Gene Symbol: Cirl
Description: Calcium-independent receptor for alpha-latrotoxin
Alias: BcDNA:GH07331, CG8639, CIRL, Dmel\CG8639, anon-WO0170980.7, anon-WO0170980.8, dCirl, dcirl, Calcium-independent receptor for alpha-latrotoxin, CG8639-PB, CG8639-PE, CG8639-PF, CG8639-PG, CG8639-PH, CG8639-PI, CG8639-PJ, CG8639-PK, Cirl-PB, Cirl-PE, Cirl-PF, Cirl-PG, Cirl-PH, Cirl-PI, Cirl-PJ, Cirl-PK, latrophilin
Species: fruit fly
van der Voet M, Harich B, Franke B, Schenck A. ADHD-associated dopamine transporter, latrophilin and neurofibromin share a dopamine-related locomotor signature in Drosophila. Mol Psychiatry. 2016;21:565-73 pubmed publisher
..is shared by pan-neuronal knockdown of orthologs of the ADHD-associated genes Dopamine transporter (DAT1) and Latrophilin (LPHN3), and of a gene causing a monogenic disorder with frequent ADHD comorbidity: Neurofibromin (NF1)...
Scholz N, Guan C, Nieberler M, Grotemeyer A, Maiellaro I, Gao S, et al
. Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons. elife. 2017;6: pubmed publisher
..Here we show that the Drosophila aGPCR Latrophilin/dCIRL acts in mechanosensory neurons by modulating ionotropic receptor currents, the initiating step of ..
Harmar A. Family-B G-protein-coupled receptors. Genome Biol. 2001;2:REVIEWS3013 pubmed
..In this article, I describe the structures and functions of family-B GPCRs and propose a simplified nomenclature for these proteins. ..
Li C, Chen M, Sang M, Liu X, Wu W, Li B. Comparative genomic analysis and evolution of family-B G protein-coupled receptors from six model insect species. Gene. 2013;519:1-12 pubmed publisher
..On the other hand, this study provides us with multiple function of GPCR-Bs in differential organisms, which will be also the potential attacking targets for new pesticides and drugs. ..
Scholz N, Gehring J, Guan C, Ljaschenko D, Fischer R, Lakshmanan V, et al
. The adhesion GPCR latrophilin/CIRL shapes mechanosensation. Cell Rep. 2015;11:866-874 pubmed publisher
..Our study characterizes the Drosophila aGPCR Latrophilin/dCirl, a prototype member of this enigmatic receptor class...
Langenhan T, Barr M, Bruchas M, Ewer J, Griffith L, Maiellaro I, et al
. Model Organisms in G Protein-Coupled Receptor Research. Mol Pharmacol. 2015;88:596-603 pubmed publisher
..Furthermore, we selectively highlight experimental advantages, shortcomings, and tools of each model organism. ..