ck

Summary

Gene Symbol: ck
Description: crinkled
Alias: 53D10S, BG:DS00929.11, CG7595, DM7a, DMyoVIIa, Dm 35B, DmVIIA, DmVIIa, Dmel\CG7595, Dro35B, ESTS:53D10S, Mhc35BC, Myo7A, Myo7B, MyoVIIA, anon-35Bb, br27, ck/MyoVIIA, l(1)35Ca, l(2)07130, l(2)35Ca, l(2)br27, l35Ca, myoVIIA, stc, stch, CG7595 gene product from transcript CG7595-RB, CG7595-PA, CG7595-PB, CG7595-PC, CG7595-PD, ck-PA, ck-PB, ck-PC, ck-PD, lethal 27 in the black-reduced region, lethal group D2, myosin 7a, myosin 7a heavy chain, myosin VII, myosin VIIa, myosin heavy chain at 35BC, myosin-VII, mysoin VIIa, stubby chaetae, transcription unit D
Species: fruit fly

Top Publications

  1. ncbi Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton
    C G Winter
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Cell 105:81-91. 2001
  2. pmc Myosin VIIA, important for human auditory function, is necessary for Drosophila auditory organ development
    Sokol V Todi
    Neuroscience Graduate Program, The University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 3:e2115. 2008
  3. pmc Drosophila crinkled, mutations of which disrupt morphogenesis and cause lethality, encodes fly myosin VIIA
    Daniel P Kiehart
    Department of Biology, Duke University, Durham, North Carolina 27708 1000, USA
    Genetics 168:1337-52. 2004
  4. ncbi Roles of myosin phosphatase during Drosophila development
    Change Tan
    Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Development 130:671-81. 2003
  5. pmc Myosin VIIA defects, which underlie the Usher 1B syndrome in humans, lead to deafness in Drosophila
    Sokol V Todi
    Neuroscience Graduate Program, Department of Biological Sciences, The University of Iowa, Iowa City, Iowa 52242, USA
    Curr Biol 15:862-8. 2005
  6. pmc The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals
    Tongchao Li
    Program in Developmental Biology, Baylor College of Medicine, Houston, United States
    elife 5:. 2016
  7. pmc The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles
    Mariam H Orme
    Chester Beatty Laboratories, The Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, Mary Jean Mitchell Green Building, 237 Fulham Road, London SW3 6JB, UK
    Nat Commun 7:10972. 2016
  8. pmc The complex contributions of genetics and nutrition to immunity in Drosophila melanogaster
    Robert L Unckless
    Department of Entomology, Cornell University, Ithaca, New York, United States of America
    PLoS Genet 11:e1005030. 2015
  9. doi Myosin VIIA regulates microvillus morphogenesis and interacts with cadherin Cad99C in Drosophila oogenesis
    Cory Glowinski
    Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, ON, M5S 2M6, Canada
    J Cell Sci 127:4821-32. 2014
  10. doi DE-Cadherin regulates unconventional Myosin ID and Myosin IC in Drosophila left-right asymmetry establishment
    Astrid G Petzoldt
    Institute of Biology Valrose, University of Nice Sophia Antipolis, UMR7277 CNRS, UMR1091 INSERM, Parc Valrose, 06108 Nice Cedex 2, France
    Development 139:1874-84. 2012

Research Grants

Scientific Experts

  • AMY M BEJSOVEC
  • DANIEL KIEHART
  • U Muller
  • P N Adler
  • Kimberly Mace
  • Bela S Desai
  • Josef D Franke
  • Yi Yang
  • Sokol V Todi
  • Daniel F Eberl
  • Mariam H Orme
  • Tongchao Li
  • Shinya Watanabe
  • Dorothea Godt
  • Robert L Unckless
  • Cory Glowinski
  • Astrid G Petzoldt
  • Hugo J Bellen
  • Ainhoa Pérez-Garijo
  • Fabio Demontis
  • Nobuhisa Umeki
  • Biao He
  • James R Sellers
  • Reiko Ikebe
  • Mitsuo Ikebe
  • SeYeon Chung
  • Yaopan Mao
  • Hamed Jafar-Nejad
  • Elzo de Wit
  • Bas van Steensel
  • Frauke Greil
  • Gianmaria Liccardi
  • David Robertson
  • Celia Monteiro Domingues
  • Sonal Nagarkar Jaiswal
  • Alexander Wepf
  • Sidonie Wicky-John
  • Eli Arama
  • Pascal Meier
  • Andrew K Groves
  • Rebecca Feltham
  • Tencho Tenev
  • Matthias Gstaiger
  • Change Tan
  • Otto Morris
  • Ling V Sun
  • Andreas Bergmann
  • Rastislav Tamaskovic
  • Paulo S Ribeiro
  • Katiuscia Bianchi
  • Tiantian Cai
  • Nina Moderau
  • Rebecca Wilson
  • Meghana Tare
  • Nikolaos Giagtzoglou
  • David Williams
  • Lior Aram
  • Brian P Lazzaro
  • Susan M Rottschaefer
  • David R P Tree
  • Xiaoyin Fei
  • Audrey Darabie
  • Xi Chen
  • George Tzolovsky
  • Ri Hua Sandy Liu
  • Pauline Speder
  • Magali Suzanne
  • Charles Geminard
  • Delphine Cerezo
  • R M Marquez
  • C G Winter
  • Stéphane Noselli
  • J S Berg
  • Y Cai
  • Jean Baptiste Coutelis
  • R A Yamashita
  • Ruth A Montague
  • Hyun Suk Jung
  • Matthew L Walker
  • Gines Morata
  • Xiang Dong Li
  • Verl Siththanandan
  • Michael Chen
  • Michelle Peckham
  • Tsuyoshi Sakai
  • Christian Dahmann
  • Evgeny Shlevkov
  • Peter J Knight
  • Thomas G Baboolal
  • Roger Craig

Detail Information

Publications54

  1. ncbi Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton
    C G Winter
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Cell 105:81-91. 2001
    ..Drosophila myosin VIIA, the homolog of the human Usher Syndrome 1B gene, also functions in conjunction with this newly defined portion ..
  2. pmc Myosin VIIA, important for human auditory function, is necessary for Drosophila auditory organ development
    Sokol V Todi
    Neuroscience Graduate Program, The University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 3:e2115. 2008
    b>Myosin VIIA (MyoVIIA) is an unconventional myosin necessary for vertebrate audition [1]-[5]. Human auditory transduction occurs in sensory hair cells with a staircase-like arrangement of apical protrusions called stereocilia...
  3. pmc Drosophila crinkled, mutations of which disrupt morphogenesis and cause lethality, encodes fly myosin VIIA
    Daniel P Kiehart
    Department of Biology, Duke University, Durham, North Carolina 27708 1000, USA
    Genetics 168:1337-52. 2004
    ..We demonstrate that mutations in crinkled (ck) disrupt the Drosophila myosin VIIA heavy chain...
  4. ncbi Roles of myosin phosphatase during Drosophila development
    Change Tan
    Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Development 130:671-81. 2003
    ..Our results indicate that the regulation of the phosphorylation of myosin regulatory light chains, or dynamic activation and inactivation of myosin II, is essential for its various functions during many developmental processes...
  5. pmc Myosin VIIA defects, which underlie the Usher 1B syndrome in humans, lead to deafness in Drosophila
    Sokol V Todi
    Neuroscience Graduate Program, Department of Biological Sciences, The University of Iowa, Iowa City, Iowa 52242, USA
    Curr Biol 15:862-8. 2005
    ..Mutations in myosin VIIA (myoVIIA), an unconventional myosin, lead to deafness and balance anomalies in humans, mice, and zebrafish; ..
  6. pmc The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals
    Tongchao Li
    Program in Developmental Biology, Baylor College of Medicine, Houston, United States
    elife 5:. 2016
    ..The mono-ubiquitination of Myosin II promotes its physical interaction with Myosin VIIa, a protein responsible for Usher syndrome type IB...
  7. pmc The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles
    Mariam H Orme
    Chester Beatty Laboratories, The Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, Mary Jean Mitchell Green Building, 237 Fulham Road, London SW3 6JB, UK
    Nat Commun 7:10972. 2016
    ..Similarly, the mammalian CK counterpart, MYO7A, binds to and impinges on CASPASE-8, revealing a new regulatory axis affecting receptor interacting protein kinase-..
  8. pmc The complex contributions of genetics and nutrition to immunity in Drosophila melanogaster
    Robert L Unckless
    Department of Entomology, Cornell University, Ithaca, New York, United States of America
    PLoS Genet 11:e1005030. 2015
    ..Functional variation in these genes is segregating in a natural population, providing the substrate for evolutionary response to pathogen pressure in the context of nutritional environment. ..
  9. doi Myosin VIIA regulates microvillus morphogenesis and interacts with cadherin Cad99C in Drosophila oogenesis
    Cory Glowinski
    Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, ON, M5S 2M6, Canada
    J Cell Sci 127:4821-32. 2014
    ..the central F-actin bundle and the enveloping plasma membrane, we investigated the expression and function of Myosin VIIA (Myo7A), which is encoded by crinkled (ck), and its interaction with cadherin Cad99C in the microvilli of the ..
  10. doi DE-Cadherin regulates unconventional Myosin ID and Myosin IC in Drosophila left-right asymmetry establishment
    Astrid G Petzoldt
    Institute of Biology Valrose, University of Nice Sophia Antipolis, UMR7277 CNRS, UMR1091 INSERM, Parc Valrose, 06108 Nice Cedex 2, France
    Development 139:1874-84. 2012
    ....
  11. pmc crinkled reveals a new role for Wingless signaling in Drosophila denticle formation
    Amy Bejsovec
    Department of Biology, Duke University, Durham, NC 27708 0338, USA
    Development 139:690-8. 2012
    ..between the Wingless (Wg) signaling pathway and a nonmuscle myosin heavy chain, encoded by the crinkled (ck) locus in Drosophila...
  12. pmc Nonmuscle myosin II is required for cell proliferation, cell sheet adhesion and wing hair morphology during wing morphogenesis
    Josef D Franke
    Department of Biology, Duke University, Durham, NC 27708, USA
    Dev Biol 345:117-32. 2010
    ..interaction studies to show that nonmuscle myosin II and an unconventional myosin, encoded by crinkled (ck/MyoVIIA), act antagonistically in multiple processes necessary for wing development...
  13. pmc A FERM domain autoregulates Drosophila myosin 7a activity
    Yi Yang
    Laboratory of Molecular Physiology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:4189-94. 2009
    Full-length Drosophila myosin 7a (myosin 7a-FL) has a complex tail containing a short predicted coiled coil followed by a MyTH4-FERM domain, an SH3 domain, and a C-terminal MyTH4-FERM domain...
  14. pmc Genome-wide HP1 binding in Drosophila: developmental plasticity and genomic targeting signals
    Elzo de Wit
    Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Genome Res 15:1265-73. 2005
    ..These results provide insights into the mechanisms of HP1 targeting in the natural genomic context...
  15. ncbi Drosophila myosin VIIA is a high duty ratio motor with a unique kinetic mechanism
    Shinya Watanabe
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Biol Chem 281:7151-60. 2006
    Mutations of myosin VIIA cause deafness in various species from human and mice to Zebrafish and Drosophila...
  16. ncbi Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin
    Hamed Jafar-Nejad
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Development 133:1683-92. 2006
    ..Our data indicate that transcription factors other than bHLH proteins can also perform the proneural function in the Drosophila peripheral nervous system...
  17. pmc Dimerized Drosophila myosin VIIa: a processive motor
    Yi Yang
    Laboratory of Molecular Physiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1762, USA
    Proc Natl Acad Sci U S A 103:5746-51. 2006
    ..We studied the molecular mechanism of Drosophila myosin VIIa, using transient kinetics and single-molecule motility assays...
  18. ncbi Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila
    Yaopan Mao
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 133:2539-51. 2006
    ..Our results implicate Dachs as a crucial downstream component of a Fat signaling pathway that influences growth, affinity and gene expression during development...
  19. ncbi Native nonmuscle myosin II stability and light chain binding in Drosophila melanogaster
    Josef D Franke
    Department of Biology, Duke University, Durham, North Carolina 27708, USA
    Cell Motil Cytoskeleton 63:604-22. 2006
    ..We identify four myosins (myosin II, myosin V, myosin VI and myosin VIIA) and a microtubule-associated protein (asp/Abnormal spindle) as binding partners for the essential light chain (..
  20. pmc The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. III. Hypomorphic and hypermorphic mutations affecting the expression of hairless
    M Ashburner
    Genetics 101:447-59. 1982
    ..A simple model is proposed to account for the interaction of l(2)br7 and H, assuming that amorphic (or hypomorphic) alleles of l(2)br7 suppress H and that hypermorphic alleles enhance H...
  21. pmc The balance between the novel protein target of wingless and the Drosophila Rho-associated kinase pathway regulates planar cell polarity in the Drosophila wing
    SeYeon Chung
    School of Biological Sciences, Seoul National University, Seoul 151 742, Korea
    Genetics 176:891-903. 2007
    ..Genetic interaction and gain-of-function studies provide evidence that Tow acts downstream of Fz/Dsh and plays a role in restricting the number of hairs that wing cells form...
  22. ncbi Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates
    F Schweisguth
    Department of Biology, University of California, San Diego, La Jolla 92093 0322
    Cell 69:1199-212. 1992
    ..The Su(H) and J kappa RBP proteins are 82% identical over most of their length, and share with bacteriophage integrates and yeast recombinases a motif that includes residues directly involved in catalyzing recombination...
  23. doi The role of Dpp and Wg in compensatory proliferation and in the formation of hyperplastic overgrowths caused by apoptotic cells in the Drosophila wing disc
    Ainhoa Pérez-Garijo
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Madrid, Spain
    Development 136:1169-77. 2009
    ..In compartments containing undead cells, the adventitious Dpp/Wg signalling results in hyperplastic overgrowths...
  24. pmc The genetics of a small chromosome region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. IV: scutoid, an antimorphic mutation
    M Ashburner
    Genetics 102:401-20. 1982
    ..The Sco phenotype is thought to result from a position effect at the newly created noc/l(2)br28 junction...
  25. pmc Characterization of the Drosophila ortholog of the human Usher Syndrome type 1G protein sans
    Fabio Demontis
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    PLoS ONE 4:e4753. 2009
    ..USH1, the most severe subtype, is associated with mutations in genes encoding myosin VIIa, harmonin, cadherin 23, protocadherin 15, and sans...
  26. pmc F-actin-based extensions of the head cyst cell adhere to the maturing spermatids to maintain them in a tight bundle and prevent their premature release in Drosophila testis
    Bela S Desai
    Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai, India
    BMC Biol 7:19. 2009
    ..However, actual significance of this process and its underlying mechanism are unclear...
  27. pmc The tail binds to the head-neck domain, inhibiting ATPase activity of myosin VIIA
    Nobuhisa Umeki
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 106:8483-8. 2009
    b>Myosin VIIA is an unconventional myosin, responsible for human Usher syndrome type 1B, which causes hearing and visual loss. Here, we studied the molecular mechanism of regulation of myosin VIIA, which is currently unknown...
  28. ncbi The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development
    T Furukawa
    Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan
    Cell 69:1191-7. 1992
    ..The results also imply that the immunoglobulin recombination signal sequence and the target sequence of the Drosophila J kappa RBP protein might have a common evolutionary origin...
  29. pmc Genetic and cytogenetic analysis of the Adh region in Drosophila melanogaster
    J O'DONNELL
    Genetics 86:553-66. 1977
    ..If one includes three other loci known to belong there (el, Adh and Sco) a total of 16 complemetation groups have been identified in the region close to Adh...
  30. pmc The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. II. Lethal mutations in the region
    R C Woodruff
    Genetics 92:133-49. 1979
    ....
  31. pmc The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. I. Characterization of deficiencies and mapping of ADH and visible mutations
    R C Woodruff
    Genetics 92:117-32. 1979
    ..These deficiencies probably include two polytene chromosome bands, 35B2 and 35B3...
  32. ncbi Mechanisms that regulate mechanosensory hair cell differentiation
    U Muller
    Friedrich Miescher Institute, Maulbeerstr 66, CH 4058 Basel, Switzerland
    Trends Cell Biol 11:334-42. 2001
    ..The studies have also provided new insights into the function of receptors such as integrins and protocadherins, and cytoplasmic proteins such as Rho-type GTPases and unconventional myosins, in organizing the actin cytoskeleton...
  33. ncbi Myosin diversity and disease
    A F Wright
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    Trends Genet 12:206-9. 1996
  34. ncbi Expanded functions in the apical cell domain to regulate the growth rate of imaginal discs
    M J Boedigheimer
    Developmental Biological Center, University of California, Irvine 92697, USA
    Dev Genet 20:103-10. 1997
    ..Overexpressing Ex protein results in a decrease in final cell number in wings, suggesting a direct relationship between Ex function and proliferation rate...
  35. ncbi One-hundred and five new potential Drosophila melanogaster genes revealed through STS analysis
    C Louis
    Institute of Molecular Biology and Biotechnology, FORTH, Heraklion, Crete, Greece
    Gene 195:187-93. 1997
    ..The data reveal a substantial number of previously undescribed potential genes, amounting to 6.1% of the number of Drosophila genes already in the sequence databases...
  36. ncbi Distinct roles for the actin and microtubule cytoskeletons in the morphogenesis of epidermal hairs during wing development in Drosophila
    C M Turner
    Biology Department and Cancer Center, University of Virginia, Charlottesville 22903, USA
    Mech Dev 70:181-92. 1998
    ..This is a phenocopy of mutations in crinkled, and suggests mutations that cause branched hairs will be in genes that encode products that interact with the actin cytoskeleton...
  37. ncbi Requirement for the vasa RNA helicase in gurken mRNA localization
    R Tinker
    Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205 2185, USA
    Dev Biol 199:1-10. 1998
    ....
  38. ncbi Identification and analysis of the myosin superfamily in Drosophila: a database approach
    R A Yamashita
    Laboratory of Molecular Cardiology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    J Muscle Res Cell Motil 21:491-505. 2000
    ..In the future comparative genomics will hopefully lead to the placement of these myosins into new classes...
  39. pmc A family of snail-related zinc finger proteins regulates two distinct and parallel mechanisms that mediate Drosophila neuroblast asymmetric divisions
    Y Cai
    Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore
    EMBO J 20:1704-14. 2001
    ....
  40. pmc Transgenic analysis of the Smad family of TGF-beta signal transducers in Drosophila melanogaster suggests new roles and new interactions between family members
    R M Marquez
    Department of Biology, Arizona State University, Tempe, Arizona 85287, USA
    Genetics 157:1639-48. 2001
    ..Overall, the study demonstrates that transgenic methods in Drosophila can provide new information about non-Drosophila members of developmentally important multigene families...
  41. pmc A millennial myosin census
    J S Berg
    Department of Cell and Molecular Physiology, CB 7545, University of North Carolina at Chapel Hill, 27599, USA
    Mol Biol Cell 12:780-94. 2001
    ....
  42. ncbi The myosin superfamily in Drosophila melanogaster
    N S Morgan
    Department of Genetics, School of Medicine, Yale University, New Haven, Connecticut 06520, USA
    J Exp Zool 273:104-17. 1995
  43. ncbi Protein kinase A and hedgehog signaling in Drosophila limb development
    J Jiang
    Howard Hughes Medical Institute, Department of Genetics and Development Columbia University College of Physicians and Surgeons, New York, New York 10032
    Cell 80:563-72. 1995
    ..We propose that the basal activity of PKA imposes a block on the transcription of dpp and wg and that hh exerts its organizing influence by alleviating this block...
  44. ncbi Frizzled signaling and cell-cell interactions in planar polarity
    P N Adler
    Biology Department and Cancer Center, Gilmer Hall, University of Virginia, Charlottesville, Virginia 22903, USA
    Curr Opin Cell Biol 13:635-40. 2001
    ..This cortical mark leads to the local activation of downstream gene products and the subsequent activation of the cytoskeleton to form a hair...
  45. ncbi The genetic control of arista lateral morphogenesis in Drosophila
    Biao He
    Biology Department and Cancer Center, University of Virginia, Charlottesville, VA 22903, USA
    Dev Genes Evol 212:218-29. 2002
    ..We also found that mutations that lead to lateral splitting typically alter the stereotypic arrangement of actin filament bundles and microtubules in laterals...
  46. ncbi Identification and phylogenetic analysis of Drosophila melanogaster myosins
    George Tzolovsky
    Institute of Cell and Molecular Biology, University of Edinburgh
    Mol Biol Evol 19:1041-52. 2002
    ..The fifth myosin shows a unique domain composition and a low homology to any of the existing classes. We propose that this is classified when similar myosins are identified in other species...
  47. ncbi The growth of Drosophila bristles and laterals is not restricted to the tip or base
    Xiaoyin Fei
    Biology Department and Cancer Center, University of Virginia, Charlottesville, VA 22903, USA
    J Cell Sci 115:3797-806. 2002
    ..The bristle microtubules are less stable. The retrograde movement of the peripheral actin appears to be counterbalanced by the distally directed movement of cytoplasm in the center of the bristle...
  48. ncbi Neoplastic transformation and aberrant cell-cell interactions in genetic mosaics of lethal(2)giant larvae (lgl), a tumor suppressor gene of Drosophila
    N Agrawal
    Drosophila Stock Center, School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, India
    Dev Biol 172:218-29. 1995
    ..These observations suggest that neoplastic transformation of imaginal discs involves loss of their normal cell-cell interactions and signaling...
  49. ncbi NDR family of AGC kinases--essential regulators of the cell cycle and morphogenesis
    Rastislav Tamaskovic
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    FEBS Lett 546:73-80. 2003
    ..melanogaster and C. elegans. In mammalians, the LATS kinase is a tumor suppressor, negatively regulating the cyclin-dependent kinase CDK1, cell proliferation rate, and modulating cell survival...
  50. pmc Protein-DNA interaction mapping using genomic tiling path microarrays in Drosophila
    Ling V Sun
    Department of Genetics and Biostatistics Division, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 100:9428-33. 2003
    ....
  51. pmc The product of the split ends gene is required for the maintenance of positional information during Drosophila development
    Kimberly Mace
    Surgical Research Lab, University of California, San Francisco, Box 1302, San Francisco, CA 94143 1302, USA
    BMC Dev Biol 4:15. 2004
    ..Although spen mutants affect only a small subset of morphological structures in embryos, it has been difficult to find a common theme in spen mutant structural alterations, or in the interactions of spen with known signaling pathways...
  52. ncbi A three-tiered mechanism for regulation of planar cell polarity
    David R P Tree
    Department of Pathology, L235, Stanford University School of Medicine, Stanford, CA 94305, USA
    Semin Cell Dev Biol 13:217-24. 2002
    ..The third modules are tissue specific, acting to translate subcellular asymmetry into the appropriate morphological manifestations in the different cell types...
  53. ncbi The influence of large deletions on the mutation frequency induced by tritiated water and X-radiation in male Drosophila melanogaster post-meiotic germ cells
    N G Fossett
    Louisiana State University, Institute for Mutagenesis, Baton Rouge 70803 1725
    Mutat Res 307:213-22. 1994
    ....

Research Grants5

  1. GENETIC CONTROL OF CELL FATE DIVERSITY IN DROSOPHILA
    Amy Bejsovec; Fiscal Year: 2003
    ..This specificity may indicate a novel function in the Wg pathway. Aim 4 describes a plan for the molecular cloning of this new gene and for the subsequent characterization of its gene product. ..
  2. MOLECULAR GENETIC ANALYSIS OF WOUND HEALING--DROSOPHILA
    DANIEL KIEHART; Fiscal Year: 2002
    ..5 to 1 billion years of evolution that separate insects from mammals. Together, they promise to bring the powerful tools of Drosophila genetics and molecular genetics to bear on this important biological problem. ..
  3. GENETIC ANALYSIS OF PREHAIR MORPHOGENESIS
    Paul Adler; Fiscal Year: 2005
    ....
  4. Myosins VIIA, VIIB & XV in Fly Hearing and Morphogenesis
    DANIEL KIEHART; Fiscal Year: 2009
    ..approach to structure/function analysis of ck/myoVIIA, 28B/myoVIIB and 10A/myoXV (together, the myosin VII subfamily) in Drosophila where we use uniquely powerful molecular genetic tools to relate protein structure-..