Gene Symbol: Cirl
Description: Calcium-independent receptor for alpha-latrotoxin
Alias: BcDNA:GH07331, CG8639, CIRL, Dmel\CG8639, anon-WO0170980.7, anon-WO0170980.8, dCirl, dcirl, Calcium-independent receptor for alpha-latrotoxin, CG8639-PB, CG8639-PE, CG8639-PF, CG8639-PG, CG8639-PH, CG8639-PI, CG8639-PJ, CG8639-PK, Cirl-PB, Cirl-PE, Cirl-PF, Cirl-PG, Cirl-PH, Cirl-PI, Cirl-PJ, Cirl-PK, latrophilin
Species: fruit fly

Top Publications

  1. van der Voet M, Harich B, Franke B, Schenck A. ADHD-associated dopamine transporter, latrophilin and neurofibromin share a dopamine-related locomotor signature in Drosophila. Mol Psychiatry. 2016;21:565-73 pubmed publisher shared by pan-neuronal knockdown of orthologs of the ADHD-associated genes Dopamine transporter (DAT1) and Latrophilin (LPHN3), and of a gene causing a monogenic disorder with frequent ADHD comorbidity: Neurofibromin (NF1)...
  2. Scholz N, Guan C, Nieberler M, Grotemeyer A, Maiellaro I, Gao S, et al. Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons. elife. 2017;6: pubmed publisher
    ..Here we show that the Drosophila aGPCR Latrophilin/dCIRL acts in mechanosensory neurons by modulating ionotropic receptor currents, the initiating step of ..
  3. Harmar A. Family-B G-protein-coupled receptors. Genome Biol. 2001;2:REVIEWS3013 pubmed
    ..In this article, I describe the structures and functions of family-B GPCRs and propose a simplified nomenclature for these proteins. ..
  4. Li C, Chen M, Sang M, Liu X, Wu W, Li B. Comparative genomic analysis and evolution of family-B G protein-coupled receptors from six model insect species. Gene. 2013;519:1-12 pubmed publisher
    ..On the other hand, this study provides us with multiple function of GPCR-Bs in differential organisms, which will be also the potential attacking targets for new pesticides and drugs. ..
  5. Scholz N, Gehring J, Guan C, Ljaschenko D, Fischer R, Lakshmanan V, et al. The adhesion GPCR latrophilin/CIRL shapes mechanosensation. Cell Rep. 2015;11:866-874 pubmed publisher
    ..Our study characterizes the Drosophila aGPCR Latrophilin/dCirl, a prototype member of this enigmatic receptor class...
  6. Langenhan T, Barr M, Bruchas M, Ewer J, Griffith L, Maiellaro I, et al. Model Organisms in G Protein-Coupled Receptor Research. Mol Pharmacol. 2015;88:596-603 pubmed publisher
    ..Furthermore, we selectively highlight experimental advantages, shortcomings, and tools of each model organism. ..