Gene Symbol: coil
Description: coilin
Alias: CG8710, Coilin, Dmel\CG8710, coilin, CG8710-PC, CG8710-PD, CG8710-PE, coil-PC, coil-PD, coil-PE, dcoilin
Species: fruit fly

Top Publications

  1. Beumer K, Trautman J, Bozas A, Liu J, Rutter J, Gall J, et al. Efficient gene targeting in Drosophila by direct embryo injection with zinc-finger nucleases. Proc Natl Acad Sci U S A. 2008;105:19821-6 pubmed publisher
    ..the application of the ZFN injection procedure to mutagenesis by NHEJ of 2 new genes in Drosophila melanogaster: coil and pask...
  2. Lee L, Davies S, Liu J. The spinal muscular atrophy protein SMN affects Drosophila germline nuclear organization through the U body-P body pathway. Dev Biol. 2009;332:142-55 pubmed publisher
    ..Taken together, our results suggest that SMN is required for the functional integrity of the U body-P body pathway, which in turn is important for maintaining proper nuclear architecture. ..
  3. Singer A, Gall J. An inducible nuclear body in the Drosophila germinal vesicle. Nucleus. 2011;2:403-9 pubmed publisher
    ..Induced bodies are formed in GVs of flies that are null for coilin or WDR79, proteins that are required for formation of Cajal bodies (CBs)...
  4. Lin S, Chang Y, Chan C. Strategies for gene disruption in Drosophila. Cell Biosci. 2014;4:63 pubmed publisher
    ..This review discuss important factors that should be taken into consideration for the selection of a strategy that best fits the specific needs of a gene knockout project. ..
  5. Nizami Z, Deryusheva S, Gall J. Cajal bodies and histone locus bodies in Drosophila and Xenopus. Cold Spring Harb Symp Quant Biol. 2010;75:313-20 pubmed publisher
    ..The Cajal body is typically identified by the presence of coilin, a protein of poorly defined function...
  6. Rajendra T, Praveen K, Matera A. Genetic analysis of nuclear bodies: from nondeterministic chaos to deterministic order. Cold Spring Harb Symp Quant Biol. 2010;75:365-74 pubmed publisher
  7. Syed M, Krudewig A, Engelen D, Stork T, Klämbt C. The CD59 family member Leaky/Coiled is required for the establishment of the blood-brain barrier in Drosophila. J Neurosci. 2011;31:7876-85 pubmed publisher
    ..Clonal rescue studies indicate that the presence of Coiled is required symmetrically on both cells engaged in septate junction formation. ..
  8. Ozawa N, Furuhashi H, Masuko K, Numao E, Makino T, Yano T, et al. Organ identity specification factor WGE localizes to the histone locus body and regulates histone expression to ensure genomic stability in Drosophila. Genes Cells. 2016;21:442-56 pubmed publisher
    ..We propose that WGE at HLB contributes to genomic stability and development by regulating heterochromatin structure via histone gene regulation. ..
  9. Kotova E, Jarnik M, Tulin A. Poly (ADP-ribose) polymerase 1 is required for protein localization to Cajal body. PLoS Genet. 2009;5:e1000387 pubmed publisher

More Information


  1. Daneshvar K, Khan A, Goodliffe J. Myc localizes to histone locus bodies during replication in Drosophila. PLoS ONE. 2011;6:e23928 pubmed publisher
    ..We investigated the identity of these puncta and demonstrate that Myc is co-localized with coilin, a marker for sub-nuclear organelles known as Cajal Bodies (CBs), in embryos, larvae and ovaries...
  2. Natalizio A, Matera A. Identification and characterization of Drosophila Snurportin reveals a role for the import receptor Moleskin/importin-7 in snRNP biogenesis. Mol Biol Cell. 2013;24:2932-42 pubmed publisher
    ..that msk-null mutants are depleted of the snRNP assembly factor, survival motor neuron, and the Cajal body marker, coilin. Consistent with a loss of snRNP import function, long-lived msk larvae show an accumulation of TMG cap signal in ..