Genomes and Genes
Gene Symbol: ck
Alias: 53D10S, BG:DS00929.11, CG7595, DM7a, DMyoVIIa, Dm 35B, DmVIIA, DmVIIa, Dmel\CG7595, Dro35B, ESTS:53D10S, Mhc35BC, Myo7A, Myo7B, MyoVIIA, anon-35Bb, br27, ck/MyoVIIA, l(1)35Ca, l(2)07130, l(2)35Ca, l(2)br27, l35Ca, myoVIIA, stc, stch, CG7595 gene product from transcript CG7595-RB, CG7595-PA, CG7595-PB, CG7595-PC, CG7595-PD, ck-PA, ck-PB, ck-PC, ck-PD, lethal 27 in the black-reduced region, lethal group D2, myosin 7a, myosin 7a heavy chain, myosin VII, myosin VIIa, myosin heavy chain at 35BC, myosin-VII, mysoin VIIa, stubby chaetae, transcription unit D
Species: fruit fly
- Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeletonC G Winter
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Cell 105:81-91. 2001..Drosophila myosin VIIA, the homolog of the human Usher Syndrome 1B gene, also functions in conjunction with this newly defined portion ..
- Myosin VIIA, important for human auditory function, is necessary for Drosophila auditory organ developmentSokol V Todi
Neuroscience Graduate Program, The University of Iowa, Iowa City, Iowa, United States of America
PLoS ONE 3:e2115. 2008b>Myosin VIIA (MyoVIIA) is an unconventional myosin necessary for vertebrate audition -. Human auditory transduction occurs in sensory hair cells with a staircase-like arrangement of apical protrusions called stereocilia...
- Drosophila crinkled, mutations of which disrupt morphogenesis and cause lethality, encodes fly myosin VIIADaniel P Kiehart
Department of Biology, Duke University, Durham, North Carolina 27708 1000, USA
Genetics 168:1337-52. 2004..We demonstrate that mutations in crinkled (ck) disrupt the Drosophila myosin VIIA heavy chain...
- Roles of myosin phosphatase during Drosophila developmentChange Tan
Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Development 130:671-81. 2003..Our results indicate that the regulation of the phosphorylation of myosin regulatory light chains, or dynamic activation and inactivation of myosin II, is essential for its various functions during many developmental processes...
- Myosin VIIA defects, which underlie the Usher 1B syndrome in humans, lead to deafness in DrosophilaSokol V Todi
Neuroscience Graduate Program, Department of Biological Sciences, The University of Iowa, Iowa City, Iowa 52242, USA
Curr Biol 15:862-8. 2005..Mutations in myosin VIIA (myoVIIA), an unconventional myosin, lead to deafness and balance anomalies in humans, mice, and zebrafish; ..
- The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammalsTongchao Li
Program in Developmental Biology, Baylor College of Medicine, Houston, United States
elife 5:. 2016..The mono-ubiquitination of Myosin II promotes its physical interaction with Myosin VIIa, a protein responsible for Usher syndrome type IB...
- The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling rolesMariam H Orme
Chester Beatty Laboratories, The Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, Mary Jean Mitchell Green Building, 237 Fulham Road, London SW3 6JB, UK
Nat Commun 7:10972. 2016..Similarly, the mammalian CK counterpart, MYO7A, binds to and impinges on CASPASE-8, revealing a new regulatory axis affecting receptor interacting protein kinase-..
- The complex contributions of genetics and nutrition to immunity in Drosophila melanogasterRobert L Unckless
Department of Entomology, Cornell University, Ithaca, New York, United States of America
PLoS Genet 11:e1005030. 2015..Functional variation in these genes is segregating in a natural population, providing the substrate for evolutionary response to pathogen pressure in the context of nutritional environment. ..
- Myosin VIIA regulates microvillus morphogenesis and interacts with cadherin Cad99C in Drosophila oogenesisCory Glowinski
Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, ON, M5S 2M6, Canada
J Cell Sci 127:4821-32. 2014..the central F-actin bundle and the enveloping plasma membrane, we investigated the expression and function of Myosin VIIA (Myo7A), which is encoded by crinkled (ck), and its interaction with cadherin Cad99C in the microvilli of the ..
- DE-Cadherin regulates unconventional Myosin ID and Myosin IC in Drosophila left-right asymmetry establishmentAstrid G Petzoldt
Institute of Biology Valrose, University of Nice Sophia Antipolis, UMR7277 CNRS, UMR1091 INSERM, Parc Valrose, 06108 Nice Cedex 2, France
Development 139:1874-84. 2012....
- crinkled reveals a new role for Wingless signaling in Drosophila denticle formationAmy Bejsovec
Department of Biology, Duke University, Durham, NC 27708 0338, USA
Development 139:690-8. 2012..between the Wingless (Wg) signaling pathway and a nonmuscle myosin heavy chain, encoded by the crinkled (ck) locus in Drosophila...
- Nonmuscle myosin II is required for cell proliferation, cell sheet adhesion and wing hair morphology during wing morphogenesisJosef D Franke
Department of Biology, Duke University, Durham, NC 27708, USA
Dev Biol 345:117-32. 2010..interaction studies to show that nonmuscle myosin II and an unconventional myosin, encoded by crinkled (ck/MyoVIIA), act antagonistically in multiple processes necessary for wing development...
- A FERM domain autoregulates Drosophila myosin 7a activityYi Yang
Laboratory of Molecular Physiology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 106:4189-94. 2009Full-length Drosophila myosin 7a (myosin 7a-FL) has a complex tail containing a short predicted coiled coil followed by a MyTH4-FERM domain, an SH3 domain, and a C-terminal MyTH4-FERM domain...
- Genome-wide HP1 binding in Drosophila: developmental plasticity and genomic targeting signalsElzo de Wit
Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
Genome Res 15:1265-73. 2005..These results provide insights into the mechanisms of HP1 targeting in the natural genomic context...
- Drosophila myosin VIIA is a high duty ratio motor with a unique kinetic mechanismShinya Watanabe
Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
J Biol Chem 281:7151-60. 2006Mutations of myosin VIIA cause deafness in various species from human and mice to Zebrafish and Drosophila...
- Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing marginHamed Jafar-Nejad
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Development 133:1683-92. 2006..Our data indicate that transcription factors other than bHLH proteins can also perform the proneural function in the Drosophila peripheral nervous system...
- Dimerized Drosophila myosin VIIa: a processive motorYi Yang
Laboratory of Molecular Physiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1762, USA
Proc Natl Acad Sci U S A 103:5746-51. 2006..We studied the molecular mechanism of Drosophila myosin VIIa, using transient kinetics and single-molecule motility assays...
- Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in DrosophilaYaopan Mao
Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
Development 133:2539-51. 2006..Our results implicate Dachs as a crucial downstream component of a Fat signaling pathway that influences growth, affinity and gene expression during development...
- Native nonmuscle myosin II stability and light chain binding in Drosophila melanogasterJosef D Franke
Department of Biology, Duke University, Durham, North Carolina 27708, USA
Cell Motil Cytoskeleton 63:604-22. 2006..We identify four myosins (myosin II, myosin V, myosin VI and myosin VIIA) and a microtubule-associated protein (asp/Abnormal spindle) as binding partners for the essential light chain (..
- The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. III. Hypomorphic and hypermorphic mutations affecting the expression of hairlessM Ashburner
Genetics 101:447-59. 1982..A simple model is proposed to account for the interaction of l(2)br7 and H, assuming that amorphic (or hypomorphic) alleles of l(2)br7 suppress H and that hypermorphic alleles enhance H...
- The balance between the novel protein target of wingless and the Drosophila Rho-associated kinase pathway regulates planar cell polarity in the Drosophila wingSeYeon Chung
School of Biological Sciences, Seoul National University, Seoul 151 742, Korea
Genetics 176:891-903. 2007..Genetic interaction and gain-of-function studies provide evidence that Tow acts downstream of Fz/Dsh and plays a role in restricting the number of hairs that wing cells form...
- Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fatesF Schweisguth
Department of Biology, University of California, San Diego, La Jolla 92093 0322
Cell 69:1199-212. 1992..The Su(H) and J kappa RBP proteins are 82% identical over most of their length, and share with bacteriophage integrates and yeast recombinases a motif that includes residues directly involved in catalyzing recombination...
- The role of Dpp and Wg in compensatory proliferation and in the formation of hyperplastic overgrowths caused by apoptotic cells in the Drosophila wing discAinhoa Pérez-Garijo
Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Madrid, Spain
Development 136:1169-77. 2009..In compartments containing undead cells, the adventitious Dpp/Wg signalling results in hyperplastic overgrowths...
- The genetics of a small chromosome region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. IV: scutoid, an antimorphic mutationM Ashburner
Genetics 102:401-20. 1982..The Sco phenotype is thought to result from a position effect at the newly created noc/l(2)br28 junction...
- Characterization of the Drosophila ortholog of the human Usher Syndrome type 1G protein sansFabio Demontis
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
PLoS ONE 4:e4753. 2009..USH1, the most severe subtype, is associated with mutations in genes encoding myosin VIIa, harmonin, cadherin 23, protocadherin 15, and sans...
- F-actin-based extensions of the head cyst cell adhere to the maturing spermatids to maintain them in a tight bundle and prevent their premature release in Drosophila testisBela S Desai
Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai, India
BMC Biol 7:19. 2009..However, actual significance of this process and its underlying mechanism are unclear...
- The tail binds to the head-neck domain, inhibiting ATPase activity of myosin VIIANobuhisa Umeki
Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
Proc Natl Acad Sci U S A 106:8483-8. 2009b>Myosin VIIA is an unconventional myosin, responsible for human Usher syndrome type 1B, which causes hearing and visual loss. Here, we studied the molecular mechanism of regulation of myosin VIIA, which is currently unknown...
- The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system developmentT Furukawa
Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan
Cell 69:1191-7. 1992..The results also imply that the immunoglobulin recombination signal sequence and the target sequence of the Drosophila J kappa RBP protein might have a common evolutionary origin...
- Genetic and cytogenetic analysis of the Adh region in Drosophila melanogasterJ O'DONNELL
Genetics 86:553-66. 1977..If one includes three other loci known to belong there (el, Adh and Sco) a total of 16 complemetation groups have been identified in the region close to Adh...
- The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. II. Lethal mutations in the regionR C Woodruff
Genetics 92:133-49. 1979....
- The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. I. Characterization of deficiencies and mapping of ADH and visible mutationsR C Woodruff
Genetics 92:117-32. 1979..These deficiencies probably include two polytene chromosome bands, 35B2 and 35B3...
- Mechanisms that regulate mechanosensory hair cell differentiationU Muller
Friedrich Miescher Institute, Maulbeerstr 66, CH 4058 Basel, Switzerland
Trends Cell Biol 11:334-42. 2001..The studies have also provided new insights into the function of receptors such as integrins and protocadherins, and cytoplasmic proteins such as Rho-type GTPases and unconventional myosins, in organizing the actin cytoskeleton...
- Myosin diversity and diseaseA F Wright
MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
Trends Genet 12:206-9. 1996
- Expanded functions in the apical cell domain to regulate the growth rate of imaginal discsM J Boedigheimer
Developmental Biological Center, University of California, Irvine 92697, USA
Dev Genet 20:103-10. 1997..Overexpressing Ex protein results in a decrease in final cell number in wings, suggesting a direct relationship between Ex function and proliferation rate...
- One-hundred and five new potential Drosophila melanogaster genes revealed through STS analysisC Louis
Institute of Molecular Biology and Biotechnology, FORTH, Heraklion, Crete, Greece
Gene 195:187-93. 1997..The data reveal a substantial number of previously undescribed potential genes, amounting to 6.1% of the number of Drosophila genes already in the sequence databases...
- Distinct roles for the actin and microtubule cytoskeletons in the morphogenesis of epidermal hairs during wing development in DrosophilaC M Turner
Biology Department and Cancer Center, University of Virginia, Charlottesville 22903, USA
Mech Dev 70:181-92. 1998..This is a phenocopy of mutations in crinkled, and suggests mutations that cause branched hairs will be in genes that encode products that interact with the actin cytoskeleton...
- Requirement for the vasa RNA helicase in gurken mRNA localizationR Tinker
Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205 2185, USA
Dev Biol 199:1-10. 1998....
- Identification and analysis of the myosin superfamily in Drosophila: a database approachR A Yamashita
Laboratory of Molecular Cardiology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
J Muscle Res Cell Motil 21:491-505. 2000..In the future comparative genomics will hopefully lead to the placement of these myosins into new classes...
- A family of snail-related zinc finger proteins regulates two distinct and parallel mechanisms that mediate Drosophila neuroblast asymmetric divisionsY Cai
Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore
EMBO J 20:1704-14. 2001....
- Transgenic analysis of the Smad family of TGF-beta signal transducers in Drosophila melanogaster suggests new roles and new interactions between family membersR M Marquez
Department of Biology, Arizona State University, Tempe, Arizona 85287, USA
Genetics 157:1639-48. 2001..Overall, the study demonstrates that transgenic methods in Drosophila can provide new information about non-Drosophila members of developmentally important multigene families...
- A millennial myosin censusJ S Berg
Department of Cell and Molecular Physiology, CB 7545, University of North Carolina at Chapel Hill, 27599, USA
Mol Biol Cell 12:780-94. 2001....
- The myosin superfamily in Drosophila melanogasterN S Morgan
Department of Genetics, School of Medicine, Yale University, New Haven, Connecticut 06520, USA
J Exp Zool 273:104-17. 1995
- Protein kinase A and hedgehog signaling in Drosophila limb developmentJ Jiang
Howard Hughes Medical Institute, Department of Genetics and Development Columbia University College of Physicians and Surgeons, New York, New York 10032
Cell 80:563-72. 1995..We propose that the basal activity of PKA imposes a block on the transcription of dpp and wg and that hh exerts its organizing influence by alleviating this block...
- Frizzled signaling and cell-cell interactions in planar polarityP N Adler
Biology Department and Cancer Center, Gilmer Hall, University of Virginia, Charlottesville, Virginia 22903, USA
Curr Opin Cell Biol 13:635-40. 2001..This cortical mark leads to the local activation of downstream gene products and the subsequent activation of the cytoskeleton to form a hair...
- The genetic control of arista lateral morphogenesis in DrosophilaBiao He
Biology Department and Cancer Center, University of Virginia, Charlottesville, VA 22903, USA
Dev Genes Evol 212:218-29. 2002..We also found that mutations that lead to lateral splitting typically alter the stereotypic arrangement of actin filament bundles and microtubules in laterals...
- Identification and phylogenetic analysis of Drosophila melanogaster myosinsGeorge Tzolovsky
Institute of Cell and Molecular Biology, University of Edinburgh
Mol Biol Evol 19:1041-52. 2002..The fifth myosin shows a unique domain composition and a low homology to any of the existing classes. We propose that this is classified when similar myosins are identified in other species...
- The growth of Drosophila bristles and laterals is not restricted to the tip or baseXiaoyin Fei
Biology Department and Cancer Center, University of Virginia, Charlottesville, VA 22903, USA
J Cell Sci 115:3797-806. 2002..The bristle microtubules are less stable. The retrograde movement of the peripheral actin appears to be counterbalanced by the distally directed movement of cytoplasm in the center of the bristle...
- Neoplastic transformation and aberrant cell-cell interactions in genetic mosaics of lethal(2)giant larvae (lgl), a tumor suppressor gene of DrosophilaN Agrawal
Drosophila Stock Center, School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, India
Dev Biol 172:218-29. 1995..These observations suggest that neoplastic transformation of imaginal discs involves loss of their normal cell-cell interactions and signaling...
- NDR family of AGC kinases--essential regulators of the cell cycle and morphogenesisRastislav Tamaskovic
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
FEBS Lett 546:73-80. 2003..melanogaster and C. elegans. In mammalians, the LATS kinase is a tumor suppressor, negatively regulating the cyclin-dependent kinase CDK1, cell proliferation rate, and modulating cell survival...
- Protein-DNA interaction mapping using genomic tiling path microarrays in DrosophilaLing V Sun
Department of Genetics and Biostatistics Division, Yale University School of Medicine, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 100:9428-33. 2003....
- The product of the split ends gene is required for the maintenance of positional information during Drosophila developmentKimberly Mace
Surgical Research Lab, University of California, San Francisco, Box 1302, San Francisco, CA 94143 1302, USA
BMC Dev Biol 4:15. 2004..Although spen mutants affect only a small subset of morphological structures in embryos, it has been difficult to find a common theme in spen mutant structural alterations, or in the interactions of spen with known signaling pathways...
- A three-tiered mechanism for regulation of planar cell polarityDavid R P Tree
Department of Pathology, L235, Stanford University School of Medicine, Stanford, CA 94305, USA
Semin Cell Dev Biol 13:217-24. 2002..The third modules are tissue specific, acting to translate subcellular asymmetry into the appropriate morphological manifestations in the different cell types...
- The influence of large deletions on the mutation frequency induced by tritiated water and X-radiation in male Drosophila melanogaster post-meiotic germ cellsN G Fossett
Louisiana State University, Institute for Mutagenesis, Baton Rouge 70803 1725
Mutat Res 307:213-22. 1994....
- GENETIC CONTROL OF CELL FATE DIVERSITY IN DROSOPHILAAmy Bejsovec; Fiscal Year: 2003..This specificity may indicate a novel function in the Wg pathway. Aim 4 describes a plan for the molecular cloning of this new gene and for the subsequent characterization of its gene product. ..
- MOLECULAR GENETIC ANALYSIS OF WOUND HEALING--DROSOPHILADANIEL KIEHART; Fiscal Year: 2002..5 to 1 billion years of evolution that separate insects from mammals. Together, they promise to bring the powerful tools of Drosophila genetics and molecular genetics to bear on this important biological problem. ..
- GENETIC ANALYSIS OF PREHAIR MORPHOGENESISPaul Adler; Fiscal Year: 2005....
- Myosins VIIA, VIIB & XV in Fly Hearing and MorphogenesisDANIEL KIEHART; Fiscal Year: 2009..approach to structure/function analysis of ck/myoVIIA, 28B/myoVIIB and 10A/myoXV (together, the myosin VII subfamily) in Drosophila where we use uniquely powerful molecular genetic tools to relate protein structure-..