Gene Symbol: Cog7
Alias: CG31040, CG7880, Dmel\CG31040, Cog7, CG31040-PA, Cog7-PA
Species: fruit fly
Belloni G, Sechi S, Riparbelli M, Fuller M, Callaini G, Giansanti M. Mutations in Cog7 affect Golgi structure, meiotic cytokinesis and sperm development during Drosophila spermatogenesis. J Cell Sci. 2012;125:5441-52 pubmed publisher
..Deletions in the human COG7 gene are associated with a rare multisystemic congenital disorder of glycosylation that causes mortality within the ..
Sechi S, Colotti G, Belloni G, Mattei V, Frappaolo A, Raffa G, et al
. GOLPH3 is essential for contractile ring formation and Rab11 localization to the cleavage site during cytokinesis in Drosophila melanogaster. PLoS Genet. 2014;10:e1004305 pubmed publisher
..Because cytokinesis failures have been associated with premalignant disease and cancer, our studies suggest novel insight into molecular circuits involving the oncogene GOLPH3 in cytokinesis. ..
Sechi S, Frappaolo A, Fraschini R, Capalbo L, Gottardo M, Belloni G, et al
. Rab1 interacts with GOLPH3 and controls Golgi structure and contractile ring constriction during cytokinesis in Drosophila melanogaster. Open Biol. 2017;7: pubmed publisher
..of Drosophila melanogaster We show that Rab1 protein colocalizes with the conserved oligomeric Golgi (COG) complex Cog7 subunit and the phosphatidylinositol 4-phosphate effector GOLPH3 at the Golgi stacks...
Ungar D, Oka T, Brittle E, Vasile E, Lupashin V, Chatterton J, et al
. Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. J Cell Biol. 2002;157:405-15 pubmed
..of yeast Sec34/35 complex subunits (Cog4, -6, and -8), and a previously unidentified Golgi-associated protein (Cog7). EM of ldlB and ldlC mutants established that COG is required for normal Golgi morphology...
Smith R, Lupashin V. Role of the conserved oligomeric Golgi (COG) complex in protein glycosylation. Carbohydr Res. 2008;343:2024-31 pubmed publisher
..A deletion of Lobe A COG subunits in yeasts causes severe growth defects while mutations in COG1, COG7, and COG8 in humans cause novel types of congenital disorders of glycosylation...
Sechi S, Frappaolo A, Belloni G, Giansanti M. The roles of the oncoprotein GOLPH3 in contractile ring assembly and membrane trafficking during cytokinesis. Biochem Soc Trans. 2015;43:117-21 pubmed publisher
..Because cytokinesis failures have been linked with pre-malignant disease and cancer, the novel connection between GOLPH3 and cytokinesis imposes new fields of investigation in cancer biology and therapy. ..