Gene Symbol: ClC-a
Description: Chloride channel-a
Alias: CG14726, CG31116, CG6942, CLC-2, Clc-a, DmClC-2, DmClC-a, DmClCa, Dmel\CG31116, FBgn0037951, chloride channel-a, CG31116-PA, CG31116-PC, CG31116-PD, CG31116-PF, CG31116-PG, CG31116-PH, CG31116-PI, ClC-a-PA, ClC-a-PC, ClC-a-PD, ClC-a-PF, ClC-a-PG, ClC-a-PH, ClC-a-PI
Species: fruit fly

Top Publications

  1. Dow J, Davies S. Integrative physiology and functional genomics of epithelial function in a genetic model organism. Physiol Rev. 2003;83:687-729 pubmed
    ..With the use of the beautiful genetic tools and extensive genomic resources characteristic of this genetic model, it has been possible to gain unique insights into the structure, function, and control of epithelia. ..
  2. Malko D, Makeev V, Mironov A, Gelfand M. Evolution of exon-intron structure and alternative splicing in fruit flies and malarial mosquito genomes. Genome Res. 2006;16:505-9 pubmed
  3. Rose U, Derst C, Wanischeck M, Marinc C, Walther C. Properties and possible function of a hyperpolarisation-activated chloride current in Drosophila. J Exp Biol. 2007;210:2489-500 pubmed
    ..DmClC-2 may serve general homeostatic mechanisms such as pH- and osmo-regulation or may support muscle function on high motor activity or during a particular neurohormonal state of the animal. ..
  4. Denholm B, Hu N, Fauquier T, Caubit X, Fasano L, Skaer H. The tiptop/teashirt genes regulate cell differentiation and renal physiology in Drosophila. Development. 2013;140:1100-10 pubmed publisher
    ..We demonstrate conservation in the expression of the family of tiptop/teashirt genes in lower insects and establish conservation in the targets of Teashirt transcription factors in mouse embryonic kidney. ..
  5. Cabrero P, Terhzaz S, Romero M, Davies S, Blumenthal E, Dow J. Chloride channels in stellate cells are essential for uniquely high secretion rates in neuropeptide-stimulated Drosophila diuresis. Proc Natl Acad Sci U S A. 2014;111:14301-6 pubmed publisher
    ..This key segregation of cation and anion transport could explain the extraordinary fluid transport rates displayed by some epithelia. ..
  6. Peterson S, Krasnow M. Subcellular trafficking of FGF controls tracheal invasion of Drosophila flight muscle. Cell. 2015;160:313-23 pubmed publisher
    ..We propose that tracheal invasion is controlled by an AP-1-dependent switch in FGF trafficking. Thus, subcellular targeting of a chemoattractant can direct outgrowth to specific domains, including inside the cell. ..