA inheritance. ..
- Nunes M, Dolezal M, Schlotterer C. Extensive paternal mtDNA leakage in natural populations of Drosophila melanogaster. Mol Ecol. 2013;22:2106-17 pubmed publisher..Our results indicate that evolutionary studies using mtDNA as a marker might be biased by paternal leakage in this species. ..
- Burnell A, Reaper C, Doherty J. The effect of acclimation temperature on enzyme activity in Drosophila melanogaster. Comp Biochem Physiol B. 1991;98:609-14 pubmed..6. The results presented here extend the data on the range of D. melanogaster enzymes which show compensation upon thermal acclimation and on the type of acclimation response which occurs. ..
- Garber E, Margoliash E. Circular dichroism studies of the binding of mammalian and non-mammalian cytochromes c to cytochrome c oxidase, cytochrome c peroxidase, and polyanions. Biochim Biophys Acta. 1994;1187:289-95 pubmed..According to this model, the exclusion of solvent changes the relative asymmetry of the environment of the electronic transitions of the heme prosthetic group of cytochrome c, resulting in observed circular dichroic effects. ..
- O Grady P, Clark J, Kidwell M. Phylogeny of the Drosophila saltans species group based on combined analysis of nuclear and mitochondrial DNA sequences. Mol Biol Evol. 1998;15:656-64 pubmed publisher..As with previous morphological studies, phylogenetic relationships within the saltans subgroup were not satisfactorily resolved by the molecular data...
- Schwarze S, Weindruch R, Aiken J. Decreased mitochondrial RNA levels without accumulation of mitochondrial DNA deletions in aging Drosophila melanogaster. Mutat Res. 1998;382:99-107 pubmed..No difference, however, was apparent in the nuclear-encoded beta-ATPase RNA level, suggesting only mitochondrial RNA (mtRNA) declines are associated with life expectancy. ..
- Montooth K, Abt D, Hofmann J, Rand D. Comparative genomics of Drosophila mtDNA: Novel features of conservation and change across functional domains and lineages. J Mol Evol. 2009;69:94-114 pubmed publisher..These oxidative phosphorylation complex-specific rates of evolution vary across lineages and may reflect physiological and ecological change across the Drosophila phylogeny. ..
- Sanchez Martinez A, Calleja M, Peralta S, Matsushima Y, Hernández Sierra R, Whitworth A, et al. Modeling pathogenic mutations of human twinkle in Drosophila suggests an apoptosis role in response to mitochondrial defects. PLoS ONE. 2012;7:e43954 pubmed publisher..Our study of d-mtDNA helicase overexpression provides a tractable Drosophila model for understanding the cellular and molecular effects of human adPEO mutations. ..
- Li T, Gao J, Lu J, Ji X, Chen H. Phylogenetic relationship among East Asian species of the Stegana genus group (Diptera, Drosophilidae). Mol Phylogenet Evol. 2013;66:412-6 pubmed publisher..It was proposed that, the evolution of the plant family Fagaceae, especially Quercus, may have played a certain role in facilitating the diversification of the Stegana genus group. ..
- Sanz A, Fernandez Ayala D, Stefanatos R, Jacobs H. Mitochondrial ROS production correlates with, but does not directly regulate lifespan in Drosophila. Aging (Albany NY). 2010;2:200-23 pubmed..In summary, these results do not systematically support the predictions of the MFRTA. Accordingly, MFRTA should be revised to accommodate these findings. ..
- Tiefenböck S, Baltzer C, Egli N, Frei C. The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling. EMBO J. 2010;29:171-83 pubmed publisher..Taken together, our data place Spargel at a nodal point for the integration of mitochondrial activity to tissue and organismal metabolism and growth. ..
- Morales Hojas R, Vieira J. Phylogenetic patterns of geographical and ecological diversification in the subgenus Drosophila. PLoS ONE. 2012;7:e49552 pubmed publisher..Also, cactophily has not resulted in an increase in the diversification rate of the repleta and related groups. It is thus concluded that the taxonomic radiations do not correspond to adaptive radiations. ..
- Gustani E, Oliveira A, Santos M, Machado L, Mateus R. Demographic Structure and Evolutionary History of Drosophila ornatifrons (Diptera, Drosophilidae) from Atlantic Forest of Southern Brazil. Zoolog Sci. 2015;32:141-50 pubmed publisher..In this work we discuss how the haplotypes found barriers to gene flow and dispersal, influenced by the biogeographic pattern of Atlantic Forest. ..
- ScialÃ² F, Sriram A, NaudÃ A, Ayala V, JovÃ© M, Pamplona R, et al. Target of rapamycin activation predicts lifespan in fruit flies. Cell Cycle. 2015;14:2949-58 pubmed publisher..Our results, dissociate metabolic rate and lifespan in wild type flies and instead link nutrient sensing signaling with longevity as predicted by the hyperfunction theory. ..
- Bratic A, Wredenberg A, Gronke S, Stewart J, Mourier A, Ruzzenente B, et al. The bicoid stability factor controls polyadenylation and expression of specific mitochondrial mRNAs in Drosophila melanogaster. PLoS Genet. 2011;7:e1002324 pubmed publisher..We thus report a novel function of BSF in flies and demonstrate that it has an important intra-mitochondrial role, which is essential for maintaining mtDNA gene expression and oxidative phosphorylation. ..
- Hill J, Chen Z, Xu H. Selective propagation of functional mitochondrial DNA during oogenesis restricts the transmission of a deleterious mitochondrial variant. Nat Genet. 2014;46:389-92 pubmed publisher..These findings establish a previously uncharacterized developmental mechanism for the selective amplification of wild-type mtDNA, which may be evolutionarily conserved to limit the transmission of deleterious mutations. ..
- Zhou L, Chen H. The genus Leucophenga (Diptera, Drosophilidae), part V: the mutabilis species group from East Asia, with morphological and molecular evidence. Zootaxa. 2015;4006:40-58 pubmed publisher..DNA sequences of the mitochondrial COI (cytochrome c oxidase subunit I) gene with BOLD process ID and GenBank accession numbers are provided for these species...
- Da Re C, Franzolin E, Biscontin A, Piazzesi A, Pacchioni B, Gagliani M, et al. Functional characterization of drim2, the Drosophila melanogaster homolog of the yeast mitochondrial deoxynucleotide transporter. J Biol Chem. 2014;289:7448-59 pubmed publisher..We conclude that the Drosophila mitochondrial carrier dRIM2 transports all DNA precursors and is essential to maintain mitochondrial function. ..
- Ding D, Lipshitz H. A molecular screen for polar-localised maternal RNAs in the early embryo of Drosophila. Zygote. 1993;1:257-71 pubmed